CL2010000715A1 - Ave transgenica que comprende un gen que codifica una glicosiltransferasa donde l oviducto del ave produce proteinas que tienen n-oligosacaridos con al menos un sacarido que en condiciones normales no ocurre; metodo para producir una proteina exogena en un ave - Google Patents

Ave transgenica que comprende un gen que codifica una glicosiltransferasa donde l oviducto del ave produce proteinas que tienen n-oligosacaridos con al menos un sacarido que en condiciones normales no ocurre; metodo para producir una proteina exogena en un ave

Info

Publication number
CL2010000715A1
CL2010000715A1 CL2010000715A CL2010000715A CL2010000715A1 CL 2010000715 A1 CL2010000715 A1 CL 2010000715A1 CL 2010000715 A CL2010000715 A CL 2010000715A CL 2010000715 A CL2010000715 A CL 2010000715A CL 2010000715 A1 CL2010000715 A1 CL 2010000715A1
Authority
CL
Chile
Prior art keywords
bird
oviduct
glycosyltransferase
oligosaccharides
saccharide
Prior art date
Application number
CL2010000715A
Other languages
English (en)
Inventor
J Harvey Alex
Original Assignee
Synageva Biopharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synageva Biopharma Corp filed Critical Synageva Biopharma Corp
Publication of CL2010000715A1 publication Critical patent/CL2010000715A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Ave transgénica que comprende un gen que codifica una glicosiltransferasa donde l oviducto del ave produce proteínas que tienen n-oligosacáridos con al menos un sacárido que en condiciones normales no ocurre; método para producir una proteína exógena en un ave.
CL2010000715A 2008-01-07 2010-07-05 Ave transgenica que comprende un gen que codifica una glicosiltransferasa donde l oviducto del ave produce proteinas que tienen n-oligosacaridos con al menos un sacarido que en condiciones normales no ocurre; metodo para producir una proteina exogena en un ave CL2010000715A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1020708P 2008-01-07 2008-01-07
PCT/US2009/000058 WO2009088998A2 (en) 2008-01-07 2009-01-07 Glycosylation in avians

Publications (1)

Publication Number Publication Date
CL2010000715A1 true CL2010000715A1 (es) 2011-01-07

Family

ID=40845683

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2010000715A CL2010000715A1 (es) 2008-01-07 2010-07-05 Ave transgenica que comprende un gen que codifica una glicosiltransferasa donde l oviducto del ave produce proteinas que tienen n-oligosacaridos con al menos un sacarido que en condiciones normales no ocurre; metodo para producir una proteina exogena en un ave

Country Status (13)

Country Link
US (1) US8431770B2 (es)
EP (1) EP2230900A4 (es)
JP (2) JP5571576B2 (es)
KR (1) KR101343485B1 (es)
CN (2) CN101932231A (es)
AU (1) AU2009204495B2 (es)
BR (1) BRPI0907239A2 (es)
CA (1) CA2706001C (es)
CL (1) CL2010000715A1 (es)
IL (1) IL205869A (es)
NZ (1) NZ585555A (es)
RU (1) RU2010133175A (es)
WO (1) WO2009088998A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101742346B1 (ko) 2010-04-23 2017-06-15 시나게바 바이오파르마, 코포레이션 리소솜 축적병 효소
BR122019021757B1 (pt) 2010-09-09 2020-12-08 Alexion Pharmaceuticals, Inc composição farmacêutica para tratamento de um paciente humano sofrendo de uma deficiência de lipase ácida lisossomal (lal)
EP2675472A4 (en) * 2011-02-15 2014-09-17 Synageva Biopharma Corp METHOD FOR THE TREATMENT OF LACK OF LYSOSOMAL SAURER LIPASE
WO2013055888A2 (en) * 2011-10-12 2013-04-18 Synageva Biopharma Corp. Recombinant human naglu protein and uses thereof
EP2956003A2 (en) * 2013-02-13 2015-12-23 Laboratoire Français du Fractionnement et des Biotechnologies Proteins with modified glycosylation and methods of production thereof
KR20160002713A (ko) 2013-02-13 2016-01-08 라보라토이레 프란카이즈 듀 프락티온네먼트 에트 데스 바이오테크놀로지스 고도로 갈락토실화된 항-tnf-알파 항체 및 이의 용도
US20150282503A1 (en) * 2014-04-02 2015-10-08 Synageva Biopharma Corp. Producing Therapeutic Proteins
WO2016077457A1 (en) * 2014-11-11 2016-05-19 Clara Foods Co. Methods and compositions for egg white protein production
FR3038517B1 (fr) 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
FI13395Y1 (fi) 2019-07-11 2023-06-06 Clara Foods Co Koostumuksia, jotka käsittävät rekombinanttia ovomukoidiproteiinia
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes

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Publication number Priority date Publication date Assignee Title
US6825396B2 (en) * 1996-06-12 2004-11-30 Board Of Trustees Operating Michigan State University Methods for tissue specific synthesis of protein in eggs of transgenic hens
US7129390B2 (en) * 1997-10-16 2006-10-31 Avigenics, Inc Poultry Derived Glycosylated Interferon Alpha 2b
US7511120B2 (en) 1997-10-16 2009-03-31 Synageva Biopharma Corp. Glycosylated G-CSF obtained from a transgenic chicken
US20040019923A1 (en) * 1997-10-16 2004-01-29 Ivarie Robert D. Exogenous proteins expressed in avians and their eggs
US8563803B2 (en) 1997-10-16 2013-10-22 Synageva Biopharma Corp. Method of making protein in an egg of a transgenic chicken
DK1088084T3 (da) 1998-06-15 2007-01-29 Gtc Biotherapeutics Inc Erythropoietin analog-humant serumalbumin fusionsprotein
US7541512B2 (en) 2001-03-30 2009-06-02 Synageva Biopharma Corp. Avians containing a lysozyme promoter transgene
US7550650B2 (en) 2001-09-18 2009-06-23 Synageva Biopharma Corp. Production of a transgenic avian by cytoplasmic injection
EP2292273A3 (en) * 2001-10-10 2011-11-23 BioGeneriX AG Remodeling and glycoconjugation of peptides
US7335761B2 (en) 2001-11-30 2008-02-26 Avigenics, Inc. Avian gene expression controlling regions
AU2003254929A1 (en) 2002-08-13 2004-03-03 Kaneka Corporation Method of expressing gene in transgenic birds using retrovirus vector and transgenic birds thus obtained
WO2004094640A1 (en) 2003-04-15 2004-11-04 University Of Georgia Research Foundation, Inc. Avian transgenesis using a chicken ovalbumin gene region
US20080064862A1 (en) 2004-12-29 2008-03-13 Avigenics, Inc. Transgene expression in a avians
US7524626B2 (en) 2005-10-05 2009-04-28 Synageva Biopharma Corp. Rapid production of high titer virus
JP2009530377A (ja) * 2006-03-17 2009-08-27 シナジェバ・バイオファーマ・コーポレイション グリコシル化ｇ−ｃｓｆ
KR20090090328A (ko) * 2006-11-09 2009-08-25 시나게바 바이오파르마, 코포레이션 조류 유래 에리트로포이어틴
KR101426667B1 (ko) * 2007-04-17 2014-08-06 스티칭 디엔스트 랜드보위쿤디그 온데조에크 비-포유동물 글리코실트랜스퍼라제의 발현에 의한 식물에서의 포유동물형 글리코실화
WO2010023928A1 (ja) * 2008-09-01 2010-03-04 国立大学法人名古屋大学 トランスジェニック鳥類及びその作製法、並びにタンパク質の生産法
WO2011040527A1 (ja) * 2009-09-30 2011-04-07 国立大学法人帯広畜産大学 α-ガラクトースエピトープを発現するトランスジェニック鳥類、ウイルス及びワクチン

Also Published As

Publication number Publication date
JP5571576B2 (ja) 2014-08-13
AU2009204495B2 (en) 2013-10-24
EP2230900A2 (en) 2010-09-29
RU2010133175A (ru) 2012-02-20
WO2009088998A2 (en) 2009-07-16
JP2011508603A (ja) 2011-03-17
CA2706001A1 (en) 2009-07-16
BRPI0907239A2 (pt) 2017-06-13
WO2009088998A3 (en) 2009-10-15
US8431770B2 (en) 2013-04-30
EP2230900A4 (en) 2013-01-09
AU2009204495A1 (en) 2009-07-16
IL205869A (en) 2015-11-30
KR101343485B1 (ko) 2013-12-20
CN101932231A (zh) 2010-12-29
KR20100120140A (ko) 2010-11-12
US20090178147A1 (en) 2009-07-09
NZ585555A (en) 2012-08-31
IL205869A0 (en) 2010-11-30
CA2706001C (en) 2014-07-15
JP2014221054A (ja) 2014-11-27
CN105052834A (zh) 2015-11-18

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