CL2012003455A1 - Procedimiento de sintesis de la ferroquina por aminacion reductora entre un derivado de ferroceno y 7 - cloroquinolin -4- amina. - Google Patents

Procedimiento de sintesis de la ferroquina por aminacion reductora entre un derivado de ferroceno y 7 - cloroquinolin -4- amina.

Info

Publication number
CL2012003455A1
CL2012003455A1 CL2012003455A CL2012003455A CL2012003455A1 CL 2012003455 A1 CL2012003455 A1 CL 2012003455A1 CL 2012003455 A CL2012003455 A CL 2012003455A CL 2012003455 A CL2012003455 A CL 2012003455A CL 2012003455 A1 CL2012003455 A1 CL 2012003455A1
Authority
CL
Chile
Prior art keywords
ferroquine
chloroquinolin
amine
reductive amination
synthesis procedure
Prior art date
Application number
CL2012003455A
Other languages
English (en)
Inventor
Julia Mateos-Caro
Régis Mondiere
Philippe Vayron
Svlvie Vigne
Vincent Ferey
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of CL2012003455A1 publication Critical patent/CL2012003455A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)

Abstract

Procedimiento de síntesis de la ferroquina por aminación reductora convergente.
CL2012003455A 2010-06-11 2012-12-07 Procedimiento de sintesis de la ferroquina por aminacion reductora entre un derivado de ferroceno y 7 - cloroquinolin -4- amina. CL2012003455A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1054625A FR2961209B1 (fr) 2010-06-11 2010-06-11 Procede de synthese de la ferroquine par amination reductrice convergente.

Publications (1)

Publication Number Publication Date
CL2012003455A1 true CL2012003455A1 (es) 2013-07-26

Family

ID=42752115

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012003455A CL2012003455A1 (es) 2010-06-11 2012-12-07 Procedimiento de sintesis de la ferroquina por aminacion reductora entre un derivado de ferroceno y 7 - cloroquinolin -4- amina.

Country Status (26)

Country Link
US (1) US8497375B2 (es)
EP (1) EP2580224B1 (es)
JP (2) JP5916721B2 (es)
KR (1) KR101839634B1 (es)
CN (1) CN102939297B (es)
AP (1) AP3020A (es)
AR (1) AR081593A1 (es)
AU (1) AU2011263354B2 (es)
BR (1) BR112012031159A2 (es)
CA (1) CA2802161C (es)
CL (1) CL2012003455A1 (es)
CO (1) CO6602116A2 (es)
EA (1) EA020392B1 (es)
FR (1) FR2961209B1 (es)
IL (1) IL223521A (es)
JO (1) JO2928B1 (es)
MA (1) MA34363B1 (es)
MX (1) MX2012014473A (es)
NZ (1) NZ605608A (es)
PH (1) PH12012502453A1 (es)
PY (1) PY1123645A (es)
SG (1) SG186247A1 (es)
TW (1) TWI485136B (es)
UY (1) UY33447A (es)
WO (1) WO2011154923A1 (es)
ZA (1) ZA201209328B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2961209B1 (fr) 2010-06-11 2013-03-01 Sanofi Aventis Procede de synthese de la ferroquine par amination reductrice convergente.
CN103254250B (zh) * 2013-05-20 2015-06-10 洛阳师范学院 二茂铁基吡嗪环钯氮杂环卡宾化合物及其制备方法和用途
CN103242378B (zh) * 2013-05-20 2015-06-03 洛阳师范学院 二茂铁基嘧啶钳形配体及其制备方法
CN103242379B (zh) * 2013-05-20 2015-09-02 洛阳师范学院 2-二茂铁基-芳基喹啉及其制备方法
EP2821412A1 (en) * 2013-07-01 2015-01-07 Universität Zürich Organometallic 2-cyano-2-aminobenzoate-propyl derivates and their use as anthelmintics
CN103848872A (zh) * 2014-03-20 2014-06-11 内蒙古大学 一种含二茂铁基团的中氮茚化合物的制备方法
US10370395B2 (en) 2015-01-02 2019-08-06 University Of Vermont And State Agricultural College Cymanquine compounds and derivatives thereof and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3856850B2 (ja) * 1994-08-18 2006-12-13 生化学工業株式会社 光学活性アミノケトン及びアミノアルコールの製造方法
FR2733985B1 (fr) * 1995-05-10 1997-07-18 Univ Lille Sciences Tech Complexes organometalliques du fer antipaludiques
JP3921703B2 (ja) * 1995-07-12 2007-05-30 住友化学株式会社 Ｎ−（α−アルキルベンジリデン）−α−フェニルアルキルアミン
JPH09124576A (ja) * 1995-10-27 1997-05-13 Sumitomo Chem Co Ltd イミン類の製造方法
EP1325914A4 (en) * 2000-09-14 2004-11-17 Kaken Pharma Co Ltd TETRAHYDROQUINOLINE COMPOUNDS
EP1481961B1 (en) * 2002-02-07 2009-11-25 Sumitomo Chemical Company, Limited Process for producing (r)-3-hydroxy-3-(2-phenylethyl)hexanoic acid and its intermediate
FR2884715B1 (fr) * 2005-04-20 2007-06-15 Sanofi Aventis Sa Association entre la ferroquine et un derive d'artemisinine pour le traitement du paludisme
FR2961209B1 (fr) 2010-06-11 2013-03-01 Sanofi Aventis Procede de synthese de la ferroquine par amination reductrice convergente.

Also Published As

Publication number Publication date
EA201291209A1 (ru) 2013-04-30
US20130096306A1 (en) 2013-04-18
PH12012502453A1 (en) 2021-06-23
CA2802161C (en) 2018-08-14
MX2012014473A (es) 2013-02-21
MA34363B1 (fr) 2013-07-03
CN102939297B (zh) 2015-09-16
IL223521A (en) 2015-02-26
CA2802161A1 (en) 2011-12-15
UY33447A (es) 2012-01-31
TW201204702A (en) 2012-02-01
AU2011263354A1 (en) 2013-01-31
TWI485136B (zh) 2015-05-21
EA020392B1 (ru) 2014-10-30
EP2580224B1 (en) 2014-05-28
PY1123645A (es) 2015-09-01
KR101839634B1 (ko) 2018-04-26
AR081593A1 (es) 2012-10-03
WO2011154923A1 (en) 2011-12-15
JP2016145214A (ja) 2016-08-12
EP2580224A1 (en) 2013-04-17
AP3020A (en) 2014-10-31
AP2012006595A0 (en) 2012-12-31
US8497375B2 (en) 2013-07-30
BR112012031159A2 (pt) 2016-11-08
AU2011263354B2 (en) 2015-09-24
FR2961209A1 (fr) 2011-12-16
JP5916721B2 (ja) 2016-05-18
NZ605608A (en) 2014-09-26
JP2013529597A (ja) 2013-07-22
ZA201209328B (en) 2014-02-26
CN102939297A (zh) 2013-02-20
CO6602116A2 (es) 2013-01-18
KR20130122709A (ko) 2013-11-08
FR2961209B1 (fr) 2013-03-01
JO2928B1 (en) 2015-09-15
SG186247A1 (en) 2013-01-30

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