CL2013001978A1 - Compuestos biciclicos o oxabiciclicos nitrogenados, antagonistas no competitivos moduladores de receptores nicotinicos; composicion farmaceutica que los comprende; uso de los compuestos para el tratamiento o la prevencion de hipertension, adiccion a la nicotina, depresion o ansiedad, detrioros cognitivos, inflamacion. - Google Patents

Compuestos biciclicos o oxabiciclicos nitrogenados, antagonistas no competitivos moduladores de receptores nicotinicos; composicion farmaceutica que los comprende; uso de los compuestos para el tratamiento o la prevencion de hipertension, adiccion a la nicotina, depresion o ansiedad, detrioros cognitivos, inflamacion.

Info

Publication number
CL2013001978A1
CL2013001978A1 CL2013001978A CL2013001978A CL2013001978A1 CL 2013001978 A1 CL2013001978 A1 CL 2013001978A1 CL 2013001978 A CL2013001978 A CL 2013001978A CL 2013001978 A CL2013001978 A CL 2013001978A CL 2013001978 A1 CL2013001978 A1 CL 2013001978A1
Authority
CL
Chile
Prior art keywords
compounds
oxabicyclic
nitrogenated
anxiety
bicyclic
Prior art date
Application number
CL2013001978A
Other languages
English (en)
Inventor
Srinivasa Rao Akireddy
Scott R Breining
Matt S Melvin
Srinivasa V Murthy
Anatoly A Mazurov
Balwinder Singh Bhatti
Jon-Paul Strachan
Ronald Joseph Heemstra
Todd Showalter
Yunde Xiao
Philip S Hammond
Lan Miao
David Kombo
Daniel Yohannes
Jason Speake
Original Assignee
Targacept Inc ;
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc ; filed Critical Targacept Inc ;
Publication of CL2013001978A1 publication Critical patent/CL2013001978A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/40—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing six carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CL2013001978A 2011-01-07 2013-07-05 Compuestos biciclicos o oxabiciclicos nitrogenados, antagonistas no competitivos moduladores de receptores nicotinicos; composicion farmaceutica que los comprende; uso de los compuestos para el tratamiento o la prevencion de hipertension, adiccion a la nicotina, depresion o ansiedad, detrioros cognitivos, inflamacion. CL2013001978A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161430640P 2011-01-07 2011-01-07

Publications (1)

Publication Number Publication Date
CL2013001978A1 true CL2013001978A1 (es) 2013-11-04

Family

ID=46457959

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013001978A CL2013001978A1 (es) 2011-01-07 2013-07-05 Compuestos biciclicos o oxabiciclicos nitrogenados, antagonistas no competitivos moduladores de receptores nicotinicos; composicion farmaceutica que los comprende; uso de los compuestos para el tratamiento o la prevencion de hipertension, adiccion a la nicotina, depresion o ansiedad, detrioros cognitivos, inflamacion.

Country Status (16)

Country Link
US (1) US20140288169A1 (es)
EP (1) EP2661421A2 (es)
JP (1) JP2014510026A (es)
KR (1) KR20140038361A (es)
CN (1) CN103402971A (es)
BR (1) BR112013017405A2 (es)
CA (1) CA2823848A1 (es)
CL (1) CL2013001978A1 (es)
CO (1) CO6821933A2 (es)
IL (2) IL227319A0 (es)
MX (1) MX2013007952A (es)
PE (1) PE20140873A1 (es)
PH (1) PH12013501453A1 (es)
RU (1) RU2013136851A (es)
SG (1) SG191884A1 (es)
WO (1) WO2012094437A2 (es)

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3514486A (en) * 1968-05-23 1970-05-26 Miles Lab 3-isopropylnorbornanamine
US4883888A (en) * 1984-07-13 1989-11-28 The Procter & Gamble Company Oxa-fenchyl amines useful for preparing high intensity sweeteners
EP0770068B1 (en) * 1994-07-11 2001-11-28 Allergan Sales, Inc. Conformationally rigid bicyclic and adamantane derivatives useful as alpha 2-adrenergic blocking agents
US5986142A (en) * 1997-09-23 1999-11-16 Poli Industria Chimica Spa Process for preparing bicycloheptanamine compounds
JP2005525293A (ja) * 2001-08-29 2005-08-25 エンドー ファーマシューティカルズ, インコーポレイティド 鎮痛薬およびその使用方法
WO2005067909A1 (en) * 2004-01-06 2005-07-28 Yale University Combination therapy with mecamylamine for the treatment of mood disorders
CA2568524A1 (en) * 2004-05-28 2005-12-15 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
JP2008521821A (ja) * 2004-11-29 2008-06-26 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体のモジュレーター
WO2006105035A2 (en) * 2005-03-28 2006-10-05 Vertex Pharmaceuticals Incorporated Muscarinic modulators
US20090264650A1 (en) * 2005-03-31 2009-10-22 Nobuo Cho Prophylactic/Therapeutic Agent for Diabetes
JP2008546784A (ja) * 2005-06-20 2008-12-25 シェーリング コーポレイション ヒスタミンh3アンタゴニストとして有用なピペリジン誘導体
AR057816A1 (es) * 2005-09-17 2007-12-19 Speedel Experimenta Ag Compuestos organicos
TW200730500A (en) * 2005-12-20 2007-08-16 Solvay Pharm Bv 4, 5-dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators
WO2007071662A1 (en) * 2005-12-20 2007-06-28 Solvay Pharmaceuticals B.V. 4,5-dihydro- (1h)-pyrazole derivatives as cannabinoid cb1 receptor modulators
AR066721A1 (es) * 2007-05-24 2009-09-09 Wyeth Corp Derivados de benzo[d]imidazol-1-il, composicion farmaceutica, proceso de preparacion y uso.
EP2271344A4 (en) * 2008-03-31 2011-04-27 Univ South Florida METHOD FOR TREATING ILLNESS-RELATED ATAXIA AND NON-ATTACHIC IMBALANCE
BRPI1010813A2 (pt) * 2009-05-29 2017-02-14 Xlterra Inc cetal ésteres de anidropentitóis e usos dos mesmos
WO2013026852A2 (en) * 2011-08-22 2013-02-28 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Derivatives of mecamylamine

Also Published As

Publication number Publication date
WO2012094437A2 (en) 2012-07-12
PH12013501453A1 (en) 2013-08-28
KR20140038361A (ko) 2014-03-28
PE20140873A1 (es) 2014-08-13
WO2012094437A3 (en) 2012-11-01
RU2013136851A (ru) 2015-02-20
CN103402971A (zh) 2013-11-20
BR112013017405A2 (pt) 2016-10-04
IL227319A0 (en) 2013-09-30
EP2661421A2 (en) 2013-11-13
SG191884A1 (en) 2013-08-30
CO6821933A2 (es) 2013-12-31
MX2013007952A (es) 2013-08-21
JP2014510026A (ja) 2014-04-24
IL230334A0 (en) 2014-03-06
US20140288169A1 (en) 2014-09-25
CA2823848A1 (en) 2012-07-12

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