CL2011002116A1 - Compuestos derivados de acetamida sustituida por n-heteroaril o 2-heteroaril como moduladores de las señales wnt; composiciones farmaceuticas que los comprenden; y su uso en el tratamiento del cancer, rechazo de injerto de riñon, osteoartritis, parkinson, entre otras. - Google Patents

Compuestos derivados de acetamida sustituida por n-heteroaril o 2-heteroaril como moduladores de las señales wnt; composiciones farmaceuticas que los comprenden; y su uso en el tratamiento del cancer, rechazo de injerto de riñon, osteoartritis, parkinson, entre otras.

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Publication number
CL2011002116A1
CL2011002116A1 CL2011002116A CL2011002116A CL2011002116A1 CL 2011002116 A1 CL2011002116 A1 CL 2011002116A1 CL 2011002116 A CL2011002116 A CL 2011002116A CL 2011002116 A CL2011002116 A CL 2011002116A CL 2011002116 A1 CL2011002116 A1 CL 2011002116A1
Authority
CL
Chile
Prior art keywords
heteroaryl
osteoarthritis
parkinson
modulators
cancer
Prior art date
Application number
CL2011002116A
Other languages
English (en)
Inventor
Cheng Dai
Zhang Guobao
Han Dong
Gao Wenqi
Pan Shifeng
Original Assignee
Novartis Ag
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42112245&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011002116(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2011002116A1 publication Critical patent/CL2011002116A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DE LAS FORMULAS (1) Y (2): Y  A  MÉTODOS  PARA MODULAR LA SENDA DE SEÑALIZACIÓN DE WNT UTILIZANDO ESTOS COMPUESTOS, EN DONDE A1, A2, B, Y Y Z REPRESENTAN TODOS ANILLOS.
CL2011002116A 2009-03-02 2011-08-30 Compuestos derivados de acetamida sustituida por n-heteroaril o 2-heteroaril como moduladores de las señales wnt; composiciones farmaceuticas que los comprenden; y su uso en el tratamiento del cancer, rechazo de injerto de riñon, osteoartritis, parkinson, entre otras. CL2011002116A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15659909P 2009-03-02 2009-03-02
US24518709P 2009-09-23 2009-09-23

Publications (1)

Publication Number Publication Date
CL2011002116A1 true CL2011002116A1 (es) 2012-01-27

Family

ID=42112245

Family Applications (1)

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CL2011002116A CL2011002116A1 (es) 2009-03-02 2011-08-30 Compuestos derivados de acetamida sustituida por n-heteroaril o 2-heteroaril como moduladores de las señales wnt; composiciones farmaceuticas que los comprenden; y su uso en el tratamiento del cancer, rechazo de injerto de riñon, osteoartritis, parkinson, entre otras.

Country Status (40)

Country Link
US (4) US8546396B2 (es)
EP (2) EP2403832B1 (es)
JP (2) JP5490153B2 (es)
KR (1) KR101359873B1 (es)
CN (2) CN102731379B (es)
AR (1) AR076067A1 (es)
AU (1) AU2010221493C1 (es)
BR (1) BRPI1009235B8 (es)
CA (1) CA2753552C (es)
CL (1) CL2011002116A1 (es)
CO (1) CO6450669A2 (es)
CR (2) CR20190039A (es)
CU (1) CU24050B1 (es)
DK (1) DK2403832T3 (es)
DO (1) DOP2011000273A (es)
EA (1) EA021225B1 (es)
EC (1) ECSP11011359A (es)
ES (2) ES2445526T3 (es)
GE (2) GEP20146082B (es)
HN (1) HN2011002346A (es)
HR (1) HRP20140156T1 (es)
IL (1) IL214516A (es)
JO (1) JO2933B1 (es)
MA (1) MA33157B1 (es)
MX (1) MX2011009246A (es)
MY (1) MY150583A (es)
NI (1) NI201100165A (es)
NZ (2) NZ595339A (es)
PE (1) PE20120650A1 (es)
PL (1) PL2403832T3 (es)
PT (1) PT2403832E (es)
SG (1) SG173467A1 (es)
SI (1) SI2403832T1 (es)
SM (1) SMT201400032B (es)
TN (1) TN2011000378A1 (es)
TW (2) TWI429644B (es)
UA (1) UA103918C2 (es)
UY (2) UY32469A (es)
WO (1) WO2010101849A1 (es)
ZA (1) ZA201106750B (es)

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US10259817B2 (en) 2015-06-23 2019-04-16 Eisai R&D Management Co., Ltd. Crystal (6S,9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
US11369623B2 (en) 2015-06-16 2022-06-28 Prism Pharma Co., Ltd. Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor
US12226409B2 (en) 2017-05-16 2025-02-18 Eisai R&D Management Co., Ltd. Treatment of hepatocellular carcinoma
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition

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UA103918C2 (en) * 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
PE20120834A1 (es) 2009-03-23 2012-07-25 Glenmark Pharmaceuticals Sa Derivados de furopirimidindiona como moduladores de trpa1
EA201201274A1 (ru) 2010-03-10 2013-04-30 Инджениум Фармасьютиклз Гмбх Ингибиторы протеинкиназ
UY33469A (es) 2010-06-29 2012-01-31 Irm Llc Y Novartis Ag Composiciones y metodos para modular la via de señalizacion de wnt
EP3915367A1 (en) 2010-08-18 2021-12-01 BioSplice Therapeutics, Inc. Diketones and hydroxyketones as catenin signaling pathway activators
EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
EP2573085A1 (en) 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
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