MA33607B1 - Molécules de liaison bispécifiques pour une thérapie anti-angiogénique - Google Patents

Molécules de liaison bispécifiques pour une thérapie anti-angiogénique

Info

Publication number
MA33607B1
MA33607B1 MA34720A MA34720A MA33607B1 MA 33607 B1 MA33607 B1 MA 33607B1 MA 34720 A MA34720 A MA 34720A MA 34720 A MA34720 A MA 34720A MA 33607 B1 MA33607 B1 MA 33607B1
Authority
MA
Morocco
Prior art keywords
binding molecules
bispecific binding
relates
angiogenic therapy
dll4
Prior art date
Application number
MA34720A
Other languages
Arabic (ar)
English (en)
Inventor
Eric Borges
Andreas Gschwind
Joachim Boucneau
Tavernier Evelyn De
Joost Kolkman
Pascal Merchiers
Hoorick Diane Van
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43431796&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33607(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA33607B1 publication Critical patent/MA33607B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention concerne des molécules de liaison bispécifiques, en particulier des domaines variables uniques d'immunoglobuline tels que des vhh et des anticorps à domaine comprenant un composant de liaison à vegf et un composant de liaison à dll4 dans une molécule. L'invention concerne également des compositions pharmaceutiques les contenant et leur utilisation dans le traitement de maladies qui sont associées à des effets à médiation par vegf et dll4 sur l'angiogenèse. L'invention concerne également des acides nucléiques codant pour les molécules de liaison bispécifiques, des cellules hôtes et des procédés pour les préparer.
MA34720A 2009-10-02 2012-03-26 Molécules de liaison bispécifiques pour une thérapie anti-angiogénique MA33607B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09172137 2009-10-02
EP10175316 2010-09-03
PCT/EP2010/064695 WO2011039370A1 (fr) 2009-10-02 2010-10-01 Molécules de liaison bispécifiques pour une thérapie anti-angiogénique

Publications (1)

Publication Number Publication Date
MA33607B1 true MA33607B1 (fr) 2012-09-01

Family

ID=43431796

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34720A MA33607B1 (fr) 2009-10-02 2012-03-26 Molécules de liaison bispécifiques pour une thérapie anti-angiogénique

Country Status (24)

Country Link
US (2) US20110172398A1 (fr)
EP (1) EP2483314A1 (fr)
JP (2) JP5833009B2 (fr)
KR (1) KR20120101375A (fr)
CN (2) CN105037542A (fr)
AP (1) AP2012006188A0 (fr)
AR (1) AR078515A1 (fr)
AU (1) AU2010302589A1 (fr)
BR (1) BR112012007239A2 (fr)
CA (1) CA2775422A1 (fr)
CL (1) CL2012000826A1 (fr)
EA (1) EA201200548A1 (fr)
EC (1) ECSP12011835A (fr)
IL (1) IL218542A0 (fr)
IN (1) IN2012DN02752A (fr)
MA (1) MA33607B1 (fr)
MX (1) MX2012003897A (fr)
NZ (2) NZ626302A (fr)
PE (1) PE20121024A1 (fr)
PH (1) PH12012500525A1 (fr)
TN (1) TN2012000145A1 (fr)
TW (1) TW201124533A (fr)
UY (1) UY32920A (fr)
WO (1) WO2011039370A1 (fr)

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WO2011039370A1 (fr) 2011-04-07
NZ598956A (en) 2014-07-25
CN102639566B (zh) 2015-07-22
US20140120095A1 (en) 2014-05-01
IL218542A0 (en) 2012-05-31
KR20120101375A (ko) 2012-09-13
TW201124533A (en) 2011-07-16
MX2012003897A (es) 2012-05-08
AU2010302589A1 (en) 2012-04-19
CN102639566A (zh) 2012-08-15
ECSP12011835A (es) 2012-06-29
EP2483314A1 (fr) 2012-08-08
AP2012006188A0 (en) 2012-04-30
PH12012500525A1 (en) 2012-11-26
IN2012DN02752A (fr) 2015-09-18
JP5833009B2 (ja) 2015-12-16
JP2013506411A (ja) 2013-02-28
PE20121024A1 (es) 2012-08-10
JP2016026207A (ja) 2016-02-12
CN105037542A (zh) 2015-11-11
AR078515A1 (es) 2011-11-16
CA2775422A1 (fr) 2011-04-07
CL2012000826A1 (es) 2012-10-19
UY32920A (es) 2011-04-29
BR112012007239A2 (pt) 2019-09-24
TN2012000145A1 (en) 2013-09-19
EA201200548A1 (ru) 2012-12-28
US20110172398A1 (en) 2011-07-14

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