CL2007003356A1 - Compuestos derivados de benzopirazoles; proceso para la preparacion de dichos compuestos; composicion farmaceutica que comprende a dichos compuestos y otro agente activo; y su uso para el tratamiento del asma, inflamacion, entre otras enfermedades. - Google Patents

Compuestos derivados de benzopirazoles; proceso para la preparacion de dichos compuestos; composicion farmaceutica que comprende a dichos compuestos y otro agente activo; y su uso para el tratamiento del asma, inflamacion, entre otras enfermedades.

Info

Publication number: CL2007003356A1
Authority: CL; Chile
Prior art keywords: compounds; benzopirazoles; asthma; inflammation; diseases
Prior art date: 2006-11-23

Application number

CL200703356A

Other languages

English (en)

Inventor

Lena Dahmen Jan Erik Bergstrom

Original Assignee

Astrazeneca Ab Bayer Schering

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-23

Filing date

2007-11-23

Publication date

2008-07-18

2007-11-23 Application filed by Astrazeneca Ab Bayer Schering filed Critical Astrazeneca Ab Bayer Schering

2008-07-18 Publication of CL2007003356A1 publication Critical patent/CL2007003356A1/es

Links

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- C07—ORGANIC CHEMISTRY
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- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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CL200703356A 2006-11-23 2007-11-23 Compuestos derivados de benzopirazoles; proceso para la preparacion de dichos compuestos; composicion farmaceutica que comprende a dichos compuestos y otro agente activo; y su uso para el tratamiento del asma, inflamacion, entre otras enfermedades. CL2007003356A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE0602501		2006-11-23

Publications (1)

Publication Number	Publication Date
CL2007003356A1 true CL2007003356A1 (es)	2008-07-18

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Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200703356A CL2007003356A1 (es)	2006-11-23	2007-11-23	Compuestos derivados de benzopirazoles; proceso para la preparacion de dichos compuestos; composicion farmaceutica que comprende a dichos compuestos y otro agente activo; y su uso para el tratamiento del asma, inflamacion, entre otras enfermedades.

Country Status (12)

Country	Link
US (1)	US8030340B2 (es)
EP (1)	EP2097384B1 (es)
JP (1)	JP2010510985A (es)
CN (1)	CN101646654B (es)
AR (1)	AR063906A1 (es)
CA (1)	CA2677335A1 (es)
CL (1)	CL2007003356A1 (es)
ES (1)	ES2393009T3 (es)
PE (1)	PE20081227A1 (es)
TW (1)	TW200829578A (es)
UY (1)	UY30736A1 (es)
WO (1)	WO2008063116A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200829578A (en)	2006-11-23	2008-07-16	Astrazeneca Ab	Chemical compounds 537
JO2754B1 (en) *	2006-12-21	2014-03-15	استرازينكا ايه بي	Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
IL187245A0 (en) *	2007-11-08	2008-12-29	Hadasit Med Res Service	Synthetic sphingolipid analogs
WO2009142589A1 (en) *	2008-05-20	2009-11-26	Astrazeneca Ab	Combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist
WO2009142568A1 (en) *	2008-05-20	2009-11-26	Astrazeneca Ab	Combination of (a) glucocorticoid receptor modulator and (b) a b2-agonist
UY31832A (es)	2008-05-20	2010-01-05	Astrazeneca Ab	Derivados de indazol sustituidos con fenilo y benzodioxinilo
WO2010008341A1 (en) *	2008-07-16	2010-01-21	Astrazeneca Ab	A combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist
EP2346868B1 (en) *	2008-09-26	2016-01-27	Boehringer Ingelheim International Gmbh	Azaindazole compounds as ccr1 receptor antagonists
WO2011061527A1 (en) *	2009-11-17	2011-05-26	Astrazeneca Ab	Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
US9223217B2 (en)	2010-02-19	2015-12-29	International Business Machines Corporation	Sulfonamide-containing topcoat and photoresist additive compositions and methods of use
US9223209B2 (en) *	2010-02-19	2015-12-29	International Business Machines Corporation	Sulfonamide-containing photoresist compositions and methods of use
CN103080108A (zh) *	2010-08-27	2013-05-01	科赛普特治疗公司	吡啶基-胺稠合的氮杂萘烷调节剂
WO2017161518A1 (en) *	2016-03-23	2017-09-28	Astrazeneca Ab	New physical form
AR113967A1 (es)	2017-12-18	2020-07-01	Gruenenthal Gmbh	Pirrolidinamidas i sustituidas
TW201927769A (zh) *	2017-12-18	2019-07-16	德商歌林達有限公司	經取代之吡咯啶醯胺ｉｉ
JP7446316B2 (ja)	2019-01-11	2024-03-08	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	置換ピロリジンアミドｉｉｉ
WO2024137742A1 (en)	2022-12-20	2024-06-27	Blueprint Medicines Corporation	Compounds and compositions as fgfr3 degraders and uses thereof

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3992441A (en) *	1972-12-26	1976-11-16	Pfizer Inc.	Sulfamylbenzoic acids
DE3000377A1 (de)	1980-01-07	1981-07-09	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3514696A1 (de)	1985-04-24	1986-11-06	Bayer Ag, 5090 Leverkusen	N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung
DE3535167A1 (de)	1985-10-02	1987-04-09	Boehringer Mannheim Gmbh	Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel
DE3632329A1 (de)	1986-09-24	1988-03-31	Bayer Ag	Substituierte phenylsulfonamide
TW224462B (es)	1992-02-24	1994-06-01	Squibb & Sons Inc
NZ247440A (en)	1992-05-06	1995-04-27	Squibb & Sons Inc	Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
CA2114981A1 (en)	1993-02-09	1994-08-10	Kazumi Ogata	Quinolonecarboxylic acid derivatives
DE4323916A1 (de)	1993-07-16	1995-01-19	Basf Ag	Substituierte 2-Phenylpyridine
US5834462A (en)	1993-07-26	1998-11-10	Eisai Co., Ltd.	Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives
GB9504854D0 (en)	1994-03-31	1995-04-26	Zeneca Ltd	Nitrogen derivatives
US5545669A (en)	1994-06-02	1996-08-13	Adams; Jerry L.	Anti-inflammatory compounds
GB9417532D0 (en)	1994-08-31	1994-10-19	Zeneca Ltd	Aromatic compounds
WO1996036595A1 (en)	1995-05-19	1996-11-21	Chiroscience Limited	3,4-disubstituted-phenylsulphonamides and their therapeutic use
TW523506B (en)	1996-12-18	2003-03-11	Ono Pharmaceutical Co	Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
TW542822B (en)	1997-01-17	2003-07-21	Ajinomoto Kk	Benzamidine derivatives
AR014195A1 (es)	1997-12-29	2001-02-07	Ortho Mcneil Pharm Inc	Compuestos de trifenilpropanamida utiles para el tratamiento de procesos inflamatorios, composiciones anti-inflamatorias que los comprenden, ymetodos para prepararlos
CA2318731C (en)	1998-01-29	2012-05-29	Tularik Inc.	Ppar-gamma modulators
DE19856475A1 (de)	1998-11-27	2000-05-31	Schering Ag	Nichtsteroidale Entzündungshemmer
AU4612300A (en)	1999-05-13	2001-05-10	Shionogi & Co., Ltd.	Preventive or therapeutic drugs for diabetes
US6569885B1 (en)	1999-12-23	2003-05-27	Icos Corporation	Cyclic AMP-specific phosphodiesterase inhibitors
AU2001282399A1 (en)	2000-09-11	2002-03-22	Pfizer Products Inc.	Resorcinol derivatives
FR2815030A1 (fr)	2000-10-05	2002-04-12	Lipha	Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant et leur utilisation pour la preparation de medicaments
JP2005523237A (ja)	2001-10-01	2005-08-04	大正製薬株式会社	Ｍｃｈ受容体アンタゴニスト
MXPA04004830A (es)	2001-11-22	2004-07-30	Ono Pharmaceutical Co	Compuestos derivados de piperidin-2-ona, y composiciones farmaceuticas que los contienen como ingredientes activos.
OA12793A (en)	2002-03-13	2006-07-10	Janssen Pharmaceutica Nv	Sulfonylamino-derivatives as novel inhibitors of histone deacetylase.
DE60335869D1 (de)	2002-04-11	2011-03-10	Merck Sharp & Dohme	1h-benzo(f)indazol-5-yl-derivate als selektive glucocorticoid-rezeptor-modulatoren
EP2399903A1 (en)	2002-05-24	2011-12-28	Millennium Pharmaceuticals, Inc.	Ccr9 inhibitors and methods of use thereof
US20050113450A1 (en)	2002-08-23	2005-05-26	Atli Thorarensen	Antibacterial agents
EA011095B1 (ru) *	2002-08-29	2008-12-30	Бёрингер Ингельхайм Фармасьютиклз, Инк.	Производные 3-(сульфонамидоэтил)индола, предназначенные для использования в качестве миметиков глюкокортикоидов при лечении воспалительных, аллергических и пролиферативных заболеваний
US6894061B2 (en)	2002-12-04	2005-05-17	Wyeth	Substituted dihydrophenanthridinesulfonamides
US7319111B2 (en)	2003-02-20	2008-01-15	Encysive Pharmaceuticals, Inc.	Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists
GB0308466D0 (en)	2003-04-11	2003-05-21	Novartis Ag	Organic compounds
US20040235892A1 (en) *	2003-05-22	2004-11-25	Yujia Dai	Indazole and benzisoxazole kinase inhibitors
US7297709B2 (en) *	2003-05-22	2007-11-20	Abbott Laboratories	Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
AU2004247136A1 (en)	2003-06-10	2004-12-23	Kalypsys, Inc.	Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease
US7393873B2 (en)	2003-07-02	2008-07-01	Merck & Co., Inc.	Arylsulfonamide derivatives
AP2006003633A0 (en)	2003-12-19	2006-06-30	Pfizer	Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-BETA-hydroxysteroid dehydrogenase type 1 (11-BETA-HSD-1) for the treatment of diabetes and obesity
JP2005263787A (ja)	2004-02-17	2005-09-29	Ishihara Sangyo Kaisha Ltd	アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤
TW200533336A (en) *	2004-03-02	2005-10-16	Fujisawa Pharmaceutical Co	Concomitant drugs
US20050250820A1 (en)	2004-03-08	2005-11-10	Amgen Inc.	Therapeutic modulation of PPARgamma activity
DE102004028862A1 (de)	2004-06-15	2005-12-29	Merck Patent Gmbh	3-Aminoindazole
EP1807391A4 (en)	2004-10-29	2010-01-06	Astrazeneca Ab	NOVEL SULFONAMIDE DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR AND FOR THE TREATMENT OF INFLAMMATORY DISEASES
SE0402635D0 (sv)	2004-10-29	2004-10-29	Astrazeneca Ab	Chemical compounds
CA2610588A1 (en)	2005-06-10	2006-12-21	Boehringer Ingelheim International Gmbh	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7888381B2 (en)	2005-06-14	2011-02-15	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
TW200815361A (en)	2005-10-20	2008-04-01	Astrazeneca Ab	Chemical compounds
GB0522880D0 (en)	2005-11-09	2005-12-21	Glaxo Group Ltd	Novel compounds
WO2007114763A1 (en)	2006-03-31	2007-10-11	Astrazeneca Ab	Sulphonamide derivates as modulators of the glucocorticoid receptor
MX2008013411A (es)	2006-04-20	2008-11-04	Glaxo Group Ltd	Nuevos compuestos.
BRPI0714811A2 (pt)	2006-07-14	2014-02-18	Lilly Co Eli	Modulador de receptor de corticóide, seus sais, composições farmacêuticas compreendendo os mesmos e uso dos referidos compostos e sais na fabricação de medicamento
GB0620406D0 (en)	2006-10-13	2006-11-22	Glaxo Group Ltd	Novel compounds
GB0620385D0 (en)	2006-10-13	2006-11-22	Glaxo Group Ltd	Novel compounds
EA200970401A1 (ru)	2006-10-23	2009-10-30	Мерк Энд Ко., Инк.	2-[1-ФЕНИЛ-5-ГИДРОКСИ ИЛИ МЕТОКСИ-4-АЛЬФА-МЕТИЛГЕКСАГИДРОЦИКЛОПЕНТА[f]ИНДАЗОЛ-5-ИЛ] ЭТИЛФЕНИЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ЛИГАНДОВ ГЛЮКОКОРТИКОИДНОГО РЕЦЕПТОРА
US8198311B2 (en)	2006-11-01	2012-06-12	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP2094692B1 (en)	2006-11-01	2012-11-28	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, ap-1 and/or nf-kappab activity and use thereof
TW200829578A (en)	2006-11-23	2008-07-16	Astrazeneca Ab	Chemical compounds 537
EP2102170A2 (en)	2006-12-06	2009-09-23	Boehringer Ingelheim International GmbH	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
JO2754B1 (en)	2006-12-21	2014-03-15	استرازينكا ايه بي	Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
WO2008079073A1 (en)	2006-12-22	2008-07-03	Astrazeneca Ab	Indazolyl sulphonamide derivatives for the treatment of glucocorticoid receptor mediated disorders
CA2683647A1 (en)	2007-04-10	2008-10-16	Boehringer Ingelheim International Gmbh	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US20100048950A1 (en)	2007-04-10	2010-02-25	Boehringer Ingelheim International Gmbh	Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof
GB0708858D0 (en)	2007-05-08	2007-06-13	Glaxo Group Ltd	Novel compounds
GB0720556D0 (en)	2007-10-19	2007-11-28	Glaxo Group Ltd	Novel compounds
GB0720557D0 (en)	2007-10-19	2007-11-28	Glaxo Group Ltd	Novel compounds
GB0720544D0 (en)	2007-10-19	2007-11-28	Glaxo Group Ltd	Novel compounds
GB0720549D0 (en)	2007-10-19	2007-11-28	Glaxo Group Ltd	Novel compounds
GB0720546D0 (en)	2007-10-19	2007-11-28	Glaxo Group Ltd	Novel compounds
GB0722211D0 (en)	2007-11-12	2007-12-27	Glaxo Group Ltd	Novel compounds
GB0724254D0 (en)	2007-12-12	2008-01-23	Glaxo Group Ltd	Novel compounds
US8338472B2 (en)	2008-02-26	2012-12-25	Merck Sharp & Dohme Corp.	Hexahydrocyclopentyl[F]indazole carboxamides and derivatives thereof as selective glucocorticoid receptor modulators
AU2009220458A1 (en)	2008-03-06	2009-09-11	Merck Sharp & Dohme Corp.	Hexahydrocyclopentyl[f]findazole sulfonamides and derivates thereof as selective glucocorticoid receptor modulators

2007
- 2007-11-12 TW TW096142666A patent/TW200829578A/zh unknown
- 2007-11-21 US US11/986,555 patent/US8030340B2/en not_active Expired - Fee Related
- 2007-11-22 JP JP2009538365A patent/JP2010510985A/ja not_active Ceased
- 2007-11-22 CA CA002677335A patent/CA2677335A1/en not_active Abandoned
- 2007-11-22 UY UY30736A patent/UY30736A1/es not_active Application Discontinuation
- 2007-11-22 CN CN2007800436841A patent/CN101646654B/zh not_active Expired - Fee Related
- 2007-11-22 EP EP07835228A patent/EP2097384B1/en not_active Not-in-force
- 2007-11-22 AR ARP070105195A patent/AR063906A1/es unknown
- 2007-11-22 WO PCT/SE2007/001031 patent/WO2008063116A1/en not_active Ceased
- 2007-11-22 ES ES07835228T patent/ES2393009T3/es active Active
- 2007-11-22 PE PE2007001623A patent/PE20081227A1/es not_active Application Discontinuation
- 2007-11-23 CL CL200703356A patent/CL2007003356A1/es unknown

Also Published As

Publication number	Publication date
ES2393009T3 (es)	2012-12-17
EP2097384A1 (en)	2009-09-09
EP2097384A4 (en)	2009-12-30
AR063906A1 (es)	2009-02-25
TW200829578A (en)	2008-07-16
US20080207721A1 (en)	2008-08-28
UY30736A1 (es)	2008-07-03
EP2097384B1 (en)	2012-09-12
CN101646654A (zh)	2010-02-10
JP2010510985A (ja)	2010-04-08
CN101646654B (zh)	2012-03-28
HK1138852A1 (en)	2010-09-03
PE20081227A1 (es)	2008-11-08
US8030340B2 (en)	2011-10-04
CA2677335A1 (en)	2008-05-29
WO2008063116A1 (en)	2008-05-29

Publication	Publication Date	Title
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