BRPI0818804A2 - Composto derivado de pirimidina, composição farmacêutica que o compreende e uso desse composto. - Google Patents

Composto derivado de pirimidina, composição farmacêutica que o compreende e uso desse composto.

Info

Publication number: BRPI0818804A2
Authority: BR; Brazil
Prior art keywords: compound; pharmaceutical composition; pyrimidine derivative; derivative compound; pyrimidine
Prior art date: 2007-11-01

Application number

Other languages

English (en)

Inventor

Martin Bolli

Claus Mueller

Boris Mathys

Olivier Nayler

Beat Steiner

Cyrille Lescop

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-11-01

Filing date

2008-10-31

Publication date

2015-04-22

2008-10-31 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2015-04-22 Publication of BRPI0818804A2 publication Critical patent/BRPI0818804A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Neurology (AREA)
Obesity (AREA)
Transplantation (AREA)
Otolaryngology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0818804 2007-11-01 2008-10-31 Composto derivado de pirimidina, composição farmacêutica que o compreende e uso desse composto. BRPI0818804A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IB2007054437		2007-11-01
PCT/IB2008/054543 WO2009057079A2 (en)	2007-11-01	2008-10-31	Novel pyrimidine derivatives

Publications (1)

Publication Number	Publication Date
BRPI0818804A2 true BRPI0818804A2 (pt)	2015-04-22

Family

ID=40577704

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0818804 BRPI0818804A2 (pt)	2007-11-01	2008-10-31	Composto derivado de pirimidina, composição farmacêutica que o compreende e uso desse composto.

Country Status (18)

Country	Link
US (1)	US8299086B2 (pt)
EP (1)	EP2217594B1 (pt)
JP (1)	JP5517944B2 (pt)
KR (1)	KR20100092473A (pt)
CN (1)	CN101970430B (pt)
AR (1)	AR069146A1 (pt)
AU (1)	AU2008320374A1 (pt)
BR (1)	BRPI0818804A2 (pt)
CA (1)	CA2700917A1 (pt)
ES (1)	ES2449749T3 (pt)
IL (1)	IL205425A0 (pt)
MA (1)	MA31849B1 (pt)
MX (1)	MX2010004576A (pt)
NZ (1)	NZ585775A (pt)
RU (1)	RU2010121969A (pt)
TW (1)	TW200920746A (pt)
WO (1)	WO2009057079A2 (pt)
ZA (1)	ZA201003875B (pt)

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CL2007002593A1 (es) *	2006-09-07	2008-06-13	Actelion Pharmaceuticals Ltd	Compuestos derivados de 4-heteroaril-piridina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como rechazo de organos transplantados, sindromes autoinmunes y cancer.
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PL2195311T3 (pl) *	2007-08-17	2011-08-31	Actelion Pharmaceuticals Ltd	Pochodne pirydynowe jako modulatory receptora S1P1/EDG1
CA2714614A1 (en) *	2008-03-06	2009-09-11	Actelion Pharmaceuticals Ltd	Novel pyrimidine-pyridine derivatives
EP2262799B1 (en) *	2008-03-06	2012-07-04	Actelion Pharmaceuticals Ltd.	Pyridine compounds
SI2252609T1 (sl) *	2008-03-07	2013-07-31	Actelion Pharmaceuticals Ltd.	Derivati piridin-2-ila kot imunomodulacijska sredstva
BRPI0910288A2 (pt) *	2008-03-07	2019-09-24	Actelion Pharmaceuticals Ltd	composto de derivados de aminometil benzeno, composição farmacêutica que compreende esse composto e uso do mesmo.
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KR101409131B1 (ko)	2009-07-16	2014-06-17	액테리온 파마슈티칼 리미티드	피리딘-4-일 유도체
US8399451B2 (en)	2009-08-07	2013-03-19	Bristol-Myers Squibb Company	Heterocyclic compounds
CN102686571B (zh)	2009-10-29	2015-11-25	百时美施贵宝公司	三环杂环化合物
ES2548683T3 (es)	2010-04-23	2015-10-20	Bristol-Myers Squibb Company	Amidas del ácido 4-(5-isoxazolil o 5-pirrazolil-1,2,4-oxadiazol-3-il)-mandélico como agonistas de receptor de esfingosina-1-fosfato 1
WO2012003501A2 (en)	2010-07-02	2012-01-05	Reviva Pharmaceuticals, Inc.	Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
CN103124727B (zh)	2010-07-20	2015-03-25	百时美施贵宝公司	取代的3-苯基-1,2,4-噁二唑化合物
WO2012040532A1 (en)	2010-09-24	2012-03-29	Bristol-Myers Squibb Company	Substituted oxadiazole compounds and their use as s1p1 agonists
WO2012061459A1 (en)	2010-11-03	2012-05-10	Bristol-Myers Squibb Company	Heterocyclic compounds as s1p1 agonists for the treatment of autoimmune and vascular diseases
SG191742A1 (en)	2011-01-19	2013-08-30	Actelion Pharmaceuticals Ltd	2-methoxy-pyridin-4-yl derivatives
EP2797870B1 (en)	2011-12-30	2019-02-20	Reviva Pharmaceuticals, Inc.	Compositions, synthesis, and methods of using 1-[1-phenyl-cyclobutyl]isobutylamine derivatives
US9115054B2 (en)	2013-02-21	2015-08-25	Bristol-Myers Squibb Company	Tetrahydronaphthalenyl compounds useful as sipi agonists
CN105189487B (zh)	2013-03-15	2017-12-26	爱杜西亚药品有限公司	吡啶‑4‑基衍生物
AR101591A1 (es)	2014-08-20	2016-12-28	Bristol Myers Squibb Co	Compuestos bicíclicos sustituidos
MY192358A (en)	2015-05-20	2022-08-17	Idorsia Pharmaceuticals Ltd	Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol
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CL2007002593A1 (es) *	2006-09-07	2008-06-13	Actelion Pharmaceuticals Ltd	Compuestos derivados de 4-heteroaril-piridina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como rechazo de organos transplantados, sindromes autoinmunes y cancer.
SI2069335T1 (sl) *	2006-09-08	2013-04-30	Actelion Pharmaceuticals Ltd.	Derivati piridin-3-ila kot imunomodulacijska sredstva
EP2069318B1 (en) *	2006-09-21	2012-09-12	Actelion Pharmaceuticals Ltd.	Phenyl derivatives and their use as immunomodulators
CN101562977A (zh)	2006-12-15	2009-10-21	艾博特公司	新的二唑化合物
WO2008091967A1 (en)	2007-01-26	2008-07-31	Smithkline Beecham Corporation	Chemical compounds
JP2010521450A (ja) *	2007-03-16	2010-06-24	アクテリオンファーマシューティカルズリミテッド	Ｓ１ｐ１／ｅｄｇ１受容体アゴニストとしてのアミノ−ピリジン誘導体
EP2262799B1 (en) *	2008-03-06	2012-07-04	Actelion Pharmaceuticals Ltd.	Pyridine compounds
BRPI0910288A2 (pt) *	2008-03-07	2019-09-24	Actelion Pharmaceuticals Ltd	composto de derivados de aminometil benzeno, composição farmacêutica que compreende esse composto e uso do mesmo.
SI2252609T1 (sl) *	2008-03-07	2013-07-31	Actelion Pharmaceuticals Ltd.	Derivati piridin-2-ila kot imunomodulacijska sredstva
HUE025984T2 (hu)	2008-05-14	2016-05-30	Scripps Research Inst	Szfingozin foszfát receptor új modulátorai
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2008
- 2008-10-31 CN CN2008801140168A patent/CN101970430B/zh not_active Expired - Fee Related
- 2008-10-31 KR KR1020107012070A patent/KR20100092473A/ko not_active Withdrawn
- 2008-10-31 ES ES08846160.3T patent/ES2449749T3/es active Active
- 2008-10-31 US US12/738,110 patent/US8299086B2/en not_active Expired - Fee Related
- 2008-10-31 AR ARP080104783A patent/AR069146A1/es not_active Application Discontinuation
- 2008-10-31 WO PCT/IB2008/054543 patent/WO2009057079A2/en not_active Ceased
- 2008-10-31 NZ NZ585775A patent/NZ585775A/en not_active IP Right Cessation
- 2008-10-31 TW TW097142254A patent/TW200920746A/zh unknown
- 2008-10-31 JP JP2010531628A patent/JP5517944B2/ja not_active Expired - Fee Related
- 2008-10-31 RU RU2010121969/04A patent/RU2010121969A/ru not_active Application Discontinuation
- 2008-10-31 BR BRPI0818804 patent/BRPI0818804A2/pt not_active IP Right Cessation
- 2008-10-31 EP EP08846160.3A patent/EP2217594B1/en not_active Not-in-force
- 2008-10-31 AU AU2008320374A patent/AU2008320374A1/en not_active Abandoned
- 2008-10-31 CA CA2700917A patent/CA2700917A1/en not_active Abandoned
- 2008-10-31 MX MX2010004576A patent/MX2010004576A/es not_active Application Discontinuation
2010
- 2010-04-29 IL IL205425A patent/IL205425A0/en unknown
- 2010-05-17 MA MA32838A patent/MA31849B1/fr unknown
- 2010-05-31 ZA ZA2010/03875A patent/ZA201003875B/en unknown

Also Published As

Publication number	Publication date
ES2449749T3 (es)	2014-03-21
CN101970430B (zh)	2013-05-08
KR20100092473A (ko)	2010-08-20
EP2217594A2 (en)	2010-08-18
US20100234346A1 (en)	2010-09-16
JP5517944B2 (ja)	2014-06-11
IL205425A0 (en)	2010-12-30
AU2008320374A1 (en)	2009-05-07
TW200920746A (en)	2009-05-16
AR069146A1 (es)	2009-12-30
RU2010121969A (ru)	2011-12-10
WO2009057079A3 (en)	2009-12-03
NZ585775A (en)	2011-12-22
MX2010004576A (es)	2010-05-17
CN101970430A (zh)	2011-02-09
EP2217594B1 (en)	2014-01-08
MA31849B1 (fr)	2010-11-01
WO2009057079A2 (en)	2009-05-07
US8299086B2 (en)	2012-10-30
ZA201003875B (en)	2012-08-29
CA2700917A1 (en)	2009-05-07
JP2011502980A (ja)	2011-01-27

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