CL2007002519A1 - Compuestos derivados de aminopiridina, inhibidores selectivo sobre aurora a; composicion farmaceutica que comprende a dichos compuestos; combinacion farmaceutica que comprende a dichos compuestos, utiles para inhibir el crecimiento de celulas tumoral - Google Patents

Compuestos derivados de aminopiridina, inhibidores selectivo sobre aurora a; composicion farmaceutica que comprende a dichos compuestos; combinacion farmaceutica que comprende a dichos compuestos, utiles para inhibir el crecimiento de celulas tumoral

Info

Publication number: CL2007002519A1
Authority: CL; Chile
Prior art keywords: compounds; aminopiridine; aurora; inhibit; growth
Prior art date: 2006-08-31

Application number

CL200702519A

Other languages

English (en)

Spanish (es)

Inventor

Yoshikazu Iwasawa

Tetsuya Kato

Nobuhiko Kawanishi

Kouta Masutani

Takashi Mita

Katsumasa Nonoshita

Mitsuru Ohkubo

Original Assignee

Banyu Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-08-31

Filing date

2007-08-29

Publication date

2008-02-08

2007-08-29 Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd

2008-02-08 Publication of CL2007002519A1 publication Critical patent/CL2007002519A1/es

Links

150000001875 compounds Chemical class 0.000 title 3
229940124639 Selective inhibitor Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
210000004881 tumor cell Anatomy 0.000 title 1
230000004614 tumor growth Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C07D241/22—Benzenesulfonamido pyrazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Oncology (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

CL200702519A 2006-08-31 2007-08-29 Compuestos derivados de aminopiridina, inhibidores selectivo sobre aurora a; composicion farmaceutica que comprende a dichos compuestos; combinacion farmaceutica que comprende a dichos compuestos, utiles para inhibir el crecimiento de celulas tumoral CL2007002519A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2006236472		2006-08-31
US92608607P	2007-04-25	2007-04-25

Publications (1)

Publication Number	Publication Date
CL2007002519A1 true CL2007002519A1 (es)	2008-02-08

Family

ID=39136042

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200702519A CL2007002519A1 (es)	2006-08-31	2007-08-29	Compuestos derivados de aminopiridina, inhibidores selectivo sobre aurora a; composicion farmaceutica que comprende a dichos compuestos; combinacion farmaceutica que comprende a dichos compuestos, utiles para inhibir el crecimiento de celulas tumoral

Country Status (27)

Country	Link
US (2)	US20100016335A1 (fr)
EP (2)	EP2061782A4 (fr)
JP (3)	JP2008081492A (fr)
KR (1)	KR20090055562A (fr)
CN (1)	CN101528731B (fr)
AR (1)	AR062585A1 (fr)
AU (1)	AU2007289609B2 (fr)
CA (1)	CA2657469C (fr)
CL (1)	CL2007002519A1 (fr)
CO (1)	CO6190529A2 (fr)
CR (1)	CR10553A (fr)
EC (1)	ECSP099062A (fr)
ES (1)	ES2389515T3 (fr)
GT (1)	GT200900008A (fr)
HN (1)	HN2009000113A (fr)
IL (1)	IL196497A0 (fr)
MA (1)	MA30719B1 (fr)
MX (1)	MX2009000390A (fr)
NO (1)	NO20091301L (fr)
NZ (1)	NZ574081A (fr)
PE (1)	PE20080835A1 (fr)
RU (1)	RU2437880C2 (fr)
SV (1)	SV2009003152A (fr)
TW (1)	TW200817363A (fr)
UA (1)	UA95972C2 (fr)
WO (2)	WO2008026768A1 (fr)
ZA (1)	ZA200900126B (fr)

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EP2254888B1 (fr) *	2008-02-22	2014-12-24	Msd K.K.	Nouveaux dérivés d'aminopyridine présentant une action inhibitrice sélective d'aurora a
KR20110014974A (ko) *	2008-03-31	2011-02-14	썬 파마슈티컬 인더스트리스 리미티드	모르피난 유사체의 개선된 제조 방법
WO2010009985A2 (fr) *	2008-07-24	2010-01-28	Nerviano Medical Sciences S.R.L.	Combinaison thérapeutique renfermant un inhibiteur de la kinase aurora et des agents antiprolifératifs
NZ713361A (en)	2009-08-17	2017-06-30	Memorial Sloan Kettering Cancer Center	Heat shock protein binding compounds, compositions, and methods for making and using same
WO2013047813A1 (fr)	2011-09-30	2013-04-04	大鵬薬品工業株式会社	Dérivé de 1,2,4-triazine-6-carboxamide
TWI485146B (zh)	2012-02-29	2015-05-21	Taiho Pharmaceutical Co Ltd	Novel piperidine compounds or salts thereof
US9630896B2 (en)	2013-11-22	2017-04-25	Tansna Therapeutics, Inc.	2,5-dialkyl-4-H/halo/ether-phenol compounds
JP6607870B2 (ja)	2014-05-13	2019-11-20	メモリアルスローンケタリングキャンサーセンター	Ｈｓｐ７０モジュレーターならびにその作製および使用方法
TWI693218B (zh) *	2014-11-14	2020-05-11	美商美國禮來大藥廠	極光ａ激酶抑制劑
WO2016149922A1 (fr) *	2015-03-25	2016-09-29	Intel Corporation	Procédé et appareil d'assurance de service informatique par grappes
CN108250191B (zh) *	2018-03-15	2020-10-20	兰州大学	一种3,5-二取代的2-氨基-吡嗪化合物及其制备工艺与应用
WO2020049208A1 (fr)	2018-09-09	2020-03-12	Fundacio Privada Institut De Recerca De La Sida - Caixa	Aurora cinasa comme cible pour traiter, prévenir ou soigner une infection par vih ou le sida
CN112898292A (zh) *	2019-12-03	2021-06-04	微境生物医药科技(上海)有限公司	新型极光激酶抑制剂及其用途
TWI785474B (zh) *	2020-01-22	2022-12-01	大陸商北京加科思新藥研發有限公司	用作選擇性Aurora A抑制劑的新型雜環化合物
CA3247183A1 (fr)	2022-04-08	2023-10-12	Eli Lilly And Company	Méthode de traitement comprenant des inhibiteurs de kras g12c et des inhibiteurs d’aurora a

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2007
- 2007-04-26 JP JP2007116649A patent/JP2008081492A/ja not_active Withdrawn
- 2007-08-29 JP JP2008532150A patent/JP4466782B2/ja active Active
- 2007-08-29 TW TW096132117A patent/TW200817363A/zh unknown
- 2007-08-29 ES ES07806706T patent/ES2389515T3/es active Active
- 2007-08-29 WO PCT/JP2007/067250 patent/WO2008026768A1/fr not_active Ceased
- 2007-08-29 MX MX2009000390A patent/MX2009000390A/es active IP Right Grant
- 2007-08-29 CA CA2657469A patent/CA2657469C/fr not_active Expired - Fee Related
- 2007-08-29 NZ NZ574081A patent/NZ574081A/en not_active IP Right Cessation
- 2007-08-29 CN CN200780032242.7A patent/CN101528731B/zh not_active Expired - Fee Related
- 2007-08-29 UA UAA200902851A patent/UA95972C2/ru unknown
- 2007-08-29 EP EP07806705A patent/EP2061782A4/fr not_active Withdrawn
- 2007-08-29 KR KR1020097004339A patent/KR20090055562A/ko not_active Ceased
- 2007-08-29 PE PE2007001171A patent/PE20080835A1/es not_active Application Discontinuation
- 2007-08-29 US US12/310,307 patent/US20100016335A1/en not_active Abandoned
- 2007-08-29 AU AU2007289609A patent/AU2007289609B2/en not_active Ceased
- 2007-08-29 CL CL200702519A patent/CL2007002519A1/es unknown
- 2007-08-29 WO PCT/JP2007/067251 patent/WO2008026769A1/fr not_active Ceased
- 2007-08-29 US US11/897,272 patent/US7915263B2/en active Active
- 2007-08-29 AR ARP070103835A patent/AR062585A1/es unknown
- 2007-08-29 EP EP07806706A patent/EP2062887B1/fr active Active
- 2007-08-29 RU RU2009111599/04A patent/RU2437880C2/ru not_active IP Right Cessation
2009
- 2009-01-07 ZA ZA200900126A patent/ZA200900126B/xx unknown
- 2009-01-13 EC EC2009009062A patent/ECSP099062A/es unknown
- 2009-01-13 GT GT200900008A patent/GT200900008A/es unknown
- 2009-01-13 CR CR10553A patent/CR10553A/es not_active Application Discontinuation
- 2009-01-13 HN HN2009000113A patent/HN2009000113A/es unknown
- 2009-01-13 IL IL196497A patent/IL196497A0/en unknown
- 2009-01-14 SV SV2009003152A patent/SV2009003152A/es unknown
- 2009-01-14 CO CO09002429A patent/CO6190529A2/es not_active Application Discontinuation
- 2009-03-20 MA MA31731A patent/MA30719B1/fr unknown
- 2009-03-30 NO NO20091301A patent/NO20091301L/no not_active Application Discontinuation
- 2009-10-29 JP JP2009248400A patent/JP5256168B2/ja active Active

Also Published As

Publication number	Publication date
AU2007289609B2 (en)	2012-02-02
RU2009111599A (ru)	2010-10-10
CA2657469C (fr)	2013-07-02
JPWO2008026769A1 (ja)	2010-01-21
US20100016335A1 (en)	2010-01-21
EP2061782A1 (fr)	2009-05-27
UA95972C2 (ru)	2011-09-26
CR10553A (es)	2009-06-28
IL196497A0 (en)	2009-09-22
EP2062887A4 (fr)	2010-03-31
KR20090055562A (ko)	2009-06-02
US7915263B2 (en)	2011-03-29
CN101528731A (zh)	2009-09-09
CN101528731B (zh)	2014-05-07
NZ574081A (en)	2011-08-26
MX2009000390A (es)	2009-01-29
TW200817363A (en)	2008-04-16
EP2061782A4 (fr)	2010-03-31
SV2009003152A (es)	2009-04-28
ECSP099062A (es)	2009-02-27
GT200900008A (es)	2010-10-04
HN2009000113A (es)	2014-01-06
CA2657469A1 (fr)	2008-03-06
EP2062887B1 (fr)	2012-07-04
AR062585A1 (es)	2008-11-19
MA30719B1 (fr)	2009-09-01
AU2007289609A1 (en)	2008-03-06
ES2389515T3 (es)	2012-10-26
US20080058347A1 (en)	2008-03-06
WO2008026768A1 (fr)	2008-03-06
JP4466782B2 (ja)	2010-05-26
NO20091301L (no)	2009-04-30
RU2437880C2 (ru)	2011-12-27
CO6190529A2 (es)	2010-08-19
JP2008081492A (ja)	2008-04-10
JP2010047602A (ja)	2010-03-04
EP2062887A1 (fr)	2009-05-27
WO2008026769A1 (fr)	2008-03-06
PE20080835A1 (es)	2008-06-14
JP5256168B2 (ja)	2013-08-07
ZA200900126B (en)	2010-01-27

Publication	Publication Date	Title
CL2007002519A1 (es)	2008-02-08	Compuestos derivados de aminopiridina, inhibidores selectivo sobre aurora a; composicion farmaceutica que comprende a dichos compuestos; combinacion farmaceutica que comprende a dichos compuestos, utiles para inhibir el crecimiento de celulas tumoral
GT200900027A (es)	2010-06-01	Compuestos organicos
CL2008001095A1 (es)	2008-10-24	Uso de compuesto derivados de pirazolopirimidinas, inhibidores de quinasas dependientes de ciclinas para inhibir el crecimiento de un tumor.
CL2007003226A1 (es)	2008-02-08	Compuestos derivados de piridinona; composicion farmaceutica; y uso para tratar el cancer.
CL2007002682A1 (es)	2008-04-04	Compuestos derivados de 4-metilpiridopirimidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar el crecimiento anormal de celulas, como cancer.
CL2007003138A1 (es)	2008-06-27	Compuestos derivados de anilinopiperazina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
DK2144889T3 (da)	2012-12-17	Quinazolin-oxim derivater som HSP90 inhibitorer
CL2007003758A1 (es)	2008-07-04	Compuestos derivados de aminopirimidina, inhibidores de plk1; composicion farmaceutica, util para el tratamiento de cancer.
BRPI0809977A2 (pt)	2014-10-07	Uso de um composto, compostos e composição farmacêutica que o contém
BRPI0814687A2 (pt)	2015-01-20	MÉTODO IN VITRO PARA INIBIR UM MEMBRO DA FAMÍLIA GTPase DE Rho, COMPOSTO, E, COMPOSIÇÃO FARMACÊUTICA.
BRPI0814593A2 (pt)	2015-01-20	Composto, composição farmacêutica que o contém e uso do composto.
SMP200900058B (it)	2010-11-12	Composti e composizioni come inibitori di proteinachinasi.
SM201000108A (it)	2011-01-19	Composti e composizioni come inibitori di proteinachinasi.
CR20140154A (es)	2014-07-23	Compuestos para inhibir la progresión mitotica
GT201000376A (es)	2013-09-09	Compuestos organicos
CL2007003100A1 (es)	2008-04-18	Compuestos derivados de pirimidina, inhibidores de cisteina proteasa; procesos de preparacion; sales de los compuestos; composicion farmaceutica; y uso para el tratamiento de la malaria.
BRPI0819218A2 (pt)	2015-05-05	Métodos, estojos e composições para administração de compostos farmacêuticos
CL2008003690A1 (es)	2009-12-18	Compuestos derivados de amonobenzamida; composicion farmceutica que comprende los compuestos; y uso para controlar parasitos.
CL2008000197A1 (es)	2008-08-01	Compuestos derivados de 2,4-diamino pirimidina, inhibidores de antranilamida de cinasa aurora; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer.
CL2008000754A1 (es)	2008-10-24	Compuesto derivado de heterociclos de nitrogeno; composicion farmaceutica que comprende a dicho compuesto; y uso para tratar cancer y trastornos hiperproliferativos.
BRPI0818804A2 (pt)	2015-04-22	Composto derivado de pirimidina, composição farmacêutica que o compreende e uso desse composto.
DOP2009000159A (es)	2015-11-30	Inhibidores de la poli(adp-ribosa) polimerasa
EP2144499A4 (fr)	2013-01-02	Compostions agrochimiques
EP2594607A4 (fr)	2014-10-29	Composition contenant un composé polymère et élément émettant de la lumière utilisant celle-ci
GT200900315A (es)	2011-10-05	Inhibición de arni de expresión de alfa-enac