CL2014000493A1 - (r)-7-(2-(1-(4-butoxifenil)-2-metilpropan-2-ilamino)-1-hidroxietil)-5-hidroxibenzo[d]tiazol-2(3h)-ona; proceso de preparacion; composicion y combinacion farmaceutica que lo comprende; y uso en el tratamiento y prevencion de la distrofia muscular, atrofia por desuso, caquexia o sarcopenia. - Google Patents

(r)-7-(2-(1-(4-butoxifenil)-2-metilpropan-2-ilamino)-1-hidroxietil)-5-hidroxibenzo[d]tiazol-2(3h)-ona; proceso de preparacion; composicion y combinacion farmaceutica que lo comprende; y uso en el tratamiento y prevencion de la distrofia muscular, atrofia por desuso, caquexia o sarcopenia.

Info

Publication number: CL2014000493A1
Authority: CL; Chile
Prior art keywords: sarcopenia; hydroxybenzo; butoxyphenyl; methylpropan; cachexia
Prior art date: 2011-09-06

Application number

CL2014000493A

Other languages

English (en)

Inventor

Tufilli Nicola

Cao Jun

Erb Bernhard

Alec Fairhurst Robin

Grandeury Arnaud

Hatakeyama Shinji

Koziczak-Holbro Magdalena

Lai Xinzhong

Lustenberger Philipp

Ullrich Thomas

Wu Xiang

Zhou Jianguang

Riebesehl Bern

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-09-06

Filing date

2014-02-27

Publication date

2014-10-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47010668&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014000493(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-02-27 Application filed by Novartis Ag filed Critical Novartis Ag

2014-10-03 Publication of CL2014000493A1 publication Critical patent/CL2014000493A1/es

Links

WQFCYLHABCBUAG-FQEVSTJZSA-N 7-[(1r)-2-[[1-(4-butoxyphenyl)-2-methylpropan-2-yl]amino]-1-hydroxyethyl]-5-hydroxy-3h-1,3-benzothiazol-2-one Chemical compound C1=CC(OCCCC)=CC=C1CC(C)(C)NC[C@H](O)C1=CC(O)=CC2=C1SC(=O)N2 WQFCYLHABCBUAG-FQEVSTJZSA-N 0.000 title 1
206010006895 Cachexia Diseases 0.000 title 1
208000020538 atrophic muscular disease Diseases 0.000 title 1
201000006938 muscular dystrophy Diseases 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
230000002265 prevention Effects 0.000 title 1
208000001076 sarcopenia Diseases 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/08—Acetic acid
- C07C53/10—Salts thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Medicinal Preparation (AREA)
Emergency Medicine (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Macromonomer-Based Addition Polymer (AREA)
Cosmetics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CL2014000493A 2011-09-06 2014-02-27 (r)-7-(2-(1-(4-butoxifenil)-2-metilpropan-2-ilamino)-1-hidroxietil)-5-hidroxibenzo[d]tiazol-2(3h)-ona; proceso de preparacion; composicion y combinacion farmaceutica que lo comprende; y uso en el tratamiento y prevencion de la distrofia muscular, atrofia por desuso, caquexia o sarcopenia. CL2014000493A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CN2011079379		2011-09-06

Publications (1)

Publication Number	Publication Date
CL2014000493A1 true CL2014000493A1 (es)	2014-10-03

Family

ID=47010668

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2014000493A CL2014000493A1 (es)	2011-09-06	2014-02-27	(r)-7-(2-(1-(4-butoxifenil)-2-metilpropan-2-ilamino)-1-hidroxietil)-5-hidroxibenzo[d]tiazol-2(3h)-ona; proceso de preparacion; composicion y combinacion farmaceutica que lo comprende; y uso en el tratamiento y prevencion de la distrofia muscular, atrofia por desuso, caquexia o sarcopenia.

Country Status (39)

Country	Link
US (6)	US8933108B2 (es)
EP (1)	EP2753609B1 (es)
JP (2)	JP6130835B2 (es)
KR (2)	KR101800140B1 (es)
CN (2)	CN103781771B (es)
AP (1)	AP3830A (es)
AR (1)	AR087787A1 (es)
AU (1)	AU2013200422C1 (es)
BR (1)	BR112014004732A2 (es)
CA (1)	CA2845766A1 (es)
CL (1)	CL2014000493A1 (es)
CO (1)	CO6900147A2 (es)
CR (1)	CR20140114A (es)
CU (1)	CU24303B1 (es)
CY (1)	CY1118585T1 (es)
DK (1)	DK2753609T3 (es)
EA (1)	EA022909B1 (es)
ES (1)	ES2615052T3 (es)
GT (1)	GT201400042A (es)
HR (1)	HRP20170075T1 (es)
HU (1)	HUE030530T2 (es)
IL (1)	IL231235A (es)
JO (1)	JO3192B1 (es)
LT (1)	LT2753609T (es)
MX (1)	MX345405B (es)
MY (1)	MY163301A (es)
PE (1)	PE20141993A1 (es)
PH (1)	PH12014500399A1 (es)
PL (1)	PL2753609T3 (es)
PT (1)	PT2753609T (es)
RS (1)	RS55468B1 (es)
SG (1)	SG2014013114A (es)
SI (1)	SI2753609T1 (es)
TN (1)	TN2014000060A1 (es)
TW (1)	TWI555738B (es)
UA (1)	UA114295C2 (es)
UY (1)	UY34312A (es)
WO (1)	WO2013035047A1 (es)
ZA (2)	ZA201401112B (es)

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UA117092C2 (uk)	2011-09-06	2018-06-25	Байєр Інтеллектуал Проперті Гмбх	Амінозаміщені імідазопіридазини
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US10967119B1 (en)	2019-04-01	2021-04-06	Azizi Bilal	Wearable medication injecting device

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2012
- 2012-09-04 JO JOP/2012/0250A patent/JO3192B1/ar active
- 2012-09-05 SI SI201230841A patent/SI2753609T1/sl unknown
- 2012-09-05 SG SG2014013114A patent/SG2014013114A/en unknown
- 2012-09-05 ES ES12770249.6T patent/ES2615052T3/es active Active
- 2012-09-05 PL PL12770249T patent/PL2753609T3/pl unknown
- 2012-09-05 PT PT127702496T patent/PT2753609T/pt unknown
- 2012-09-05 EA EA201490573A patent/EA022909B1/ru not_active IP Right Cessation
- 2012-09-05 CN CN201280043386.3A patent/CN103781771B/zh not_active Expired - Fee Related
- 2012-09-05 PE PE2014000312A patent/PE20141993A1/es not_active Application Discontinuation
- 2012-09-05 HR HRP20170075TT patent/HRP20170075T1/hr unknown
- 2012-09-05 WO PCT/IB2012/054580 patent/WO2013035047A1/en not_active Ceased
- 2012-09-05 DK DK12770249.6T patent/DK2753609T3/en active
- 2012-09-05 US US13/603,990 patent/US8933108B2/en not_active Expired - Fee Related
- 2012-09-05 CA CA2845766A patent/CA2845766A1/en not_active Abandoned
- 2012-09-05 MY MYPI2014000358A patent/MY163301A/en unknown
- 2012-09-05 KR KR1020167007782A patent/KR101800140B1/ko not_active Expired - Fee Related
- 2012-09-05 TW TW101132414A patent/TWI555738B/zh not_active IP Right Cessation
- 2012-09-05 AU AU2013200422A patent/AU2013200422C1/en not_active Ceased
- 2012-09-05 RS RS20161145A patent/RS55468B1/sr unknown
- 2012-09-05 UY UY0001034312A patent/UY34312A/es not_active Application Discontinuation
- 2012-09-05 CN CN201610536836.2A patent/CN106187942B/zh not_active Expired - Fee Related
- 2012-09-05 LT LTEP12770249.6T patent/LT2753609T/lt unknown
- 2012-09-05 KR KR1020147008777A patent/KR101628585B1/ko not_active Expired - Fee Related
- 2012-09-05 EP EP12770249.6A patent/EP2753609B1/en active Active
- 2012-09-05 MX MX2014002688A patent/MX345405B/es active IP Right Grant
- 2012-09-05 UA UAA201401193A patent/UA114295C2/uk unknown
- 2012-09-05 JP JP2014529113A patent/JP6130835B2/ja not_active Expired - Fee Related
- 2012-09-05 BR BR112014004732A patent/BR112014004732A2/pt not_active Application Discontinuation
- 2012-09-05 PH PH1/2014/500399A patent/PH12014500399A1/en unknown
- 2012-09-05 HU HUE12770249A patent/HUE030530T2/en unknown
- 2012-09-05 AP AP2014007462A patent/AP3830A/en active
- 2012-09-05 CU CUP2014000028A patent/CU24303B1/es unknown
- 2012-09-06 AR ARP120103276A patent/AR087787A1/es unknown
2014
- 2014-02-10 TN TNP2014000060A patent/TN2014000060A1/en unknown
- 2014-02-13 ZA ZA2014/01112A patent/ZA201401112B/en unknown
- 2014-02-27 IL IL231235A patent/IL231235A/en active IP Right Grant
- 2014-02-27 CL CL2014000493A patent/CL2014000493A1/es unknown
- 2014-03-04 GT GT201400042A patent/GT201400042A/es unknown
- 2014-03-06 CR CR20140114A patent/CR20140114A/es unknown
- 2014-03-06 CO CO14048375A patent/CO6900147A2/es not_active Application Discontinuation
- 2014-12-10 US US14/566,021 patent/US20150094346A1/en not_active Abandoned
2015
- 2015-02-03 ZA ZA2015/00790A patent/ZA201500790B/en unknown
- 2015-08-03 US US14/817,175 patent/US20150336914A1/en not_active Abandoned
- 2015-11-20 US US14/947,458 patent/US20160075670A1/en not_active Abandoned
2016
- 2016-06-10 US US15/178,579 patent/US9913828B2/en not_active Expired - Fee Related
2017
- 2017-02-02 CY CY20171100153T patent/CY1118585T1/el unknown
- 2017-03-01 JP JP2017038701A patent/JP6340103B2/ja not_active Expired - Fee Related
2018
- 2018-01-22 US US15/876,619 patent/US10251868B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
LT2753609T (lt)	2017-01-10
CN106187942B (zh)	2020-06-26
IL231235A (en)	2017-09-28
DK2753609T3 (en)	2017-02-06
HUE030530T2 (en)	2017-05-29
US10251868B2 (en)	2019-04-09
JP2017132781A (ja)	2017-08-03
EP2753609A1 (en)	2014-07-16
TWI555738B (zh)	2016-11-01
AR087787A1 (es)	2014-04-16
JP6130835B2 (ja)	2017-05-17
US20180140582A1 (en)	2018-05-24
JO3192B1 (ar)	2018-03-08
CN103781771B (zh)	2016-08-24
KR101628585B1 (ko)	2016-06-08
CR20140114A (es)	2014-05-06
JP2014525472A (ja)	2014-09-29
UA114295C2 (uk)	2017-05-25
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US20160279107A1 (en)	2016-09-29
US9913828B2 (en)	2018-03-13
AU2013200422B2 (en)	2014-08-07
CU20140028A7 (es)	2014-05-27
AP3830A (en)	2016-09-30
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ZA201500790B (en)	2017-04-26
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Publication	Publication Date	Title
IL251285A0 (en)	2017-05-29	3-substituted 5-amino-h6-triazolo[5,4-d]pyrimidine-7,2-dione compounds for the treatment and prevention of viral infection
CL2014002518A1 (es)	2014-12-05	Compuestos derivados heterociclicos nitrogenados, inhibidores de la bace-1 o de la bace-2; composicion farmaceutica que los comprende; combinacion farmaceutica; su uso en el tratamiento o prevencion de la enfermedad de alzheimer o un deterioro cognitivo leve.
BR112013013435A2 (pt)	2016-10-11	composto, composição farmacêutica, uso de um composto, método para a profilaxia ou tratamento de um estado ou condição de doença mediados por uma cinase de fgfr, e, processo para a preparação de um composto.
BR112014010179A8 (pt)	2018-01-09	composto, composição farmacêutica, uso de um composto, e, método para a profilaxia ou tratamento de um estado ou condição
CL2007002261A1 (es)	2008-05-02	Compuestos derivados de imidazo[1,2-b]piridazina, inhibidores de quinasa; composicion farmaceutica; y uso en el tratamiento o prevencion del cancer.
CL2013002125A1 (es)	2013-12-20	Compuestos derivados de imidazo[5,1-f][1,2,4]triazinas; composicion farmaceutica; y uso en el tratamiento del deterioro cognitivo asociado con esquizofrenia.
CL2014000493A1 (es)	2014-10-03	(r)-7-(2-(1-(4-butoxifenil)-2-metilpropan-2-ilamino)-1-hidroxietil)-5-hidroxibenzo[d]tiazol-2(3h)-ona; proceso de preparacion; composicion y combinacion farmaceutica que lo comprende; y uso en el tratamiento y prevencion de la distrofia muscular, atrofia por desuso, caquexia o sarcopenia.
EP3172214A4 (en)	2018-02-07	2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof
BR112014010206A2 (pt)	2017-05-16	composto, composição farmacêutica, uso de composto, e, método para a profilaxia ou tratamento de um estado ou condição de doença
CL2014002100A1 (es)	2015-10-23	Compuestos biciclicos nitrogenados; composicion farmaceutica que los comprende y uso para el tratamiento de la atrofia muscular espinal.
EP2841068B8 (en)	2019-03-06	Crhr1 antagonists for use in the treatment of patients having crh overactivity
IL213489A0 (en)	2011-07-31	Compositions and methods for the treatment of the prevention of e. coli infections and for the eradication or reduction of e. coli surfaces
CL2007000806A1 (es)	2008-05-30	Compuestos derivados de heteropentaciclos sustituidos; proceso de preparacion; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento del cancer.
BR112014010177A2 (pt)	2017-04-25	composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou tratamento de um estado ou uma condição de doença
BRPI0915084A2 (pt)	2015-10-27	composto, processo para a preparação de um composto, composição farmacêutica, uso de um composto, métodos para a profilaxia ou tratamento de um estado de doença ou uma condição e de câncer
CL2008001122A1 (es)	2008-10-24	Compuestos derivados de imidazo[1,2,3-ij]-1,8-naftiridin-4,9-diona; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de infecciones bacterianas.
CL2013000727A1 (es)	2013-08-23	Compuestos derivados de nucleosidos de imidazo[1,2-f][1,2,4]triazinilo; composicion farmaceutica que los comprende; y su uso para el tratamiento de una infeccion por virus flaviviridae, particularmente infecciones por el virus de la hepatitis c.
BR112013011737A2 (pt)	2016-08-09	composto, uso de um composto composição farmacêutica, e, método de tratamento ou prevenção de uma infecção por hiv
CL2014002557A1 (es)	2014-12-19	Compuestos bicíclicos de pirazinona; procedimiento de preparacion; composicion farmaceutica; kit; y uso en el tratamiento y/o prevencion de enfermedades cardiovasculares, cancer, entre otras.
CL2014000849A1 (es)	2014-08-29	Compuestos derivados de benzilindazoles sustituido, inhibidores de la quinasa bub1; procedimiento de fabricacion; composicion farmaceutica; combinacion farmaceutica; y su uso en el tratamiento de enfermedades hiperproliferativas.
CL2013001591A1 (es)	2013-12-27	Compuestos derivados de triazolopiridina; inhibidores de pde10a; proceso de obtencion; composicion farmaceutica; y uso en el tratamiento o profilaxis de trastornos psicoticos, esquizofrenia, ansiedad, entre otras enfermedades.
CL2014000819A1 (es)	2014-09-22	Compuestos heterociclicos derivados de etinilo, moduladores alostericos mglur5; proceso de preparacion; composicion farmaceutica; uso en la prevencion o el tratamiento de esquizofrenia, enfermedades cognitivas, sindrome de la x fragil o autismo.
PL3082806T3 (pl)	2021-09-13	Stosowanie pochodnych izoksazoliny w leczeniu i profilaktyce infestacji stawonogów u drobiu
BRPI0919231A2 (pt)	2018-01-09	agonista de receptor de neuropeptídeo-2, composição farmacêutica que o compreende, seu uso e método para o tratamento ou profilaxia de enfermidades
BRPI0720323A2 (pt)	2016-08-09	composto, método de tratamento, composição farmacêutica e uso do composto