CR20150648A - Derivados de nucleósido 4´-azido, 3´-desoxi-3´-fluoro sustituido - Google Patents

Derivados de nucleósido 4´-azido, 3´-desoxi-3´-fluoro sustituido

Info

Publication number
CR20150648A
CR20150648A CR20150648A CR20150648A CR20150648A CR 20150648 A CR20150648 A CR 20150648A CR 20150648 A CR20150648 A CR 20150648A CR 20150648 A CR20150648 A CR 20150648A CR 20150648 A CR20150648 A CR 20150648A
Authority
CR
Costa Rica
Prior art keywords
fluoro
desoxi
azido
replaced
nucleoside derivatives
Prior art date
Application number
CR20150648A
Other languages
English (en)
Inventor
Mark Smith
Klaus G Klumpp
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of CR20150648A publication Critical patent/CR20150648A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)

Abstract

La presente invención se refiere a derivados denucleósidos 4'-fluoro-2'-metilo sustituidos, composicionesfarmacéuticas de los mismos, y métodos para usar talescompuestos y/o composiciones de los mismos para eltratamiento del HCV.
CR20150648A 2013-05-16 2015-12-08 Derivados de nucleósido 4´-azido, 3´-desoxi-3´-fluoro sustituido CR20150648A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361824030P 2013-05-16 2013-05-16
PCT/US2014/038287 WO2014186637A1 (en) 2013-05-16 2014-05-15 4'-fluor0-2'-methyl substituted nucleoside derivatives

Publications (1)

Publication Number Publication Date
CR20150648A true CR20150648A (es) 2016-03-09

Family

ID=51895938

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20150648A CR20150648A (es) 2013-05-16 2015-12-08 Derivados de nucleósido 4´-azido, 3´-desoxi-3´-fluoro sustituido

Country Status (23)

Country Link
US (1) US9895442B2 (es)
EP (1) EP2996695B1 (es)
JP (1) JP6366693B2 (es)
KR (1) KR102241198B1 (es)
CN (1) CN105307662B (es)
AU (1) AU2014265293B2 (es)
BR (1) BR112015028764B1 (es)
CA (1) CA2912682C (es)
CL (1) CL2015003357A1 (es)
CR (1) CR20150648A (es)
EA (1) EA035301B1 (es)
HK (1) HK1217294A1 (es)
IL (1) IL242605B (es)
MA (2) MA46490A1 (es)
MX (1) MX2015015782A (es)
MY (1) MY186547A (es)
NZ (1) NZ714927A (es)
PE (1) PE20160120A1 (es)
PH (1) PH12015502588A1 (es)
SG (1) SG11201509424VA (es)
UA (1) UA123533C2 (es)
WO (1) WO2014186637A1 (es)
ZA (1) ZA201509056B (es)

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US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
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BR112016029994A2 (pt) * 2014-06-24 2017-08-22 Alios Biopharma Inc métodos de preparação de análogos de nucleotídeo substituídos
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AU2018335411B2 (en) * 2017-09-21 2024-06-27 Riboscience Llc 4'-fluoro-2'-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
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IL277160B2 (en) * 2018-03-07 2024-10-01 Univ Emory 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto
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Also Published As

Publication number Publication date
PH12015502588B1 (en) 2016-02-29
MA46490A1 (fr) 2021-04-30
CN105307662A (zh) 2016-02-03
MY186547A (en) 2021-07-26
SG11201509424VA (en) 2015-12-30
PE20160120A1 (es) 2016-02-24
EP2996695A4 (en) 2016-12-14
BR112015028764B1 (pt) 2022-09-27
KR20160040141A (ko) 2016-04-12
IL242605B (en) 2018-08-30
MA38675A1 (fr) 2017-12-29
HK1217294A1 (zh) 2017-01-06
AU2014265293A1 (en) 2015-12-24
UA123533C2 (uk) 2021-04-21
CA2912682C (en) 2021-07-06
EA035301B1 (ru) 2020-05-26
BR112015028764A2 (pt) 2017-07-25
CA2912682A1 (en) 2014-11-20
CL2015003357A1 (es) 2016-11-04
EP2996695B1 (en) 2022-04-13
MX2015015782A (es) 2016-06-02
HK1219900A1 (zh) 2017-04-21
EA201592184A1 (ru) 2016-04-29
NZ714927A (en) 2020-09-25
PH12015502588A1 (en) 2016-02-29
WO2014186637A1 (en) 2014-11-20
EP2996695A1 (en) 2016-03-23
ZA201509056B (en) 2016-11-30
JP2016518453A (ja) 2016-06-23
US20140341847A1 (en) 2014-11-20
JP6366693B2 (ja) 2018-08-01
US9895442B2 (en) 2018-02-20
AU2014265293B2 (en) 2019-07-18
CN105307662B (zh) 2019-06-04
KR102241198B1 (ko) 2021-04-15

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