CL2012001007A1 - Formas cristalinas a-hcl, b-hci y b de n-(4-(7-azabiciclo [2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolina-3-carboxamida, modulador de cfrt; sus composiciones farmaceuticas; metodo para modular cfrt; y su uso para el tratamiento de la fibrosis quistica, asma, entre otros. - Google Patents

Formas cristalinas a-hcl, b-hci y b de n-(4-(7-azabiciclo [2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolina-3-carboxamida, modulador de cfrt; sus composiciones farmaceuticas; metodo para modular cfrt; y su uso para el tratamiento de la fibrosis quistica, asma, entre otros.

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Publication number
CL2012001007A1
CL2012001007A1 CL2012001007A CL2012001007A CL2012001007A1 CL 2012001007 A1 CL2012001007 A1 CL 2012001007A1 CL 2012001007 A CL2012001007 A CL 2012001007A CL 2012001007 A CL2012001007 A CL 2012001007A CL 2012001007 A1 CL2012001007 A1 CL 2012001007A1
Authority
CL
Chile
Prior art keywords
cfrt
trifluoromethyl
hcl
dihydroquinoline
heptan
Prior art date
Application number
CL2012001007A
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English (en)
Inventor
Beili Zhang
Mariusz Krawiec
Brian Luisi
Ales Medek
Original Assignee
Vertex Pharma
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Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of CL2012001007A1 publication Critical patent/CL2012001007A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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Abstract

FORMAS CRISTALINAS A-HCl, By B-HCL DE N-(4-(7-A2ABlCICLO [22.1]HEPTAN-7-IL)-2-(TRIFLUOROMETlL)FENIL}4{JXo-5(TRIFLUOROMETlL)-l,4-DIHIDROQUINOLlNA-3-EARBOXAMIDA, MODULADOR DE CFRT; COMPOSICIONES FARMACÉUTICAS;<br /> MÉTODO PARA MODULAR CFRT; Y SU USO PARA EL TRATAMIENTO DE LA FIBROSIS QUISTlCA, ASMA, ENTRE OTRAS.  
CL2012001007A 2009-10-23 2012-04-20 Formas cristalinas a-hcl, b-hci y b de n-(4-(7-azabiciclo [2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolina-3-carboxamida, modulador de cfrt; sus composiciones farmaceuticas; metodo para modular cfrt; y su uso para el tratamiento de la fibrosis quistica, asma, entre otros. CL2012001007A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25461409P 2009-10-23 2009-10-23

Publications (1)

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CL2012001007A1 true CL2012001007A1 (es) 2012-09-07

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ID=43334525

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012001007A CL2012001007A1 (es) 2009-10-23 2012-04-20 Formas cristalinas a-hcl, b-hci y b de n-(4-(7-azabiciclo [2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolina-3-carboxamida, modulador de cfrt; sus composiciones farmaceuticas; metodo para modular cfrt; y su uso para el tratamiento de la fibrosis quistica, asma, entre otros.

Country Status (18)

Country Link
US (2) US8389727B2 (es)
EP (1) EP2491042A1 (es)
JP (1) JP5877157B2 (es)
KR (1) KR20120102645A (es)
CN (1) CN102666546B (es)
AR (1) AR078766A1 (es)
AU (1) AU2010310617A1 (es)
BR (1) BR112012009584A2 (es)
CA (1) CA2778493A1 (es)
CL (1) CL2012001007A1 (es)
IL (1) IL219327A0 (es)
MX (1) MX2012004791A (es)
NZ (1) NZ599703A (es)
RU (1) RU2568608C2 (es)
TW (1) TWI507409B (es)
UA (1) UA108087C2 (es)
WO (1) WO2011050220A1 (es)
ZA (1) ZA201202919B (es)

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ATE512145T1 (de) 2005-08-11 2011-06-15 Vertex Pharma Modulatoren des cystic fibrosis transmembrane conductance regulators
EP1945632B1 (en) 2005-11-08 2013-09-18 Vertex Pharmaceuticals Incorporated Heterocyclic modulators of atp-binding cassette transporters
AU2006336504C9 (en) 2005-12-28 2015-05-14 Vertex Pharmaceuticals Incorporated 1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis
WO2007079139A2 (en) 2005-12-28 2007-07-12 Vertex Pharmaceuticals, Inc. Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
NZ571803A (en) 2006-04-07 2011-12-22 Vertex Pharma Amide indole derivatives as modulators of ATP-binding cassette transporters
US8563573B2 (en) * 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
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SI2217572T1 (sl) 2007-11-16 2014-05-30 Vertex Pharmaceuticals Incorporated Izokinolinski modulatorji prenaĺ alcev z atp-vezavno kaseto
SI2225230T1 (sl) 2007-12-07 2017-03-31 Vertex Pharmaceuticals Incorporated Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline
EP2639224B1 (en) 2007-12-07 2016-08-24 Vertex Pharmaceuticals Incorporated Process for producing cycloalkylcarboxiamido-pyridine benzoic acids
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US20100036130A1 (en) 2007-12-07 2010-02-11 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
NZ720282A (en) 2008-02-28 2017-12-22 Vertex Pharma Heteroaryl derivatives as cftr modulators
EP2271621B1 (en) 2008-03-31 2013-11-20 Vertex Pharmaceuticals Incorporated Pyridyl derivatives as cftr modulators
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
JP2012504143A (ja) * 2008-09-29 2012-02-16 バーテックス ファーマシューティカルズ インコーポレイテッド ３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の用量単位
NZ592685A (en) * 2008-10-23 2013-04-26 Vertex Pharma Modulators of cystic fibrosis transmembrane conductance regulator
PT2358680E (pt) * 2008-10-23 2013-05-14 Vertex Pharma Formas sólidas de n-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2- (trifluorometil)fenil)-4-oxo- 5-(trifluorometil)-1,4- dihidroquinolina-3-carboxamida
SI2408750T1 (sl) 2009-03-20 2015-11-30 Vertex Pharmaceuticals Incorporated Postopek za izdelavo modulatorjev cistično-fibroznega transmembranskega regulatorja prevodnosti
BR112012006031A2 (pt) * 2009-09-17 2019-09-24 Vertex Pharma processo para preparação de compostos azabicíclicos.
WO2011050220A1 (en) * 2009-10-23 2011-04-28 Vertex Pharmaceuticals Incorporated Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
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