CL2012003684A1 - Una solucion oftalmica que incluye por lo menos una prostaglandina, un agente solubilizador, un agente gelificador carbomero, un agente inhibidor de la polimerizacion del carbomero y un agente co-gelificador/co-solubilizador, la cual tiene una viscosidad entre 8 y 20 mpa.s y no contiene conservadores antimicrobianos; y frasco que la comprende. - Google Patents
Una solucion oftalmica que incluye por lo menos una prostaglandina, un agente solubilizador, un agente gelificador carbomero, un agente inhibidor de la polimerizacion del carbomero y un agente co-gelificador/co-solubilizador, la cual tiene una viscosidad entre 8 y 20 mpa.s y no contiene conservadores antimicrobianos; y frasco que la comprende.Info
- Publication number
- CL2012003684A1 CL2012003684A1 CL2012003684A CL2012003684A CL2012003684A1 CL 2012003684 A1 CL2012003684 A1 CL 2012003684A1 CL 2012003684 A CL2012003684 A CL 2012003684A CL 2012003684 A CL2012003684 A CL 2012003684A CL 2012003684 A1 CL2012003684 A1 CL 2012003684A1
- Authority
- CL
- Chile
- Prior art keywords
- carbomer
- gelling
- solubilizing agent
- agent
- prostaglandin
- Prior art date
Links
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 title abstract 4
- 229920002125 Sokalan® Polymers 0.000 title abstract 4
- 229960001631 carbomer Drugs 0.000 title abstract 4
- 239000002904 solvent Substances 0.000 title abstract 4
- 230000000845 anti-microbial effect Effects 0.000 title abstract 2
- 239000003349 gelling agent Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 229940054534 ophthalmic solution Drugs 0.000 title abstract 2
- 239000002997 ophthalmic solution Substances 0.000 title abstract 2
- 238000006116 polymerization reaction Methods 0.000 title abstract 2
- 239000003755 preservative agent Substances 0.000 title abstract 2
- 150000003180 prostaglandins Chemical class 0.000 title abstract 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una solución oftálmica que incluye por lo menos una prostaglandina, un agente solubilizador, un agente gelificador carbomero, un agente inhibidor de la polimerización del carbomero y un agente co-gelificador/co-solubilizador, la cual tiene una viscosidad entre 8 y 20 MPA.S y no contiene conservadores antimicrobianos; y frasco que la comprende.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35969910P | 2010-06-29 | 2010-06-29 | |
| FR1055236A FR2961694B1 (fr) | 2010-06-29 | 2010-06-29 | Systeme de delivrance polymerique d'une solution non visqueuse a base de prostaglandine sans conservateur |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012003684A1 true CL2012003684A1 (es) | 2013-03-08 |
Family
ID=43064334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012003684A CL2012003684A1 (es) | 2010-06-29 | 2012-12-26 | Una solucion oftalmica que incluye por lo menos una prostaglandina, un agente solubilizador, un agente gelificador carbomero, un agente inhibidor de la polimerizacion del carbomero y un agente co-gelificador/co-solubilizador, la cual tiene una viscosidad entre 8 y 20 mpa.s y no contiene conservadores antimicrobianos; y frasco que la comprende. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20110319487A1 (es) |
| EP (1) | EP2588078B1 (es) |
| JP (2) | JP5657789B2 (es) |
| KR (1) | KR101809713B1 (es) |
| CN (2) | CN104274396B (es) |
| AU (1) | AU2011273549B2 (es) |
| BR (1) | BR112012033435B1 (es) |
| CA (1) | CA2802816C (es) |
| CL (1) | CL2012003684A1 (es) |
| CO (1) | CO6660508A2 (es) |
| DK (1) | DK2588078T3 (es) |
| EA (1) | EA025026B1 (es) |
| ES (1) | ES2486793T3 (es) |
| FR (1) | FR2961694B1 (es) |
| HR (1) | HRP20140631T1 (es) |
| MA (1) | MA34324B1 (es) |
| MX (1) | MX2012014503A (es) |
| PL (1) | PL2588078T3 (es) |
| PT (1) | PT2588078E (es) |
| RS (1) | RS53417B (es) |
| SG (1) | SG186361A1 (es) |
| SI (1) | SI2588078T1 (es) |
| SM (1) | SMT201400098B (es) |
| TN (1) | TN2012000588A1 (es) |
| UA (1) | UA107718C2 (es) |
| WO (1) | WO2012001009A1 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3828172A1 (en) | 2009-05-01 | 2021-06-02 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| FR2961694B1 (fr) | 2010-06-29 | 2013-01-25 | Thea Lab | Systeme de delivrance polymerique d'une solution non visqueuse a base de prostaglandine sans conservateur |
| US9278132B2 (en) * | 2012-02-13 | 2016-03-08 | Bausch & Lomb Incorporated | Ophthalmic pharmaceutical compositions and methods of making and using same |
| US10113033B2 (en) | 2013-03-08 | 2018-10-30 | Polyactiva Pty Ltd | Polymer conjugate for delivery of a bioactive agent |
| NZ711392A (en) | 2013-03-08 | 2020-05-29 | Polyactiva Pty Ltd | Polymer conjugate for delivery of a bioactive agent |
| CN104288092A (zh) * | 2013-07-16 | 2015-01-21 | 广东东阳光药业有限公司 | 拉坦前列素滴眼剂 |
| US9115109B2 (en) * | 2013-08-15 | 2015-08-25 | Chirogate International Inc. | Processes and intermediates for the preparations of isomer free prostaglandins |
| EP3057575B1 (en) * | 2013-10-15 | 2021-09-08 | Pharmathen S.A. | Preservative free pharmaceutical compositions for ophthalmic administration |
| GR1008330B (el) * | 2013-10-17 | 2014-10-20 | "Φαρματεν Α.Β.Ε.Ε.", | Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση εχoν βελτιωμενες φυσικες ιδιοτητες και ογκο σταγονας |
| GR1008483B (el) * | 2013-12-23 | 2015-05-12 | Rafarm Α.Ε.Β.Ε., | Οφθαλμικη φαρμακευτικη συνθεση και μεθοδος για την παρασκευη αυτης |
| CN105012231A (zh) * | 2014-04-30 | 2015-11-04 | 四川科伦药物研究院有限公司 | 一种包含PGF2α衍生物的稳定性良好的眼用制剂及其制备方法 |
| ES2584534B1 (es) * | 2015-03-27 | 2017-03-13 | Retinset, S.L. | Formulación tópica oftálmica de bosentan |
| PL3103439T3 (pl) * | 2015-06-09 | 2019-12-31 | Medproject Pharma-Entwicklungs- Und Vertriebsgesellschaft Mbh | Zdolny do tworzenia kropli oftalmiczny żel bimatoprostu |
| GR1009040B (el) | 2016-04-19 | 2017-05-19 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Φαρμακευτικο οφθαλμικο σκευασμα ελευθερο συντηρητικου |
| WO2018033854A1 (en) * | 2016-08-15 | 2018-02-22 | Santen Pharmaceutical Co., Ltd. | Ophthalmic composition and a method for treating ocular hypertension and glaucoma |
| KR102568079B1 (ko) | 2016-08-31 | 2023-08-17 | 에어리 파마슈티컬즈, 인코포레이티드 | 안과용 조성물 |
| IT201600103956A1 (it) * | 2016-10-17 | 2018-04-17 | Omikron Italia S R L | Formulazione oftalmica comprendente citicolina veicolata da liposomi per il trattamento del glaucoma |
| KR101770324B1 (ko) | 2016-11-09 | 2017-08-22 | 주식회사태준제약 | 안압 강하용 점안 조성물 |
| JP7355649B2 (ja) | 2017-03-14 | 2023-10-03 | ポリアクティヴァ・プロプライエタリー・リミテッド | 薬物-ポリマーコンジュゲート |
| US11696955B2 (en) | 2017-03-14 | 2023-07-11 | Polyactiva Pty Ltd | Drug-polymer conjugate |
| US11207417B2 (en) | 2017-03-14 | 2021-12-28 | Polyactiva Pty Ltd | Drug-polymer conjugate |
| AU2018243687C1 (en) | 2017-03-31 | 2020-12-24 | Alcon Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| EP3643297A4 (en) | 2017-06-22 | 2021-03-17 | Yonsung Fine Chemical Co., Ltd. | OPHTHALMIC COMPOSITION FOR THE TREATMENT OF GLAUCOMA |
| AU2019300203B2 (en) | 2018-07-12 | 2025-01-30 | Nicox S.A. | Ophthalmic compositions containing a nitric oxide releasing prostamide |
| CA3145888A1 (en) * | 2018-07-31 | 2020-02-06 | Isilay KAVADARLI | Ophthalmic formulations and uses thereof |
| CA3112391A1 (en) | 2018-09-14 | 2020-03-19 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CN110711175A (zh) * | 2019-11-12 | 2020-01-21 | 南京华盖制药有限公司 | 一种他氟前列素滴眼剂及其制备方法 |
| BR112022010871A2 (pt) * | 2019-12-05 | 2022-08-23 | Vanda Pharmaceuticals Inc | Composições farmacêuticas oftalmológicas |
| US11857538B2 (en) * | 2022-01-14 | 2024-01-02 | Somerset Therapeutics, Llc | Stable pilocarpine formulations with modified buffer characteristics and related methods |
| US12156868B2 (en) | 2022-02-09 | 2024-12-03 | Somerset Therapeutics, Llc | Formulations of pilocarpine and brimonidine compounds and related methods |
| CN116687842A (zh) * | 2022-02-28 | 2023-09-05 | 山东新时代药业有限公司 | 一种拉坦前列素滴眼液及其制备方法 |
| CN115671037A (zh) * | 2022-11-21 | 2023-02-03 | 山东诺明康药物研究院有限公司 | 一种溴莫尼定噻吗洛尔pH敏感型原位凝胶及其制备方法 |
| CN118526450A (zh) * | 2024-05-24 | 2024-08-23 | 兆科(广州)眼科药物有限公司 | 一种拉坦前列素眼用凝胶剂及其制备方法与用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10021A (en) * | 1853-09-13 | Screw-eastemtito- for boots and shoes | ||
| IL80298A (en) | 1986-10-14 | 1993-01-31 | Res & Dev Co Ltd | Eye drops |
| US5631287A (en) | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| US6646001B2 (en) * | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| JP2002510627A (ja) * | 1998-04-02 | 2002-04-09 | ノバルティス アクチエンゲゼルシャフト | 抗酸化剤の特別な使用により医薬組成物を安定化するための方法 |
| US20030018079A1 (en) * | 2000-11-13 | 2003-01-23 | Richardson Helene | Treatment |
| US7074827B2 (en) * | 2002-10-24 | 2006-07-11 | Sucampo Ag (Usa) Inc. | Method for treating ocular hypertension and glaucoma |
| FR2918891B1 (fr) | 2007-07-20 | 2009-09-25 | Thea Sa Lab | Solution ophtalmique a base de prostaglandines sans conservateur |
| ES2667945T3 (es) * | 2007-10-08 | 2018-05-16 | Aurinia Pharmaceuticals Inc. | Composiciones oftálmicas que comprenden inhibidores de calcineurina o Inhibidores de mTOR |
| US9629852B2 (en) * | 2007-10-16 | 2017-04-25 | Sun Pharma Advanced Research Company Ltd. | Ophthalmic composition comprising a prostaglandin |
| EP2127638A1 (en) * | 2008-05-30 | 2009-12-02 | Santen Pharmaceutical Co., Ltd | Method and composition for treating ocular hypertension and glaucoma |
| FR2961694B1 (fr) * | 2010-06-29 | 2013-01-25 | Thea Lab | Systeme de delivrance polymerique d'une solution non visqueuse a base de prostaglandine sans conservateur |
-
2010
- 2010-06-29 FR FR1055236A patent/FR2961694B1/fr active Active
-
2011
- 2011-06-28 CN CN201410538280.1A patent/CN104274396B/zh active Active
- 2011-06-28 CN CN201180032001.9A patent/CN102958509B/zh active Active
- 2011-06-28 SI SI201130234T patent/SI2588078T1/sl unknown
- 2011-06-28 ES ES11727707.9T patent/ES2486793T3/es active Active
- 2011-06-28 HR HRP20140631AT patent/HRP20140631T1/hr unknown
- 2011-06-28 AU AU2011273549A patent/AU2011273549B2/en active Active
- 2011-06-28 EP EP11727707.9A patent/EP2588078B1/fr active Active
- 2011-06-28 SG SG2012092284A patent/SG186361A1/en unknown
- 2011-06-28 RS RS20140353A patent/RS53417B/sr unknown
- 2011-06-28 US US13/170,716 patent/US20110319487A1/en not_active Abandoned
- 2011-06-28 WO PCT/EP2011/060848 patent/WO2012001009A1/fr not_active Ceased
- 2011-06-28 MA MA35472A patent/MA34324B1/fr unknown
- 2011-06-28 PL PL11727707T patent/PL2588078T3/pl unknown
- 2011-06-28 EA EA201291307A patent/EA025026B1/ru not_active IP Right Cessation
- 2011-06-28 DK DK11727707.9T patent/DK2588078T3/da active
- 2011-06-28 PT PT117277079T patent/PT2588078E/pt unknown
- 2011-06-28 BR BR112012033435-2A patent/BR112012033435B1/pt active IP Right Grant
- 2011-06-28 CA CA2802816A patent/CA2802816C/fr active Active
- 2011-06-28 MX MX2012014503A patent/MX2012014503A/es active IP Right Grant
- 2011-06-28 UA UAA201301063A patent/UA107718C2/ru unknown
- 2011-06-28 JP JP2013517254A patent/JP5657789B2/ja active Active
- 2011-06-28 KR KR1020127033996A patent/KR101809713B1/ko active Active
-
2012
- 2012-08-27 US US13/595,165 patent/US8637054B2/en active Active
- 2012-12-12 TN TNP2012000588A patent/TN2012000588A1/fr unknown
- 2012-12-26 CL CL2012003684A patent/CL2012003684A1/es unknown
- 2012-12-27 CO CO12234226A patent/CO6660508A2/es not_active Application Discontinuation
-
2014
- 2014-07-23 SM SM201400098T patent/SMT201400098B/xx unknown
- 2014-09-19 JP JP2014191849A patent/JP5877885B2/ja active Active
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