CL2011001692A1 - Composicion farmaceutica que entrega acido butirico y glutamina directamente en el colon, para inducir la liberacion de una hormona intestinal desde celulas l del colon; su uso en diabetes tipo i o tipo ii y obesidad, entre otros. - Google Patents

Composicion farmaceutica que entrega acido butirico y glutamina directamente en el colon, para inducir la liberacion de una hormona intestinal desde celulas l del colon; su uso en diabetes tipo i o tipo ii y obesidad, entre otros.

Info

Publication number
CL2011001692A1
CL2011001692A1 CL2011001692A CL2011001692A CL2011001692A1 CL 2011001692 A1 CL2011001692 A1 CL 2011001692A1 CL 2011001692 A CL2011001692 A CL 2011001692A CL 2011001692 A CL2011001692 A CL 2011001692A CL 2011001692 A1 CL2011001692 A1 CL 2011001692A1
Authority
CL
Chile
Prior art keywords
colon
type
obesity
glutamine
diabetes
Prior art date
Application number
CL2011001692A
Other languages
English (en)
Inventor
Jerzy Ryszard Szewczyk
Original Assignee
Biokier Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biokier Inc filed Critical Biokier Inc
Publication of CL2011001692A1 publication Critical patent/CL2011001692A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Composición para inducir liberación de una hormona intestinal desde las células L en el colon, que comprende ácido butírico, un Ac. biliar, Ac. Graso de cadena larga y glutamina, formulada para que no se libere en estómago ni en tracto gi superior; y uso en el tratamiento y prevención de enfermedades tales como diabetes y obesidad.
CL2011001692A 2009-01-12 2011-07-11 Composicion farmaceutica que entrega acido butirico y glutamina directamente en el colon, para inducir la liberacion de una hormona intestinal desde celulas l del colon; su uso en diabetes tipo i o tipo ii y obesidad, entre otros. CL2011001692A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14395109P 2009-01-12 2009-01-12
US29377310P 2010-01-11 2010-01-11

Publications (1)

Publication Number Publication Date
CL2011001692A1 true CL2011001692A1 (es) 2012-04-13

Family

ID=42317190

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011001692A CL2011001692A1 (es) 2009-01-12 2011-07-11 Composicion farmaceutica que entrega acido butirico y glutamina directamente en el colon, para inducir la liberacion de una hormona intestinal desde celulas l del colon; su uso en diabetes tipo i o tipo ii y obesidad, entre otros.

Country Status (23)

Country Link
US (2) US8470885B2 (es)
EP (1) EP2376077B1 (es)
JP (1) JP5702306B2 (es)
KR (4) KR20170138573A (es)
CN (1) CN102355896A (es)
AU (1) AU2010203413B2 (es)
BR (1) BRPI1006145B8 (es)
CA (1) CA2748827C (es)
CL (1) CL2011001692A1 (es)
CY (1) CY1119010T1 (es)
DK (1) DK2376077T3 (es)
EA (1) EA022631B1 (es)
ES (1) ES2628233T3 (es)
HR (1) HRP20170886T1 (es)
HU (1) HUE034551T2 (es)
LT (1) LT2376077T (es)
MX (1) MX2011007393A (es)
PL (1) PL2376077T3 (es)
PT (1) PT2376077T (es)
RS (1) RS56054B1 (es)
SI (1) SI2376077T1 (es)
SM (1) SMT201700278T1 (es)
WO (1) WO2010081079A2 (es)

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US20220071895A1 (en) * 2009-01-12 2022-03-10 Biokier, Inc. Composition and method for treatment of diabetes
US20150224081A1 (en) * 2009-01-12 2015-08-13 Biokier, Inc. Composition and method for treatment of diabetes
WO2012161670A2 (en) 2010-04-07 2012-11-29 Incube Labs, Llc Method for treating diabetes and other glucose regulation disorders using stem cells
CN103429739B (zh) 2010-05-12 2018-11-13 哥伦比亚大学纽约管理委员会 制备产生和分泌胰岛素的肠内分泌细胞的方法
CN103702668A (zh) * 2011-05-02 2014-04-02 拜奥基尔公司 治疗糖尿病的组合物和方法
KR20130055220A (ko) 2011-11-18 2013-05-28 삼성전자주식회사 동박적층판 및 이를 사용한 금속코어기판의 제조방법
CN108478551A (zh) * 2011-11-21 2018-09-04 埃默斯医疗股份有限公司 用于治疗糖尿病和相关病症的方法和组合物
US20150073057A1 (en) * 2013-09-06 2015-03-12 Biokier, Inc. Composition and method for treatment of diabetes
EP3160503B1 (en) 2014-06-26 2021-02-17 The Trustees of Columbia University in the City of New York Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells
WO2016172479A1 (en) * 2015-04-22 2016-10-27 Cedars-Sinai Medical Center Enterically delivered bitter oligopeptides for the treatment for type 2 diabetes
WO2016210384A2 (en) 2015-06-25 2016-12-29 Synlogic, Inc. Bacteria engineered to treat metabolic diseases
US9668991B1 (en) 2015-12-09 2017-06-06 International Business Machines Corporation SCFA colonic composition
CN107684550B (zh) * 2016-08-03 2020-04-10 徐天宏 糖尿病治疗产品及其制备与应用
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
WO2019165309A1 (en) 2018-02-23 2019-08-29 Ambra Bioscience Llc Compositions and methods for hunger control and weight management
MA52971A (fr) 2018-06-20 2021-04-28 Axcella Health Inc Compositions et procédés pour le traitement de l'infiltration de graisse dans le muscle
CN114340615A (zh) 2019-08-12 2022-04-12 麻省理工学院 用于施用治疗剂的制品和方法
US20230190686A1 (en) * 2021-12-17 2023-06-22 Biokier, Inc. Composition and method for treatment of diabetes

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Also Published As

Publication number Publication date
MX2011007393A (es) 2011-10-06
SMT201700278T1 (it) 2017-07-18
EP2376077B1 (en) 2017-03-15
JP2012515163A (ja) 2012-07-05
AU2010203413B2 (en) 2015-05-14
US20110275716A1 (en) 2011-11-10
US8470885B2 (en) 2013-06-25
KR20110120866A (ko) 2011-11-04
RS56054B1 (sr) 2017-09-29
EA201190068A1 (ru) 2012-01-30
EP2376077A2 (en) 2011-10-19
AU2010203413A1 (en) 2011-07-14
WO2010081079A2 (en) 2010-07-15
ES2628233T3 (es) 2017-08-02
BRPI1006145A2 (pt) 2017-05-30
US20130102581A1 (en) 2013-04-25
CA2748827C (en) 2017-10-10
EA022631B1 (ru) 2016-02-29
CY1119010T1 (el) 2018-01-10
DK2376077T3 (en) 2017-06-26
SI2376077T1 (sl) 2017-09-29
HRP20170886T1 (hr) 2017-09-08
HUE034551T2 (en) 2018-02-28
KR20170034928A (ko) 2017-03-29
JP5702306B2 (ja) 2015-04-15
CA2748827A1 (en) 2010-07-15
CN102355896A (zh) 2012-02-15
KR20190062609A (ko) 2019-06-05
US8680085B2 (en) 2014-03-25
WO2010081079A3 (en) 2010-11-25
BRPI1006145B8 (pt) 2021-05-25
PL2376077T3 (pl) 2017-10-31
LT2376077T (lt) 2017-08-10
KR20170138573A (ko) 2017-12-15
EP2376077A4 (en) 2012-08-29
PT2376077T (pt) 2017-06-23
BRPI1006145B1 (pt) 2021-03-09

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