UA110519C2 - Паразитоцидні сполуки дигідроізоксазолу - Google Patents
Паразитоцидні сполуки дигідроізоксазолуInfo
- Publication number
- UA110519C2 UA110519C2 UAA201313451A UAA201313451A UA110519C2 UA 110519 C2 UA110519 C2 UA 110519C2 UA A201313451 A UAA201313451 A UA A201313451A UA A201313451 A UAA201313451 A UA A201313451A UA 110519 C2 UA110519 C2 UA 110519C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compounds
- parasitocide
- digidroisoxazole
- animals
- dihydroisoxazole
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 241001465754 Metazoa Species 0.000 abstract 3
- FJRPOHLDJUJARI-UHFFFAOYSA-N 2,3-dihydro-1,2-oxazole Chemical compound C1NOC=C1 FJRPOHLDJUJARI-UHFFFAOYSA-N 0.000 abstract 2
- 206010061217 Infestation Diseases 0.000 abstract 2
- 230000003071 parasitic effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Запропоновані сполуки дигідроізоксазолу формули І, придатні для боротьби з паразитами як у тварин, так і у сільськогосподарських культур. Крім того запропоновані способи боротьби з паразитарними інвазіями у тварин шляхом введення тварині ефективної кількості сполуки, описаної вище, або її фармацевтично прийнятної солі, а також у вигляді композицій для боротьби з паразитарними інвазіями з використанням сполук, описаних вище, або їх прийнятної солі і прийнятного носія. Також запропоновані сполуки і способи, придатні для одержання сполук дигідроізоксазолу.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2011/074294 WO2012155352A1 (en) | 2011-05-19 | 2011-05-19 | Dihydroisoxazole compounds, parasiticidal uses and formulations thereof |
| PCT/CN2012/072878 WO2012155676A1 (en) | 2011-05-19 | 2012-03-23 | Parasiticidal compounds, methods, and formulations |
| PCT/US2012/036883 WO2012158396A1 (en) | 2011-05-19 | 2012-05-08 | Parasiticidal dihydroisoxazole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA110519C2 true UA110519C2 (uk) | 2016-01-12 |
Family
ID=47176150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201313451A UA110519C2 (uk) | 2011-05-19 | 2012-05-08 | Паразитоцидні сполуки дигідроізоксазолу |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US8648081B2 (uk) |
| EP (2) | EP2918583A1 (uk) |
| JP (1) | JP5989099B2 (uk) |
| KR (1) | KR101586553B1 (uk) |
| CN (1) | CN103547576B (uk) |
| AR (1) | AR086296A1 (uk) |
| AU (1) | AU2012256220B2 (uk) |
| BR (1) | BR112013028132B1 (uk) |
| CA (1) | CA2835436C (uk) |
| CL (1) | CL2013003287A1 (uk) |
| CO (1) | CO6811873A2 (uk) |
| CR (1) | CR20130486A (uk) |
| CY (1) | CY1116450T1 (uk) |
| DK (1) | DK2710000T3 (uk) |
| EA (1) | EA023711B1 (uk) |
| ES (1) | ES2543392T3 (uk) |
| HR (1) | HRP20150588T1 (uk) |
| IL (1) | IL229007A (uk) |
| ME (1) | ME02113B (uk) |
| MX (1) | MX341739B (uk) |
| PE (1) | PE20141041A1 (uk) |
| PH (1) | PH12013502374A1 (uk) |
| PL (1) | PL2710000T3 (uk) |
| PT (1) | PT2710000E (uk) |
| RS (1) | RS54048B1 (uk) |
| SG (1) | SG194836A1 (uk) |
| SI (1) | SI2710000T1 (uk) |
| TW (1) | TWI554508B (uk) |
| UA (1) | UA110519C2 (uk) |
| WO (3) | WO2012155352A1 (uk) |
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| UY33403A (es) * | 2010-06-17 | 2011-12-30 | Novartis Ag | Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales |
| WO2012155352A1 (en) | 2011-05-19 | 2012-11-22 | Eli Lilly And Company | Dihydroisoxazole compounds, parasiticidal uses and formulations thereof |
| CA2897700C (en) | 2012-12-11 | 2022-05-03 | Bracco Imaging S.P.A. | Continuous process for the preparation of (s)-2-acetyloxypropionic acid chloride |
| JP6321042B2 (ja) | 2013-02-06 | 2018-05-09 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 新規なハロゲン置換された化合物 |
| KR20160104065A (ko) | 2014-01-03 | 2016-09-02 | 바이엘 애니멀 헬스 게엠베하 | 농약으로서의 신규 피라졸릴헤테로아릴아미드 |
| WO2015172099A1 (en) * | 2014-05-09 | 2015-11-12 | Kineta, Inc. | Anti-viral compounds, pharmaceutical compositions, and methods of use thereof |
| DK3154928T3 (da) * | 2014-06-10 | 2020-05-18 | Bracco Imaging Spa | Fremgangsmåde til fremstilling af (s)-2-acetyloxypropionsyre og derivater deraf |
| JP2017521441A (ja) | 2014-07-15 | 2017-08-03 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ａｎｉｍａｌ Ｈｅａｌｔｈ Ｇｍｂｈ | 有害生物防除剤としてのアリール−トリアゾリルピリジン類 |
| CN107750159B (zh) | 2015-06-23 | 2021-10-29 | 英特维特国际股份有限公司 | 用于消毒的饮用水的含有维生素的异噁唑啉溶液 |
| CN119033777A (zh) * | 2016-05-10 | 2024-11-29 | 瑞士伊兰科动物保健有限公司 | 用于控制海虱的二氢异噁唑化合物 |
| WO2018081733A1 (en) * | 2016-10-31 | 2018-05-03 | The California Institute For Biomedical Research | Methods and compositions for preventing vector-borne disease transmission |
| WO2018137959A1 (en) | 2017-01-25 | 2018-08-02 | Basf Se | Process for preparation of benzylic amides |
| WO2018166855A1 (en) * | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
| AR113997A1 (es) | 2017-12-21 | 2020-07-08 | Intervet Int Bv | Composiciones antiparasitarias para unción dorsal continua |
| US20210340113A1 (en) * | 2018-10-29 | 2021-11-04 | Basf Se | Process for preparation of optically enriched aldol compounds |
| US11744874B2 (en) | 2019-12-20 | 2023-09-05 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing toll-like receptor (“TLR”) agonist prodrugs useful in the treatment of cancer and methods thereof |
| CA3211576A1 (en) * | 2021-03-11 | 2022-09-15 | In The Bowl Animal Health, Inc. | Oral canine feed and methods for controlling tick infestations in a canine |
| BR112023017446A2 (pt) * | 2021-03-11 | 2023-11-07 | In The Bowl Animal Health Inc | Ração canina oral e métodos para controle de infestações de pulgas em um canino |
| KR20230161996A (ko) * | 2021-03-11 | 2023-11-28 | 인 더 보울 애니멀 헬스, 인크. | 포유동물에서 벼룩 및 진드기 감염을 제어하는 방법 |
| EP4347587A1 (en) * | 2021-06-02 | 2024-04-10 | FMC Corporation | Fused pyridines for controlling invertebrate pests |
| KR20240051920A (ko) * | 2021-06-25 | 2024-04-22 | 인 더 보울 애니멀 헬스, 인크. | 고양잇과의 진드기 감염을 구제하기 위한 경구용 고양잇과 사료 및 방법 |
| CA3224225A1 (en) * | 2021-06-25 | 2022-12-29 | In The Bowl Animal Health, Inc. | Oral feline feed and methods for controlling flea infestations in a feline |
| CN114085159B (zh) * | 2021-11-25 | 2023-04-07 | 浙江大学 | 一种1,3-环己二酮还原胺化制备3-氨基环己酮的方法 |
| WO2023208447A1 (en) | 2022-04-25 | 2023-11-02 | Basf Se | An emulsifiable concentrate having a (substituted) benzaldehyde-based solvent system |
| EP4342885A1 (en) | 2022-09-20 | 2024-03-27 | Basf Se | N-(3-(aminomethyl)-phenyl)-5-(4-phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-amine derivatives and similar compounds as pesticides |
| EP4389210A1 (en) | 2022-12-21 | 2024-06-26 | Basf Se | Heteroaryl compounds for the control of invertebrate pests |
| EP4455137A1 (en) | 2023-04-24 | 2024-10-30 | Basf Se | Pyrimidine compounds for the control of invertebrate pests |
| EP4467535A1 (en) | 2023-05-25 | 2024-11-27 | Basf Se | Lactam pesticidal compounds |
| EP4488273A1 (en) | 2023-07-06 | 2025-01-08 | Basf Se | Triazole compounds for the control of invertebrate pests |
| EP4488269A1 (en) | 2023-07-06 | 2025-01-08 | Basf Se | Triazole compounds for the control of invertebrate pests |
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| WO2025117659A1 (en) | 2023-11-29 | 2025-06-05 | Basf Corporation | Insecticide delivery by nanocarriers |
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| WO2025242699A1 (en) | 2024-05-22 | 2025-11-27 | Basf Se | Method for improving rainfastness of an agrochemical active ingredient |
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| WO2011073098A1 (de) * | 2009-12-15 | 2011-06-23 | Bayer Cropscience Ag | 1-(heteroaryl)-pyrazol-4-yl-essigsäuren, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren |
| CN103270036B (zh) | 2010-08-05 | 2015-11-25 | 佐蒂斯有限责任公司 | 作为抗寄生物剂的异噁唑啉衍生物 |
| BR112013006686A2 (pt) * | 2010-09-24 | 2017-11-14 | Zoetis Llc | isoxazolina oximas como agentes antiparasitários |
| US20130324538A1 (en) * | 2011-02-10 | 2013-12-05 | Noëlle Gauvry | Isoxazoline derivatives for controlling invertebrate pests |
| WO2012155352A1 (en) | 2011-05-19 | 2012-11-22 | Eli Lilly And Company | Dihydroisoxazole compounds, parasiticidal uses and formulations thereof |
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