CL2014001765A1 - Proceso para la fabricacion de 1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazina. - Google Patents
Proceso para la fabricacion de 1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazina.Info
- Publication number
- CL2014001765A1 CL2014001765A1 CL2014001765A CL2014001765A CL2014001765A1 CL 2014001765 A1 CL2014001765 A1 CL 2014001765A1 CL 2014001765 A CL2014001765 A CL 2014001765A CL 2014001765 A CL2014001765 A CL 2014001765A CL 2014001765 A1 CL2014001765 A1 CL 2014001765A1
- Authority
- CL
- Chile
- Prior art keywords
- dimethylphenylsulfanyl
- piperazine
- phenyl
- manufacture
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- YQNWZWMKLDQSAC-UHFFFAOYSA-N vortioxetine Chemical compound CC1=CC(C)=CC=C1SC1=CC=CC=C1N1CCNCC1 YQNWZWMKLDQSAC-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201200006 | 2012-01-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014001765A1 true CL2014001765A1 (es) | 2014-10-03 |
Family
ID=48744991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014001765A CL2014001765A1 (es) | 2012-01-03 | 2014-06-30 | Proceso para la fabricacion de 1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazina. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9133144B2 (es) |
| EP (1) | EP2800746B1 (es) |
| JP (1) | JP6018644B2 (es) |
| KR (1) | KR102008039B1 (es) |
| CN (1) | CN104011034B (es) |
| AU (1) | AU2012364402B2 (es) |
| BR (1) | BR112014016322B8 (es) |
| CA (1) | CA2860103C (es) |
| CL (1) | CL2014001765A1 (es) |
| CO (1) | CO7000771A2 (es) |
| CY (1) | CY1121629T1 (es) |
| DK (1) | DK2800746T3 (es) |
| HR (1) | HRP20190769T1 (es) |
| IL (1) | IL233093A (es) |
| LT (1) | LT2800746T (es) |
| MX (1) | MX344144B (es) |
| PL (1) | PL2800746T3 (es) |
| RS (1) | RS58683B1 (es) |
| RU (1) | RU2608307C2 (es) |
| SG (1) | SG11201403835UA (es) |
| SI (1) | SI2800746T1 (es) |
| SM (1) | SMT201900248T1 (es) |
| WO (1) | WO2013102573A1 (es) |
| ZA (1) | ZA201404881B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2013MU03121A (es) | 2013-09-30 | 2015-07-17 | Cadila Healthcare Ltd | |
| EP2878596A1 (en) | 2013-11-29 | 2015-06-03 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)lithium intermediates |
| EP2894154A1 (en) | 2014-01-14 | 2015-07-15 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)aniline intermediates |
| CN103788020B (zh) * | 2014-01-22 | 2015-11-04 | 苏州明锐医药科技有限公司 | 沃替西汀的制备方法 |
| CN103788019B (zh) * | 2014-01-22 | 2015-10-07 | 苏州明锐医药科技有限公司 | 沃替西汀的制备方法 |
| EA029060B1 (ru) | 2014-01-31 | 2018-02-28 | Эгиш Дьёдьсердьяр Зрт. | Способ получения солей вортиоксетина |
| EP2930171A1 (en) | 2014-04-07 | 2015-10-14 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2,4-dimethylphenyl)(2-iodophenyl)sulfane intermediate |
| CN104974110A (zh) * | 2014-04-10 | 2015-10-14 | 江苏豪森药业股份有限公司 | 1-[2-(2,4-二甲基苯基硫基)苯基]哌嗪氢溴酸盐的新晶型及其制备方法和用途 |
| US9926286B2 (en) * | 2014-05-09 | 2018-03-27 | Shanghai Syncores Technologies Inc. Ltd. | Vortioxetine intermediate and synthesis process thereof |
| CN105254590B (zh) * | 2014-05-09 | 2019-09-03 | 江苏豪森药业集团有限公司 | 沃替西汀氢溴酸盐晶型及其制备方法和用途 |
| CN104059030B (zh) * | 2014-05-30 | 2016-05-04 | 镇江圣安医药有限公司 | [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途 |
| CN104292183B (zh) * | 2014-09-29 | 2016-01-06 | 杨献美 | 一种抗抑郁药物沃替西汀的制备方法 |
| WO2016079751A2 (en) | 2014-11-17 | 2016-05-26 | Megafine Pharma (P) Ltd. | A process for preparation of vortioxetine and polymorphs thereof |
| ES2634496T3 (es) * | 2014-11-21 | 2017-09-28 | Dipharma Francis S.R.L. | Proceso para la preparación de un antidepresivo y los intermedios del mismo |
| CN104356092B (zh) * | 2014-11-27 | 2017-03-22 | 合肥创新医药技术有限公司 | 沃替西汀的制备方法 |
| WO2016125191A2 (en) | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Processes for the preparation of vortioxetine hydrobromide |
| WO2016135636A1 (en) | 2015-02-25 | 2016-09-01 | Lupin Limited | Process for the preparation of vortioxetine |
| CN104650004B (zh) * | 2015-03-06 | 2017-06-06 | 中山万汉制药有限公司 | 一种氢溴酸沃替西汀的制备方法 |
| CN105061364A (zh) * | 2015-08-17 | 2015-11-18 | 河北国龙制药有限公司 | 氢溴酸沃替西汀的制备方法 |
| US20180237386A1 (en) * | 2015-08-19 | 2018-08-23 | Amneal Pharmaceuticals Company Gmbh | Process For Preparation Of Vortioxetine Hydrobromide |
| CN106556663B (zh) * | 2015-09-30 | 2018-05-29 | 成都弘达药业有限公司 | 一种1-[2-(2,4-二甲基苯基硫烷基)苯基]哌嗪或其盐的检测方法 |
| BR112018003930A2 (pt) | 2016-07-01 | 2018-09-25 | H Lundbeck As | regimes de dosagem de vortioxetina para início rápido de efeito antidepressivo |
| US10519121B2 (en) | 2016-12-30 | 2019-12-31 | Apicore Us Llc | Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts |
| CN106831652B (zh) * | 2017-01-23 | 2019-01-11 | 齐鲁天和惠世制药有限公司 | 一种沃赛汀的制备方法 |
| CN108017595A (zh) * | 2017-12-20 | 2018-05-11 | 安徽源久源科技有限公司 | 一种1-[2-(2,5-二甲基苯硫基)苯基]哌嗪的制备方法 |
| ES2976985T3 (es) | 2018-06-20 | 2024-08-14 | Vio Ag Pharmaceuticals S A | Enfoque de activación C-H organo-pseudocatalítica de un recipiente para la preparación de vortioxetina y producto intermedio de vortioxetina |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
| CN109438390A (zh) * | 2018-11-26 | 2019-03-08 | 合肥创新医药技术有限公司 | 一种氢溴酸沃替西汀杂质的合成方法 |
| WO2022052391A1 (zh) | 2020-09-10 | 2022-03-17 | 苏州富德兆丰生化科技有限公司 | 伏硫西汀的合成方法 |
| CN112250642A (zh) * | 2020-10-28 | 2021-01-22 | 合肥亿帆生物制药有限公司 | 一种氢溴酸伏硫西汀杂质标准品的制备方法 |
| CN115368318B (zh) * | 2022-06-22 | 2023-11-03 | 山东辰龙药业有限公司 | 一种伏硫西汀的合成方法及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07110050A (ja) | 1993-10-13 | 1995-04-25 | Daikin Mfg Co Ltd | 捩じり振動減衰装置 |
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| CN100457738C (zh) * | 2001-12-20 | 2009-02-04 | H·隆德贝克有限公司 | 芳氧基苯基和芳硫基苯基衍生物 |
| KR101627901B1 (ko) | 2006-06-16 | 2016-06-13 | 하. 룬트벡 아크티에 셀스카브 | 인지기능 장애의 치료를 위한, 세로토닌 재흡수, 5-ht3 및 5-ht1a 활성이 조합된 화합물로서의 1-[2-(2,4-디메틸페닐술파닐)-페닐]피페라진 |
| TW201033181A (en) * | 2009-02-17 | 2010-09-16 | Lundbeck & Co As H | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
-
2012
- 2012-12-20 DK DK12815676.7T patent/DK2800746T3/da active
- 2012-12-20 SM SM20190248T patent/SMT201900248T1/it unknown
- 2012-12-20 AU AU2012364402A patent/AU2012364402B2/en active Active
- 2012-12-20 HR HRP20190769TT patent/HRP20190769T1/hr unknown
- 2012-12-20 JP JP2014550676A patent/JP6018644B2/ja active Active
- 2012-12-20 SI SI201231600T patent/SI2800746T1/sl unknown
- 2012-12-20 CA CA2860103A patent/CA2860103C/en active Active
- 2012-12-20 MX MX2014008052A patent/MX344144B/es active IP Right Grant
- 2012-12-20 WO PCT/EP2012/076377 patent/WO2013102573A1/en not_active Ceased
- 2012-12-20 RS RS20190553A patent/RS58683B1/sr unknown
- 2012-12-20 PL PL12815676T patent/PL2800746T3/pl unknown
- 2012-12-20 EP EP12815676.7A patent/EP2800746B1/en active Active
- 2012-12-20 LT LTEP12815676.7T patent/LT2800746T/lt unknown
- 2012-12-20 CN CN201280065665.XA patent/CN104011034B/zh active Active
- 2012-12-20 KR KR1020147018202A patent/KR102008039B1/ko active Active
- 2012-12-20 BR BR112014016322A patent/BR112014016322B8/pt active IP Right Grant
- 2012-12-20 US US14/370,322 patent/US9133144B2/en active Active
- 2012-12-20 RU RU2014131943A patent/RU2608307C2/ru active
- 2012-12-20 SG SG11201403835UA patent/SG11201403835UA/en unknown
-
2014
- 2014-06-12 IL IL233093A patent/IL233093A/en active IP Right Grant
- 2014-06-27 CO CO14139608A patent/CO7000771A2/es unknown
- 2014-06-30 CL CL2014001765A patent/CL2014001765A1/es unknown
- 2014-07-02 ZA ZA2014/04881A patent/ZA201404881B/en unknown
-
2019
- 2019-05-07 CY CY20191100483T patent/CY1121629T1/el unknown
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