CL2013003287A1 - Compuestos derivados de 5-trifluorometil-4,5-dihidro-isoxazol; compuestos intermediarios; procedimiento de preparacion; composiciones farmaceuticas que los comprenden; y uso en el tratamiento de una infestacion de parasitos en animales. - Google Patents
Compuestos derivados de 5-trifluorometil-4,5-dihidro-isoxazol; compuestos intermediarios; procedimiento de preparacion; composiciones farmaceuticas que los comprenden; y uso en el tratamiento de una infestacion de parasitos en animales.Info
- Publication number
- CL2013003287A1 CL2013003287A1 CL2013003287A CL2013003287A CL2013003287A1 CL 2013003287 A1 CL2013003287 A1 CL 2013003287A1 CL 2013003287 A CL2013003287 A CL 2013003287A CL 2013003287 A CL2013003287 A CL 2013003287A CL 2013003287 A1 CL2013003287 A1 CL 2013003287A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- isoxazole
- dihydro
- trifluoromethyl
- animals
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- LJXRBOOQMTZAPS-UHFFFAOYSA-N 5-(trifluoromethyl)-4,5-dihydro-1,2-oxazole Chemical class FC(F)(F)C1CC=NO1 LJXRBOOQMTZAPS-UHFFFAOYSA-N 0.000 title abstract 2
- 206010061217 Infestation Diseases 0.000 title abstract 2
- 241001465754 Metazoa Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 244000045947 parasite Species 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
COMPUESTOS DERIVADOS DE 5-TRIFLUOROMETIL-4,5-DIHIDRO-ISOXAZOL DE FÓRMULA 1 COMPUESTOS INTERMEDIARIOS; PROCEDIMIENTO DE PREPARACIÓN; COMPOSICIONES FARMACÉUTICAS QUE LOS COMPRENDEN; Y USO EN EL TRATAMIENTO DE UNA INFESTACIÓN DE PARÁSITOS EN ANIMALES.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2011/074294 WO2012155352A1 (en) | 2011-05-19 | 2011-05-19 | Dihydroisoxazole compounds, parasiticidal uses and formulations thereof |
| PCT/CN2012/072878 WO2012155676A1 (en) | 2011-05-19 | 2012-03-23 | Parasiticidal compounds, methods, and formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013003287A1 true CL2013003287A1 (es) | 2014-07-25 |
Family
ID=47176150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013003287A CL2013003287A1 (es) | 2011-05-19 | 2013-11-15 | Compuestos derivados de 5-trifluorometil-4,5-dihidro-isoxazol; compuestos intermediarios; procedimiento de preparacion; composiciones farmaceuticas que los comprenden; y uso en el tratamiento de una infestacion de parasitos en animales. |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US8648081B2 (es) |
| EP (2) | EP2710000B1 (es) |
| JP (1) | JP5989099B2 (es) |
| KR (1) | KR101586553B1 (es) |
| CN (1) | CN103547576B (es) |
| AR (1) | AR086296A1 (es) |
| AU (1) | AU2012256220B2 (es) |
| BR (1) | BR112013028132B1 (es) |
| CA (1) | CA2835436C (es) |
| CL (1) | CL2013003287A1 (es) |
| CO (1) | CO6811873A2 (es) |
| CR (1) | CR20130486A (es) |
| CY (1) | CY1116450T1 (es) |
| DK (1) | DK2710000T3 (es) |
| EA (1) | EA023711B1 (es) |
| ES (1) | ES2543392T3 (es) |
| HR (1) | HRP20150588T1 (es) |
| IL (1) | IL229007A (es) |
| ME (1) | ME02113B (es) |
| MX (1) | MX341739B (es) |
| PE (1) | PE20141041A1 (es) |
| PH (1) | PH12013502374A1 (es) |
| PL (1) | PL2710000T3 (es) |
| PT (1) | PT2710000E (es) |
| RS (1) | RS54048B1 (es) |
| SG (1) | SG194836A1 (es) |
| SI (1) | SI2710000T1 (es) |
| TW (1) | TWI554508B (es) |
| UA (1) | UA110519C2 (es) |
| WO (3) | WO2012155352A1 (es) |
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| UY33403A (es) * | 2010-06-17 | 2011-12-30 | Novartis Ag | Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales |
| WO2012155352A1 (en) | 2011-05-19 | 2012-11-22 | Eli Lilly And Company | Dihydroisoxazole compounds, parasiticidal uses and formulations thereof |
| KR102044772B1 (ko) * | 2012-12-11 | 2019-11-14 | 브라코 이미징 에스.피.에이. | (s)-2-아세틸옥시프로피온산 클로라이드의 제조를 위한 연속식 공정 |
| PL2953942T3 (pl) | 2013-02-06 | 2018-03-30 | Bayer Cropscience Aktiengesellschaft | Podstawione halogenem pochodne pirazolu jako środki do zwalczania szkodników |
| MX2016008653A (es) | 2014-01-03 | 2016-09-26 | Bayer Animal Health Gmbh | Nuevas pirazolil-heteroarilamidas como agentes plaguicidas. |
| JP6419313B2 (ja) * | 2014-05-09 | 2018-11-07 | キネタ・インコーポレイテッドＫｉｎｅｔａ， Ｉｎｃ． | 抗ウイルスの化合物、医薬組成物およびその使用方法 |
| LT3154928T (lt) | 2014-06-10 | 2020-05-11 | Bracco Imaging S.P.A. | (s)-2-acetiloksipropioninės rūgšties ir jos darinių gavimo būdas |
| JP2017521441A (ja) | 2014-07-15 | 2017-08-03 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ａｎｉｍａｌ Ｈｅａｌｔｈ Ｇｍｂｈ | 有害生物防除剤としてのアリール−トリアゾリルピリジン類 |
| HUE059228T2 (hu) | 2015-06-23 | 2022-10-28 | Intervet Int Bv | E vitamint tartalmazó izoxazolin oldat, fertõtlenített ivóvízzel való felhasználásra |
| CN119033777A (zh) * | 2016-05-10 | 2024-11-29 | 瑞士伊兰科动物保健有限公司 | 用于控制海虱的二氢异噁唑化合物 |
| MX2019005040A (es) * | 2016-10-31 | 2019-10-30 | Tropiq Health Sciences | Métodos y composiciones para prevenir la transmisión de enfermedades vectoriales. |
| US10961213B2 (en) | 2017-01-25 | 2021-03-30 | Basf Se | Process for preparation of benzylic amides |
| WO2018166855A1 (en) * | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
| AR113997A1 (es) | 2017-12-21 | 2020-07-08 | Intervet Int Bv | Composiciones antiparasitarias para unción dorsal continua |
| CN112955426A (zh) * | 2018-10-29 | 2021-06-11 | 巴斯夫欧洲公司 | 制备光学富集的羟醛化合物的方法 |
| JP7829485B2 (ja) | 2019-12-20 | 2026-03-13 | ナミ セラピューティクス， インコーポレイテッド | がんの処置において有用なＴｏｌｌ様受容体（「ＴＬＲ」）アゴニストプロドラッグを含有する製剤化および／または共製剤化リポソーム組成物ならびにその方法 |
| JP2024513690A (ja) * | 2021-03-11 | 2024-03-27 | イン ザ ボウル アニマル ヘルス，インコーポレーテッド | 哺乳動物におけるノミおよびダニの侵入を制御する方法 |
| CN117412673A (zh) * | 2021-03-11 | 2024-01-16 | 碗中动物健康公司 | 犬科动物口服饲料和在犬科动物中控制蚤侵袭的方法 |
| KR20230162001A (ko) * | 2021-03-11 | 2023-11-28 | 인 더 보울 애니멀 헬스, 인크. | 갯과에서 진드기 감염을 방제하기 위한 경구용 갯과 사료 및 방법 |
| US20250092054A1 (en) * | 2021-06-02 | 2025-03-20 | Fmc Corporation | Fused pyridines for controlling invertebrate pests |
| KR20240051920A (ko) * | 2021-06-25 | 2024-04-22 | 인 더 보울 애니멀 헬스, 인크. | 고양잇과의 진드기 감염을 구제하기 위한 경구용 고양잇과 사료 및 방법 |
| CN117915782A (zh) * | 2021-06-25 | 2024-04-19 | 碗中动物健康公司 | 猫科动物口服饲料和在猫科动物中控制蚤侵袭的方法 |
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| EP4342885A1 (en) | 2022-09-20 | 2024-03-27 | Basf Se | N-(3-(aminomethyl)-phenyl)-5-(4-phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-amine derivatives and similar compounds as pesticides |
| EP4389210A1 (en) | 2022-12-21 | 2024-06-26 | Basf Se | Heteroaryl compounds for the control of invertebrate pests |
| EP4455137A1 (en) | 2023-04-24 | 2024-10-30 | Basf Se | Pyrimidine compounds for the control of invertebrate pests |
| EP4467535A1 (en) | 2023-05-25 | 2024-11-27 | Basf Se | Lactam pesticidal compounds |
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| CA2747354C (en) | 2008-12-19 | 2016-12-06 | Novartis Ag | Isoxazoline derivatives and their use as pesticide |
| JP2011098956A (ja) * | 2009-10-09 | 2011-05-19 | Sumitomo Chemical Co Ltd | イソオキサゾリン化合物及びその用途 |
| WO2011073098A1 (de) * | 2009-12-15 | 2011-06-23 | Bayer Cropscience Ag | 1-(heteroaryl)-pyrazol-4-yl-essigsäuren, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren |
| ES2682303T3 (es) | 2010-08-05 | 2018-09-19 | Zoetis Services Llc | Derivados de isoxazolina como agentes antiparasitarios |
| EP2619189B1 (en) * | 2010-09-24 | 2020-04-15 | Zoetis Services LLC | Isoxazoline oximes as antiparasitic agents |
| WO2012107533A1 (en) * | 2011-02-10 | 2012-08-16 | Novartis Ag | Isoxazoline derivatives for controlling invertebrate pests |
| WO2012155352A1 (en) | 2011-05-19 | 2012-11-22 | Eli Lilly And Company | Dihydroisoxazole compounds, parasiticidal uses and formulations thereof |
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2011
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