CL2013000589A1 - Metodo para preparar derivados del acido 3-amino-4-(3,4,5,5-tetrasustituido)-2-oxo-piperidin-1-il)-4-butirico por reaccion entre un acido 3,4-diaminobutanoico y un acido 5-hidroxipentanoico. - Google Patents
Metodo para preparar derivados del acido 3-amino-4-(3,4,5,5-tetrasustituido)-2-oxo-piperidin-1-il)-4-butirico por reaccion entre un acido 3,4-diaminobutanoico y un acido 5-hidroxipentanoico.Info
- Publication number
- CL2013000589A1 CL2013000589A1 CL2013000589A CL2013000589A CL2013000589A1 CL 2013000589 A1 CL2013000589 A1 CL 2013000589A1 CL 2013000589 A CL2013000589 A CL 2013000589A CL 2013000589 A CL2013000589 A CL 2013000589A CL 2013000589 A1 CL2013000589 A1 CL 2013000589A1
- Authority
- CL
- Chile
- Prior art keywords
- acid
- piperidin
- oxo
- tetrasubstituted
- amino
- Prior art date
Links
- XQKAYTBBWLDCBB-UHFFFAOYSA-N 3,4-diaminobutanoic acid Chemical compound NCC(N)CC(O)=O XQKAYTBBWLDCBB-UHFFFAOYSA-N 0.000 title 1
- PHOJOSOUIAQEDH-UHFFFAOYSA-N 5-hydroxypentanoic acid Chemical compound OCCCCC(O)=O PHOJOSOUIAQEDH-UHFFFAOYSA-N 0.000 title 1
- MLSDXFYOVWDZFI-UHFFFAOYSA-N 2-(2-oxopiperidin-1-yl)butanoic acid Chemical compound CCC(C(O)=O)N1CCCCC1=O MLSDXFYOVWDZFI-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Método para la preparación de un compuesto derivado de ácido 2-oxo-piperidin-1-il-butírico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20100086619 | 2010-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013000589A1 true CL2013000589A1 (es) | 2013-07-12 |
Family
ID=45023417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013000589A CL2013000589A1 (es) | 2010-09-03 | 2013-03-01 | Metodo para preparar derivados del acido 3-amino-4-(3,4,5,5-tetrasustituido)-2-oxo-piperidin-1-il)-4-butirico por reaccion entre un acido 3,4-diaminobutanoico y un acido 5-hidroxipentanoico. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US8741927B2 (es) |
| EP (1) | EP2611776B1 (es) |
| JP (1) | JP5705985B2 (es) |
| KR (1) | KR101378984B1 (es) |
| CN (1) | CN103080088B (es) |
| AP (1) | AP3270A (es) |
| AR (1) | AR082881A1 (es) |
| AU (1) | AU2011296767B2 (es) |
| BR (1) | BR112013004988B1 (es) |
| CA (1) | CA2810393C (es) |
| CL (1) | CL2013000589A1 (es) |
| CO (1) | CO6700826A2 (es) |
| DK (1) | DK2611776T3 (es) |
| EA (1) | EA022500B1 (es) |
| EC (1) | ECSP13012471A (es) |
| ES (1) | ES2607089T3 (es) |
| HU (1) | HUE032484T2 (es) |
| IL (1) | IL224954B (es) |
| MA (1) | MA34490B1 (es) |
| MX (1) | MX2013002277A (es) |
| MY (1) | MY157423A (es) |
| NZ (1) | NZ607694A (es) |
| PE (1) | PE20131128A1 (es) |
| PH (1) | PH12013500343A1 (es) |
| PL (1) | PL2611776T3 (es) |
| PT (1) | PT2611776T (es) |
| SG (1) | SG188329A1 (es) |
| SI (1) | SI2611776T1 (es) |
| TW (1) | TWI438188B (es) |
| UA (1) | UA107721C2 (es) |
| UY (1) | UY33589A (es) |
| WO (1) | WO2012030106A2 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2995612A1 (en) * | 2014-09-12 | 2016-03-16 | Université de Strasbourg | Novel non-natural amino acids, their process of preparation and uses thereof |
| KR102068754B1 (ko) * | 2017-04-20 | 2020-01-21 | 주식회사 엘지화학 | 의약품 합성용 중간체 화합물의 제조 방법 |
| PE20201169A1 (es) * | 2017-09-28 | 2020-10-28 | Lg Chemical Ltd | Metodo de produccion de un compuesto intermedio para sintetizar un medicamento |
| WO2019066578A1 (ko) * | 2017-09-28 | 2019-04-04 | 주식회사 엘지화학 | 의약품 합성용 중간체 화합물의 제조 방법 |
| RU2741389C1 (ru) * | 2017-11-16 | 2021-01-25 | ЭлДжи КЕМ, ЛТД. | Способ получения промежуточного соединения для синтеза лекарственного средства |
| WO2019098551A1 (ko) * | 2017-11-16 | 2019-05-23 | 주식회사 엘지화학 | 의약품 합성용 중간체 화합물의 제조 방법 |
| CN113861061A (zh) * | 2021-10-25 | 2021-12-31 | 成都市科隆化学品有限公司 | 一种不含无机铵盐的氨基酸酰胺盐酸盐及其合成方法 |
| CN117682981A (zh) * | 2022-09-02 | 2024-03-12 | 中国科学院大连化学物理研究所 | 一种吉格列汀药物前体的制备方法 |
| KR20250155700A (ko) | 2024-04-24 | 2025-10-31 | 주식회사 다산제약 | 제미글립틴 산부가염 제조방법 및 이를 유효성분으로 포함하는 dpp-4 저해용 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4456768A (en) * | 1980-10-08 | 1984-06-26 | The University Of Chicago | Chemical synthesis |
| US5556982A (en) * | 1985-01-14 | 1996-09-17 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| DE3705272A1 (de) * | 1987-02-19 | 1988-09-01 | Basf Ag | Verfahren zur reduktion von mono- und dicarbonsaeuren |
| US5417023A (en) * | 1993-12-27 | 1995-05-23 | Mandish; Theodore O. | Building panel apparatus and method |
| AU2001250850A1 (en) * | 2000-03-17 | 2001-10-03 | Dupont Pharmaceuticals Company | Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha |
| TWI357902B (en) * | 2005-04-01 | 2012-02-11 | Lg Life Science Ltd | Dipeptidyl peptidase-iv inhibiting compounds, meth |
| US20100210706A1 (en) * | 2006-08-09 | 2010-08-19 | Smithkline Beecham Corporation | Pyrrolidinone anilines as progesterone receptor modulators |
| KR20080071476A (ko) * | 2007-01-30 | 2008-08-04 | 주식회사 엘지생명과학 | 신규한 디펩티딜 펩티데이즈 ｉｖ(ｄｐｐ-ｉｖ) 저해제 |
| AU2008341352B2 (en) * | 2007-12-21 | 2013-08-01 | Lg Chem, Ltd. | Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent |
-
2011
- 2011-08-25 PT PT118220813T patent/PT2611776T/pt unknown
- 2011-08-25 JP JP2013527003A patent/JP5705985B2/ja active Active
- 2011-08-25 ES ES11822081.3T patent/ES2607089T3/es active Active
- 2011-08-25 PH PH1/2013/500343A patent/PH12013500343A1/en unknown
- 2011-08-25 AU AU2011296767A patent/AU2011296767B2/en active Active
- 2011-08-25 AP AP2013006763A patent/AP3270A/xx active
- 2011-08-25 EA EA201390336A patent/EA022500B1/ru unknown
- 2011-08-25 CN CN201180041893.9A patent/CN103080088B/zh active Active
- 2011-08-25 DK DK11822081.3T patent/DK2611776T3/en active
- 2011-08-25 NZ NZ607694A patent/NZ607694A/en unknown
- 2011-08-25 EP EP11822081.3A patent/EP2611776B1/en active Active
- 2011-08-25 SG SG2013014931A patent/SG188329A1/en unknown
- 2011-08-25 HU HUE11822081A patent/HUE032484T2/en unknown
- 2011-08-25 MA MA35699A patent/MA34490B1/fr unknown
- 2011-08-25 WO PCT/KR2011/006260 patent/WO2012030106A2/en not_active Ceased
- 2011-08-25 MX MX2013002277A patent/MX2013002277A/es active IP Right Grant
- 2011-08-25 PL PL11822081T patent/PL2611776T3/pl unknown
- 2011-08-25 US US13/820,197 patent/US8741927B2/en active Active
- 2011-08-25 CA CA2810393A patent/CA2810393C/en active Active
- 2011-08-25 UA UAA201302600A patent/UA107721C2/ru unknown
- 2011-08-25 BR BR112013004988-0A patent/BR112013004988B1/pt active IP Right Grant
- 2011-08-25 PE PE2013000351A patent/PE20131128A1/es active IP Right Grant
- 2011-08-25 MY MYPI2013000673A patent/MY157423A/en unknown
- 2011-08-25 SI SI201131045A patent/SI2611776T1/sl unknown
- 2011-09-02 UY UY0001033589A patent/UY33589A/es unknown
- 2011-09-02 KR KR1020110089110A patent/KR101378984B1/ko active Active
- 2011-09-02 TW TW100131640A patent/TWI438188B/zh active
- 2011-09-02 AR ARP110103214A patent/AR082881A1/es active IP Right Grant
-
2013
- 2013-02-27 IL IL224954A patent/IL224954B/en active IP Right Grant
- 2013-03-01 CL CL2013000589A patent/CL2013000589A1/es unknown
- 2013-03-01 CO CO13042032A patent/CO6700826A2/es unknown
- 2013-03-01 EC ECSP13012471 patent/ECSP13012471A/es unknown
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