CL2012000913A1 - Uso de una combinacion farmaceutica de compuestos especificos derivados de 4-morfolintieno[3,2-d]pirimidina con 3,4-difluoro-2-(2-fluoro-4-iodofenilamino)fenil)(3-hidroxi-3-((2s)piperidin-2-il)azetidin-1-il)metanona para tratar localmente un tumor solido avanzado o metastasico. - Google Patents

Uso de una combinacion farmaceutica de compuestos especificos derivados de 4-morfolintieno[3,2-d]pirimidina con 3,4-difluoro-2-(2-fluoro-4-iodofenilamino)fenil)(3-hidroxi-3-((2s)piperidin-2-il)azetidin-1-il)metanona para tratar localmente un tumor solido avanzado o metastasico.

Info

Publication number
CL2012000913A1
CL2012000913A1 CL2012000913A CL2012000913A CL2012000913A1 CL 2012000913 A1 CL2012000913 A1 CL 2012000913A1 CL 2012000913 A CL2012000913 A CL 2012000913A CL 2012000913 A CL2012000913 A CL 2012000913A CL 2012000913 A1 CL2012000913 A1 CL 2012000913A1
Authority
CL
Chile
Prior art keywords
advanced
morpholinthieno
iodophenylamino
azetidin
methanone
Prior art date
Application number
CL2012000913A
Other languages
English (en)
Inventor
Marcia Belvin
Iris T Chan
Lori Friedman
Klaus Hoeflich
John Prescott
Jaffrey Walin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43072663&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012000913(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2012000913A1 publication Critical patent/CL2012000913A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Método de tratamiento para tumores sólidos localmente avanzados o metastásicos que consiste en administrar una combinación farmacéutica que contiene un compuesto de fórmula I o II y un compuesto de fórmula III.
CL2012000913A 2009-10-12 2012-04-11 Uso de una combinacion farmaceutica de compuestos especificos derivados de 4-morfolintieno[3,2-d]pirimidina con 3,4-difluoro-2-(2-fluoro-4-iodofenilamino)fenil)(3-hidroxi-3-((2s)piperidin-2-il)azetidin-1-il)metanona para tratar localmente un tumor solido avanzado o metastasico. CL2012000913A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25085209P 2009-10-12 2009-10-12

Publications (1)

Publication Number Publication Date
CL2012000913A1 true CL2012000913A1 (es) 2012-09-14

Family

ID=43072663

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012000913A CL2012000913A1 (es) 2009-10-12 2012-04-11 Uso de una combinacion farmaceutica de compuestos especificos derivados de 4-morfolintieno[3,2-d]pirimidina con 3,4-difluoro-2-(2-fluoro-4-iodofenilamino)fenil)(3-hidroxi-3-((2s)piperidin-2-il)azetidin-1-il)metanona para tratar localmente un tumor solido avanzado o metastasico.

Country Status (24)

Country Link
US (1) US20110086837A1 (es)
EP (1) EP2488178B1 (es)
JP (2) JP2013507415A (es)
KR (1) KR101489045B1 (es)
CN (1) CN102740851B (es)
AR (1) AR078588A1 (es)
AU (1) AU2010314287A1 (es)
BR (1) BR112012008483A2 (es)
CA (1) CA2776944A1 (es)
CL (1) CL2012000913A1 (es)
CO (1) CO6531463A2 (es)
CR (1) CR20120173A (es)
EC (1) ECSP12011865A (es)
ES (1) ES2609767T3 (es)
IL (1) IL219105A0 (es)
MA (1) MA33974B1 (es)
MX (1) MX345155B (es)
NZ (1) NZ599939A (es)
PE (1) PE20121816A1 (es)
PH (1) PH12012500709A1 (es)
RU (1) RU2563193C2 (es)
TW (1) TWI428336B (es)
WO (1) WO2011054620A1 (es)
ZA (1) ZA201202618B (es)

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US9463251B2 (en) 2012-08-02 2016-10-11 Genentech, Inc. Anti-ETBR antibodies and immunoconjugates
RU2015106673A (ru) 2012-08-02 2016-09-20 Дженентек, Инк. Антитела к рецептору эндотелина типа в (etbr) и иммуноконъюгаты
JP6335169B2 (ja) * 2012-08-17 2018-05-30 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト コビメチニブ及びメベムラフェニブを投与することを含むメラノーマの併用療法
AU2014239903A1 (en) * 2013-03-14 2015-09-17 Genentech, Inc. Combinations of a MEK inhibitor compound with an HER3/EGFR inhibitor compound and methods of use
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WO2016040806A1 (en) * 2014-09-11 2016-03-17 The Regents Of The University Of California mTORC1 INHIBITORS
JP7467423B2 (ja) 2018-09-11 2024-04-15 キュリス，インコーポレイテッド 亜鉛結合部分を有するホスホイノシチド３－キナーゼ阻害剤との併用療法
CN110420330B (zh) * 2019-07-19 2020-05-29 南京医科大学 一种pi3k与mth1靶向药组合物的制药用途
JP2022547358A (ja) 2019-09-13 2022-11-14 ジ インスティテュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル 治療組成物、組み合わせ、及び使用方法
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Also Published As

Publication number Publication date
AU2010314287A1 (en) 2012-05-03
CN102740851B (zh) 2013-12-18
MX345155B (es) 2017-01-18
NZ599939A (en) 2014-02-28
US20110086837A1 (en) 2011-04-14
CN102740851A (zh) 2012-10-17
AR078588A1 (es) 2011-11-16
KR20120064132A (ko) 2012-06-18
ES2609767T3 (es) 2017-04-24
IL219105A0 (en) 2012-06-28
MX2012004286A (es) 2012-05-22
RU2563193C2 (ru) 2015-09-20
TW201118082A (en) 2011-06-01
AU2010314287A2 (en) 2012-07-12
CA2776944A1 (en) 2011-05-12
CO6531463A2 (es) 2012-09-28
PH12012500709A1 (en) 2012-10-29
JP2015038110A (ja) 2015-02-26
ECSP12011865A (es) 2012-06-29
JP2013507415A (ja) 2013-03-04
EP2488178B1 (en) 2016-11-16
TWI428336B (zh) 2014-03-01
CR20120173A (es) 2012-07-04
ZA201202618B (en) 2014-10-29
RU2012118974A (ru) 2013-11-20
BR112012008483A2 (pt) 2019-09-24
MA33974B1 (fr) 2013-02-01
HK1175125A1 (en) 2013-06-28
JP5745678B2 (ja) 2015-07-08
EP2488178A1 (en) 2012-08-22
PE20121816A1 (es) 2013-01-02
WO2011054620A1 (en) 2011-05-12
KR101489045B1 (ko) 2015-02-02

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