UA110519C2 - Паразитоцидні сполуки дигідроізоксазолу - Google Patents
Паразитоцидні сполуки дигідроізоксазолуInfo
- Publication number
- UA110519C2 UA110519C2 UAA201313451A UAA201313451A UA110519C2 UA 110519 C2 UA110519 C2 UA 110519C2 UA A201313451 A UAA201313451 A UA A201313451A UA A201313451 A UAA201313451 A UA A201313451A UA 110519 C2 UA110519 C2 UA 110519C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compounds
- parasitocide
- digidroisoxazole
- animals
- dihydroisoxazole
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 241001465754 Metazoa Species 0.000 abstract 3
- FJRPOHLDJUJARI-UHFFFAOYSA-N 2,3-dihydro-1,2-oxazole Chemical compound C1NOC=C1 FJRPOHLDJUJARI-UHFFFAOYSA-N 0.000 abstract 2
- 206010061217 Infestation Diseases 0.000 abstract 2
- 230000003071 parasitic effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Запропоновані сполуки дигідроізоксазолу формули І, придатні для боротьби з паразитами як у тварин, так і у сільськогосподарських культур. Крім того запропоновані способи боротьби з паразитарними інвазіями у тварин шляхом введення тварині ефективної кількості сполуки, описаної вище, або її фармацевтично прийнятної солі, а також у вигляді композицій для боротьби з паразитарними інвазіями з використанням сполук, описаних вище, або їх прийнятної солі і прийнятного носія. Також запропоновані сполуки і способи, придатні для одержання сполук дигідроізоксазолу.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2011/074294 WO2012155352A1 (en) | 2011-05-19 | 2011-05-19 | Dihydroisoxazole compounds, parasiticidal uses and formulations thereof |
| PCT/CN2012/072878 WO2012155676A1 (en) | 2011-05-19 | 2012-03-23 | Parasiticidal compounds, methods, and formulations |
| PCT/US2012/036883 WO2012158396A1 (en) | 2011-05-19 | 2012-05-08 | Parasiticidal dihydroisoxazole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA110519C2 true UA110519C2 (uk) | 2016-01-12 |
Family
ID=47176150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201313451A UA110519C2 (uk) | 2011-05-19 | 2012-05-08 | Паразитоцидні сполуки дигідроізоксазолу |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US8648081B2 (uk) |
| EP (2) | EP2918583A1 (uk) |
| JP (1) | JP5989099B2 (uk) |
| KR (1) | KR101586553B1 (uk) |
| CN (1) | CN103547576B (uk) |
| AR (1) | AR086296A1 (uk) |
| AU (1) | AU2012256220B2 (uk) |
| BR (1) | BR112013028132B1 (uk) |
| CA (1) | CA2835436C (uk) |
| CL (1) | CL2013003287A1 (uk) |
| CO (1) | CO6811873A2 (uk) |
| CR (1) | CR20130486A (uk) |
| CY (1) | CY1116450T1 (uk) |
| DK (1) | DK2710000T3 (uk) |
| EA (1) | EA023711B1 (uk) |
| ES (1) | ES2543392T3 (uk) |
| HR (1) | HRP20150588T1 (uk) |
| IL (1) | IL229007A (uk) |
| ME (1) | ME02113B (uk) |
| MX (1) | MX341739B (uk) |
| PE (1) | PE20141041A1 (uk) |
| PH (1) | PH12013502374A1 (uk) |
| PL (1) | PL2710000T3 (uk) |
| PT (1) | PT2710000E (uk) |
| RS (1) | RS54048B1 (uk) |
| SG (1) | SG194836A1 (uk) |
| SI (1) | SI2710000T1 (uk) |
| TW (1) | TWI554508B (uk) |
| UA (1) | UA110519C2 (uk) |
| WO (3) | WO2012155352A1 (uk) |
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| UY33403A (es) * | 2010-06-17 | 2011-12-30 | Novartis Ag | Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales |
| WO2012155352A1 (en) | 2011-05-19 | 2012-11-22 | Eli Lilly And Company | Dihydroisoxazole compounds, parasiticidal uses and formulations thereof |
| HUE040143T2 (hu) * | 2012-12-11 | 2019-02-28 | Bracco Imaging Spa | Folyamatos eljárás (S)-2-acetiloxipropionsav elõállítására |
| ES2656012T3 (es) | 2013-02-06 | 2018-02-22 | Bayer Cropscience Aktiengesellschaft | Derivados de pirazol sustituidos con halógeno como pesticidas |
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| TW201623265A (zh) | 2014-05-09 | 2016-07-01 | 奇尼塔公司 | 抗病毒化合物、醫藥組合物及其使用方法 |
| EP3154928B1 (en) * | 2014-06-10 | 2020-03-04 | Bracco Imaging S.p.A | Method for the preparation of (s)-2-acetyloxypropionic acid and derivatives thereof |
| MX2017000673A (es) | 2014-07-15 | 2017-04-27 | Bayer Animal Health Gmbh | Nueva piridina triazolil arilo como pesticida. |
| BR112017027855B1 (pt) | 2015-06-23 | 2022-11-16 | Intervet International B.V. | Composição farmacêutica, seu uso, água potável medicamentosa e método para sua preparação |
| CN119033777A (zh) * | 2016-05-10 | 2024-11-29 | 瑞士伊兰科动物保健有限公司 | 用于控制海虱的二氢异噁唑化合物 |
| JP2020503369A (ja) * | 2016-10-31 | 2020-01-30 | ザ・スクリップス・リサーチ・インスティテュート | 媒介体由来疾患伝染を予防する方法と組成物 |
| CN110234645A (zh) | 2017-01-25 | 2019-09-13 | 巴斯夫欧洲公司 | 制备卞型酰胺的方法 |
| WO2018166855A1 (en) * | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
| AR113997A1 (es) | 2017-12-21 | 2020-07-08 | Intervet Int Bv | Composiciones antiparasitarias para unción dorsal continua |
| EP3873881A1 (en) * | 2018-10-29 | 2021-09-08 | Basf Se | Process for preparation of optically enriched aldol compounds |
| WO2021126281A1 (en) | 2019-12-20 | 2021-06-24 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing toll-like receptor ("tlr") agonist prodrugs useful in the treatment of cancer and methods thereof |
| JP2024513690A (ja) * | 2021-03-11 | 2024-03-27 | イン ザ ボウル アニマル ヘルス，インコーポレーテッド | 哺乳動物におけるノミおよびダニの侵入を制御する方法 |
| JP2024511956A (ja) * | 2021-03-11 | 2024-03-18 | イン ザ ボウル アニマル ヘルス，インコーポレーテッド | 経口のイヌ科動物の飼料およびイヌ科動物におけるダニの侵入を制御する方法 |
| WO2022192623A1 (en) * | 2021-03-11 | 2022-09-15 | In The Bowl Animal Health, Inc. | Oral canine feed and methods for controlling flea infestations in a canine |
| MX2023014308A (es) * | 2021-06-02 | 2024-01-22 | Fmc Corp | Piridinas condensadas para controlar plagas de invertebrados. |
| CN117769356A (zh) * | 2021-06-25 | 2024-03-26 | 碗中动物健康公司 | 猫科动物口服饲料和在猫科动物中控制蜱侵袭的方法 |
| CN117915782A (zh) * | 2021-06-25 | 2024-04-19 | 碗中动物健康公司 | 猫科动物口服饲料和在猫科动物中控制蚤侵袭的方法 |
| CN114085159B (zh) * | 2021-11-25 | 2023-04-07 | 浙江大学 | 一种1,3-环己二酮还原胺化制备3-氨基环己酮的方法 |
| WO2023208447A1 (en) | 2022-04-25 | 2023-11-02 | Basf Se | An emulsifiable concentrate having a (substituted) benzaldehyde-based solvent system |
| EP4342885A1 (en) | 2022-09-20 | 2024-03-27 | Basf Se | N-(3-(aminomethyl)-phenyl)-5-(4-phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-amine derivatives and similar compounds as pesticides |
| EP4389210A1 (en) | 2022-12-21 | 2024-06-26 | Basf Se | Heteroaryl compounds for the control of invertebrate pests |
| EP4455137A1 (en) | 2023-04-24 | 2024-10-30 | Basf Se | Pyrimidine compounds for the control of invertebrate pests |
| EP4467535A1 (en) | 2023-05-25 | 2024-11-27 | Basf Se | Lactam pesticidal compounds |
| EP4488269A1 (en) | 2023-07-06 | 2025-01-08 | Basf Se | Triazole compounds for the control of invertebrate pests |
| EP4488270A1 (en) | 2023-07-06 | 2025-01-08 | Basf Se | Triazole compounds for the control of invertebrate pests |
| EP4488273A1 (en) | 2023-07-06 | 2025-01-08 | Basf Se | Triazole compounds for the control of invertebrate pests |
| WO2025117659A1 (en) | 2023-11-29 | 2025-06-05 | Basf Corporation | Insecticide delivery by nanocarriers |
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| WO2025242699A1 (en) | 2024-05-22 | 2025-11-27 | Basf Se | Method for improving rainfastness of an agrochemical active ingredient |
| WO2026037853A1 (en) | 2024-08-14 | 2026-02-19 | Basf Se | Benzoxazole derivatives as pesticidal compounds |
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| CN103270036B (zh) | 2010-08-05 | 2015-11-25 | 佐蒂斯有限责任公司 | 作为抗寄生物剂的异噁唑啉衍生物 |
| BR112013006686A2 (pt) * | 2010-09-24 | 2017-11-14 | Zoetis Llc | isoxazolina oximas como agentes antiparasitários |
| JP2014505089A (ja) * | 2011-02-10 | 2014-02-27 | ノバルティス アーゲー | 無脊椎有害動物を防除するためのイソオキサゾリン誘導体 |
| WO2012155352A1 (en) | 2011-05-19 | 2012-11-22 | Eli Lilly And Company | Dihydroisoxazole compounds, parasiticidal uses and formulations thereof |
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