CL2009000091A1 - Enzima n-acetilgalactosamina-6-sulfatasa (galns) humana recombinante; usos de la enzima galns contra mucopolisacaridosis tipo iv o sindrome de morquio a o deficiencias de multiples sulfatasas. - Google Patents

Enzima n-acetilgalactosamina-6-sulfatasa (galns) humana recombinante; usos de la enzima galns contra mucopolisacaridosis tipo iv o sindrome de morquio a o deficiencias de multiples sulfatasas.

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Publication number
CL2009000091A1
CL2009000091A1 CL2009000091A CL2009000091A CL2009000091A1 CL 2009000091 A1 CL2009000091 A1 CL 2009000091A1 CL 2009000091 A CL2009000091 A CL 2009000091A CL 2009000091 A CL2009000091 A CL 2009000091A CL 2009000091 A1 CL2009000091 A1 CL 2009000091A1
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Chile
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enzyme
galns
sulfatase
acetylgalactosamine
recombinant human
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CL2009000091A
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English (en)
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Erno Pungor
Michel Claude Vellard
Vish Koppaka
Melita Dvorak-Ewell
Charles Hague
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    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06004—N-Acetylgalactosamine-6-sulfatase (3.1.6.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06014—N-Acetylglucosamine-6-sulfatase (3.1.6.14)
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    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
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Abstract

UNA ENZIMA N-ACETILGALACTOSAMINA-6-SULFATASA (GALNS( HUMANA RECOMBINANTE DE UNA SECUENCIA DE AMINOACIDOS CON AL MENOS 95°'O DE IDENTIDAD RESPECTO A LOS AMINOACIDOS 27 A 522 DE SEQ ID NO: 4, DONDE DICHA ENZIMA GALNS: (A) TIENE AL MENOS UNA CONVERSIÓN DEL 50% DEL RESIDUO DE CISTEINA EN (A POSICIÓN 53 EN CN-FORMILGLICINA (FGIY); Y (B) ESTÁ GLICOSILADA CON ENLACE N EN LOS RESIDUOS DE ASPARAGINA EN LAS POSICIONES 178 Y 397, DONDE AL MENOS SO% DE LAS CADENAS DE OLIGOMANOSA ADHERIDAS AL RESIDUO ASPARAGINA EN LA POSICIÓN 178 SON BIS-FOSFORILADAS; DONDE DICHA ENZIMA CONSISTE DE UNA BANDA DE 55-60 KDA. USO DE DICHA ENZIMA PARA EL TRATAMIENTO DE MUCOPOLISACARIDOSIS TIPO IVA (MPS IVA) O SÍNDROME DE MORQUÍO A, O DEFICIENCIA DE MÚLTIPLES SULFATASAS (MSD).
CL2009000091A 2008-01-18 2009-01-16 Enzima n-acetilgalactosamina-6-sulfatasa (galns) humana recombinante; usos de la enzima galns contra mucopolisacaridosis tipo iv o sindrome de morquio a o deficiencias de multiples sulfatasas. CL2009000091A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2217908P 2008-01-18 2008-01-18
US9937308P 2008-09-23 2008-09-23
US11024608P 2008-10-31 2008-10-31

Publications (1)

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CL2009000091A1 true CL2009000091A1 (es) 2009-03-27

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CL2009000091A CL2009000091A1 (es) 2008-01-18 2009-01-16 Enzima n-acetilgalactosamina-6-sulfatasa (galns) humana recombinante; usos de la enzima galns contra mucopolisacaridosis tipo iv o sindrome de morquio a o deficiencias de multiples sulfatasas.

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US (7) US8128925B2 (es)
EP (3) EP2245145B1 (es)
JP (1) JP5687069B2 (es)
KR (1) KR101744142B1 (es)
CN (3) CN105274072A (es)
AR (1) AR070198A1 (es)
AU (1) AU2009205978B2 (es)
BR (1) BRPI0906948B1 (es)
CA (2) CA3295047A1 (es)
CL (1) CL2009000091A1 (es)
CY (2) CY1118984T1 (es)
DK (2) DK2245145T3 (es)
ES (1) ES2984846T3 (es)
FI (1) FI3219795T3 (es)
HR (2) HRP20170366T1 (es)
HU (3) HUE066911T2 (es)
IL (1) IL206975A (es)
LT (3) LT3219795T (es)
MX (1) MX2010007846A (es)
NL (1) NL300874I2 (es)
NO (1) NO2017024I1 (es)
PE (2) PE20091319A1 (es)
PL (2) PL3219795T3 (es)
PT (2) PT2245145T (es)
RU (1) RU2510820C2 (es)
SI (2) SI2245145T1 (es)
TW (1) TWI395816B (es)
WO (1) WO2009091994A2 (es)
ZA (1) ZA201004674B (es)

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