CL2012000585A1 - Composición inmunogénica que comprende un compuesto agonista de un receptor tipo toll 7 (tlr7) o una sal de este, un antígeno, y un adyuvante que contiene aluminio; método para mejorar la efectividad de una composición inmunogénica que comprende adicionar dicha composición que contiene un agonista de tlr7; y su uso como inmunoestimulante. - Google Patents

Composición inmunogénica que comprende un compuesto agonista de un receptor tipo toll 7 (tlr7) o una sal de este, un antígeno, y un adyuvante que contiene aluminio; método para mejorar la efectividad de una composición inmunogénica que comprende adicionar dicha composición que contiene un agonista de tlr7; y su uso como inmunoestimulante.

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Publication number
CL2012000585A1
CL2012000585A1 CL2012000585A CL2012000585A CL2012000585A1 CL 2012000585 A1 CL2012000585 A1 CL 2012000585A1 CL 2012000585 A CL2012000585 A CL 2012000585A CL 2012000585 A CL2012000585 A CL 2012000585A CL 2012000585 A1 CL2012000585 A1 CL 2012000585A1
Authority
CL
Chile
Prior art keywords
aluminum
tlr7
immunogenic composition
composition
antigen
Prior art date
Application number
CL2012000585A
Other languages
English (en)
Inventor
Manmoham Singh
Siddhartha Jain
David Skibinski
Francesco Doro
Simona Cianetti
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2012000585A1 publication Critical patent/CL2012000585A1/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UNA COMPOSICIÓN INMUNOGENICA QUE COMPRENDE (I) UN COMPUESTO DE FÓRMULA (I), Ó UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO, (II) UN ANTIGENO, Y (III) UN ADYUVANTE QUE CONTIENE ALUMINIO: EN DONDE EL ADYUVANTE QUE CONTIENE ALUMINIO ES SELECCIONADO DE HIDRÓXIDO DE ALUMINIO, OXIHIDROXIDO DE ALUMINIO, Y HIDROXIFOSFATO DE ALUMINIO: Y EN DONDE EL COMPUESTO DE FÓRMULA (I) ES UN AGONISTA DE TLR7; UN MÉTODO PARA MEJORAR SU EFECTIVIDAD, Y SU USO PARA AUMENTAR LA RESPUESTA INMUNE.
CL2012000585A 2009-09-02 2012-03-02 Composición inmunogénica que comprende un compuesto agonista de un receptor tipo toll 7 (tlr7) o una sal de este, un antígeno, y un adyuvante que contiene aluminio; método para mejorar la efectividad de una composición inmunogénica que comprende adicionar dicha composición que contiene un agonista de tlr7; y su uso como inmunoestimulante. CL2012000585A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23915609P 2009-09-02 2009-09-02

Publications (1)

Publication Number Publication Date
CL2012000585A1 true CL2012000585A1 (es) 2012-09-14

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ID=43415378

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CL2012000585A CL2012000585A1 (es) 2009-09-02 2012-03-02 Composición inmunogénica que comprende un compuesto agonista de un receptor tipo toll 7 (tlr7) o una sal de este, un antígeno, y un adyuvante que contiene aluminio; método para mejorar la efectividad de una composición inmunogénica que comprende adicionar dicha composición que contiene un agonista de tlr7; y su uso como inmunoestimulante.

Country Status (15)

Country Link
US (1) US9950062B2 (es)
EP (1) EP2459216B1 (es)
JP (1) JP5988492B2 (es)
CN (1) CN102844047B (es)
AU (1) AU2010290896B2 (es)
BR (1) BR112012004806B8 (es)
CA (1) CA2772916C (es)
CL (1) CL2012000585A1 (es)
DK (1) DK2459216T3 (es)
EA (1) EA026401B1 (es)
ES (1) ES2443952T3 (es)
MX (1) MX2012002723A (es)
NZ (1) NZ598654A (es)
SG (1) SG178954A1 (es)
WO (1) WO2011027222A2 (es)

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Publication number Priority date Publication date Assignee Title
US12037355B2 (en) 2015-11-06 2024-07-16 Adjuvance Technologies, Inc. Triterpene saponin analogues
US11324821B2 (en) 2017-10-16 2022-05-10 Adjuvance Technologies, Inc. Triterpene saponin analogues

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CN102844047B (zh) 2017-04-05
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EP2459216A2 (en) 2012-06-06
ES2443952T3 (es) 2014-02-21
US20120237546A1 (en) 2012-09-20
EA201270356A1 (ru) 2012-09-28
BR112012004806B1 (pt) 2020-12-29
MX2012002723A (es) 2012-04-11
WO2011027222A2 (en) 2011-03-10
JP5988492B2 (ja) 2016-09-07
JP2013503845A (ja) 2013-02-04
EP2459216B1 (en) 2013-10-30
EA026401B1 (ru) 2017-04-28
SG178954A1 (en) 2012-04-27
DK2459216T3 (da) 2013-12-09
US9950062B2 (en) 2018-04-24
CN102844047A (zh) 2012-12-26
BR112012004806B8 (pt) 2022-10-04
NZ598654A (en) 2014-05-30
BR112012004806A2 (pt) 2016-11-29
AU2010290896A1 (en) 2012-04-05
WO2011027222A3 (en) 2011-05-05
AU2010290896B2 (en) 2014-07-03

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