CL2012003012A1 - Composicion farmaceutica oral de liberacion prolongada que comprenden a) al menos un material de liberacion prolongada y b) hidromorfona o una sal y naloxona o una sal en una relacion 2:1 a 1:3; metodo de preparacion. - Google Patents

Composicion farmaceutica oral de liberacion prolongada que comprenden a) al menos un material de liberacion prolongada y b) hidromorfona o una sal y naloxona o una sal en una relacion 2:1 a 1:3; metodo de preparacion.

Info

Publication number: CL2012003012A1
Authority: CL; Chile
Prior art keywords: salt; hydromorphone; naloxone; extended; preparation
Prior art date: 2010-05-10

Application number

CL2012003012A

Other languages

English (en)

Inventor

Helen Kathleen Danagher

Hassan Mohammad

Malcolm Walden

Geoffrey Gerard Hayes

Jonathon Oliver Whitehouse

Thinnayam Naganathan Krishnamurthy

Rincon Ricardo Alberto Vargas

Original Assignee

Euro Celtique Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-05-10

Filing date

2012-10-26

Publication date

2014-02-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42983574&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012003012(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-10-26 Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa

2014-02-21 Publication of CL2012003012A1 publication Critical patent/CL2012003012A1/es

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Nutrition Science (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Physiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CL2012003012A 2010-05-10 2012-10-26 Composicion farmaceutica oral de liberacion prolongada que comprenden a) al menos un material de liberacion prolongada y b) hidromorfona o una sal y naloxona o una sal en una relacion 2:1 a 1:3; metodo de preparacion. CL2012003012A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP10162428		2010-05-10

Publications (1)

Publication Number	Publication Date
CL2012003012A1 true CL2012003012A1 (es)	2014-02-21

Family

ID=42983574

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2012003012A CL2012003012A1 (es)	2010-05-10	2012-10-26	Composicion farmaceutica oral de liberacion prolongada que comprenden a) al menos un material de liberacion prolongada y b) hidromorfona o una sal y naloxona o una sal en una relacion 2:1 a 1:3; metodo de preparacion.

Country Status (36)

Country	Link
US (1)	US9700508B2 (es)
EP (1)	EP2568967B2 (es)
JP (1)	JP5671609B2 (es)
KR (2)	KR20130030260A (es)
CN (2)	CN105832687A (es)
AP (1)	AP3441A (es)
AR (1)	AR083150A1 (es)
AU (1)	AU2011252039B2 (es)
BR (1)	BR112012028773A2 (es)
CA (1)	CA2739751C (es)
CH (1)	CH705273B1 (es)
CL (1)	CL2012003012A1 (es)
CO (1)	CO6640216A2 (es)
CR (1)	CR20120549A (es)
DE (1)	DE112011101605T5 (es)
DK (1)	DK178741B1 (es)
EA (1)	EA201291211A1 (es)
EC (1)	ECSP12012236A (es)
ES (1)	ES2408343B2 (es)
GB (1)	GB2492037A (es)
GT (1)	GT201200304A (es)
IL (1)	IL222772B (es)
MX (1)	MX347105B (es)
MY (1)	MY157673A (es)
NI (1)	NI201200157A (es)
NO (1)	NO20121414A1 (es)
NZ (2)	NZ700732A (es)
PE (1)	PE20130657A1 (es)
PH (1)	PH12012502011A1 (es)
SE (1)	SE1251371A1 (es)
SG (1)	SG184523A1 (es)
TN (1)	TN2012000488A1 (es)
TW (2)	TWI590835B (es)
UA (1)	UA106278C2 (es)
WO (1)	WO2011141488A2 (es)
ZA (1)	ZA201207603B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011141490A1 (en)	2010-05-10	2011-11-17	Euro-Celtique S.A.	Combination of active loaded granules with additional actives
SG184523A1 (en)	2010-05-10	2012-11-29	Euro Celtique Sa	Pharmaceutical compositions comprising hydromorphone and naloxone
MX340188B (es)	2010-05-10	2016-06-30	Euro-Celtique S A *	Elaboracion de granulos sin activos y tabletas que comprenden los mismos.
RU2665372C2 (ru) *	2012-09-03	2018-08-29	Дайити Санкио Компани, Лимитед	Пероральная фармацевтическая композиция замедленного высвобождения, содержащая гидрохлорид гидроморфона
CA2881144A1 (en) *	2012-11-09	2014-05-09	Purdue Pharma	Pharmaceutical compositions comprising hydromorphone and naloxone
US9517208B2 (en) *	2013-03-15	2016-12-13	Purdue Pharma L.P.	Abuse-deterrent dosage forms
GB201313915D0 (en)	2013-08-02	2013-09-18	Johnson Matthey Plc	Process
JP6232135B2 (ja) *	2013-11-13	2017-11-15	ユーロ−セルティークエス．エイ．	疼痛およびオピオイドによる腸機能障害症候群の治療のためのヒドロモルホンおよびナロキソン
CA2847781C (en) *	2014-03-28	2019-03-12	Purdue Pharma	Reducing drug liking in a subject
EP3229785A2 (de) *	2014-12-08	2017-10-18	Develco Pharma Schweiz AG	Naloxon-monopräparat und mehrschichttablette
CA3166250A1 (en)	2020-02-05	2021-08-12	Gregory G. Plucinski	Drug products for intranasal administration and uses thereof
CN121401263A (zh)	2020-02-14	2026-01-27	帝国制药美国公司	外用纳洛酮组合物及其使用方法

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE49324B1 (en)	1979-12-19	1985-09-18	Euro Celtique Sa	Controlled release compositions
US4457933A (en) *	1980-01-24	1984-07-03	Bristol-Myers Company	Prevention of analgesic abuse
HU190619B (en)	1983-11-11	1986-09-29	Bezzegh,Denes,Hu	Process for producing tablets with controlled dissolution of active ingredients
EP0164669B1 (de)	1984-06-13	1991-01-23	Röhm Gmbh	Verfahren zum Überziehen von Arzneiformen
US4769372A (en) *	1986-06-18	1988-09-06	The Rockefeller University	Method of treating patients suffering from chronic pain or chronic cough
GB8626098D0 (en)	1986-10-31	1986-12-03	Euro Celtique Sa	Controlled release hydromorphone composition
EP0352361A1 (en)	1988-07-29	1990-01-31	The Rockefeller University	Method of treating patients suffering from chronic pain or chronic cough
FR2653337B1 (fr)	1989-10-23	1992-02-07	Dow Corning Sa	Element a liberation prolongee et procede pour le fabriquer.
US5662933A (en)	1993-09-09	1997-09-02	Edward Mendell Co., Inc.	Controlled release formulation (albuterol)
US5965161A (en)	1994-11-04	1999-10-12	Euro-Celtique, S.A.	Extruded multi-particulates
DE4443105C2 (de)	1994-12-03	1997-03-13	Hoechst Ag	Verfahren zur Herstellung Molsidomin-haltiger Tabletten
US6488961B1 (en)	1996-09-20	2002-12-03	Ethypharm, Inc.	Effervescent granules and methods for their preparation
DE19651551C2 (de) *	1996-12-11	2000-02-03	Klinge Co Chem Pharm Fab	Opioidantagonisthaltige galenische Formulierung
US6306438B1 (en)	1997-07-02	2001-10-23	Euro-Celtique, S.A.	Stabilized sustained release tramadol formulations
TR200001942T2 (tr)	1997-12-22	2000-11-21	Euro-Celtique, S.A.	Opioid agonist/antagonist kombinasyonlar
ECSP003314A (es)	2000-01-11	2000-03-22		Formulaciones medicamentosas retardadas que contienen una combinacion de un opioide y un - agonista
US6716449B2 (en)	2000-02-08	2004-04-06	Euro-Celtique S.A.	Controlled-release compositions containing opioid agonist and antagonist
SI2283842T1 (sl)	2000-02-08	2015-07-31	Euro-Celtique S.A.	Oralne formulacije opioidnih agonistov, varne pred zlorabo
US20040115133A1 (en)	2000-05-10	2004-06-17	Wermeling Daniel P.	Intranasal opioid compositions
GB0102342D0 (en)	2001-01-30	2001-03-14	Smithkline Beecham Plc	Pharmaceutical formulation
EP1387673B1 (en)	2001-05-11	2010-12-29	Endo Pharmaceuticals Inc.	Abuse-resistant controlled-release opioid dosage form
ATE345112T1 (de) *	2001-05-11	2006-12-15	Endo Pharmaceuticals Inc	Opioid enthaltende arzneiform gegen missbrauch
JP2004534056A (ja)	2001-06-08	2004-11-11	エンドーファーマシューティカルズ，インコーポレイティド	アクリルポリマーを使用する制御放出投薬形態、およびそれを作製するためのプロセス
US7332182B2 (en) *	2001-08-06	2008-02-19	Purdue Pharma L.P.	Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant
ES2326794T3 (es) *	2001-08-06	2009-10-20	Euro-Celtique S.A.	Formulaciones de agonistas opioides con antagonista liberable y secuestrado.
AU2002319774B2 (en)	2001-08-06	2005-04-21	Euro-Celtique S.A.	Compositions and methods to prevent abuse of opioids
US7435817B2 (en)	2001-08-23	2008-10-14	N.V. Organon	C-14 oxidation of morphine derivatives
DE10146275A1 (de)	2001-09-18	2003-04-24	Gruenenthal Gmbh	Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz
DE10215131A1 (de) *	2002-04-05	2003-10-16	Euro Celtique Sa	Matrix zur verzögerten, gleichbleibenden und unabhängigen Freisetzung von Wirkstoffen
LT2425821T (lt)	2002-04-05	2017-07-25	Euro-Celtique S.A.	Farmacinis preparatas, turintis oksikodono ir naloksono
EP1521571A1 (en)	2002-07-04	2005-04-13	Janssen Pharmaceutica N.V.	Solid dispersion comprising two different polymer matrixes
PL2368554T3 (pl)	2003-04-08	2015-05-29	Progenics Pharm Inc	Preparaty farmaceutyczne zawierające metylonaltrekson
JP2006522817A (ja)	2003-04-08	2006-10-05	プロジェニックスファーマシューティカルズ，インコーポレーテッド	過敏性腸症候群を処置するための末梢オピオイドアンタゴニスト、特にメチルナルトレキソンの使用
MXPA05010821A (es)	2003-04-08	2006-03-30	Progenics Pharm Inc	Terapia de combinacion para constipacion que comprende un laxante y un antagonista opioide periferico.
BRPI0409945A (pt)	2003-04-30	2006-04-25	Purdue Pharma Lp	forma de dosagem resistente à alteração
US9114199B2 (en)	2003-07-31	2015-08-25	Boston Scientific Scimed, Inc.	Implantable or insertable medical devices containing acrylic copolymer for controlled delivery of therapeutic agent
US20050079221A1 (en)	2003-10-10	2005-04-14	Groenewoud Pieter Jurjen	Ibuprofen narcotic composition and method for making same
US20050232987A1 (en)	2004-03-12	2005-10-20	Viswanathan Srinivasan	Dosage form containing a morphine derivative and another drug
US20050165038A1 (en)	2004-01-22	2005-07-28	Maxwell Gordon	Analgetic dosage forms that are resistant to parenteral and inhalation dosing and have reduced side effects
DE602005009321D1 (de)	2004-02-06	2008-10-09	Euro Celtique Sa	Hinonen und 3-o-geschützten morphinondienolcarboxylaten
GB0501638D0 (en) *	2005-01-28	2005-03-02	Euro Celtique Sa	Particulates
TWI350762B (en)	2004-02-12	2011-10-21	Euro Celtique Sa	Particulates
US9016221B2 (en)	2004-02-17	2015-04-28	University Of Florida Research Foundation, Inc.	Surface topographies for non-toxic bioadhesion control
TWI365880B (en)	2004-03-30	2012-06-11	Euro Celtique Sa	Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
US7700626B2 (en)	2004-06-04	2010-04-20	Adolor Corporation	Compositions containing opioid antagonists
EP1604666A1 (en)	2004-06-08	2005-12-14	Euro-Celtique S.A.	Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1604667A1 (en)	2004-06-08	2005-12-14	Euro-Celtique S.A.	Opioids for the treatment of the restless leg syndrome
GB2418854B (en)	2004-08-31	2009-12-23	Euro Celtique Sa	Multiparticulates
WO2006038226A2 (en)	2004-10-08	2006-04-13	Rubicon Research Pvt. Ltd.	Process for making a highly compressible controlled delivery compositions of metformin
GB0423103D0 (en)	2004-10-19	2004-11-17	Boots Healthcare Int Ltd	Therapeutic agents
AU2006206454A1 (en)	2005-01-20	2006-07-27	Progenics Pharmaceuticals, Inc.	Use of methylnaltrexone and related compounds to treat post-operative gastrointestinal dysfunction
KR100905511B1 (ko)	2005-01-28	2009-07-01	유로-셀띠끄 소시에떼 아노님	알코올 저항성 제형
EP1695700A1 (en) *	2005-02-28	2006-08-30	Euro-Celtique S.A.	Dosage form containing oxycodone and naloxone
NL1028460C2 (nl) *	2005-03-04	2006-09-06	Sara Lee De Nv	Inrichting voor het bereiden en afgeven van al dan niet althans gedeeltelijk opgeschuimde dranken.
JP4741865B2 (ja)	2005-03-24	2011-08-10	共和薬品工業株式会社	ペルゴリド錠剤の製造方法
US20070026025A1 (en)	2005-04-12	2007-02-01	Aquegel Cosmetics, Llc	Topical ointment and method for making and using same
TWI366460B (en)	2005-06-16	2012-06-21	Euro Celtique Sa	Cannabinoid active pharmaceutical ingredient for improved dosage forms
US20070059360A1 (en)	2005-07-29	2007-03-15	Ashish Jaiswal	Water-dispersible anti-retroviral pharmaceutical compositions
US20070048364A1 (en)	2005-08-04	2007-03-01	Yingxu Peng	Free flowing granules containing carbomer
DE102005047561A1 (de)	2005-10-04	2007-04-05	Bayer Healthcare Ag	Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
EP1962808B1 (en)	2005-12-14	2010-09-29	F. Hoffmann-La Roche AG	Hcv prodrug formulation
US20070141147A1 (en)	2005-12-21	2007-06-21	Auriga Laboratories, Inc.	Sequential release pharmaceutical formulations
EP1813276A1 (en)	2006-01-27	2007-08-01	Euro-Celtique S.A.	Tamper resistant dosage forms
US7799790B2 (en)	2006-07-20	2010-09-21	Helm Ag	Amorphous aripiprazole and process for the preparation thereof
SA07280459B1 (ar)	2006-08-25	2011-07-20	بيورديو فارما إل. بي.	أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
DE102006051020A1 (de)	2006-10-26	2008-04-30	Evonik Röhm Gmbh	Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung
GB2447898B (en)	2007-03-24	2011-08-17	Reckitt Benckiser Healthcare	A tablet having improved stability with at least two actives
PT2379066E (pt)	2008-09-16	2014-07-04	Imuneks Farma Ilaç Sanayi Ve Ticaret A S	Uso de antagonistas opioides para a preparação de um medicamento no tratamento das doenças degenerativas da retina
CN102159193B (zh)	2008-09-18	2015-09-16	普渡制药公司	包含聚(ε-己内酯)的药物剂型
EP2326313B1 (en)	2008-09-24	2015-03-04	Evonik Röhm GmbH	Ph-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethanol
KR101528957B1 (ko)	2008-09-24	2015-06-17	에보니크 룀 게엠베하	에탄올의 영향에 대하여 내성을 갖는 ｐｈ-의존성 조절 방출 제약학적 오피오이드 조성물
SI2352494T1 (sl)	2008-10-30	2019-12-31	Gruenenthal Gmbh	Nove in potentne dozirne oblike tapentadola
US20100143486A1 (en)	2008-12-10	2010-06-10	Nipun Davar	Polyethylene glycol-coated sodium carbonate as a pharmaceutical excipient and compositions produced from the same
EP2381937A2 (en)	2008-12-31	2011-11-02	Upsher-Smith Laboratories, Inc.	Opioid-containing oral pharmaceutical compositions and methods
CN102341389A (zh)	2009-01-09	2012-02-01	哈佛学院董事会	含氟化合物和其使用方法
AU2010206724A1 (en)	2009-01-22	2011-07-28	Nanotherapeutics, Inc.	Process for preparing particles of opioids and compositions produced thereby
ES2607209T3 (es)	2009-02-06	2017-03-29	Egalet Ltd.	Composiciones farmacéuticas resistentes al abuso
JP5778042B2 (ja)	2009-02-17	2015-09-16	マリンクロッドエルエルシー	ノルモルフィナンの還元的アルキル化のためのプロセス
CN102325777B (zh)	2009-02-23	2015-08-12	马林克罗特公司	(+)-吗啡喃*n-氧化物及其制备方法
JP5784507B2 (ja)	2009-02-23	2015-09-24	マリンクロッドエルエルシー	（＋）−モルフィナニウム第四級塩およびその生成方法
US20100227876A1 (en)	2009-03-06	2010-09-09	Rechfensen Llp	Methods of Reducing Side Effects of Analgesics
PL2405915T3 (pl)	2009-03-10	2019-05-31	Euro Celtique Sa	Kompozycje farmaceutyczne o natychmiastowym uwalnianiu zawierające oksykodon i nalokson
US20110311631A1 (en)	2009-03-18	2011-12-22	Evonik Röhm Gmbh	Controlled release pharmaceutical composition with resistance against the influence of ethanol employing a coating comprising a polymer mixture and excipients
JP5619130B2 (ja)	2009-03-18	2014-11-05	エボニックレームゲゼルシャフトミットベシュレンクテルハフツングＥｖｏｎｉｋＲｏｅｈｍＧｍｂＨ	中性ビニルポリマーおよび賦形剤を含むコーティングを使用するエタノールの影響に対する耐性を有する制御放出性医薬組成物
CA2756397A1 (en)	2009-04-02	2010-10-07	Shire Llc	Novel dicarboxylic acid linked amino acid and peptide prodrugs of opioids and uses thereof
WO2010120232A1 (en)	2009-04-14	2010-10-21	Yki, Ytkemiska Institutet Ab	A prodrug comprising beta-keto carboxylic acid, beta-keto carboxylic acid salt or beta-keto carboxylic acid ester for drug delivery
WO2010123999A2 (en)	2009-04-21	2010-10-28	Auspex Pharmaceuticals, Inc.	1-methylpyrazole modulators of substance p, calcitonin gene-related peptide, adrenergic receptor, and/or 5-ht receptor
CN102481257B (zh)	2009-04-24	2014-08-13	Omya国际股份公司	用于控释活性成分的颗粒材料
WO2010141505A1 (en)	2009-06-01	2010-12-09	Protect Pharmaceutical Corporation	Abuse-resistant delivery systems
GB0909680D0 (en)	2009-06-05	2009-07-22	Euro Celtique Sa	Dosage form
CA2764915C (en)	2009-06-11	2017-07-11	Mallinckrodt Llc	Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer
FR2946533A1 (fr)	2009-06-12	2010-12-17	Ethypharm Sa	Reduction des fluctuations plasmatiques d'opioides.
US8829020B2 (en)	2009-07-16	2014-09-09	Mallinckrodt Llc	Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
ES2534908T3 (es)	2009-07-22	2015-04-30	Grünenthal GmbH	Forma de dosificación de liberación controlada extruida por fusión en caliente
BR112012001466A2 (pt)	2009-07-22	2020-08-11	Grünenthal GmbH	forma de dosagem resistente à falsificação para opioides sensíveis à oxidação, seu processo de fabricação, e embalagem
GB0914338D0 (en)	2009-08-17	2009-09-30	Johnson Matthey Plc	Improved process
JP2013503862A (ja)	2009-09-08	2013-02-04	シグネーチャーセラピューティクス，インク．	酵素切断可能なケトン修飾オピオイドプロドラッグとその任意選択のインヒビターとを含んでなる組成物
EP3064064A1 (en)	2009-09-30	2016-09-07	Acura Pharmaceuticals, Inc.	Methods and compositions for deterring abuse
WO2011041470A2 (en)	2009-09-30	2011-04-07	Mallinckrodt Inc.	Sustained-release opiate and opiate derivative compositions
WO2011141490A1 (en)	2010-05-10	2011-11-17	Euro-Celtique S.A.	Combination of active loaded granules with additional actives
SG184523A1 (en)	2010-05-10	2012-11-29	Euro Celtique Sa	Pharmaceutical compositions comprising hydromorphone and naloxone
MX340188B (es)	2010-05-10	2016-06-30	Euro-Celtique S A *	Elaboracion de granulos sin activos y tabletas que comprenden los mismos.
GB201020895D0 (en)	2010-12-09	2011-01-26	Euro Celtique Sa	Dosage form

2011
- 2011-05-10 SG SG2012075040A patent/SG184523A1/en unknown
- 2011-05-10 TW TW103137424A patent/TWI590835B/zh not_active IP Right Cessation
- 2011-05-10 MX MX2012013119A patent/MX347105B/es active IP Right Grant
- 2011-05-10 CA CA2739751A patent/CA2739751C/en not_active Expired - Fee Related
- 2011-05-10 GB GB1219275.3A patent/GB2492037A/en not_active Withdrawn
- 2011-05-10 AR ARP110101621A patent/AR083150A1/es unknown
- 2011-05-10 TW TW100116427A patent/TWI483748B/zh not_active IP Right Cessation
- 2011-05-10 KR KR1020127029438A patent/KR20130030260A/ko not_active Ceased
- 2011-05-10 AU AU2011252039A patent/AU2011252039B2/en not_active Ceased
- 2011-05-10 AP AP2012006606A patent/AP3441A/xx active
- 2011-05-10 KR KR1020157004528A patent/KR101858797B1/ko not_active Expired - Fee Related
- 2011-05-10 CN CN201610284534.0A patent/CN105832687A/zh active Pending
- 2011-05-10 CH CH02357/12A patent/CH705273B1/de not_active IP Right Cessation
- 2011-05-10 NZ NZ700732A patent/NZ700732A/en not_active IP Right Cessation
- 2011-05-10 CN CN2011800231922A patent/CN102946870A/zh active Pending
- 2011-05-10 ES ES201290081A patent/ES2408343B2/es not_active Expired - Fee Related
- 2011-05-10 WO PCT/EP2011/057566 patent/WO2011141488A2/en not_active Ceased
- 2011-05-10 JP JP2013509554A patent/JP5671609B2/ja not_active Expired - Fee Related
- 2011-05-10 PH PH1/2012/502011A patent/PH12012502011A1/en unknown
- 2011-05-10 MY MYPI2012004553A patent/MY157673A/en unknown
- 2011-05-10 DE DE112011101605T patent/DE112011101605T5/de not_active Withdrawn
- 2011-05-10 PE PE2012002146A patent/PE20130657A1/es not_active Application Discontinuation
- 2011-05-10 EP EP11718747.6A patent/EP2568967B2/en active Active
- 2011-05-10 BR BR112012028773A patent/BR112012028773A2/pt not_active Application Discontinuation
- 2011-05-10 SE SE1251371A patent/SE1251371A1/sv not_active Application Discontinuation
- 2011-05-10 NZ NZ603497A patent/NZ603497A/en not_active IP Right Cessation
- 2011-05-10 EA EA201291211A patent/EA201291211A1/ru unknown
- 2011-05-10 US US13/697,197 patent/US9700508B2/en not_active Expired - Fee Related
- 2011-10-05 UA UAA201212796A patent/UA106278C2/uk unknown
2012
- 2012-10-08 EC ECSP12012236 patent/ECSP12012236A/es unknown
- 2012-10-09 TN TNP2012000488A patent/TN2012000488A1/en unknown
- 2012-10-10 ZA ZA2012/07603A patent/ZA201207603B/en unknown
- 2012-10-22 NI NI201200157A patent/NI201200157A/es unknown
- 2012-10-26 CL CL2012003012A patent/CL2012003012A1/es unknown
- 2012-10-29 CR CR20120549A patent/CR20120549A/es unknown
- 2012-10-30 IL IL222772A patent/IL222772B/en not_active IP Right Cessation
- 2012-11-05 DK DKPA201270677A patent/DK178741B1/da not_active IP Right Cessation
- 2012-11-08 CO CO12201488A patent/CO6640216A2/es unknown
- 2012-11-09 GT GT201200304A patent/GT201200304A/es unknown
- 2012-11-26 NO NO20121414A patent/NO20121414A1/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
US20130178492A1 (en)	2013-07-11
US9700508B2 (en)	2017-07-11
ES2408343A2 (es)	2013-06-20
KR20130030260A (ko)	2013-03-26
MX347105B (es)	2017-04-12
DK201270677A (en)	2012-11-05
KR101858797B1 (ko)	2018-05-16
AU2011252039B2 (en)	2014-06-12
TN2012000488A1 (en)	2014-04-01
AP2012006606A0 (en)	2012-12-31
IL222772A0 (en)	2012-12-31
GB201219275D0 (en)	2012-12-12
ECSP12012236A (es)	2013-02-28
NO20121414A1 (no)	2013-02-11
EP2568967B2 (en)	2022-07-27
AU2011252039A1 (en)	2012-11-08
MY157673A (en)	2016-07-15
MX2012013119A (es)	2013-02-11
DK178741B1 (da)	2016-12-19
PH12012502011A1 (en)	2016-05-25
TW201206501A (en)	2012-02-16
ES2408343B2 (es)	2014-07-17
SG184523A1 (en)	2012-11-29
AR083150A1 (es)	2013-02-06
JP2013526508A (ja)	2013-06-24
TWI590835B (zh)	2017-07-11
NZ603497A (en)	2015-02-27
CN105832687A (zh)	2016-08-10
TW201503913A (zh)	2015-02-01
CO6640216A2 (es)	2013-03-22
CH705273B1 (de)	2016-06-15
BR112012028773A2 (pt)	2016-07-19
DE112011101605T5 (de)	2013-04-25
KR20150028367A (ko)	2015-03-13
JP5671609B2 (ja)	2015-02-18
CA2739751A1 (en)	2011-11-10
EP2568967B1 (en)	2018-10-24
GT201200304A (es)	2014-06-09
TWI483748B (zh)	2015-05-11
AP3441A (en)	2015-10-31
WO2011141488A3 (en)	2012-04-05
PE20130657A1 (es)	2013-06-15
EA201291211A1 (ru)	2013-05-30
UA106278C2 (uk)	2014-08-11
WO2011141488A2 (en)	2011-11-17
CA2739751C (en)	2014-08-12
ZA201207603B (en)	2014-12-23
CN102946870A (zh)	2013-02-27
IL222772B (en)	2018-11-29
EP2568967A2 (en)	2013-03-20
CR20120549A (es)	2013-03-08
NI201200157A (es)	2013-02-05
SE1251371A1 (sv)	2012-12-27
NZ700732A (en)	2015-08-28
ES2408343R1 (es)	2013-08-28
GB2492037A (en)	2012-12-19

Publication	Publication Date	Title
IL274602A (en)	2020-06-30	Pharmaceutical tablets containing eltrombopag olamine, methods for their preparation and use thereof in the preparation of medicaments for treating thrombocytopenia
JP2007527914A5 (es)	2008-04-10
IL241361A (en)	2017-01-31	Use of a medicinal product containing a main species of her2-acidic variants for the preparation of a pharmaceutical product
PT2120878E (pt)	2014-11-05	Forma farmacêutica contendo duas ou mais substancias ativas em diferentes formas físicas
IL223783B (en)	2018-06-28	Compound 1-converted indole for use in the treatment of a disease or condition, a pharmaceutical preparation containing the compound and use of the compound to prepare a medicine
ATE517619T1 (de)	2011-08-15	Stabilisierte pharmazeutische zusammensetzung mit fesoterodin
CL2011002248A1 (es)	2012-01-27	Composicion farmaceutica oral de liberacion inmediata que comprende oxicodona y naloxona en una proporcion 2:1 en peso; uso de la composicion farmaceutica para tratar dolor intercurrente en paciente que sufren de dolor.
PT2344198T (pt)	2020-12-04	Preparações farmacêuticas à base de lípidos para aplicação tópica
IL232447A0 (en)	2014-06-30	Local topical administration formulations containing indoxacarb
BRPI0818193A2 (pt)	2017-12-12	composto, sal farmacêuticamente aceitável de um composto, composição farmacêutica, e, uso de um composto
CL2011001621A1 (es)	2012-03-30	Composicion farmaceutica oral de liberacion sostenida que comprende en una forma de dosificacion unitaria, una matriz hidrofilica, un opioide, una sal de un aine, y opcionalmente un surfactante aniónico; y uso para preparar medicamentos utiles en la prevencion, alivio o disminución del nivel del dolor y supresión de la tos.
CL2007002921A1 (es)	2008-05-30	Forma solida de dosificacion farmaceutica de administracion oral, que comprende una forma cristalina o amorfa de un compuesto microincluido en un polimero ionico insoluble en agua en proporcion 5:1 a 1:5; y metodo de preparacion.
IL204658A (en)	2015-10-29	Pharmaceutical preparation for topical use in the form of an opaque gel-gel containing diclofenac diethylammonium salt
CL2014000844A1 (es)	2014-09-12	Formulacion farmaceutica oral de liberacion prolongada en forma de multiparticulas, que comprende a) 40-o-(2-hidroxi)etil-rapamicina y b) al menos un recubrimiento de liberacion prolongada.
EP2351581A4 (en)	2013-02-27	VACCINE COMPOSITION AGAINST MALE AND CLAUSE DISEASE AND PREPARATION METHOD THEREFOR
BRPI0913822A2 (pt)	2015-10-20	forma farmacêutica oral e uso da forma farmacêutica
EP2474522A4 (en)	2013-03-20	AGOME ELITE AND PHARMACEUTICAL COMPOSITIONS THEREOF
FR2934156B1 (fr)	2010-09-24	Medicament appetissant a administration orale sous forme solide
BRPI1013988A2 (pt)	2016-04-05	composto, composição farmacêutica , e, uso de um composto ou um sal farmacologicamente aceitável do mesmo
BRPI1009392A2 (pt)	2016-03-08	"formulação farmacêutica, e, uso de uma quantidade farmaceuticamente eficaz de uma formulação farmacêutica."
GT201200304A (es)	2014-06-09	Composiciones farmacéuticas que comprenden hidromorfona y naloxona
CL2008000610A1 (es)	2008-09-05	Composicion en forma de dosificacion transdermica o transmucosa que comprende una relacion en peso de buprenorfina a naloxona entre 2,1:1 y 8:1, util para el tratamiento del dolor.
CO6801754A2 (es)	2013-11-29	Una composición farmacéutica para tratar una enfermedad en la cavidad oral que comprende rebamipida
IL210204A (en)	2015-03-31	Ligand, method for preparing it, antibody and pharmaceutical composition comprising same and use thereof in the manufacture of a medicament for treating msrv-associated disease
CL2013001564A1 (es)	2014-05-02	Metodo para tratar sobrepeso u obesidad que comprende administrar naltrexona y bupropion; metodo para incrementar la biodisponibilidad de naltrexona y bupropion en una terapia combinada; uso de naltrexona y bupropion para tratar sobrepeso u obesisdad e incrementar la biodisponibilidad de estos farmacos; composicion farmaceutica.