CL2010001109A1 - Composicion que contiene un arn de interferencia de longitud entre 19 a 49 nucleotidos; y su uso para atenuar la expresion del arnm de la enzima convertidora de tnf alfa (div.sol.no.1434-07). - Google Patents

Composicion que contiene un arn de interferencia de longitud entre 19 a 49 nucleotidos; y su uso para atenuar la expresion del arnm de la enzima convertidora de tnf alfa (div.sol.no.1434-07).

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Publication number
CL2010001109A1
CL2010001109A1 CL2010001109A CL2010001109A CL2010001109A1 CL 2010001109 A1 CL2010001109 A1 CL 2010001109A1 CL 2010001109 A CL2010001109 A CL 2010001109A CL 2010001109 A CL2010001109 A CL 2010001109A CL 2010001109 A1 CL2010001109 A1 CL 2010001109A1
Authority
CL
Chile
Prior art keywords
interference
div
attenuate
nucleotides
sol
Prior art date
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CL2010001109A
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English (en)
Inventor
Steven T Miller
Daniel A Gamache
John M Yanni
Jon E Chatterton
Diane Michelle Senchyna
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Alcon Res Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38702032&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2010001109(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Res Ltd filed Critical Alcon Res Ltd
Publication of CL2010001109A1 publication Critical patent/CL2010001109A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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Abstract

Composición que contiene un arn de interferencia de longitud entre 19 a 49 nucleótidos; y su uso para atenuar la expresión del arnm de la enzima convertidora de tnf alfa (div.sol.no.1434-07).
CL2010001109A 2006-05-19 2010-10-08 Composicion que contiene un arn de interferencia de longitud entre 19 a 49 nucleotidos; y su uso para atenuar la expresion del arnm de la enzima convertidora de tnf alfa (div.sol.no.1434-07). CL2010001109A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80178806P 2006-05-19 2006-05-19

Publications (1)

Publication Number Publication Date
CL2010001109A1 true CL2010001109A1 (es) 2011-03-11

Family

ID=38702032

Family Applications (2)

Application Number Title Priority Date Filing Date
CL200701434A CL2007001434A1 (es) 2006-05-19 2007-05-18 Uso de un arn de interferencia de la enzima convertidora del factor de necrosis tumoral alfa (tace) para tratar enfermedades relacionadas con tnf alfa; y composicion que lo comprende.
CL2010001109A CL2010001109A1 (es) 2006-05-19 2010-10-08 Composicion que contiene un arn de interferencia de longitud entre 19 a 49 nucleotidos; y su uso para atenuar la expresion del arnm de la enzima convertidora de tnf alfa (div.sol.no.1434-07).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL200701434A CL2007001434A1 (es) 2006-05-19 2007-05-18 Uso de un arn de interferencia de la enzima convertidora del factor de necrosis tumoral alfa (tace) para tratar enfermedades relacionadas con tnf alfa; y composicion que lo comprende.

Country Status (17)

Country Link
US (7) US7732421B2 (es)
EP (1) EP2018426B1 (es)
JP (4) JP2009537566A (es)
KR (2) KR20120093306A (es)
CN (2) CN101448943B (es)
AR (1) AR061064A1 (es)
AU (1) AU2007253776B2 (es)
CA (1) CA2650416A1 (es)
CL (2) CL2007001434A1 (es)
ES (1) ES2413804T3 (es)
MX (1) MX2008014260A (es)
PL (1) PL2018426T3 (es)
RU (1) RU2469090C2 (es)
TW (1) TWI472344B (es)
UY (1) UY30361A1 (es)
WO (1) WO2007137129A2 (es)
ZA (1) ZA200809203B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7612196B2 (en) 2002-11-14 2009-11-03 Dharmacon, Inc. siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
US9771586B2 (en) 2002-11-14 2017-09-26 Thermo Fisher Scientific Inc. RNAi targeting ZNF205
US7635770B2 (en) 2002-11-14 2009-12-22 Dharmacon, Inc. siRNA targeting protein kinase N-3 (PKN-3)
US10011836B2 (en) 2002-11-14 2018-07-03 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
US9719094B2 (en) 2002-11-14 2017-08-01 Thermo Fisher Scientific Inc. RNAi targeting SEC61G
US9879266B2 (en) 2002-11-14 2018-01-30 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
US9719092B2 (en) 2002-11-14 2017-08-01 Thermo Fisher Scientific Inc. RNAi targeting CNTD2
AU2003295600A1 (en) 2002-11-14 2004-06-15 Dharmacon, Inc. Functional and hyperfunctional sirna
US7691998B2 (en) 2002-11-14 2010-04-06 Dharmacon, Inc. siRNA targeting nucleoporin 62kDa (Nup62)
US7951935B2 (en) 2002-11-14 2011-05-31 Dharmacon, Inc. siRNA targeting v-myc myelocytomatosis viral oncogene homolog (MYC)
US9228186B2 (en) 2002-11-14 2016-01-05 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
WO2006006948A2 (en) 2002-11-14 2006-01-19 Dharmacon, Inc. METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
US7781575B2 (en) 2002-11-14 2010-08-24 Dharmacon, Inc. siRNA targeting tumor protein 53 (p53)
US9839649B2 (en) 2002-11-14 2017-12-12 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
US7825099B2 (en) 2006-01-20 2010-11-02 Quark Pharmaceuticals, Inc. Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
US7732421B2 (en) * 2006-05-19 2010-06-08 Alcon Research, Ltd. RNAI-mediated inhibition of tumor necrosis factor α-related conditions
AU2007339334A1 (en) * 2006-12-19 2008-07-10 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring, and treatment of ocular disease
GB0708662D0 (en) * 2007-05-04 2007-06-13 Galapagos Nv shRNA sequences
WO2009001359A2 (en) 2007-06-27 2008-12-31 Quark Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of pro-apoptotic genes
UY31267A1 (es) 2007-08-03 2009-01-05 Alcon Res Ltd Inhibición del pasaje de senalización del tnfa relacionada con arni para el tratamiento de la angiogénesis ocular
TW200914052A (en) 2007-08-03 2009-04-01 Alcon Res Ltd RNAi-related inhibition of TNFα signaling pathway for treatment of glaucoma
CA2694091A1 (en) * 2007-10-01 2009-04-09 Alcon Research, Ltd. Self complementary aav-mediated delivery of interfering rna molecules to treat or prevent ocular disorders
US20090098136A1 (en) * 2007-10-15 2009-04-16 Alcon Research, Ltd. Use of tnf receptor antagonists for treating dry eye
CN102178959B (zh) * 2011-03-15 2013-10-23 清华大学深圳研究生院 抑制肺转移肿瘤生长的siRNA及其寡聚核酸组合与应用
EP2746396A1 (en) * 2012-12-20 2014-06-25 PLS-Design GmbH Selective local inhibition of TNFR1-mediated functions at the site of antigen/allergen presentation
US9617544B2 (en) 2013-04-11 2017-04-11 The Board Of Trustees Of The University Of Illinois Nanoparticle mediated delivery of siRNA
CN107904239B (zh) * 2014-12-25 2020-11-27 广州市锐博生物科技有限公司 抑制ADAMTS-5基因的siRNA及其应用
CN104560997B (zh) * 2014-12-25 2018-05-04 中国科学院广州生物医药与健康研究院 抑制ADAMTS-5和ADAM17基因的siRNA组合物及其应用
EP3237619B8 (en) * 2014-12-25 2021-03-10 Guangzhou Ribobio Co., Ltd. Compositions and methods for inhibiting expression of adamts-5 and adam17
CN104498498A (zh) * 2014-12-25 2015-04-08 广州市锐博生物科技有限公司 抑制ADAM17基因的siRNA及其应用
CN105349502A (zh) * 2015-12-09 2016-02-24 山西医科大学 Tnfr1基因重组腺病毒及其构建
KR102692717B1 (ko) * 2016-09-23 2024-08-08 (주)아모레퍼시픽 Tnfrsf14 억제 물질을 포함하는 피부 미백용 조성물 및 tnfrsf14 억제 물질의 스크리닝 방법
US10709793B2 (en) 2016-09-30 2020-07-14 Industry-University Cooperation Foundation Hanyang University Gene/carrier complex for preventing or treating inflammatory diseases
US11225507B2 (en) 2017-01-25 2022-01-18 The Board Of Trustees Of The University Of Illinois Conformation switchable antimicrobial peptides and methods of using the same
US11642365B2 (en) 2017-09-22 2023-05-09 John Mansell Compositions and methods for treatment of sepsis-related disorders
KR102163667B1 (ko) * 2018-03-27 2020-10-08 한양대학교 산학협력단 염증성 질환 예방 또는 치료용 유전자／전달체 복합체
CN114410627B (zh) * 2021-12-20 2023-08-08 硅羿科技（上海）有限公司 一种特异性敲降TNF-α基因表达的siRNA及其应用
WO2023129496A2 (en) * 2021-12-27 2023-07-06 Apellis Pharmaceuticals, Inc. Rnas for complement inhibition

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180403B1 (en) * 1999-10-28 2001-01-30 Isis Pharmaceuticals Inc. Antisense inhibition of tumor necrosis factor alpha converting enzyme (TACE) expression
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) * 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
WO2000027421A2 (en) * 1998-11-06 2000-05-18 The Schepens Eye Research Institute, Inc. LOCAL USE OF SOLUBLE TUMOR NECROSIS RECEPTOR I (sTNFRI) FOR PROPHYLAXIS AND TREATMENT OF CORNEAL TRANSPLANT REJECTION AND OTHER DISORDERS OF THE EYE
US6632667B1 (en) * 1999-10-28 2003-10-14 Isis Pharmaceuticals, Inc. Modulation of L-selectin shedding via inhibition of tumor necrosis factor-α converting enzyme (TACE)
WO2002048168A1 (en) * 2000-10-24 2002-06-20 Isis Pharmaceuticals, Inc. Antisense modulation of tnfr1 expression
US20050227935A1 (en) 2001-05-18 2005-10-13 Sirna Therapeutics, Inc. RNA interference mediated inhibition of TNF and TNF receptor gene expression using short interfering nucleic acid (siNA)
EP1392322A1 (en) * 2001-05-21 2004-03-03 Alcon, Inc. Method of treating dry eye disorders
AU2003295600A1 (en) * 2002-11-14 2004-06-15 Dharmacon, Inc. Functional and hyperfunctional sirna
EP1576007A2 (en) * 2002-12-23 2005-09-21 Ingenium Pharmaceuticals AG Methods and agents for diagnosis and prevention, amelioration or treatment of goblet cell-related disorders
CA2518475C (en) * 2003-03-07 2014-12-23 Alnylam Pharmaceuticals, Inc. Irna agents comprising asymmetrical modifications
WO2004113387A2 (en) 2003-06-24 2004-12-29 Merck Patent Gmbh Tumour necrosis factor receptor molecules with reduced immunogenicity
WO2005076998A2 (en) * 2004-02-05 2005-08-25 Intradigm Corporation Rnai therapeutics for treatment of eye neovascularization diseases
WO2005116204A1 (ja) * 2004-05-11 2005-12-08 Rnai Co., Ltd. Ｒｎａ干渉を生じさせるポリヌクレオチド、および、これを用いた遺伝子発現抑制方法
EP1877556B1 (en) * 2005-03-25 2011-09-14 Medtronic, Inc. Use of anti-tnf or anti-il1 rnai to suppress pro- inflammatory cytokine actions locally to treat pain
US7732421B2 (en) * 2006-05-19 2010-06-08 Alcon Research, Ltd. RNAI-mediated inhibition of tumor necrosis factor α-related conditions
US20090098136A1 (en) * 2007-10-15 2009-04-16 Alcon Research, Ltd. Use of tnf receptor antagonists for treating dry eye

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JP2013049727A (ja) 2013-03-14
TWI472344B (zh) 2015-02-11
US9447419B2 (en) 2016-09-20
US20130338213A1 (en) 2013-12-19
US20100166676A1 (en) 2010-07-01
ES2413804T3 (es) 2013-07-17
RU2008150324A (ru) 2010-06-27
US20160369283A1 (en) 2016-12-22
US20070281901A1 (en) 2007-12-06
CN101448943B (zh) 2013-07-17
JP2016033153A (ja) 2016-03-10
CN103285026B (zh) 2017-08-04
AU2007253776A1 (en) 2007-11-29
AR061064A1 (es) 2008-07-30
RU2469090C2 (ru) 2012-12-10
MX2008014260A (es) 2008-11-26
ZA200809203B (en) 2010-02-24
US8541389B2 (en) 2013-09-24
HK1128090A1 (en) 2009-10-16
EP2018426B1 (en) 2013-05-15
US20190032061A1 (en) 2019-01-31
UY30361A1 (es) 2007-08-31
WO2007137129A2 (en) 2007-11-29
KR20090010234A (ko) 2009-01-29
WO2007137129A3 (en) 2008-04-10
PL2018426T3 (pl) 2013-10-31
CL2007001434A1 (es) 2008-02-22
US20110142767A1 (en) 2011-06-16
KR20120093306A (ko) 2012-08-22
JP2013049728A (ja) 2013-03-14
CN101448943A (zh) 2009-06-03
CN103285026A (zh) 2013-09-11
JP2009537566A (ja) 2009-10-29
EP2018426A2 (en) 2009-01-28
CA2650416A1 (en) 2007-11-29
AU2007253776B2 (en) 2012-04-26
US20140357694A1 (en) 2014-12-04
US7732421B2 (en) 2010-06-08
TW200812623A (en) 2008-03-16

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