BRPI0411268C8 - Processo para a preparação de compostos 3-aril butil-amina substituído - Google Patents

Processo para a preparação de compostos 3-aril butil-amina substituído

Info

Publication number
BRPI0411268C8
BRPI0411268C8 BRPI0411268A BRPI0411268A BRPI0411268C8 BR PI0411268 C8 BRPI0411268 C8 BR PI0411268C8 BR PI0411268 A BRPI0411268 A BR PI0411268A BR PI0411268 A BRPI0411268 A BR PI0411268A BR PI0411268 C8 BRPI0411268 C8 BR PI0411268C8
Authority
BR
Brazil
Prior art keywords
substituted
preparation
amine compounds
butyl amine
aryl
Prior art date
Application number
BRPI0411268A
Other languages
English (en)
Inventor
Bernhard Akteries
Detlef Heller
Hans-Joachim Drexler
Hartmut LÖBERMANN
Heinrich Buschmann Helmut
Jörg Holenz
Markus Kegel
Stefan Gladow
Wolfgang Hell
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33494923&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0411268(C8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of BRPI0411268A publication Critical patent/BRPI0411268A/pt
Publication of BRPI0411268B1 publication Critical patent/BRPI0411268B1/pt
Publication of BRPI0411268B8 publication Critical patent/BRPI0411268B8/pt
Publication of BRPI0411268C1 publication Critical patent/BRPI0411268C1/pt
Publication of BRPI0411268C8 publication Critical patent/BRPI0411268C8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/70—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by reduction of unsaturated amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
    • C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C07C215/62—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

processo para a preparação de um composto 3-aril butil-amina substituído, a presente invenção se relaciona a um processo por desidratação de compostos 1-amino-3-aril-butan-3-ol substituído para a preparação de compostos 3-aril butil-amina substituído.
BRPI0411268A 2003-06-06 2004-06-04 Processo para a preparação de compostos 3-aril butil-amina substituído BRPI0411268C8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10326097A DE10326097A1 (de) 2003-06-06 2003-06-06 Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen
DE10326097.8 2003-06-06
PCT/EP2004/006027 WO2004108658A1 (de) 2003-06-06 2004-06-04 Verfahren zur herstellung substituierter 3-aryl-butyl-aminverbindungen

Publications (5)

Publication Number Publication Date
BRPI0411268A BRPI0411268A (pt) 2006-08-01
BRPI0411268B1 BRPI0411268B1 (pt) 2020-11-03
BRPI0411268B8 BRPI0411268B8 (pt) 2021-01-19
BRPI0411268C1 BRPI0411268C1 (pt) 2021-05-25
BRPI0411268C8 true BRPI0411268C8 (pt) 2021-11-16

Family

ID=33494923

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411268A BRPI0411268C8 (pt) 2003-06-06 2004-06-04 Processo para a preparação de compostos 3-aril butil-amina substituído

Country Status (25)

Country Link
US (1) US7417170B2 (pt)
EP (1) EP1633697B1 (pt)
JP (1) JP4848268B2 (pt)
KR (1) KR101146205B1 (pt)
CN (1) CN1829681B (pt)
AT (1) ATE425136T1 (pt)
AU (1) AU2004245223C1 (pt)
BR (1) BRPI0411268C8 (pt)
CA (1) CA2528087C (pt)
CY (1) CY1109088T1 (pt)
DE (2) DE10326097A1 (pt)
DK (1) DK1633697T3 (pt)
EC (1) ECSP056218A (pt)
ES (1) ES2323870T3 (pt)
HR (1) HRP20090333T1 (pt)
IL (1) IL172357A (pt)
MX (1) MXPA05013193A (pt)
NO (1) NO335587B1 (pt)
NZ (1) NZ544231A (pt)
PL (1) PL1633697T3 (pt)
PT (1) PT1633697E (pt)
RU (1) RU2380355C2 (pt)
SI (1) SI1633697T1 (pt)
WO (1) WO2004108658A1 (pt)
ZA (1) ZA200600109B (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10328316A1 (de) 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE102005052588A1 (de) * 2005-11-02 2007-05-10 Grünenthal GmbH Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse
TWI496762B (zh) 2006-07-24 2015-08-21 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
TWI401237B (zh) 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
ATE455752T1 (de) 2006-07-24 2010-02-15 Janssen Pharmaceutica Nv Herstellung von (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpent namin
ES2764451T3 (es) * 2007-12-07 2020-06-03 Gruenenthal Gmbh Modificaciones cristalinas del (1R,2R)-3-(3-dimetilamino-1-etil-2-metilpropil)fenol
WO2010100477A2 (en) * 2009-03-03 2010-09-10 Shire Llc Amino acid and peptide carbamate prodrugs of tapentadol and uses thereof
CN102002065B (zh) * 2009-09-02 2014-09-10 上海特化医药科技有限公司 他喷他多的制备方法及其中间体
US8288592B2 (en) 2009-09-22 2012-10-16 Actavis Group Ptc Ehf Solid state forms of tapentadol salts
IT1397189B1 (it) * 2009-12-01 2013-01-04 Archimica Srl Nuovo processo per la preparazione di tapentadol e suoi intermedi.
AU2010337825A1 (en) 2009-12-29 2012-07-05 Mapi Pharma Limited Intermediate compounds and processes for the preparation of tapentadol and related compounds
WO2011092719A2 (en) * 2010-02-01 2011-08-04 Ind-Swift Laboratories Limited Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives
US20130096346A1 (en) 2010-03-05 2013-04-18 Actavis Group Ptc Ehf Resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol
AU2011241897A1 (en) 2010-04-05 2012-09-27 Actavis Group Ptc Ehf Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof
ITMI20100924A1 (it) * 2010-05-21 2011-11-22 Fidia Farmaceutici Nuovo metodo di sintesi delle due forme enantiomeriche del tapentadol
WO2011157390A2 (en) 2010-06-15 2011-12-22 Grünenthal GmbH Process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
IT1401109B1 (it) 2010-07-02 2013-07-12 Archimica Srl Nuovo processo per la preparazione di tapentadol e suoi intermedi.
EP2595971A1 (en) * 2010-07-23 2013-05-29 Grünenthal GmbH Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
EP2606030B1 (en) 2010-08-16 2016-05-18 Indoco Remedies Limited Process for the preparation of tapentadol
WO2012038974A1 (en) * 2010-09-20 2012-03-29 Ind-Swift Laboratories Limited Process for preparing l-phenyl-3-dimethylaminopropane derivative
CN102477016B (zh) * 2010-11-26 2014-12-17 中国医学科学院药物研究所 他喷他多的中间体的合成与应用
CZ2010997A3 (cs) * 2010-12-30 2012-02-08 Zentiva, K.S. Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu)
CZ302993B6 (cs) * 2010-12-30 2012-02-08 Zentiva, K.S. Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu)
WO2012089181A1 (en) * 2010-12-30 2012-07-05 Zentiva, K.S. O-substituted (2r,3r)-3-(3-hydroxyphenyl)-2-methyl-4-pentenoic acids and a method of obtaining the same
WO2012146978A2 (en) 2011-04-28 2012-11-01 Actavis Group Ptc Ehf A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
WO2013016840A1 (zh) 2011-07-29 2013-02-07 安徽省新星药物开发有限责任公司 用于合成他喷他多或其类似物的新中间体
WO2013105109A1 (en) 2011-11-09 2013-07-18 Indoco Remedies Limited Process for the preparation of tapentadol
US20130150622A1 (en) 2011-12-12 2013-06-13 Boehringer Ingelheim International Gmbh Stereoselective synthesis of tapentadol and its salts
WO2013120466A1 (en) 2012-02-17 2013-08-22 Zentiva, K.S. A new solid form of tapentadol and a method of its preparation
EP2674414A1 (en) 2012-06-15 2013-12-18 Siegfried AG Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds
CN103159633B (zh) * 2012-07-06 2015-08-12 江苏恩华药业股份有限公司 他喷他多的制备方法及用于制备他喷他多的化合物
IN2013MU03670A (pt) 2013-11-21 2015-07-31 Unimark Remedies Ltd
SI3083551T1 (en) 2013-12-16 2018-04-30 Farma Grs, D.O.O. CRYSTAL FORM INTERMEDIATE TAPENTADOL
CZ307492B6 (cs) 2014-02-04 2018-10-17 Zentiva, K.S. Pevná forma maleátu tapentadolu a způsob její přípravy
HUE068166T2 (hu) 2015-07-10 2024-12-28 SpecGx LLC Kétlépéses eljárás 3-szubsztituált fenil-alkilaminok elõállítására
EP4269384A1 (en) 2022-04-26 2023-11-01 KRKA, d.d., Novo mesto Method for crystallizing tapentadol intermediate, tapentadol intermediate of high purity, method of making tapentadol and tapentadol of high purity

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DE10000311A1 (de) * 2000-01-05 2001-07-12 Gruenenthal Gmbh Aminomethyl-Phonyl-Cyclohexanonderivate

Also Published As

Publication number Publication date
BRPI0411268A (pt) 2006-08-01
BRPI0411268B8 (pt) 2021-01-19
ES2323870T3 (es) 2009-07-27
ECSP056218A (es) 2006-04-19
IL172357A (en) 2014-09-30
BRPI0411268B1 (pt) 2020-11-03
DE502004009142D1 (de) 2009-04-23
US7417170B2 (en) 2008-08-26
IL172357A0 (en) 2009-02-11
KR20060036923A (ko) 2006-05-02
EP1633697A1 (de) 2006-03-15
WO2004108658A1 (de) 2004-12-16
KR101146205B1 (ko) 2012-05-25
ATE425136T1 (de) 2009-03-15
DK1633697T3 (da) 2009-06-02
JP4848268B2 (ja) 2011-12-28
AU2004245223C1 (en) 2010-06-10
BRPI0411268C1 (pt) 2021-05-25
RU2005141518A (ru) 2007-07-20
ZA200600109B (en) 2007-01-31
HK1088597A1 (zh) 2006-11-10
EP1633697B1 (de) 2009-03-11
PT1633697E (pt) 2009-06-04
PL1633697T3 (pl) 2009-08-31
DE10326097A1 (de) 2005-01-05
JP2006527178A (ja) 2006-11-30
CN1829681B (zh) 2013-02-06
AU2004245223A1 (en) 2004-12-16
US20060194988A1 (en) 2006-08-31
RU2380355C2 (ru) 2010-01-27
NZ544231A (en) 2009-06-26
CN1829681A (zh) 2006-09-06
NO335587B1 (no) 2015-01-05
CA2528087C (en) 2012-05-01
CA2528087A1 (en) 2004-12-16
SI1633697T1 (sl) 2009-08-31
MXPA05013193A (es) 2006-03-09
CY1109088T1 (el) 2014-07-02
AU2004245223B2 (en) 2010-01-28
NO20060044L (no) 2006-01-04
HRP20090333T1 (hr) 2009-07-31

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