CL2011002432A1 - Composicion que comprende al menos una enzima digestiva y al menos un portador, en donde el portador comprende celulosa microcristalina que tiene un tamaño de particulas mayor que 100 um; una forma de dosificacion; el envase que la contiene; un proceso para preparar la composicion; y sus usos. - Google Patents

Composicion que comprende al menos una enzima digestiva y al menos un portador, en donde el portador comprende celulosa microcristalina que tiene un tamaño de particulas mayor que 100 um; una forma de dosificacion; el envase que la contiene; un proceso para preparar la composicion; y sus usos.

Info

Publication number
CL2011002432A1
CL2011002432A1 CL2011002432A CL2011002432A CL2011002432A1 CL 2011002432 A1 CL2011002432 A1 CL 2011002432A1 CL 2011002432 A CL2011002432 A CL 2011002432A CL 2011002432 A CL2011002432 A CL 2011002432A CL 2011002432 A1 CL2011002432 A1 CL 2011002432A1
Authority
CL
Chile
Prior art keywords
composition
carrier
dosage form
prepare
container
Prior art date
Application number
CL2011002432A
Other languages
English (en)
Inventor
Giovanni Ortenzi
Franza Giuseppe De
Danilo Clementi
Original Assignee
Aptalis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45044628&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011002432(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aptalis Pharma Ltd filed Critical Aptalis Pharma Ltd
Publication of CL2011002432A1 publication Critical patent/CL2011002432A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCIÓN SE DIRIGE A COMPOSICIONES O FORMAS DE DOSIFICACIÓN FARMACÉUTICAS QUE TIENEN UN CONTENIDO<br /> DE ENZIMAS DIGESTIVAS BAJO (DILUIDO) ESTABLE QUE COMPRENDE AL MENOS UNA ENZIMA DIGESTIVA Y AL MENOS UN PORTADOR<br /> O UNA FORMA DE DOSIFICACIÓN DEL MISMO. LA INVENCIÓN TAMBIÉN SE DIRIGE A UN PROCESO PARA LA PREPARACIÓN DE LA<br /> COMPOSICIÓN O LA FORMA DE DOSIFICACIÓN. ADICIONALMENTE, LA INVENCIÓN SE DIRIGE AL TRATAMIENTO Y LA PREVENCIÓN DE<br /> TRASTORNOS O AFECCIONES ASOCIADOS CON UNA DEFICIENCIA ENZIMÁTICA DIGESTIVA EN UN PACIENTE QUE LO NECESITA QUE<br /> COMPRENDEN ADMINISTRAR A DICHO PACIENTE UNA CANTIDAD FARMACÉUTICAMENTE ACEPTABLE DE LA COMPOSICIÓN QUE TIENE<br /> UN CONTENIDO DE ENZIMAS DIGESTIVAS BAJO ESTABLE O UNA FORMA DE DOSIFICACIÓN DE LA MISMA.
CL2011002432A 2010-10-01 2011-09-30 Composicion que comprende al menos una enzima digestiva y al menos un portador, en donde el portador comprende celulosa microcristalina que tiene un tamaño de particulas mayor que 100 um; una forma de dosificacion; el envase que la contiene; un proceso para preparar la composicion; y sus usos. CL2011002432A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38903710P 2010-10-01 2010-10-01

Publications (1)

Publication Number Publication Date
CL2011002432A1 true CL2011002432A1 (es) 2012-04-20

Family

ID=45044628

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011002432A CL2011002432A1 (es) 2010-10-01 2011-09-30 Composicion que comprende al menos una enzima digestiva y al menos un portador, en donde el portador comprende celulosa microcristalina que tiene un tamaño de particulas mayor que 100 um; una forma de dosificacion; el envase que la contiene; un proceso para preparar la composicion; y sus usos.

Country Status (26)

Country Link
US (2) US11364205B2 (es)
EP (2) EP2621476B8 (es)
JP (2) JP6043929B2 (es)
KR (2) KR101968457B1 (es)
CN (2) CN108187033A (es)
AR (1) AR093181A1 (es)
AU (2) AU2011309763B2 (es)
BR (1) BR112013007640A2 (es)
CA (1) CA2812862C (es)
CL (1) CL2011002432A1 (es)
CO (1) CO6700848A2 (es)
DK (1) DK2621476T4 (es)
EA (3) EA030450B1 (es)
ES (2) ES2515715T5 (es)
HR (1) HRP20140995T1 (es)
IL (1) IL225504A (es)
MX (1) MX348118B (es)
PL (1) PL2621476T5 (es)
PT (1) PT2621476E (es)
RS (1) RS53587B1 (es)
SA (1) SA111320804B1 (es)
SI (1) SI2621476T1 (es)
SM (1) SMT201400149B (es)
UA (1) UA111726C2 (es)
WO (1) WO2012042372A1 (es)
ZA (1) ZA201303087B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632429B1 (en) 1999-12-17 2003-10-14 Joan M. Fallon Methods for treating pervasive development disorders
US20070053895A1 (en) 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
US8030002B2 (en) 2000-11-16 2011-10-04 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
AR065405A1 (es) 2007-02-20 2009-06-03 Eurand Pharmaceuticals Ltd Composiciones estables de enzimas digestivas
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
US9320780B2 (en) 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
ES2732453T3 (es) 2008-07-01 2019-11-22 Curemark Llc Métodos y composiciones para el tratamiento de síntomas de trastornos neurológicos y de salud mental
US10776453B2 (en) 2008-08-04 2020-09-15 Galenagen, Llc Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
US20100092447A1 (en) 2008-10-03 2010-04-15 Fallon Joan M Methods and compositions for the treatment of symptoms of prion diseases
CN102300989B (zh) 2009-01-06 2015-12-09 柯尔朗恩有限责任公司 用于治疗或预防金黄色葡萄球菌感染以及用于根除或减少表面上金黄色葡萄球菌的组合物和方法
EP2373693A4 (en) 2009-01-06 2012-04-25 Curelon Llc COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF ORAL INFECTIONS BY E. COLI
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
US9511125B2 (en) 2009-10-21 2016-12-06 Curemark Llc Methods and compositions for the treatment of influenza
EP2621476B8 (en) 2010-10-01 2020-12-23 Société des Produits Nestlé S.A. Enteric coated, low-strength pancrelipase formulations
CN103619348B (zh) 2011-04-21 2016-10-26 柯尔马克有限责任公司 用于治疗神经精神障碍的化合物
CN103732245B (zh) 2011-08-08 2016-07-06 阿普塔利斯制药有限公司 用于含有消化酶的组合物的溶出度测试的方法
US10350278B2 (en) * 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
ES2707211T3 (es) 2013-03-15 2019-04-02 Allergan Pharmaceuticals Int Ltd Proceso para la preparación de una composición que contiene enzimas digestivas y nutrientes adecuada para su administración enteral
MX2016001593A (es) 2013-08-09 2016-09-29 Allergan Pharmaceuticals Int Ltd Composicion de enzima digestiva adecuada para administracion enterica.
RU2015155470A (ru) * 2013-11-05 2017-08-21 Апталис Фарма Лтд. Высокоэффективные фармацевтические композиции панкреатина
EP3157568A1 (en) 2014-06-19 2017-04-26 Aptalis Pharma Limited Methods for removing viral contaminants from pancreatic extracts
EP3609528A4 (en) 2017-04-10 2020-12-23 Curemark, LLC COMPOSITIONS FOR THE TREATMENT OF ADDICTION
JP6442659B1 (ja) * 2017-12-28 2018-12-26 株式会社フクハラ 細菌増殖警報器付き除菌フィルタ
WO2020257802A1 (en) * 2019-06-21 2020-12-24 Das Aditya Spray dried oral pharmaceutical compositions for enteric hepatic or intestinal delivery
CN110801024A (zh) * 2019-10-25 2020-02-18 运鸿集团股份有限公司 降低血糖血脂及糖化血红蛋白的多糖复合多肽及制备方法
JP7816927B2 (ja) * 2020-05-28 2026-02-18 ロート製薬株式会社 圧縮固形組成物
FR3111559A1 (fr) * 2020-06-18 2021-12-24 Azurrx Biopharma, Inc. Formulations non porcines et leurs procédés
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses
WO2025008458A1 (en) * 2023-07-06 2025-01-09 Perseo Pharma Ag Functionalized biocatalytical compositions comprising pancreatic enzymes
AU2024290815A1 (en) * 2023-07-06 2026-01-08 Perseo Pharma Ag Biocatalytical compositions

Family Cites Families (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2751330A (en) 1952-08-27 1956-06-19 Armour & Co Use of a salt in the extraction slurry in recovering proteolytic enzymes from pancreas gland material
FR1484458A (es) 1965-06-25 1967-09-15
GB1342409A (en) 1970-07-23 1974-01-03 Ciba Geigy Ag Flowable pancreatin preparation of low microorgan ism content and a process for its manufacture
DE2460334C3 (de) 1974-12-20 1979-09-06 Hoechst Ag, 6000 Frankfurt Verfahren zur Gewinnung von Insulin und Pankreatin aus Schweinepankreas
GB1509866A (en) 1975-06-10 1978-05-04 Johnson & Johnson Enteric coated digestive enzyme compositions
US4237229A (en) 1975-06-10 1980-12-02 W. R. Grace & Co. Immobilization of biological material with polyurethane polymers
GB1590432A (en) † 1976-07-07 1981-06-03 Novo Industri As Process for the production of an enzyme granulate and the enzyme granuate thus produced
JPS5535031A (en) 1978-09-04 1980-03-11 Shin Etsu Chem Co Ltd Enteric coating composition
DE2923279C2 (de) 1979-06-08 1987-07-09 Kali-Chemie Pharma Gmbh, 3000 Hannover Verfahren zur Herstellung von Pankreatin-Pellets und diese enthaltende Arzneimittel
JPS5885159A (ja) 1981-11-17 1983-05-21 Furointo Sangyo Kk 溶出試験装置
EP0115023B1 (de) 1982-12-30 1988-07-27 Nordmark Arzneimittel GmbH Verfahren zur Gewinnung von Pankreatin
US4447412A (en) 1983-02-01 1984-05-08 Bilton Gerald L Enzyme-containing digestive aid compostions
US4704295A (en) 1983-09-19 1987-11-03 Colorcon, Inc. Enteric film-coating compositions
DE3445301A1 (de) 1984-12-12 1986-06-12 Hoechst Ag, 6230 Frankfurt Pankreasenzympraeparate und verfahren zu deren herstellung
WO1987004184A1 (fr) 1985-12-27 1987-07-16 Showa Denko Kabushiki Kaisha Procede de granulation d'enzyme
US4849227A (en) 1986-03-21 1989-07-18 Eurasiam Laboratories, Inc. Pharmaceutical compositions
WO1987005505A1 (en) 1986-03-21 1987-09-24 Eurasiam Laboratories, Inc. Pharmaceutical compositions
GB2189698A (en) 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
FR2603804B1 (fr) 1986-09-17 1989-10-27 Jouveinal Sa Lipases et extraits lipasiques, leur procede de preparation et leur application en therapeutique
IT1205716B (it) 1987-01-21 1989-03-31 Samil Spa Procedimento per la preparazione di microsfere gastroresistenti ed enterosolubili di enzima digestivo e preparato faramceutico a microsfere cosi' prodotto
DK435687D0 (da) † 1987-08-21 1987-08-21 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
US5733763A (en) † 1988-08-19 1998-03-31 Novo Nordisk A/S Enzyme granulate formed of an enzyme-containing core and an enzyme-containing shell
DK78189D0 (da) † 1989-02-20 1989-02-20 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
DK78089D0 (da) † 1989-02-20 1989-02-20 Novo Industri As Detergentholdigt granulat og fremgangsmaade til fremstilling deraf
DK306289D0 (da) † 1989-06-21 1989-06-21 Novo Nordisk As Detergentadditiv i granulatform
DE3927286C2 (de) 1989-08-18 1997-07-24 Roehm Gmbh Wäßrige Enzym-Flüssigformulierungen
PH30058A (en) 1989-11-24 1996-11-08 Biochemie Gmbh Pancreation preparations
IT1246350B (it) 1990-07-11 1994-11-17 Eurand Int Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili
JPH0790565B2 (ja) 1991-08-06 1995-10-04 株式会社日本製鋼所 樹脂成形プレスのスライド制御方法及びその装置
US5225202A (en) 1991-09-30 1993-07-06 E. R. Squibb & Sons, Inc. Enteric coated pharmaceutical compositions
WO1993007859A1 (en) 1991-10-23 1993-04-29 Warner-Lambert Company Novel pharmaceutical pellets and process for their production
SE9200858L (sv) 1992-03-20 1993-09-21 Kabi Pharmacia Ab Metod för framställning av pellets med fördröjd frisättning
HRP930935A2 (en) 1992-06-11 1994-12-31 Astra Ab New dna sequences
US5460812A (en) † 1992-06-22 1995-10-24 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5578304A (en) 1992-06-22 1996-11-26 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5260074A (en) 1992-06-22 1993-11-09 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5308832A (en) 1992-07-27 1994-05-03 Abbott Laboratories Nutritional product for persons having a neurological injury
DE4227385A1 (de) 1992-08-19 1994-02-24 Kali Chemie Pharma Gmbh Pankreatinmikropellets
JP3264027B2 (ja) 1993-02-24 2002-03-11 ソニー株式会社 放電セル及びその製造方法
US5955448A (en) 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
RU94017352A (ru) 1994-05-11 1996-07-27 Товарищество с ограниченной ответственностью "Инвест" Способ лечения онкологических больных, перенесших операцию на желудочно-кишечном тракте
DE4422433A1 (de) † 1994-06-28 1996-01-04 Cognis Bio Umwelt Mehrenzymgranulat
PL179210B1 (pl) 1994-08-05 2000-08-31 Smithkline Beecham Plc Pojemnik z substancja wrazliwa na wilgoc PL PL PL PL
US5733575A (en) 1994-10-07 1998-03-31 Bpsi Holdings, Inc. Enteric film coating compositions, method of coating therewith, and coated forms
ATE287725T1 (de) 1995-05-31 2005-02-15 Medzyme N V Zusammensetzungen zur verbesserung der verdaulichkeit und ausnutzung von nähestoffen
US6057139A (en) * 1995-06-29 2000-05-02 Mcneil-Ppc, Inc. Preblend of microcrystalline cellulose and lactase for making tablets
US5665428A (en) 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
US5750104A (en) 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
DE19622131A1 (de) † 1996-06-01 1997-12-04 Solvay Enzymes Gmbh & Co Kg Neue Enzymgranulate
WO1997046860A2 (en) 1996-06-04 1997-12-11 Euro-Celtique, S.A. Improvements in detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form
JPH1023888A (ja) 1996-07-10 1998-01-27 Kao Corp 酵素造粒物の製造方法
DE19724845A1 (de) 1996-08-28 1998-03-05 Solvay Pharm Gmbh Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen
US8828432B2 (en) 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
GB9623205D0 (en) 1996-11-07 1997-01-08 Eurand Int Novel pharmaceutical compositions
CA2198317C (en) 1997-02-24 2003-01-07 Mouhsine El Abboudi Method for preparing pancreatin which contains low amounts of residual organic solvent and product thereof
JPH10295374A (ja) 1997-04-30 1998-11-10 Amano Pharmaceut Co Ltd 安定な酵素顆粒の製造法
DE19721467A1 (de) 1997-05-22 1998-11-26 Basf Ag Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe
SE9702338D0 (sv) 1997-06-18 1997-06-18 Astra Ab An analytical method and industrial process including the same
ES2137862B1 (es) 1997-07-31 2000-09-16 Intexim S A Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
JP3611456B2 (ja) 1997-09-30 2005-01-19 日研化学株式会社 テオフィリン徐放性錠剤
KR19990072826A (ko) 1998-02-26 1999-09-27 우재영 판크레아틴장용코팅과립의제조방법
US7201923B1 (en) 1998-03-23 2007-04-10 General Mills, Inc. Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles
JPH11315043A (ja) 1998-04-30 1999-11-16 Lion Corp ヒドロキシエーテル化合物の製造方法及び洗浄剤組成物
US20010024660A1 (en) 1999-09-29 2001-09-27 Ismat Ullah Enteric coated pharmaceutical composition and method of manufacturing
US7122207B2 (en) 1998-05-22 2006-10-17 Bristol-Myers Squibb Company High drug load acid labile pharmaceutical composition
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
NZ511442A (en) 1998-11-02 2003-02-28 Elan Corp Plc Multiparticulate modified release composition for multiple dosing of ADD patients with methylphenidate HCl
AU7405400A (en) 1999-10-01 2001-05-10 Novozymes A/S Enzyme granulate
US20010046493A1 (en) 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
WO2001070047A1 (en) 2000-03-24 2001-09-27 Société des Produits Nestlé S.A. Nutritional composition comprising hydrolysed protein
AU2001244093A1 (en) 2000-04-03 2001-10-15 Novozymes A/S Enzyme tablets for cleaning improvement
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
AR032392A1 (es) 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.
AUPR272901A0 (en) 2001-01-25 2001-02-22 Gainful Plan Limited Method of preparing biological materials and preparations produced using same
EP1279402B1 (en) 2001-07-26 2006-11-29 Ethypharm Coated granules of allylamine-or benzylamine-anti-mycotics, process for preparation thereof and orodispersible tablets containing said coated granules
JP4187085B2 (ja) 2001-08-24 2008-11-26 三菱電機株式会社 車両用乗員保護装置
US20040197321A1 (en) * 2002-03-19 2004-10-07 Tibor Sipos Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients
CN1156308C (zh) 2002-04-19 2004-07-07 北京世诺医药科技有限公司 多酶组合胶囊
US20040132826A1 (en) 2002-10-25 2004-07-08 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
WO2004049820A1 (ja) * 2002-11-29 2004-06-17 Freund Corporation 水性セラック皮膜剤、その製造方法、該皮膜剤を用いたコーテッド食品、その製造方法、コーテッド医薬品、その製造方法、油性菓子の艶付用組成物、艶付方法、及び艶付油性菓子
CA2419572A1 (en) 2003-02-18 2004-08-18 Axcan Pharma Inc. High dosage protease formulation
US20040213847A1 (en) 2003-04-23 2004-10-28 Matharu Amol Singh Delayed release pharmaceutical compositions containing proton pump inhibitors
JP2007509982A (ja) 2003-10-29 2007-04-19 アルタス ファーマシューティカルズ インコーポレイテッド 血漿コレシストキニン（ｃｃｋ）濃度を制御するための非膵臓プロテアーゼおよび痛みを処置するための非膵臓プロテアーゼ
US7670624B2 (en) 2004-01-29 2010-03-02 Astella Pharma Inc. Gastrointestinal-specific multiple drug release system
PL1729797T3 (pl) 2004-03-22 2009-02-27 Abbott Laboratories Gmbh Doustne kompozycje farmaceutyczne produktów zawierających lipazę, a zwłaszcza pankreatynę, zawierające środki powierzchniowo czynne
US20050281876A1 (en) 2004-06-18 2005-12-22 Shun-Por Li Solid dosage form for acid-labile active ingredient
US20060013807A1 (en) * 2004-07-13 2006-01-19 Chapello William J Rapidly disintegrating enzyme-containing solid oral dosage compositions
US20060198838A1 (en) 2004-09-28 2006-09-07 Fallon Joan M Combination enzyme for cystic fibrosis
ES2614157T3 (es) 2004-10-14 2017-05-29 Eli Lilly And Co. Composiciones que contienen lipasa, proteasa y amilasa para el tratamiento de la insuficiencia pancreática
CN1247106C (zh) * 2004-11-01 2006-03-29 广东溢多利生物科技股份有限公司 多色微丸型饲用复合酶及其制造方法
JP4891549B2 (ja) 2005-01-19 2012-03-07 富士フイルム株式会社 プラスチック成形用金型
US20070025977A1 (en) * 2005-07-21 2007-02-01 Mulberg Andrew E Method of treating steatorrhea in infants
KR101199196B1 (ko) 2005-07-25 2012-11-07 (주)다산메디켐 구형의 판크레아틴 과립의 제조방법
BRPI0614914A2 (pt) 2005-07-29 2011-04-19 Solvay Pharm Gmbh processos para a fabricação de pó de pancreatina esterilizada
SI1931316T2 (sl) 2005-08-15 2017-05-31 Abbott Laboratories Gmbh Farmacevtski sestavki z nadzorovanim sproščanjem za kislinsko labilna zdravila
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
ATE418329T1 (de) 2005-08-15 2009-01-15 Solvay Pharm Gmbh Pankreatin-mikropellets geeignet für magensaftresistente überzüge
US8071089B2 (en) 2005-11-01 2011-12-06 Bio-Cat, Inc. Composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrosis as well as people suffering from pancreatic lipase insufficiency
US20070141151A1 (en) 2005-12-20 2007-06-21 Silver David I Lansoprazole orally disintegrating tablets
WO2007074856A1 (ja) † 2005-12-28 2007-07-05 Takeda Pharmaceutical Company Limited 口腔内崩壊性固形製剤の製造法
RU2433817C2 (ru) 2006-01-21 2011-11-20 Эбботт Гмбх Унд Ко.Кг Лекарственная форма и способ для доставки вызывающих зависимость лекарственных веществ
AU2007267560B2 (en) 2006-05-26 2010-10-21 Nestec S.A. Methods of use and nutritional compositions of Touchi Extract
US20080031998A1 (en) † 2006-08-07 2008-02-07 Novozymes A/S Enzyme Granules for Animal Feed
KR100804096B1 (ko) † 2006-08-31 2008-02-18 (주)아모레퍼시픽 고농도 계면활성제 계에서도 안정한 효소 캡슐 제제를포함하는 피부 세정용 조성물 및 그 제조방법
US9011843B2 (en) * 2006-12-14 2015-04-21 Master Supplements, Inc. Formulations including monovalent alginate to enhance effectiveness of administered digestive enzymes
US8066986B2 (en) 2007-02-01 2011-11-29 Master Supplements, Inc. Formulations including digestive enzymes and polysorbate surfactants that enhance the colonization of administered probiotics microoganisms
US20080199448A1 (en) 2007-02-16 2008-08-21 Ross Mairi R Enzyme composition for improving food digestion
AR065405A1 (es) 2007-02-20 2009-06-03 Eurand Pharmaceuticals Ltd Composiciones estables de enzimas digestivas
RU2445952C2 (ru) 2007-02-20 2012-03-27 Юранд Фармасьютикалз Лимитед Стабильные композиции пищеварительных ферментов
US20090117180A1 (en) † 2007-02-20 2009-05-07 Giovanni Ortenzi Stable digestive enzyme compositions
AU2008239737A1 (en) 2007-04-13 2008-10-23 Beth Israel Deaconess Medical Center, Inc. Novel nutritional food products for improved digestion and intestinal absorption
CN101440361A (zh) * 2007-11-22 2009-05-27 珠海百康生物技术有限公司 一种制备稳定的包被颗粒酶的方法
US20110008423A1 (en) 2008-01-03 2011-01-13 Abbott Products Gmbh Pharmaceutical compositions comprising granules of purified microbial lipase and methods for preventing or treating digestive disorders
CN101249081A (zh) 2008-02-15 2008-08-27 南京大渊美容保健有限公司 口服控释给药药片
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
WO2010025126A1 (en) 2008-08-26 2010-03-04 Cystic Fibrosis Foundation Therapeutics, Inc. Rapidly disintegrating tablets comprising lipase, amylase, and protease
CN101430279A (zh) 2008-10-27 2009-05-13 江南大学 荧光分光光度法筛选催化非水相体系转酯化反应用酶的方法
CN101623269A (zh) * 2009-08-04 2010-01-13 南京大渊美容保健有限公司 口服缓释给药的颗粒
US8784884B2 (en) 2009-09-17 2014-07-22 Stephen Perrett Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency
JP2011093845A (ja) 2009-10-29 2011-05-12 宏之 ▲今▼西 胃瘻用注入剤及びその注入装置
US20110135728A1 (en) † 2009-12-08 2011-06-09 Miller Jennifer L Gastric retentive pharmaceutical compositions for extended release of polypeptides
AU2011228743A1 (en) 2010-03-19 2012-10-11 Aptalis Pharma Canada, Inc. Gastro-resistant enzyme pharmaceutical compositions
GB201006178D0 (en) 2010-04-14 2010-06-02 Ayanda As Composition
EP2558216B1 (en) 2010-04-14 2020-03-18 Dow Global Technologies LLC Dispensing device for both froth and non-froth coatings
TW201210517A (en) 2010-08-06 2012-03-16 Aptalis Pharma Ltd Predigested nutritional formula
AR082943A1 (es) 2010-08-06 2013-01-23 Aptalis Pharma Ltd Formula nutricional predigerida
EP2621476B8 (en) † 2010-10-01 2020-12-23 Société des Produits Nestlé S.A. Enteric coated, low-strength pancrelipase formulations
TW201216951A (en) 2010-10-21 2012-05-01 Aptalis Pharma Ltd Oral dosing device for administration of medication
ES2552656T3 (es) 2011-03-27 2015-12-01 Cellresin Technologies, Llc Composiciones, artículos y métodos a base de ciclodextrina
CN103732245B (zh) 2011-08-08 2016-07-06 阿普塔利斯制药有限公司 用于含有消化酶的组合物的溶出度测试的方法
CN103060296B (zh) 2012-12-30 2014-05-21 青岛九龙生物医药有限公司 从动物胰脏中提取胰蛋白酶的方法
ES2707211T3 (es) 2013-03-15 2019-04-02 Allergan Pharmaceuticals Int Ltd Proceso para la preparación de una composición que contiene enzimas digestivas y nutrientes adecuada para su administración enteral
WO2015019198A2 (en) 2013-07-22 2015-02-12 Aptalis Pharma S.R.L. High potency pancreatin pharmaceutical compositions
MX2016001593A (es) 2013-08-09 2016-09-29 Allergan Pharmaceuticals Int Ltd Composicion de enzima digestiva adecuada para administracion enterica.
RU2015155470A (ru) 2013-11-05 2017-08-21 Апталис Фарма Лтд. Высокоэффективные фармацевтические композиции панкреатина
EP3157568A1 (en) 2014-06-19 2017-04-26 Aptalis Pharma Limited Methods for removing viral contaminants from pancreatic extracts
EP3035780A1 (de) 2014-12-18 2016-06-22 Siemens Aktiengesellschaft Kühlkörper
CN204811577U (zh) † 2015-07-09 2015-12-02 佛山市南海中宇渔具有限公司 渔轮及其线壳

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