CL2014001863A1 - Sal fosfato de dihidropirrolo [1,2-c] imidazolilo, inhibidor de la aldosterona sintasa o aromatasa; forma cristalina a; sal nitrato; procedimiento para preparar una sal nitrato o fosfato cristalina; composicion farmaceutica; y su uso para el tratamiento del sindrome de cushing. - Google Patents

Sal fosfato de dihidropirrolo [1,2-c] imidazolilo, inhibidor de la aldosterona sintasa o aromatasa; forma cristalina a; sal nitrato; procedimiento para preparar una sal nitrato o fosfato cristalina; composicion farmaceutica; y su uso para el tratamiento del sindrome de cushing.

Info

Publication number: CL2014001863A1
Authority: CL; Chile
Prior art keywords: phosphate; salt; nitrate salt; crystalline; dihydropyrrolo
Prior art date: 2012-01-17

Application number

CL2014001863A

Other languages

English (en)

Inventor

Paul Sutton

Eric Loeser

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-01-17

Filing date

2014-07-15

Publication date

2014-11-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47604250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014001863(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-07-15 Application filed by Novartis Ag filed Critical Novartis Ag

2014-11-07 Publication of CL2014001863A1 publication Critical patent/CL2014001863A1/es

Links

150000002823 nitrates Chemical class 0.000 title 2
OVPRCEAXGAKBQI-UHFFFAOYSA-N 1h-imidazol-2-yl dihydrogen phosphate Chemical class OP(O)(=O)OC1=NC=CN1 OVPRCEAXGAKBQI-UHFFFAOYSA-N 0.000 title 1
229940123338 Aldosterone synthase inhibitor Drugs 0.000 title 1
229940122815 Aromatase inhibitor Drugs 0.000 title 1
208000014311 Cushing syndrome Diseases 0.000 title 1
108010009911 Cytochrome P-450 CYP11B2 Proteins 0.000 title 1
102100024329 Cytochrome P450 11B2, mitochondrial Human genes 0.000 title 1
229910019142 PO4 Inorganic materials 0.000 title 1
239000003886 aromatase inhibitor Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title 1
239000010452 phosphate Substances 0.000 title 1
201000009395 primary hyperaldosteronism Diseases 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

CL2014001863A 2012-01-17 2014-07-15 Sal fosfato de dihidropirrolo [1,2-c] imidazolilo, inhibidor de la aldosterona sintasa o aromatasa; forma cristalina a; sal nitrato; procedimiento para preparar una sal nitrato o fosfato cristalina; composicion farmaceutica; y su uso para el tratamiento del sindrome de cushing. CL2014001863A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201261587280P	2012-01-17	2012-01-17

Publications (1)

Publication Number	Publication Date
CL2014001863A1 true CL2014001863A1 (es)	2014-11-07

Family

ID=47604250

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2014001863A CL2014001863A1 (es)	2012-01-17	2014-07-15	Sal fosfato de dihidropirrolo [1,2-c] imidazolilo, inhibidor de la aldosterona sintasa o aromatasa; forma cristalina a; sal nitrato; procedimiento para preparar una sal nitrato o fosfato cristalina; composicion farmaceutica; y su uso para el tratamiento del sindrome de cushing.

Country Status (40)

Country	Link
US (2)	US9334276B2 (es)
EP (1)	EP2804863B1 (es)
JP (1)	JP5749410B2 (es)
KR (2)	KR20140141687A (es)
CN (1)	CN104039793B (es)
AP (1)	AP2014007762A0 (es)
AR (1)	AR089728A1 (es)
AU (1)	AU2013209952B2 (es)
BR (1)	BR112014017260A8 (es)
CA (1)	CA2863339C (es)
CL (1)	CL2014001863A1 (es)
CO (1)	CO7000775A2 (es)
CR (1)	CR20140345A (es)
CU (1)	CU20140086A7 (es)
CY (1)	CY1117914T1 (es)
DK (1)	DK2804863T3 (es)
EA (1)	EA026232B1 (es)
ES (1)	ES2564143T3 (es)
GT (1)	GT201400155A (es)
HR (1)	HRP20160178T1 (es)
HU (1)	HUE026984T2 (es)
IL (1)	IL233541B (es)
IN (1)	IN2014DN06781A (es)
JO (1)	JO3137B1 (es)
MA (1)	MA35858B1 (es)
MX (1)	MX2014008686A (es)
NZ (1)	NZ626277A (es)
PE (1)	PE20142358A1 (es)
PH (1)	PH12014501638A1 (es)
PL (1)	PL2804863T3 (es)
RS (1)	RS54589B1 (es)
SG (1)	SG11201404061YA (es)
SI (1)	SI2804863T1 (es)
SM (1)	SMT201600083B (es)
TN (1)	TN2014000256A1 (es)
TW (1)	TWI609869B (es)
UA (1)	UA114803C2 (es)
UY (1)	UY34576A (es)
WO (1)	WO2013109514A1 (es)
ZA (1)	ZA201404314B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUE041967T2 (hu) *	2010-01-14	2019-06-28	Novartis Ag	Mellékvese hormon-módosító szer alkalmazása
EP2815749A1 (en)	2013-06-20	2014-12-24	IP Gesellschaft für Management mbH	Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
PH12016502540B1 (en)	2014-07-07	2022-07-20	Recordati Ag	Pharmaceutical dosage forms
MX2017009839A (es) *	2015-01-29	2017-11-02	Novartis Ag	Proceso para la produccion de derivados de imidazolo condensados.
WO2016164476A2 (en) *	2015-04-06	2016-10-13	Millendo Therapeutics, Inc.	Combination therapy for treating disorders associated with excess cortisol production
WO2018078049A1 (en) *	2016-10-27	2018-05-03	Damian Pharma Ag	Aldosterone synthase inhibitor
CN109890389B (zh) *	2016-10-27	2022-07-01	达米安制药股份公司	醛固酮合酶抑制剂
JP7470050B2 (ja)	2018-05-03	2024-04-17	ダミアンファーマアーゲー	アルドステロン症の治療における使用のためのｒ－ファドロゾール

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1315449A (en) *	1918-11-15	1919-09-09	Frank B Yingling	Shaper-feed.
US4617307A (en) *	1984-06-20	1986-10-14	Ciba-Geigy Corporation	Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
US5066656A (en)	1989-11-01	1991-11-19	Janssen Pharmaceutica N.V.	Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives
MTP1076B (en)	1990-01-12	1991-09-30	Ciba Geigy Ag	Hemihydrate
CA2127689A1 (en)	1992-01-27	1993-08-05	Marcel A. C. Janssen	Pyrroloimidazolyl and imidazopyridinyl substituted 1h-benzimidazole derivatives as aromatase inhibitors
WO2004046145A1 (en)	2002-11-18	2004-06-03	Novartis Ag	Imidazo[1, 5a]pyridine derivatives and methods for treating aldosterone mediated diseases
GT200600381A (es) *	2005-08-25	2007-03-28		Compuestos organicos
CN101578272A (zh)	2006-12-18	2009-11-11	诺瓦提斯公司	1-取代的咪唑衍生物和它们作为醛固酮合酶抑制剂的用途
ES2472446T3 (es)	2009-11-30	2014-07-01	Novartis Ag	Derivados de imidazol como inhibidores de aldosterona sintasa
HUE041967T2 (hu) *	2010-01-14	2019-06-28	Novartis Ag	Mellékvese hormon-módosító szer alkalmazása

2013
- 2013-01-15 JO JOP/2013/0014A patent/JO3137B1/ar active
- 2013-01-15 EA EA201491374A patent/EA026232B1/ru not_active IP Right Cessation
- 2013-01-15 JP JP2014552375A patent/JP5749410B2/ja active Active
- 2013-01-15 KR KR20147030158A patent/KR20140141687A/ko not_active Ceased
- 2013-01-15 EP EP13701194.6A patent/EP2804863B1/en active Active
- 2013-01-15 AU AU2013209952A patent/AU2013209952B2/en active Active
- 2013-01-15 SG SG11201404061YA patent/SG11201404061YA/en unknown
- 2013-01-15 SI SI201330142A patent/SI2804863T1/sl unknown
- 2013-01-15 CA CA2863339A patent/CA2863339C/en active Active
- 2013-01-15 UY UY0001034576A patent/UY34576A/es not_active Application Discontinuation
- 2013-01-15 HU HUE13701194A patent/HUE026984T2/en unknown
- 2013-01-15 AR ARP130100119A patent/AR089728A1/es unknown
- 2013-01-15 AP AP2014007762A patent/AP2014007762A0/xx unknown
- 2013-01-15 IN IN6781DEN2014 patent/IN2014DN06781A/en unknown
- 2013-01-15 ES ES13701194.6T patent/ES2564143T3/es active Active
- 2013-01-15 DK DK13701194.6T patent/DK2804863T3/en active
- 2013-01-15 RS RS20160109A patent/RS54589B1/sr unknown
- 2013-01-15 PE PE2014001112A patent/PE20142358A1/es not_active Application Discontinuation
- 2013-01-15 PL PL13701194T patent/PL2804863T3/pl unknown
- 2013-01-15 TW TW102101537A patent/TWI609869B/zh not_active IP Right Cessation
- 2013-01-15 UA UAA201406492A patent/UA114803C2/uk unknown
- 2013-01-15 KR KR1020147016954A patent/KR20140093726A/ko not_active Ceased
- 2013-01-15 CN CN201380005054.0A patent/CN104039793B/zh active Active
- 2013-01-15 US US14/370,124 patent/US9334276B2/en active Active
- 2013-01-15 NZ NZ626277A patent/NZ626277A/en not_active IP Right Cessation
- 2013-01-15 WO PCT/US2013/021521 patent/WO2013109514A1/en not_active Ceased
- 2013-01-15 BR BR112014017260A patent/BR112014017260A8/pt not_active Application Discontinuation
- 2013-01-15 MX MX2014008686A patent/MX2014008686A/es unknown
- 2013-01-15 HR HRP20160178T patent/HRP20160178T1/hr unknown
2014
- 2014-06-11 ZA ZA2014/04314A patent/ZA201404314B/en unknown
- 2014-06-12 TN TNP2014000256A patent/TN2014000256A1/en unknown
- 2014-07-07 IL IL233541A patent/IL233541B/en active IP Right Grant
- 2014-07-08 CO CO14146898A patent/CO7000775A2/es unknown
- 2014-07-11 MA MA37199A patent/MA35858B1/fr unknown
- 2014-07-15 CU CU2014000086A patent/CU20140086A7/es unknown
- 2014-07-15 CL CL2014001863A patent/CL2014001863A1/es unknown
- 2014-07-17 PH PH12014501638A patent/PH12014501638A1/en unknown
- 2014-07-17 GT GT201400155A patent/GT201400155A/es unknown
- 2014-07-17 CR CR20140345A patent/CR20140345A/es unknown
2016
- 2016-02-09 US US15/018,953 patent/US20160176883A1/en not_active Abandoned
- 2016-02-26 CY CY20161100163T patent/CY1117914T1/el unknown
- 2016-03-23 SM SM201600083T patent/SMT201600083B/xx unknown

Also Published As

Publication number	Publication date
HUE026984T2 (en)	2016-08-29
TN2014000256A1 (en)	2015-09-30
CR20140345A (es)	2014-09-09
US20160176883A1 (en)	2016-06-23
GT201400155A (es)	2017-09-28
IN2014DN06781A (es)	2015-05-22
PE20142358A1 (es)	2015-01-30
ZA201404314B (en)	2015-08-26
TW201335161A (zh)	2013-09-01
AU2013209952A1 (en)	2014-07-24
DK2804863T3 (en)	2016-03-07
UY34576A (es)	2013-09-02
KR20140141687A (ko)	2014-12-10
PH12014501638B1 (en)	2014-10-13
MA35858B1 (fr)	2014-12-01
HK1198536A1 (en)	2015-05-15
KR20140093726A (ko)	2014-07-28
CN104039793B (zh)	2017-05-10
CA2863339C (en)	2021-03-23
IL233541B (en)	2018-12-31
TWI609869B (zh)	2018-01-01
IL233541A0 (en)	2014-08-31
MX2014008686A (es)	2014-08-27
EP2804863A1 (en)	2014-11-26
AR089728A1 (es)	2014-09-10
WO2013109514A1 (en)	2013-07-25
JO3137B1 (ar)	2017-09-20
SI2804863T1 (sl)	2016-05-31
EP2804863B1 (en)	2015-12-02
BR112014017260A2 (pt)	2017-06-13
ES2564143T8 (es)	2020-11-18
SMT201600083B (it)	2016-04-29
CO7000775A2 (es)	2014-07-21
JP2015503627A (ja)	2015-02-02
RS54589B1 (sr)	2016-08-31
HRP20160178T1 (hr)	2016-03-25
UA114803C2 (uk)	2017-08-10
JP5749410B2 (ja)	2015-07-15
NZ626277A (en)	2015-10-30
AP2014007762A0 (en)	2014-07-31
CU20140086A7 (es)	2014-12-26
PL2804863T3 (pl)	2016-06-30
PH12014501638A1 (en)	2014-10-13
AU2013209952B2 (en)	2016-09-01
US20140364470A1 (en)	2014-12-11
ES2564143T3 (es)	2016-03-18
CN104039793A (zh)	2014-09-10
SG11201404061YA (en)	2014-08-28
CA2863339A1 (en)	2013-07-25
EA026232B1 (ru)	2017-03-31
BR112014017260A8 (pt)	2017-07-04
EA201491374A1 (ru)	2014-12-30
CY1117914T1 (el)	2017-05-17
US9334276B2 (en)	2016-05-10

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