CL2014001299A1 - Uso de un conjugado de anticuerpo-fármaco anti-egfrviii (factor de crecimiento epidermico) para tratar tumor. - Google Patents
Uso de un conjugado de anticuerpo-fármaco anti-egfrviii (factor de crecimiento epidermico) para tratar tumor.Info
- Publication number
- CL2014001299A1 CL2014001299A1 CL2014001299A CL2014001299A CL2014001299A1 CL 2014001299 A1 CL2014001299 A1 CL 2014001299A1 CL 2014001299 A CL2014001299 A CL 2014001299A CL 2014001299 A CL2014001299 A CL 2014001299A CL 2014001299 A1 CL2014001299 A1 CL 2014001299A1
- Authority
- CL
- Chile
- Prior art keywords
- conjugate
- drug
- growth factor
- epidermal growth
- treat tumor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6819—Plant toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161560731P | 2011-11-16 | 2011-11-16 | |
| US201261727029P | 2012-11-15 | 2012-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014001299A1 true CL2014001299A1 (es) | 2014-10-10 |
Family
ID=47258124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014001299A CL2014001299A1 (es) | 2011-11-16 | 2014-05-16 | Uso de un conjugado de anticuerpo-fármaco anti-egfrviii (factor de crecimiento epidermico) para tratar tumor. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20140314667A1 (es) |
| EP (1) | EP2780040A1 (es) |
| JP (1) | JP2015500205A (es) |
| KR (1) | KR20140091064A (es) |
| CN (1) | CN104168922A (es) |
| AP (1) | AP2014007638A0 (es) |
| AU (1) | AU2012340174A1 (es) |
| BR (1) | BR112014011912A2 (es) |
| CA (1) | CA2855746A1 (es) |
| CL (1) | CL2014001299A1 (es) |
| CO (1) | CO6980620A2 (es) |
| CR (1) | CR20140267A (es) |
| EA (1) | EA201490974A1 (es) |
| HK (1) | HK1202252A1 (es) |
| IL (1) | IL232497A0 (es) |
| MX (1) | MX2014005957A (es) |
| PE (1) | PE20141937A1 (es) |
| PH (1) | PH12014501103A1 (es) |
| SG (1) | SG11201402365RA (es) |
| WO (1) | WO2013075048A1 (es) |
| ZA (1) | ZA201403541B (es) |
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| MXPA05014155A (es) | 2003-06-27 | 2006-05-25 | Abgenix Inc | Anticuerpos dirigidos a los mutantes de delecion de receptor de factor de crecimiento epidermico y sus usos. |
| EP3964237B1 (en) | 2013-03-15 | 2026-02-18 | Regeneron Pharmaceuticals, Inc. | Biologically active molecules, conjugates thereof, and therapeutic uses |
| DK2992020T3 (da) | 2013-05-03 | 2020-02-10 | Ohio State Innovation Foundation | Cs1-specifik kimær antigenreceptor-manipulerede immuneffektorceller |
| WO2015000062A1 (en) * | 2013-07-05 | 2015-01-08 | Avidbiologics Inc. | Egfr antibody conjugates |
| AU2015229591B2 (en) * | 2014-03-11 | 2020-10-22 | Regeneron Pharmaceuticals, Inc. | Anti-EGFRvlll antibodies and uses thereof |
| CA2968510C (en) | 2014-11-25 | 2020-11-03 | Pharmabcine Inc. | Novel egfrviii antibody and composition comprising same |
| CN107530424A (zh) * | 2015-02-20 | 2018-01-02 | 俄亥俄州国家创新基金会 | 针对nkg2d和肿瘤相关抗原的二价抗体 |
| WO2016146143A1 (en) | 2015-03-16 | 2016-09-22 | Amal Therapeutics Sa | Cell penetrating peptides and complexes comprising the same |
| CN108367057B (zh) | 2015-04-06 | 2022-11-22 | 赛通免疫股份有限公司 | 用于胶质母细胞瘤的egfr导向的car疗法 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| EA039859B1 (ru) | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| ES2904593T3 (es) * | 2016-01-21 | 2022-04-05 | Pfizer | Anticuerpos monoespecíficos y biespecíficos para la variante III del receptor del factor de crecimiento epidérmico y CD3 y sus usos |
| MX390630B (es) | 2016-01-25 | 2025-03-21 | Regeneron Pharma | Derivados de maitansinoide, conjugados de los mismos y metodos de uso. |
| AR107582A1 (es) | 2016-02-03 | 2018-05-16 | Amgen Res Munich Gmbh | Constructos de anticuerpo biespecíficos para psma y cd3 que se ligan a células t |
| WO2017142294A1 (ko) * | 2016-02-15 | 2017-08-24 | 사회복지법인 삼성생명공익재단 | EGFRvIII에 대한 항체 및 이의 용도 |
| SG11201806597XA (en) | 2016-02-15 | 2018-09-27 | Samsung Life Public Welfare Foundation | ANTIBODY AGAINST EGFRvIII AND USE THEREOF |
| EP3429618B1 (en) | 2016-03-16 | 2024-02-21 | Amal Therapeutics SA | Combination of an immune checkpoint modulator and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist for use in medicine |
| KR20190057345A (ko) | 2016-09-21 | 2019-05-28 | 아말 테라퓨틱스 에스에이 | 암 치료를 위한, 세포 투과 펩타이드, 멀티 에피토프 및 tlr 펩타이드 작용제를 포함하는 융합체 |
| US20210032351A1 (en) * | 2017-12-13 | 2021-02-04 | Xdcexplorer (Shanghai) Co., Ltd. | Egfrviii antibody and conjugate, and preparation method and use thereof |
| CA3133155A1 (en) | 2019-03-19 | 2020-09-24 | Fundacio Privada Institut D'investigacio Oncologica De Vall Hebron | Combination therapy for the treatment for cancer |
| MX2021011750A (es) | 2019-03-27 | 2021-12-10 | Nat Res Council Canada | Anticuerpos anti-egfrviii y fragmentos de union a antigenos de los mismos. |
| CN113082216B (zh) * | 2021-04-25 | 2022-07-01 | 吉林大学 | 含miR-124的胶质瘤细胞外泌体及其制备方法和应用 |
| AU2021467228A1 (en) * | 2021-09-29 | 2024-04-04 | National Research Council Of Canada | Humanized anti-egfrviii antibodies and antigen-binding fragments thereof |
| EP4590328A2 (en) * | 2022-09-19 | 2025-07-30 | Sonoma Biotherapeutics, Inc. | Citrullinated antigen-specific chimeric antigen receptors for targeting regulatory t cells to treat hidradenitis suppurativa |
| WO2024089013A1 (en) | 2022-10-25 | 2024-05-02 | Peptomyc, S.L. | Combination therapy for the treatment of cancer |
| IL325025A (en) | 2023-06-07 | 2026-01-01 | Fundaci? Privada Inst Dinvestigaci? Oncol?Gica De Vall Hebron | Combination therapy with BRAF inhibitors for cancer treatment |
| EP4724100A1 (en) | 2023-06-07 | 2026-04-15 | Fundació Privada Institut d'Investigació Oncològica de Vall Hebron | Combination therapy with mek inhibitors for the treatment of cancer |
| EP4473974A1 (en) | 2023-06-07 | 2024-12-11 | Peptomyc, S.L. | Omomyc and kras inhibitors combination therapy for the treatment of cancer |
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-
2012
- 2012-11-16 AU AU2012340174A patent/AU2012340174A1/en not_active Abandoned
- 2012-11-16 CA CA2855746A patent/CA2855746A1/en not_active Abandoned
- 2012-11-16 AP AP2014007638A patent/AP2014007638A0/xx unknown
- 2012-11-16 SG SG11201402365RA patent/SG11201402365RA/en unknown
- 2012-11-16 HK HK15102782.1A patent/HK1202252A1/xx unknown
- 2012-11-16 WO PCT/US2012/065707 patent/WO2013075048A1/en not_active Ceased
- 2012-11-16 JP JP2014542531A patent/JP2015500205A/ja not_active Withdrawn
- 2012-11-16 MX MX2014005957A patent/MX2014005957A/es not_active Application Discontinuation
- 2012-11-16 PE PE2014000701A patent/PE20141937A1/es not_active Application Discontinuation
- 2012-11-16 BR BR112014011912A patent/BR112014011912A2/pt not_active IP Right Cessation
- 2012-11-16 EP EP12791937.1A patent/EP2780040A1/en not_active Withdrawn
- 2012-11-16 US US14/358,641 patent/US20140314667A1/en not_active Abandoned
- 2012-11-16 EA EA201490974A patent/EA201490974A1/ru unknown
- 2012-11-16 KR KR1020147016092A patent/KR20140091064A/ko not_active Withdrawn
- 2012-11-16 CN CN201280067232.8A patent/CN104168922A/zh active Pending
-
2014
- 2014-05-07 IL IL232497A patent/IL232497A0/en unknown
- 2014-05-15 ZA ZA2014/03541A patent/ZA201403541B/en unknown
- 2014-05-16 CL CL2014001299A patent/CL2014001299A1/es unknown
- 2014-05-16 PH PH12014501103A patent/PH12014501103A1/en unknown
- 2014-06-09 CR CR20140267A patent/CR20140267A/es unknown
- 2014-06-12 CO CO14127687A patent/CO6980620A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012340174A1 (en) | 2014-05-29 |
| ZA201403541B (en) | 2015-12-23 |
| CR20140267A (es) | 2014-08-27 |
| CA2855746A1 (en) | 2013-05-23 |
| PH12014501103A1 (en) | 2014-10-20 |
| CO6980620A2 (es) | 2014-06-27 |
| WO2013075048A1 (en) | 2013-05-23 |
| HK1202252A1 (en) | 2015-09-25 |
| IL232497A0 (en) | 2014-06-30 |
| US20140314667A1 (en) | 2014-10-23 |
| KR20140091064A (ko) | 2014-07-18 |
| JP2015500205A (ja) | 2015-01-05 |
| PE20141937A1 (es) | 2014-12-18 |
| EA201490974A1 (ru) | 2014-09-30 |
| SG11201402365RA (en) | 2014-06-27 |
| MX2014005957A (es) | 2015-02-04 |
| CN104168922A (zh) | 2014-11-26 |
| AP2014007638A0 (en) | 2014-05-31 |
| BR112014011912A2 (pt) | 2017-05-16 |
| EP2780040A1 (en) | 2014-09-24 |
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