CL2011002657A1 - Proceso para preparar una mezcla racemica de acidos cis- y trans-octahidro ciclopenta[c]pirrol-1-carboxilicos; compuestos intermediarios. - Google Patents

Proceso para preparar una mezcla racemica de acidos cis- y trans-octahidro ciclopenta[c]pirrol-1-carboxilicos; compuestos intermediarios.

Info

Publication number
CL2011002657A1
CL2011002657A1 CL2011002657A CL2011002657A CL2011002657A1 CL 2011002657 A1 CL2011002657 A1 CL 2011002657A1 CL 2011002657 A CL2011002657 A CL 2011002657A CL 2011002657 A CL2011002657 A CL 2011002657A CL 2011002657 A1 CL2011002657 A1 CL 2011002657A1
Authority
CL
Chile
Prior art keywords
pyrrol
cis
trans
preparing
carboxylic acids
Prior art date
Application number
CL2011002657A
Other languages
English (en)
Inventor
Gerarld J Tanoury
Minzhang Cochran John E Looker Adam Jurkauskas Valdas Chen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43032514&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011002657(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CL2011002657A1 publication Critical patent/CL2011002657A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Proceso para preparar una mezcla racémica de ácidos cis- y trans-octahidro ciclopenta[c]pirrol-1-carboxílicos; compuestos intermediarios.
CL2011002657A 2009-04-27 2011-10-26 Proceso para preparar una mezcla racemica de acidos cis- y trans-octahidro ciclopenta[c]pirrol-1-carboxilicos; compuestos intermediarios. CL2011002657A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/430,207 US8399615B2 (en) 2005-08-19 2009-04-27 Processes and intermediates

Publications (1)

Publication Number Publication Date
CL2011002657A1 true CL2011002657A1 (es) 2012-05-25

Family

ID=43032514

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011002657A CL2011002657A1 (es) 2009-04-27 2011-10-26 Proceso para preparar una mezcla racemica de acidos cis- y trans-octahidro ciclopenta[c]pirrol-1-carboxilicos; compuestos intermediarios.

Country Status (16)

Country Link
US (2) US8399615B2 (es)
EP (1) EP2477966A1 (es)
JP (1) JP2012525392A (es)
KR (1) KR20120061062A (es)
CN (1) CN102639499A (es)
AU (1) AU2010241800A1 (es)
BR (1) BRPI1013338A2 (es)
CA (1) CA2760163A1 (es)
CL (1) CL2011002657A1 (es)
IL (1) IL215893A0 (es)
MX (1) MX2011011272A (es)
NZ (1) NZ595817A (es)
RU (1) RU2531588C2 (es)
SG (1) SG175800A1 (es)
WO (1) WO2010126881A1 (es)
ZA (1) ZA201108502B (es)

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EP2825534A1 (en) 2012-03-16 2015-01-21 Sandoz AG Process for the synthesis of telaprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof
ITMI20120990A1 (it) * 2012-06-07 2013-12-08 Dipharma Francis Srl Sintesi di un inibitore delle proteasi virali
IN2014MN02533A (es) * 2012-06-13 2015-07-24 Janssen Pharmaceutica Nv
WO2013189978A1 (en) 2012-06-20 2013-12-27 Sandoz Ag PROCESS FOR PREPARING ß-AMINO ACID DERIVATIVES AND USE OF SAID PROCESS FOR PREPARING TELAPREVIR
WO2014102816A1 (en) * 2012-12-26 2014-07-03 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Process for preparation of telaprevir and intermediates
CN103288671B (zh) * 2013-06-20 2014-10-29 上海步越化工科技有限公司 一种(3s)-3-氨基-n-环丙基-2-羟基己酰胺盐酸盐的合成方法
WO2014203208A1 (en) 2013-06-21 2014-12-24 Ranbaxy Laboratories Limited Process for the preparation of telaprevir and intermediates thereof
CN104558106B (zh) * 2013-10-19 2019-12-10 广东东阳光药业有限公司 一种治疗丙肝药物的制备方法
EP3265109B1 (en) 2015-03-06 2020-10-21 Stealth BioTherapeutics Corp Processes for preparing pharmaceutically relevant peptides
CN105111129A (zh) * 2015-08-24 2015-12-02 上海合全药业股份有限公司 (1S,3aR,6aS)-八氢环戊烯并[C]吡咯-1-羧酸叔丁酯草酸盐的制备方法
IL298324A (en) 2020-06-10 2023-01-01 Aligos Therapeutics Inc Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
CA3224494A1 (en) 2021-07-09 2023-01-12 Koen Vandyck Anti-viral compounds
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections

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ES2381410T3 (es) 2007-05-04 2012-05-28 Vertex Pharmceuticals Incorporated Terapia de combinación paa el tratamiento de infecciones por VHC
AU2008254435A1 (en) 2007-05-21 2008-11-27 Vertex Pharmaceuticals Incorporated Dose forms comprising VX- 950 and their dosage regimen
WO2009032198A1 (en) 2007-08-30 2009-03-12 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
JP2011503060A (ja) 2007-11-05 2011-01-27 バーテックス ファーマシューティカルズ インコーポレイテッド Ｖｘ−９５０、ｐｅｇ−ｉｆｎおよびリババリンを含むｈｃｖ併用治療剤
EP2280709A1 (en) 2008-04-23 2011-02-09 Vertex Pharmaceuticals Incorporated Treatment of hepatitis c virus infections with telaprevir (vx-950) in patients non-responsive to treatment with pegylated interfer0n-alpha-2a/2b and ribavirin
RU2011103770A (ru) 2008-07-03 2012-08-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) ПОЛУЧЕНИЕ ЗАЩИЩЕННЫХ СЛОЖНЫХ α-КЕТО-β-АМИНОЭФИРОВ И АМИДОВ
EP2328656A1 (en) 2008-09-24 2011-06-08 Vertex Pharmaceuticals Incorporated Therapeutic regimen comprising peg- interferon, ribavirin and vx-950 for the treatment of hepatitis "
WO2010053942A1 (en) 2008-11-05 2010-05-14 Vertex Pharmaceuticals Incorporated Methods for treating hepatitis c virus infection
EP2396028A2 (en) 2009-02-12 2011-12-21 Vertex Pharmceuticals Incorporated Hcv combination therapies comprising pegylated interferon, ribavirin and telaprevir
CN102844030A (zh) 2010-01-29 2012-12-26 沃泰克斯药物股份有限公司 用于治疗丙型肝炎病毒感染的疗法
EP2593105A1 (en) 2010-07-14 2013-05-22 Vertex Pharmaceuticals Incorporated Palatable pharmaceutical composition comprising vx-950
US20130195797A1 (en) 2012-01-31 2013-08-01 Vertex Pharmaceuticals Incorporated High potency formulations of vx-950

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SG175800A1 (en) 2011-12-29
IL215893A0 (en) 2012-01-31
AU2010241800A1 (en) 2011-12-01
RU2531588C2 (ru) 2014-10-20
US20100063252A1 (en) 2010-03-11
EP2477966A1 (en) 2012-07-25
US20130172276A1 (en) 2013-07-04
BRPI1013338A2 (pt) 2016-03-29
MX2011011272A (es) 2011-11-04
CN102639499A (zh) 2012-08-15
CA2760163A1 (en) 2010-11-04
KR20120061062A (ko) 2012-06-12
US8871904B2 (en) 2014-10-28
ZA201108502B (en) 2012-08-29
US8399615B2 (en) 2013-03-19
JP2012525392A (ja) 2012-10-22
WO2010126881A1 (en) 2010-11-04

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