CL2012000826A1 - Molécula de unión biespecífica que comprende un componente de unión al ligando tipo delta 4 (dll4 o dii4) y un componente de unión al factor de crecimiento endotelial vascular (vegf); molécula de ácido nucleico aislada que la codifica; vector; célula huésped, método de elaboración; composición farmacéutica que la comprende; usos de la composición en tratamiento de cáncer; y vhh de unión a dll4. - Google Patents

Molécula de unión biespecífica que comprende un componente de unión al ligando tipo delta 4 (dll4 o dii4) y un componente de unión al factor de crecimiento endotelial vascular (vegf); molécula de ácido nucleico aislada que la codifica; vector; célula huésped, método de elaboración; composición farmacéutica que la comprende; usos de la composición en tratamiento de cáncer; y vhh de unión a dll4.

Info

Publication number
CL2012000826A1
CL2012000826A1 CL2012000826A CL2012000826A CL2012000826A1 CL 2012000826 A1 CL2012000826 A1 CL 2012000826A1 CL 2012000826 A CL2012000826 A CL 2012000826A CL 2012000826 A CL2012000826 A CL 2012000826A CL 2012000826 A1 CL2012000826 A1 CL 2012000826A1
Authority
CL
Chile
Prior art keywords
dll4
binding
binding component
composition
molecule
Prior art date
Application number
CL2012000826A
Other languages
English (en)
Inventor
Eric Borges
Andreas Gschwind
Tavernier Evelyn De
Joost Kolkman
Pascal Merchiers
Hoorick Diane Van
Joachim Boucneau
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43431796&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012000826(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2012000826A1 publication Critical patent/CL2012000826A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
CL2012000826A 2009-10-02 2012-04-02 Molécula de unión biespecífica que comprende un componente de unión al ligando tipo delta 4 (dll4 o dii4) y un componente de unión al factor de crecimiento endotelial vascular (vegf); molécula de ácido nucleico aislada que la codifica; vector; célula huésped, método de elaboración; composición farmacéutica que la comprende; usos de la composición en tratamiento de cáncer; y vhh de unión a dll4. CL2012000826A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09172137 2009-10-02
EP10175316 2010-09-03

Publications (1)

Publication Number Publication Date
CL2012000826A1 true CL2012000826A1 (es) 2012-10-19

Family

ID=43431796

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012000826A CL2012000826A1 (es) 2009-10-02 2012-04-02 Molécula de unión biespecífica que comprende un componente de unión al ligando tipo delta 4 (dll4 o dii4) y un componente de unión al factor de crecimiento endotelial vascular (vegf); molécula de ácido nucleico aislada que la codifica; vector; célula huésped, método de elaboración; composición farmacéutica que la comprende; usos de la composición en tratamiento de cáncer; y vhh de unión a dll4.

Country Status (24)

Country Link
US (2) US20110172398A1 (es)
EP (1) EP2483314A1 (es)
JP (2) JP5833009B2 (es)
KR (1) KR20120101375A (es)
CN (2) CN105037542A (es)
AP (1) AP2012006188A0 (es)
AR (1) AR078515A1 (es)
AU (1) AU2010302589A1 (es)
BR (1) BR112012007239A2 (es)
CA (1) CA2775422A1 (es)
CL (1) CL2012000826A1 (es)
EA (1) EA201200548A1 (es)
EC (1) ECSP12011835A (es)
IL (1) IL218542A0 (es)
IN (1) IN2012DN02752A (es)
MA (1) MA33607B1 (es)
MX (1) MX2012003897A (es)
NZ (2) NZ626302A (es)
PE (1) PE20121024A1 (es)
PH (1) PH12012500525A1 (es)
TN (1) TN2012000145A1 (es)
TW (1) TW201124533A (es)
UY (1) UY32920A (es)
WO (1) WO2011039370A1 (es)

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CN102639566B (zh) 2015-07-22
US20140120095A1 (en) 2014-05-01
IL218542A0 (en) 2012-05-31
MA33607B1 (fr) 2012-09-01
KR20120101375A (ko) 2012-09-13
TW201124533A (en) 2011-07-16
MX2012003897A (es) 2012-05-08
AU2010302589A1 (en) 2012-04-19
CN102639566A (zh) 2012-08-15
ECSP12011835A (es) 2012-06-29
EP2483314A1 (en) 2012-08-08
AP2012006188A0 (en) 2012-04-30
PH12012500525A1 (en) 2012-11-26
IN2012DN02752A (es) 2015-09-18
JP5833009B2 (ja) 2015-12-16
JP2013506411A (ja) 2013-02-28
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JP2016026207A (ja) 2016-02-12
CN105037542A (zh) 2015-11-11
AR078515A1 (es) 2011-11-16
CA2775422A1 (en) 2011-04-07
UY32920A (es) 2011-04-29
BR112012007239A2 (pt) 2019-09-24
TN2012000145A1 (en) 2013-09-19
EA201200548A1 (ru) 2012-12-28
US20110172398A1 (en) 2011-07-14

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