CL2012000271A1 - Compuestos derivados de metilpirrolo[3,2-d]pirimidincarboxamida, inhibidores de pde5; composición farmacéutica que los comprende; y uso en el tratamiento en enfermedades de las vías respiratorias, hipertensión portal, nefritis, cirrosis hepática, entre otras. - Google Patents

Compuestos derivados de metilpirrolo[3,2-d]pirimidincarboxamida, inhibidores de pde5; composición farmacéutica que los comprende; y uso en el tratamiento en enfermedades de las vías respiratorias, hipertensión portal, nefritis, cirrosis hepática, entre otras.

Info

Publication number
CL2012000271A1
CL2012000271A1 CL2012000271A CL2012000271A CL2012000271A1 CL 2012000271 A1 CL2012000271 A1 CL 2012000271A1 CL 2012000271 A CL2012000271 A CL 2012000271A CL 2012000271 A CL2012000271 A CL 2012000271A CL 2012000271 A1 CL2012000271 A1 CL 2012000271A1
Authority
CL
Chile
Prior art keywords
treatment
respiratory tract
pyrimidinecarboxamide
methylpyrrolo
nephritis
Prior art date
Application number
CL2012000271A
Other languages
English (en)
Inventor
Beate Schmidt
Josef Stadlwieser
Heiko Bernsmann
Torsten Dunkern
Ewald Benediktus
Andreas Pahl
Ragna Hussong
Olaf Nimz
Matthias Müller
Martin Viertelhaus
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41698276&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012000271(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CL2012000271A1 publication Critical patent/CL2012000271A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCIÓN DESCRIBE COMPUESTOS DE FÓRMULA (1) LAS SALES FARMACÉUTICAS DE LOS MISMOS, Y LOS ESTEREOISÓMEROS DE LOS COMPUESTOS Y LAS SALES FARMACÉUTICAS DE LOS MISMOS EN DONDE RL, R2, R3, R21, R22, R23, R24 Y Y TIENEN LOS SIGNIFICADOS COMO SE INDICA EN LA MEMORIA DESCRIPTIVA Y PLIEGO DE REIVINDICACIONES; ADICIONALMENTE<br /> SE DESCRIBEN LAS COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN A DICHOS COMPUESTOS; Y AL USO DE LOS MISMOS EN LA PREPARACIÓN DE UN MEDICAMENTO ÚTIL EN EL TRATAMIENTO O PROFILAXIS DE UNA ENFERMEDAD AGUDA O CRÓNICA DE LAS VÍAS RESPIRATORIAS, ENTRE ELLAS HIPERTENSIÓN ARTERIAL PULMONAR, Y EL TRATAMIENTO O PROFILAXIS DE ENFERMEDAD ARTERIAL PERIFÉRICA, DÍABETES MELLITUS, SÍNDROME DE RAYNAUD, VEJIGA HIPERACTIVA, SÍNTOMAS DEL TRACTO URINARIO INFERIOR (LUTS), HIPERTENSION PORTAL, NEFRITIS, ENTRE OTRAS.  
CL2012000271A 2009-08-26 2012-02-01 Compuestos derivados de metilpirrolo[3,2-d]pirimidincarboxamida, inhibidores de pde5; composición farmacéutica que los comprende; y uso en el tratamiento en enfermedades de las vías respiratorias, hipertensión portal, nefritis, cirrosis hepática, entre otras. CL2012000271A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09168685 2009-08-26

Publications (1)

Publication Number Publication Date
CL2012000271A1 true CL2012000271A1 (es) 2012-08-31

Family

ID=41698276

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012000271A CL2012000271A1 (es) 2009-08-26 2012-02-01 Compuestos derivados de metilpirrolo[3,2-d]pirimidincarboxamida, inhibidores de pde5; composición farmacéutica que los comprende; y uso en el tratamiento en enfermedades de las vías respiratorias, hipertensión portal, nefritis, cirrosis hepática, entre otras.

Country Status (25)

Country Link
US (2) US8927557B2 (es)
EP (1) EP2470536B1 (es)
JP (1) JP5791606B2 (es)
KR (1) KR101762884B1 (es)
CN (1) CN102574861B (es)
AR (1) AR077898A1 (es)
AU (1) AU2010288550B2 (es)
BR (1) BR112012003616A8 (es)
CA (1) CA2771938A1 (es)
CL (1) CL2012000271A1 (es)
CO (1) CO6491110A2 (es)
EA (1) EA021103B1 (es)
EC (1) ECSP12011678A (es)
ES (1) ES2529563T3 (es)
IL (1) IL218126A (es)
MX (1) MX2012002432A (es)
MY (1) MY159031A (es)
NZ (1) NZ598777A (es)
PE (1) PE20121133A1 (es)
SG (1) SG178481A1 (es)
TN (1) TN2012000034A1 (es)
TW (1) TWI471327B (es)
UA (1) UA106628C2 (es)
WO (1) WO2011023693A1 (es)
ZA (1) ZA201200616B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
MX2013014888A (es) 2011-06-17 2014-02-27 Takeda Gmbh Novedosos derivados de ftalazinona-pirrolopirimidinacarboxamida.
CA2901636A1 (en) 2013-02-21 2014-08-28 Adverio Pharma Gmbh Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate
JP2020097527A (ja) * 2017-03-31 2020-06-25 武田薬品工業株式会社 複素環化合物
CN107286160A (zh) * 2017-06-05 2017-10-24 毛佳婧 一种抗肝炎药物的哌啶并吡啶并吡唑‑锌配合物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2754260B1 (fr) 1996-10-04 1998-10-30 Adir Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6187777B1 (en) * 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
CA2411013A1 (en) * 2000-06-07 2001-12-13 Jose Manuel Prieto Soto 6-phenylpyrrolopyrimidinedione derivatives
MXPA03004926A (es) 2001-02-14 2005-02-14 Warner Lambert Co Inhibidores de metaloproteinasas de matriz basados en pirimidinonas fusionadas.
CN100374441C (zh) * 2003-06-06 2008-03-12 天津倍方科技发展有限公司 二氢吡咯[2，3-d]嘧啶-4-酮衍生物，其制备方法及其制药用途
US20050124623A1 (en) * 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
WO2006049952A1 (en) 2004-10-29 2006-05-11 Eli Lilly And Company Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
AU2006221957A1 (en) * 2005-03-09 2006-09-14 Nycomed Gmbh Amido-substituted 6-phenylphenanthridines
ES2362805T3 (es) 2006-09-07 2011-07-13 Industrial Research Limited Inhibidores aminoacíclicos de nucleósido fosforilasas e hidrolasas.
JP4837701B2 (ja) * 2007-04-20 2011-12-14 田辺三菱製薬株式会社 医薬組成物
AR070454A1 (es) 2008-02-27 2010-04-07 Nycomed Gmbh Pirrolopirimidincarboxamidas y composiciones farmaceuticas que las comprenden

Also Published As

Publication number Publication date
TWI471327B (zh) 2015-02-01
HK1169411A1 (zh) 2013-01-25
BR112012003616A8 (pt) 2018-02-06
PE20121133A1 (es) 2012-08-30
MY159031A (en) 2016-12-15
CA2771938A1 (en) 2011-03-03
EA021103B1 (ru) 2015-04-30
CO6491110A2 (es) 2012-07-31
BR112012003616A2 (pt) 2016-02-23
ZA201200616B (en) 2012-10-31
EP2470536A1 (en) 2012-07-04
TW201111384A (en) 2011-04-01
US20150073001A1 (en) 2015-03-12
IL218126A0 (en) 2012-06-28
KR20120107458A (ko) 2012-10-02
AU2010288550B2 (en) 2015-01-29
KR101762884B1 (ko) 2017-07-28
EA201200322A1 (ru) 2012-09-28
MX2012002432A (es) 2012-04-11
US9376442B2 (en) 2016-06-28
JP5791606B2 (ja) 2015-10-07
SG178481A1 (en) 2012-03-29
CN102574861B (zh) 2015-08-05
WO2011023693A1 (en) 2011-03-03
AU2010288550A1 (en) 2012-04-12
EP2470536B1 (en) 2014-11-12
JP2013503131A (ja) 2013-01-31
ECSP12011678A (es) 2012-03-30
AR077898A1 (es) 2011-09-28
CN102574861A (zh) 2012-07-11
UA106628C2 (uk) 2014-09-25
US20120149721A1 (en) 2012-06-14
ES2529563T3 (es) 2015-02-23
IL218126A (en) 2015-08-31
US8927557B2 (en) 2015-01-06
TN2012000034A1 (en) 2013-09-19
NZ598777A (en) 2013-10-25

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