CL2007001911A1 - Uso de un componente neurotoxico de un complejo de toxina de clostridium botulinum, en donde la composicion carece de cualquier otro componente proteico del complejo para tratar una afeccion asociada con la inervacion colinergica muscular hiperactiva - Google Patents
Uso de un componente neurotoxico de un complejo de toxina de clostridium botulinum, en donde la composicion carece de cualquier otro componente proteico del complejo para tratar una afeccion asociada con la inervacion colinergica muscular hiperactivaInfo
- Publication number
- CL2007001911A1 CL2007001911A1 CL200701911A CL2007001911A CL2007001911A1 CL 2007001911 A1 CL2007001911 A1 CL 2007001911A1 CL 200701911 A CL200701911 A CL 200701911A CL 2007001911 A CL2007001911 A CL 2007001911A CL 2007001911 A1 CL2007001911 A1 CL 2007001911A1
- Authority
- CL
- Chile
- Prior art keywords
- complex
- component
- hypercular
- inervation
- affection
- Prior art date
Links
- 108030001720 Bontoxilysin Proteins 0.000 title 1
- 241000193155 Clostridium botulinum Species 0.000 title 1
- 229940053031 botulinum toxin Drugs 0.000 title 1
- 230000003387 muscular Effects 0.000 title 1
- 231100000189 neurotoxic Toxicity 0.000 title 1
- 230000002887 neurotoxic effect Effects 0.000 title 1
- 235000004252 protein component Nutrition 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81775606P | 2006-06-29 | 2006-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2007001911A1 true CL2007001911A1 (es) | 2008-03-14 |
Family
ID=38462381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200701911A CL2007001911A1 (es) | 2006-06-29 | 2007-06-28 | Uso de un componente neurotoxico de un complejo de toxina de clostridium botulinum, en donde la composicion carece de cualquier otro componente proteico del complejo para tratar una afeccion asociada con la inervacion colinergica muscular hiperactiva |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US8557255B2 (es) |
| EP (2) | EP2484373A1 (es) |
| JP (2) | JP5897784B2 (es) |
| KR (3) | KR20090027732A (es) |
| CN (1) | CN101460190A (es) |
| AR (1) | AR061669A1 (es) |
| AU (1) | AU2007264008B2 (es) |
| BR (1) | BRPI0713061A2 (es) |
| CA (1) | CA2654214C (es) |
| CL (1) | CL2007001911A1 (es) |
| IL (1) | IL195201A (es) |
| MX (1) | MX2009000253A (es) |
| RU (1) | RU2453333C2 (es) |
| TW (1) | TWI519310B (es) |
| UY (1) | UY30450A1 (es) |
| WO (1) | WO2008000490A1 (es) |
| ZA (1) | ZA200808491B (es) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10792344B2 (en) * | 2006-06-29 | 2020-10-06 | Merz Pharma Gmbh & Co. Kgaa | High frequency application of botulinum toxin therapy |
| AR061669A1 (es) * | 2006-06-29 | 2008-09-10 | Merz Pharma Gmbh & Co Kgaa | Aplicacion de alta frecuencia de terapia con toxina botulinica |
| EP1985276A1 (en) * | 2007-04-26 | 2008-10-29 | Merz Pharma GmbH & Co. KGaA | Treatment of movement disorders by a combined use of a chemodenervating agent and automated movement therapy |
| RU2009149604A (ru) * | 2007-06-01 | 2011-07-20 | Мерц Фарма Гмбх Унд Ко. Кгаа (De) | Способ предоставления устойчивого к температуре миорелаксанта на основе нейротоксичного компонента ботулинического токсина в твердой форме |
| US7473429B1 (en) * | 2007-07-27 | 2009-01-06 | Renfroe J Ben | Method for treatment of laminitis in animals |
| US8455459B2 (en) * | 2007-08-02 | 2013-06-04 | Medicis Pharmaceutical Corporation | Method of applying an injectable filler |
| US20090204101A1 (en) * | 2007-08-20 | 2009-08-13 | Wortzman Mitchell S | Method of applying an injectable filler |
| US9161970B2 (en) | 2007-12-12 | 2015-10-20 | Allergan, Inc. | Dermal filler |
| US9044477B2 (en) * | 2007-12-12 | 2015-06-02 | Allergan, Inc. | Botulinum toxin formulation |
| EP2072057A1 (en) | 2007-12-21 | 2009-06-24 | Merz Pharma GmbH & Co.KGaA | Early administration of Botulinum toxin in the treatment of cerebrovascular event and spinal cord injury |
| EP2072039A1 (en) * | 2007-12-21 | 2009-06-24 | Merz Pharma GmbH & Co.KGaA | Use of a neurotoxic component of Clostridium botulinum toxin complex to reduce or prevent side effects |
| US20110033431A1 (en) * | 2008-03-31 | 2011-02-10 | The Chemo-Sero-Therapeutic Research Institute | Type a2 botulinum toxin preparation |
| KR20110060903A (ko) | 2008-08-29 | 2011-06-08 | 메르츠 파마 게엠베하 운트 코. 카가아 | 지속성이 변경된 클로스트리듐 신경독 |
| EP2161033B1 (en) | 2008-09-09 | 2013-05-01 | Susanne Dr. Grafe | Botulinum toxin to introduce temporal infertiliy in a vertebrate (e.g. human) |
| EP2248518B1 (en) * | 2009-04-17 | 2013-01-16 | Merz Pharma GmbH & Co. KGaA | Formulation for stabilizing proteins, peptides or mixtures thereof. |
| EP2246065A1 (en) | 2009-04-29 | 2010-11-03 | Merz Pharma GmbH & Co. KGaA | Intrastriatal botulinum toxin therapy |
| WO2011023213A1 (en) * | 2009-08-28 | 2011-03-03 | Merz Pharma Gmbh & Co. Kgaa | Modified chemodenervating agents |
| SI2490986T1 (sl) * | 2009-10-21 | 2018-12-31 | Revance Therapeutics, Inc. | Metode in sistemi za prečiščenje nekompleksiranega nevrotoksina botulina |
| KR101134146B1 (ko) | 2010-05-31 | 2012-04-19 | 메덱스젠 주식회사 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
| EP2399601A1 (en) | 2010-06-24 | 2011-12-28 | Merz Pharma GmbH & Co. KGaA | Botulinum toxin therapy |
| WO2012048854A2 (en) | 2010-10-12 | 2012-04-19 | Merz Pharma Gmbh & Co. Kgaa | Formulation suitable for stabilizing proteins, which is free of mammalian excipients |
| RU2454170C1 (ru) * | 2011-02-21 | 2012-06-27 | Федеральное государственное учреждение "Нижегородский научно-исследовательский институт травматологии и ортопедии" Министерства здравоохранения и социального развития Российской Федерации | Способ лечения спастичности мышц у больных с позвоночно-спинномозговой травмой |
| MX370929B (es) | 2012-10-28 | 2020-01-08 | Revance Therapeutics Inc | Composiciones y usos de las mismas para el tratamiento seguro de la rinitis. |
| RU2535115C1 (ru) | 2013-05-15 | 2014-12-10 | Бости Трейдинг Лтд | Фармацевтический состав, содержащий нейротоксин ботулина |
| HK1225744A1 (zh) * | 2013-07-30 | 2017-09-15 | Merz Pharma Gmbh & Co. Kgaa | 制备高纯度的肉毒杆菌毒素神经毒性组分的方法及其应用 |
| WO2015039206A1 (en) * | 2013-09-20 | 2015-03-26 | Mddt Inc. | Diagnosing and treating movement disorders |
| JP6498678B2 (ja) | 2013-09-20 | 2019-04-10 | エムディディティ・インコーポレイテッドMddt Inc. | 運動障害の診断および処置 |
| WO2015188942A1 (en) * | 2014-06-13 | 2015-12-17 | Merz Pharma Gmbh & Co. Kgaa | Novel uses of recombinant clostridial neurotoxins with decreased duration of effect |
| US20170112907A1 (en) * | 2014-06-13 | 2017-04-27 | Merz Pharma Gmbh & Co. Kgaa | Novel uses of recombinant clostridial neurotoxins with decreased duration of effect |
| US11484580B2 (en) | 2014-07-18 | 2022-11-01 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
| EP3285800B1 (en) * | 2015-04-24 | 2019-09-18 | Consiglio Nazionale Delle Ricerche | A new therapeutic use of the botulinum neurotoxin serotype a |
| WO2018146550A1 (en) * | 2017-02-10 | 2018-08-16 | De Maio Domingos Mauricio | Methods and systems for preventing, correcting, transforming, and modifying facial, aesthetics, and consulting patients regarding the same |
| KR20210130711A (ko) * | 2019-02-21 | 2021-11-01 | 메르츠 파마 게엠베하 운트 코. 카가아 | 진전의 치료를 위한 보툴리눔 신경독의 신규 용도 |
| RU2721300C2 (ru) * | 2019-10-17 | 2020-05-18 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ лечения нейрогенной дисфункции мочевого пузыря, проявляющейся функциональной инфравезикальной обструкцией у женщин |
| US10987411B1 (en) | 2019-10-18 | 2021-04-27 | Penland Foundation | Treatment of chronic obstructive pulmonary disease using botulinum toxin |
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| US11241479B2 (en) | 2019-10-18 | 2022-02-08 | Penland Foundation | Treatment methods using botulinum toxins |
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| US10960060B1 (en) | 2019-10-18 | 2021-03-30 | Penland Foundation | Treatment of cardiac arrhythmia using botulinum toxin |
| WO2021231666A1 (en) | 2020-05-15 | 2021-11-18 | Penland Foundation | Treatment of asthma using botulinum toxin |
| WO2021137667A1 (ko) * | 2019-12-30 | 2021-07-08 | 주식회사 에이티지씨 | 보툴리눔 신경독소를 포함하는 파킨슨병 치료용 조성물 및 이를 이용한 파킨슨병 치료 방법 |
| WO2023287728A1 (en) | 2021-07-12 | 2023-01-19 | Penland Foundation | Treatment of diabetes and chronic pancreatitis using botulinum toxin |
| USD1108809S1 (en) * | 2023-08-21 | 2026-01-13 | Taizhou Info Plastic Mould Co., Ltd. | Storage box |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3888977A (en) * | 1973-02-01 | 1975-06-10 | Murray J Sanders | Modified neurotoxin |
| US4932936A (en) * | 1988-01-29 | 1990-06-12 | Regents Of The University Of Minnesota | Method and device for pharmacological control of spasticity |
| US5919665A (en) * | 1989-10-31 | 1999-07-06 | Ophidian Pharmaceuticals, Inc. | Vaccine for clostridium botulinum neurotoxin |
| GB9120306D0 (en) * | 1991-09-24 | 1991-11-06 | Graham Herbert K | Method and compositions for the treatment of cerebral palsy |
| US5562907A (en) * | 1993-05-14 | 1996-10-08 | Arnon; Stephen S. | Method to prevent side-effects and insensitivity to the therapeutic uses of toxins |
| DE122009000066I2 (de) * | 1993-06-10 | 2010-12-30 | Allergan Inc | Behandlung von neuromuskulären Störungen und Zuständen mit verschiedenen botulinen Serotypen |
| US7037680B2 (en) * | 1993-09-21 | 2006-05-02 | The United States Of America As Represented By The Secretary Of The Army | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy |
| DE69428813T2 (de) * | 1993-12-28 | 2002-04-04 | Allergan Sales Inc | Verwendung von Botulinustoxin zur Behandlung von Spannungs-Kopfschmerz |
| US8557256B2 (en) * | 1993-12-28 | 2013-10-15 | Allergan, Inc. | Treatment for cervical dystonia with the neurotoxic component of a botulinum toxin |
| US8187612B2 (en) * | 1993-12-28 | 2012-05-29 | Allergan, Inc. | Use of the neurotoxic component of a botulinum toxin for treating a spastic muscle |
| US6974578B1 (en) * | 1993-12-28 | 2005-12-13 | Allergan, Inc. | Method for treating secretions and glands using botulinum toxin |
| US5670484A (en) * | 1994-05-09 | 1997-09-23 | Binder; William J. | Method for treatment of skin lesions associated with cutaneous cell-proliferative disorders |
| KR100544060B1 (ko) * | 1997-07-15 | 2006-01-23 | 더 리젠트스 오브 더 유니버시티 오브 콜로라도 | 비뇨기과학 및 관련 부전증을 치료하기 위한 신경독요법의 용도 |
| WO2000001777A1 (en) * | 1998-07-07 | 2000-01-13 | Sun Chemical Corporation | Low voc cationic curable lithographic printing inks |
| TW574036B (en) * | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
| DE69943220D1 (de) | 1998-09-11 | 2011-04-07 | Gr Intellectual Reserve Llc | Verfahren und system für biometrische erkennung basiert auf elektrischen und/oder magnetischen eigenschaften |
| DE19856897A1 (de) * | 1998-12-10 | 2000-06-15 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum zur Unterdrückung von Schnarchgeräuschen |
| DE19925739A1 (de) * | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
| US6348434B1 (en) * | 1999-07-01 | 2002-02-19 | Basf Aktiengesellschaft | Herbicidal emulsifiable concentrate |
| US20030180289A1 (en) * | 1999-09-23 | 2003-09-25 | Foster Keith Alan | Inhibition of secretion from non-neuronal cells |
| JP2003512603A (ja) | 1999-10-05 | 2003-04-02 | テクノロジィ ファイナンス コーポレイション(プロプライエタリー) リミテッド | 回転軸におけるトルクによるねじれの測定 |
| US6113915A (en) | 1999-10-12 | 2000-09-05 | Allergan Sales, Inc. | Methods for treating pain |
| AU770851B2 (en) | 1999-10-14 | 2004-03-04 | Mine Safety Appliances Company | Lanyard with integral fall arrest energy absorber |
| US6306423B1 (en) * | 2000-06-02 | 2001-10-23 | Allergan Sales, Inc. | Neurotoxin implant |
| US20030219462A1 (en) * | 2000-07-21 | 2003-11-27 | Allergan Sales, Inc | Clostridial neurotoxin compositions and modified clostridial neurotoxins |
| DE10043982A1 (de) * | 2000-09-05 | 2002-03-14 | Armin Maurer | Verfahren zur Verbesserung des Haarwuchses menschlichen Kopfhaares |
| US20020086036A1 (en) * | 2000-12-05 | 2002-07-04 | Allergan Sales, Inc. | Methods for treating hyperhidrosis |
| DK1411978T3 (da) * | 2001-07-27 | 2009-01-05 | Univ Louisiana State | Botulinum-toksin ved behandlingen eller forebyggelsen af acne |
| US7115399B2 (en) * | 2001-07-31 | 2006-10-03 | Allergan, Inc. | Pinna reflex assay |
| US20050106183A1 (en) * | 2002-01-31 | 2005-05-19 | Lamb Gregory B. | Method of treating pain |
| US7022329B2 (en) * | 2002-02-25 | 2006-04-04 | Allergan, Inc. | Method for treating neurogenic inflammation pain with botulinum toxin and substance P components |
| US7140371B2 (en) * | 2002-03-14 | 2006-11-28 | Allergan, Inc. | Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins |
| US7300412B2 (en) * | 2002-05-10 | 2007-11-27 | Hospital For Joint Diseases | Methods for therapeutic treatment of carpal tunnel syndrome |
| US7691394B2 (en) * | 2002-05-28 | 2010-04-06 | Botulinum Toxin Research Associates, Inc. | High-potency botulinum toxin formulations |
| US20030224020A1 (en) * | 2002-05-31 | 2003-12-04 | Zabudkin Alexander F. | Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use |
| US6776991B2 (en) * | 2002-06-26 | 2004-08-17 | Allergan, Inc. | Methods for treating priapism |
| US20040009180A1 (en) * | 2002-07-11 | 2004-01-15 | Allergan, Inc. | Transdermal botulinum toxin compositions |
| JPWO2004016783A1 (ja) | 2002-08-06 | 2006-01-19 | 株式会社ジェノックス創薬研究所 | アトピー性皮膚炎の検査方法 |
| EP2272340B1 (en) * | 2002-08-19 | 2018-03-14 | Ira Sanders | Botulinum toxin |
| US7824693B2 (en) * | 2002-08-19 | 2010-11-02 | Ira Sanders | Treatment of fine wrinkles with clostridia neurotoxins |
| US20040115222A1 (en) * | 2002-09-06 | 2004-06-17 | Michael Kane | Method for reduction of wrinkles |
| EP1398907B1 (de) * | 2002-09-10 | 2010-12-08 | Siemens Aktiengesellschaft | Verfahren zur Kontrolle von Übertragungsressourcen eines paketorientierten Kommunikationsnetzes bei Topologieänderungen |
| US7422753B2 (en) * | 2003-04-25 | 2008-09-09 | Allergan, Inc. | Methods for treating trichotillomania |
| US6838434B2 (en) | 2003-05-02 | 2005-01-04 | Allergan, Inc. | Methods for treating sinus headache |
| US20050042775A1 (en) * | 2003-08-21 | 2005-02-24 | Nicholas Pomato | Botulinum antitoxin compositions and methods |
| US7148041B2 (en) | 2003-09-25 | 2006-12-12 | Allergan, Inc. | Animal product free media and processes for obtaining a botulinum toxin |
| US20050144029A1 (en) * | 2003-12-31 | 2005-06-30 | Rakowski Richard R. | Systems and methods for aesthetic improvement |
| ES2338017T3 (es) * | 2004-01-05 | 2010-05-03 | Botulinum Toxin Research Associates, Inc. | Metodos de utilizacion de la toxina botulinica para el tratamiento de la deformacion de los labios hipervolemica (ectropion de los labios). |
| US9078892B2 (en) * | 2004-02-26 | 2015-07-14 | Allergan, Inc. | Methods for treating pain and for treating a medication overuse disorder |
| US7691381B2 (en) * | 2004-04-15 | 2010-04-06 | Allergan, Inc. | Stabilized biodegradable neurotoxin implants |
| EP2266599B1 (en) * | 2004-07-26 | 2014-04-16 | Merz Pharma GmbH & Co. KGaA | Therapeutic composition with a botulinum neurotoxin |
| US20060057165A1 (en) * | 2004-09-10 | 2006-03-16 | Dimitrios Dimitrakoudis | Clostridium botulinum toxin formulation and method for reducing weight |
| AU2005288758A1 (en) * | 2004-09-27 | 2006-04-06 | Merz Pharma Gmbh & Co. Kgaa | Clostridial neurotoxins for use in tissue healing |
| US20060073208A1 (en) * | 2004-10-01 | 2006-04-06 | Allergan, Inc. | Cosmetic neurotoxin compositions and methods |
| GB0426394D0 (en) * | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
| AU2005311086B2 (en) * | 2004-12-01 | 2012-03-29 | Allergan, Inc. | Fusion proteins |
| FR2879462B1 (fr) * | 2004-12-21 | 2008-12-26 | Sod Conseils Rech Applic | Utilisation de toxine botulique pour une insensibilisation locale prolongee |
| US20080220021A1 (en) * | 2005-02-14 | 2008-09-11 | Pankaj Modi | Topical Botulinum Toxin Compositions for the Treatment of Hyperhidrosis |
| US20090232849A1 (en) * | 2005-03-03 | 2009-09-17 | Universite Catholique De Louvain | Methods and compositions for the treatment of cancer |
| US20060269574A1 (en) * | 2005-05-31 | 2006-11-30 | De Beer Johann F | Method of repairing tendons by surgery |
| US8105611B2 (en) * | 2005-06-17 | 2012-01-31 | Allergan, Inc. | Treatment of autoimmune disorder with a neurotoxin |
| US20070128226A1 (en) * | 2005-12-01 | 2007-06-07 | Philip Radovic | Methods of treating pain associated with abnormalities of the first metatarsophalangeal joint of the foot |
| US7824694B2 (en) * | 2006-01-12 | 2010-11-02 | Allergan, Inc. | Methods for enhancing therapeutic effects of a neurotoxin |
| US8658391B2 (en) * | 2006-04-27 | 2014-02-25 | Anterios, Inc. | Assessment of the effects of topical administration of chemodenervating pharmaceuticals |
| AR061669A1 (es) * | 2006-06-29 | 2008-09-10 | Merz Pharma Gmbh & Co Kgaa | Aplicacion de alta frecuencia de terapia con toxina botulinica |
| EP1985276A1 (en) * | 2007-04-26 | 2008-10-29 | Merz Pharma GmbH & Co. KGaA | Treatment of movement disorders by a combined use of a chemodenervating agent and automated movement therapy |
| RU2009149604A (ru) * | 2007-06-01 | 2011-07-20 | Мерц Фарма Гмбх Унд Ко. Кгаа (De) | Способ предоставления устойчивого к температуре миорелаксанта на основе нейротоксичного компонента ботулинического токсина в твердой форме |
| US8586081B2 (en) * | 2007-09-20 | 2013-11-19 | University Of Massachusetts | Detoxified recombinant botulinum neurotoxin |
| US9038912B2 (en) * | 2007-12-18 | 2015-05-26 | Microsoft Technology Licensing, Llc | Trade card services |
| KR20110060903A (ko) * | 2008-08-29 | 2011-06-08 | 메르츠 파마 게엠베하 운트 코. 카가아 | 지속성이 변경된 클로스트리듐 신경독 |
| CA2751311C (en) * | 2009-02-19 | 2019-08-06 | Merz Pharma Gmbh & Co. Kgaa | Means and methods for manufacturing highly pure neurotoxin |
| BRPI1014253A2 (pt) * | 2009-07-02 | 2016-04-12 | Merz Pharma Gmbh & Co Kgaa | polinucleotídeo codificado um polipeptídeo de neurotoxina, vetor, célula hospedeira, anticorpo, uso de um polinucleotídeo, método para a fabricação de um polipeptídeo de neurotoxina e método para a fabricação de um medicamento |
| US9310386B2 (en) * | 2010-01-22 | 2016-04-12 | Merz Pharma Gmbh & Co. Kgaa | In vitro assay for quantifying clostridial neurotoxin activity |
| EP2776454A1 (en) * | 2011-11-09 | 2014-09-17 | Merz Pharma GmbH & Co. KGaA | Modified neurotoxins with poly-glycine and uses thereof |
| HK1225744A1 (zh) * | 2013-07-30 | 2017-09-15 | Merz Pharma Gmbh & Co. Kgaa | 制备高纯度的肉毒杆菌毒素神经毒性组分的方法及其应用 |
-
2007
- 2007-06-27 AR ARP070102861A patent/AR061669A1/es unknown
- 2007-06-28 KR KR1020097001114A patent/KR20090027732A/ko not_active Ceased
- 2007-06-28 KR KR1020157031398A patent/KR20150126979A/ko not_active Ceased
- 2007-06-28 MX MX2009000253A patent/MX2009000253A/es active IP Right Grant
- 2007-06-28 KR KR1020147032748A patent/KR20140142377A/ko not_active Ceased
- 2007-06-28 CA CA2654214A patent/CA2654214C/en active Active
- 2007-06-28 BR BRPI0713061-9A patent/BRPI0713061A2/pt not_active IP Right Cessation
- 2007-06-28 AU AU2007264008A patent/AU2007264008B2/en active Active
- 2007-06-28 JP JP2009517002A patent/JP5897784B2/ja active Active
- 2007-06-28 EP EP12001562A patent/EP2484373A1/en not_active Withdrawn
- 2007-06-28 RU RU2009102848/15A patent/RU2453333C2/ru active
- 2007-06-28 CL CL200701911A patent/CL2007001911A1/es unknown
- 2007-06-28 TW TW096123534A patent/TWI519310B/zh active
- 2007-06-28 UY UY30450A patent/UY30450A1/es not_active Application Discontinuation
- 2007-06-28 WO PCT/EP2007/005754 patent/WO2008000490A1/en not_active Ceased
- 2007-06-28 CN CNA2007800206820A patent/CN101460190A/zh active Pending
- 2007-06-28 EP EP07764931A patent/EP2032157A1/en not_active Ceased
- 2007-06-29 US US11/824,393 patent/US8557255B2/en active Active
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2008
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2013
- 2013-09-13 US US14/026,289 patent/US9095523B2/en active Active
- 2013-09-27 JP JP2013201656A patent/JP2014015476A/ja not_active Withdrawn
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2015
- 2015-06-25 US US14/749,834 patent/US9572871B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007264008A1 (en) | 2008-01-03 |
| US20080003241A1 (en) | 2008-01-03 |
| AR061669A1 (es) | 2008-09-10 |
| US20150290303A1 (en) | 2015-10-15 |
| WO2008000490A1 (en) | 2008-01-03 |
| UY30450A1 (es) | 2009-04-30 |
| IL195201A (en) | 2015-11-30 |
| TWI519310B (zh) | 2016-02-01 |
| JP5897784B2 (ja) | 2016-03-30 |
| AU2007264008B2 (en) | 2012-06-28 |
| US8557255B2 (en) | 2013-10-15 |
| KR20090027732A (ko) | 2009-03-17 |
| JP2014015476A (ja) | 2014-01-30 |
| US20140010803A1 (en) | 2014-01-09 |
| RU2453333C2 (ru) | 2012-06-20 |
| CN101460190A (zh) | 2009-06-17 |
| KR20150126979A (ko) | 2015-11-13 |
| EP2032157A1 (en) | 2009-03-11 |
| RU2009102848A (ru) | 2010-08-10 |
| JP2009541396A (ja) | 2009-11-26 |
| CA2654214A1 (en) | 2008-01-03 |
| IL195201A0 (en) | 2009-08-03 |
| TW200819140A (en) | 2008-05-01 |
| MX2009000253A (es) | 2009-01-22 |
| ZA200808491B (en) | 2009-11-25 |
| US9095523B2 (en) | 2015-08-04 |
| BRPI0713061A2 (pt) | 2012-04-10 |
| EP2484373A1 (en) | 2012-08-08 |
| US9572871B2 (en) | 2017-02-21 |
| KR20140142377A (ko) | 2014-12-11 |
| CA2654214C (en) | 2023-07-04 |
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