CL2007003356A1 - Compuestos derivados de benzopirazoles; proceso para la preparacion de dichos compuestos; composicion farmaceutica que comprende a dichos compuestos y otro agente activo; y su uso para el tratamiento del asma, inflamacion, entre otras enfermedades. - Google Patents

Compuestos derivados de benzopirazoles; proceso para la preparacion de dichos compuestos; composicion farmaceutica que comprende a dichos compuestos y otro agente activo; y su uso para el tratamiento del asma, inflamacion, entre otras enfermedades.

Info

Publication number: CL2007003356A1
Authority: CL; Chile
Prior art keywords: compounds; benzopirazoles; asthma; inflammation; diseases
Prior art date: 2006-11-23

Application number

CL200703356A

Other languages

English (en)

Inventor

Lena Dahmen Jan Erik Bergstrom

Original Assignee

Astrazeneca Ab Bayer Schering

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-23

Filing date

2007-11-23

Publication date

2008-07-18

2007-11-23 Application filed by Astrazeneca Ab Bayer Schering filed Critical Astrazeneca Ab Bayer Schering

2008-07-18 Publication of CL2007003356A1 publication Critical patent/CL2007003356A1/es

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Neurology (AREA)
Immunology (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Otolaryngology (AREA)
Communicable Diseases (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Ophthalmology & Optometry (AREA)
Virology (AREA)

CL200703356A 2006-11-23 2007-11-23 Compuestos derivados de benzopirazoles; proceso para la preparacion de dichos compuestos; composicion farmaceutica que comprende a dichos compuestos y otro agente activo; y su uso para el tratamiento del asma, inflamacion, entre otras enfermedades. CL2007003356A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE0602501		2006-11-23

Publications (1)

Publication Number	Publication Date
CL2007003356A1 true CL2007003356A1 (es)	2008-07-18

Family

ID=39429960

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200703356A CL2007003356A1 (es)	2006-11-23	2007-11-23	Compuestos derivados de benzopirazoles; proceso para la preparacion de dichos compuestos; composicion farmaceutica que comprende a dichos compuestos y otro agente activo; y su uso para el tratamiento del asma, inflamacion, entre otras enfermedades.

Country Status (12)

Country	Link
US (1)	US8030340B2 (es)
EP (1)	EP2097384B1 (es)
JP (1)	JP2010510985A (es)
CN (1)	CN101646654B (es)
AR (1)	AR063906A1 (es)
CA (1)	CA2677335A1 (es)
CL (1)	CL2007003356A1 (es)
ES (1)	ES2393009T3 (es)
PE (1)	PE20081227A1 (es)
TW (1)	TW200829578A (es)
UY (1)	UY30736A1 (es)
WO (1)	WO2008063116A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200829578A (en)	2006-11-23	2008-07-16	Astrazeneca Ab	Chemical compounds 537
JO2754B1 (en) *	2006-12-21	2014-03-15	استرازينكا ايه بي	Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
IL187245A0 (en) *	2007-11-08	2008-12-29	Hadasit Med Res Service	Synthetic sphingolipid analogs
TWI445705B (zh) *	2008-05-20	2014-07-21	Astrazeneca Ab	經苯基及苯并二基取代之吲唑衍生物
WO2009142568A1 (en) *	2008-05-20	2009-11-26	Astrazeneca Ab	Combination of (a) glucocorticoid receptor modulator and (b) a b2-agonist
WO2009142589A1 (en) *	2008-05-20	2009-11-26	Astrazeneca Ab	Combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist
WO2010008341A1 (en) *	2008-07-16	2010-01-21	Astrazeneca Ab	A combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist
JP5507567B2 (ja) *	2008-09-26	2014-05-28	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｃｃｒ１受容体拮抗薬としてのアザインダゾール化合物
WO2011061527A1 (en) *	2009-11-17	2011-05-26	Astrazeneca Ab	Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
US9223209B2 (en) *	2010-02-19	2015-12-29	International Business Machines Corporation	Sulfonamide-containing photoresist compositions and methods of use
US9223217B2 (en) *	2010-02-19	2015-12-29	International Business Machines Corporation	Sulfonamide-containing topcoat and photoresist additive compositions and methods of use
MX2013002186A (es) *	2010-08-27	2013-06-28	Corcept Therapeutics Inc	Moduladores de azadecalina de piridil-amina fusionada.
WO2017161518A1 (en)	2016-03-23	2017-09-28	Astrazeneca Ab	New physical form
TW201927769A (zh) *	2017-12-18	2019-07-16	德商歌林達有限公司	經取代之吡咯啶醯胺ｉｉ
CN111556867A (zh) *	2017-12-18	2020-08-18	格吕伦塔尔有限公司	经取代的吡咯烷酰胺i
CN113382990B (zh)	2019-01-11	2024-11-19	格吕伦塔尔有限公司	取代的吡咯烷酰胺iii
WO2024137742A1 (en)	2022-12-20	2024-06-27	Blueprint Medicines Corporation	Compounds and compositions as fgfr3 degraders and uses thereof

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3992441A (en)	1972-12-26	1976-11-16	Pfizer Inc.	Sulfamylbenzoic acids
DE3000377A1 (de)	1980-01-07	1981-07-09	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3514696A1 (de)	1985-04-24	1986-11-06	Bayer Ag, 5090 Leverkusen	N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung
DE3535167A1 (de)	1985-10-02	1987-04-09	Boehringer Mannheim Gmbh	Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel
DE3632329A1 (de)	1986-09-24	1988-03-31	Bayer Ag	Substituierte phenylsulfonamide
TW224462B (es)	1992-02-24	1994-06-01	Squibb & Sons Inc
NZ247440A (en)	1992-05-06	1995-04-27	Squibb & Sons Inc	Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
CA2114981A1 (en)	1993-02-09	1994-08-10	Kazumi Ogata	Quinolonecarboxylic acid derivatives
DE4323916A1 (de)	1993-07-16	1995-01-19	Basf Ag	Substituierte 2-Phenylpyridine
WO1995003279A1 (en)	1993-07-26	1995-02-02	Eisai Co., Ltd.	Sulfonamide and sulfonic ester derivatives each having tricyclic hetero ring
GB9504854D0 (en)	1994-03-31	1995-04-26	Zeneca Ltd	Nitrogen derivatives
US5545669A (en)	1994-06-02	1996-08-13	Adams; Jerry L.	Anti-inflammatory compounds
GB9417532D0 (en)	1994-08-31	1994-10-19	Zeneca Ltd	Aromatic compounds
AU5772296A (en)	1995-05-19	1996-11-29	Chiroscience Limited	3,4-disubstituted-phenylsulphonamides and their therapeutic use
TW523506B (en)	1996-12-18	2003-03-11	Ono Pharmaceutical Co	Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
TW542822B (en)	1997-01-17	2003-07-21	Ajinomoto Kk	Benzamidine derivatives
ZA9811898B (en)	1997-12-29	2000-06-28	Ortho Mcneil Pharm Inc	Anti-Inflammatory Compounds.
WO1999038845A1 (en)	1998-01-29	1999-08-05	Tularik Inc.	Ppar-gamma modulators
DE19856475A1 (de)	1998-11-27	2000-05-31	Schering Ag	Nichtsteroidale Entzündungshemmer
WO2001024786A1 (en)	1999-05-13	2001-04-12	Shionogi & Co., Ltd.	Preventive or therapeutic drugs for diabetes
US6569885B1 (en)	1999-12-23	2003-05-27	Icos Corporation	Cyclic AMP-specific phosphodiesterase inhibitors
DE60106954T2 (de)	2000-09-11	2005-12-01	Pfizer Products Inc., Groton	Resorcin-derivate
FR2815030A1 (fr)	2000-10-05	2002-04-12	Lipha	Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant et leur utilisation pour la preparation de medicaments
AU2002334733B2 (en)	2001-10-01	2006-11-23	Arena Pharmaceuticals, Inc.	MCH receptors antagonists
RU2004118719A (ru)	2001-11-22	2005-03-27	Оно Фармасьютикал Ко., Лтд. (Jp)	Производные пиперидин-2-она и фармацевтические композиции, содержащие такие соединения в качестве активного ингредиента
ES2306880T3 (es)	2002-03-13	2008-11-16	Janssen Pharmaceutica Nv	Derivados de sulfonilamino como inhibidores novedosos de la histona desacetilasa.
AU2003221706B2 (en)	2002-04-11	2008-02-28	Merck Sharp & Dohme Corp.	1H-Benzo[F]indazol-5-YL derivatives as selective glucocorticoid receptor modulators
EP2399903A1 (en)	2002-05-24	2011-12-28	Millennium Pharmaceuticals, Inc.	Ccr9 inhibitors and methods of use thereof
US20050113450A1 (en)	2002-08-23	2005-05-26	Atli Thorarensen	Antibacterial agents
JP4619786B2 (ja)	2002-08-29	2011-01-26	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	炎症性、アレルギー性及び増殖性疾患の治療において糖質コルチコイドミメティックスとして使用するための３−（スルホンアミドエチル）−インドール誘導体
US6894061B2 (en)	2002-12-04	2005-05-17	Wyeth	Substituted dihydrophenanthridinesulfonamides
CA2515780C (en)	2003-02-20	2012-12-11	Encysive Pharmaceuticals Inc.	Phenylenediamine urotensin-ii receptor antagonists and ccr-9 antagonists
GB0308466D0 (en)	2003-04-11	2003-05-21	Novartis Ag	Organic compounds
US20040235892A1 (en) *	2003-05-22	2004-11-25	Yujia Dai	Indazole and benzisoxazole kinase inhibitors
US7297709B2 (en) *	2003-05-22	2007-11-20	Abbott Laboratories	Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
EP1635800A2 (en)	2003-06-10	2006-03-22	Kalypsys, Inc.	Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease
WO2005004810A2 (en)	2003-07-02	2005-01-20	Merck & Co., Inc.	Arylsulfonamide derivatives
BRPI0417687A (pt)	2003-12-19	2007-04-03	Pfizer	derivados de benzenossulfonilamino-piridin-2-ila e compostos relacionados como inibidores de 11-beta-hidroxiesteróide desidrogenase tipo 1 (11-beta-hsd-1) para o tratamento de diabetes e obesidade
JP2005263787A (ja)	2004-02-17	2005-09-29	Ishihara Sangyo Kaisha Ltd	アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤
US20050197376A1 (en) *	2004-03-02	2005-09-08	Fujisawa Pharmaceutical Co. Ltd.	Concomitant drugs
US20050250820A1 (en)	2004-03-08	2005-11-10	Amgen Inc.	Therapeutic modulation of PPARgamma activity
DE102004028862A1 (de)	2004-06-15	2005-12-29	Merck Patent Gmbh	3-Aminoindazole
CA2584413A1 (en)	2004-10-29	2006-05-04	Astrazeneca Ab	Novel sulphonamide derivatives as glucocorticoid receptor modulators for the treatment of inflammatory diseases
SE0402635D0 (sv)	2004-10-29	2004-10-29	Astrazeneca Ab	Chemical compounds
MX2007014811A (es)	2005-06-10	2008-02-14	Boehringer Ingelheim Int	Mimeticos de glucocorticoides, metodos para su fabricacion, composiciones farmaceuticas y usos de los mismos.
US7888381B2 (en)	2005-06-14	2011-02-15	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
TW200815361A (en) *	2005-10-20	2008-04-01	Astrazeneca Ab	Chemical compounds
GB0522880D0 (en)	2005-11-09	2005-12-21	Glaxo Group Ltd	Novel compounds
US20090170898A1 (en)	2006-03-31	2009-07-02	Malena Bengtsson	Sulphonamide Derivatives as Modulators of the Glucocorticoid Receptor
KR20090003349A (ko)	2006-04-20	2009-01-09	글락소 그룹 리미티드	화합물
KR20090020694A (ko)	2006-07-14	2009-02-26	일라이 릴리 앤드 캄파니	글루코코르티코이드 수용체 조절제 및 이의 사용 방법
GB0620385D0 (en)	2006-10-13	2006-11-22	Glaxo Group Ltd	Novel compounds
GB0620406D0 (en)	2006-10-13	2006-11-22	Glaxo Group Ltd	Novel compounds
MX2009004385A (es)	2006-10-23	2009-05-22	Merck & Co Inc	Derivados de 2-[1-fenil-5-hidroxi-4alfa-metil-hexahidrociclopenta [f]indazol-5-il]etil fenilo como ligandos del receptor glucocorticoide.
US8067447B2 (en)	2006-11-01	2011-11-29	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
CN101573340A (zh)	2006-11-01	2009-11-04	百时美施贵宝公司	糖皮质激素受体AP-1和/或NF-κB活性的调节剂及其用途
TW200829578A (en)	2006-11-23	2008-07-16	Astrazeneca Ab	Chemical compounds 537
MX2009005264A (es)	2006-12-06	2009-05-28	Boehringer Ingelheim Int	Mimeticos de glucocorticoides, metodos para su fabricacion, composiciones farmaceuticas y usos de los mismos.
JO2754B1 (en)	2006-12-21	2014-03-15	استرازينكا ايه بي	Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
WO2008079073A1 (en)	2006-12-22	2008-07-03	Astrazeneca Ab	Indazolyl sulphonamide derivatives for the treatment of glucocorticoid receptor mediated disorders
JP2010523689A (ja)	2007-04-10	2010-07-15	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	グルココルチコイドミメティックス、その製造方法、医薬組成物及びその使用
WO2008124745A1 (en)	2007-04-10	2008-10-16	Boehringer Ingelheim International Gmbh	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
GB0708858D0 (en)	2007-05-08	2007-06-13	Glaxo Group Ltd	Novel compounds
GB0720549D0 (en)	2007-10-19	2007-11-28	Glaxo Group Ltd	Novel compounds
GB0720546D0 (en)	2007-10-19	2007-11-28	Glaxo Group Ltd	Novel compounds
GB0720556D0 (en)	2007-10-19	2007-11-28	Glaxo Group Ltd	Novel compounds
GB0720544D0 (en)	2007-10-19	2007-11-28	Glaxo Group Ltd	Novel compounds
GB0720557D0 (en)	2007-10-19	2007-11-28	Glaxo Group Ltd	Novel compounds
GB0722211D0 (en)	2007-11-12	2007-12-27	Glaxo Group Ltd	Novel compounds
GB0724254D0 (en)	2007-12-12	2008-01-23	Glaxo Group Ltd	Novel compounds
CA2714607A1 (en)	2008-02-26	2009-09-03	Merck Sharp & Dohme Corp.	Hexahydrocyclopentyl[f]indazole carboxamides and derivatives thereof as selective glucocorticoid receptor modulators
AU2009220458A1 (en)	2008-03-06	2009-09-11	Merck Sharp & Dohme Corp.	Hexahydrocyclopentyl[f]findazole sulfonamides and derivates thereof as selective glucocorticoid receptor modulators

2007
- 2007-11-12 TW TW096142666A patent/TW200829578A/zh unknown
- 2007-11-21 US US11/986,555 patent/US8030340B2/en not_active Expired - Fee Related
- 2007-11-22 CN CN2007800436841A patent/CN101646654B/zh not_active Expired - Fee Related
- 2007-11-22 EP EP07835228A patent/EP2097384B1/en not_active Not-in-force
- 2007-11-22 AR ARP070105195A patent/AR063906A1/es unknown
- 2007-11-22 JP JP2009538365A patent/JP2010510985A/ja not_active Ceased
- 2007-11-22 WO PCT/SE2007/001031 patent/WO2008063116A1/en not_active Ceased
- 2007-11-22 ES ES07835228T patent/ES2393009T3/es active Active
- 2007-11-22 UY UY30736A patent/UY30736A1/es not_active Application Discontinuation
- 2007-11-22 CA CA002677335A patent/CA2677335A1/en not_active Abandoned
- 2007-11-22 PE PE2007001623A patent/PE20081227A1/es not_active Application Discontinuation
- 2007-11-23 CL CL200703356A patent/CL2007003356A1/es unknown

Also Published As

Publication number	Publication date
CN101646654B (zh)	2012-03-28
HK1138852A1 (en)	2010-09-03
EP2097384A1 (en)	2009-09-09
EP2097384B1 (en)	2012-09-12
JP2010510985A (ja)	2010-04-08
US20080207721A1 (en)	2008-08-28
WO2008063116A1 (en)	2008-05-29
US8030340B2 (en)	2011-10-04
CN101646654A (zh)	2010-02-10
CA2677335A1 (en)	2008-05-29
ES2393009T3 (es)	2012-12-17
AR063906A1 (es)	2009-02-25
UY30736A1 (es)	2008-07-03
TW200829578A (en)	2008-07-16
PE20081227A1 (es)	2008-11-08
EP2097384A4 (en)	2009-12-30

Publication	Publication Date	Title
CL2008000691A1 (es)	2008-09-12	Compuestos derivados de dihidro y tetrahidro oxazolopirimidinonas sustituidas; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de la esquizofrenia, epilepsia, entre otras enfermedades.
BRPI0806531A2 (pt)	2014-04-22	Composto, composição farmacêutica, agente terapêutico, e, uso do composto.
ES2526606T3 (es)	2015-01-13	Composición farmacéutica sólida que comprende amlodipina y losartán
CL2007002121A1 (es)	2008-02-22	Compuestos derivados de pirazoles, activadores de glucoquinasa; proceso de preparacion de dichos compuestos; composicion farmaceutica que comprende dichos compuestos; y uso para el tratamiento de enfermedades y/o trastornos metabolicos, tal como diab
UY29086A1 (es)	2006-03-31	Nuevas composiciones farmacéuticas para el tratamiento de trastornos hiperproliferativos.
CL2008000593A1 (es)	2008-09-05	Uso de compuestos derivados de heterociclos sustituidos; composicion farmaceutica que comprende a dichos compuestos y otros agentes activos; y su uso para tratar diabetes, enfermedad aterosclerotica de las arterias entre otras enfermedades.
BRPI0809164B8 (pt)	2023-02-28	Composição para administração tópica e composição farmacêutica compreendendo a referida composição
CL2008000442A1 (es)	2008-08-22	Composicion farmaceutica que comprende a un quitosano, un ingrediente activo cosmetico o farmaceutico, y un solvente volatil; y su uso para tratar psoriasis, micosis entre otras enfermedades.
CL2007003341A1 (es)	2008-04-18	Compuestos derivados de imidazotriazinas; composicion farmaceutica, util para el tratamiento del cancer, arteroesclerosis y enfermedades cardiovasculares entre otras.
CL2007003520A1 (es)	2008-08-22	Compuestos derivados de heterociclos sustituidos con morfolina, inhibidores de la actividad pi3 quinasa; composicion farmaceutica que comprende a dichos compuestos; kit farmaceutico; y su uso para el tratamiento profilactico o terapeutico del cancer.
CL2007002641A1 (es)	2008-06-20	Compuestos derivados de pirimidinas; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de trastornos alergicos, autoinmunes, enfermedades inflamatorias.
CL2007003797A1 (es)	2008-07-18	Compuestos derivados de pirrolo piridina; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de la enfermedad de alzheimer, parkinson, cancer, entre otras enfermedades.
CL2013001436A1 (es)	2014-02-14	Composicion que comprende al menos una n-acetil-lactosamina, al menos un oligosacarido sialilado y al menos un oligosacarido fucosilado; y su uso para la prevencion y/o tratamiento de las condiciones de la piel y enfermedades de la piel.
CL2007003832A1 (es)	2008-07-25	Compuestos derivados de azaespiro; procedimiento de preparacion; composicion farmaceutica; y su uso para prevenir y tratar ansiedad, trastornos depresivos, entre otras enfermedades.
CL2007001838A1 (es)	2008-02-08	Compuestos derivados de 4-oxoquinolina; composicion farmaceutica; y uso del compuesto para la produccion de un agente anti-vih.
CL2007003331A1 (es)	2008-07-04	Metodo para tratar cancer mediante la administracion de un agente radiosensibilizante derivado de benzo[a]trinden-4,6-diona; composicion farmaceutica que comprende dicho agente.
CL2013001982A1 (es)	2014-01-10	Metodo para reducir los niveles de glucosa y tratar trastornos del metabolismo de la misma; composicion farmaceutica que comprende metformina y otro agente antidiabetico o antiobesidad.
ECSP088239A (es)	2008-04-28	Composición de liberación de fármaco sostenida
AR059350A1 (es)	2008-03-26	Formulacion farmaceutica para aerosoles con dos o mas principios activos y al menos una sustancia tensioactiva
ZA200809864B (en)	2010-03-31	Pharmaceutical formulations for the sustained release of active ingredients(s), as well as their applications, especially therapeutic
UY31079A1 (es)	2009-01-05	Derivados de fenilaminobenceno sustituidos de utilidad para el tratamiento de trastornos y enfermedades hiperproliferativos asociados con actividad quinasa extracelular mediada por mitógenos
CL2008000594A1 (es)	2008-09-05	Uso de compuestos derivados de heterociclos; composicion farmaceutica que comprende a dichos compuestos y otros agentes activos; y su uso para tratar diabetes, enfermedad arterial coronaria entre otras enfermedades.
BRPI0807285A2 (pt)	2014-05-06	"composição, método para preparar composição farmacêutica, forma unitária de dosagem, método para admnistrar um agente biologicamente ativo a um animal necessitando o agente, método para aumentar a biodisponibilidade de um agente biologicamente ativo, método para preparar uma composição e composto"
PE20140255A1 (es)	2014-03-11	Tableta dispersable en forma oral
BRPI0815577A2 (pt)	2015-03-03	Peptídeo foxm1 e agente medicinal compreendendo o mesmo.