CL2014001917A1 - Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y análogos para tratar enfermedades neoplastica y células madre de cáncer que incluyen glioblastoma multiforme y meduloblastoma. - Google Patents
Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y análogos para tratar enfermedades neoplastica y células madre de cáncer que incluyen glioblastoma multiforme y meduloblastoma.Info
- Publication number
- CL2014001917A1 CL2014001917A1 CL2014001917A CL2014001917A CL2014001917A1 CL 2014001917 A1 CL2014001917 A1 CL 2014001917A1 CL 2014001917 A CL2014001917 A CL 2014001917A CL 2014001917 A CL2014001917 A CL 2014001917A CL 2014001917 A1 CL2014001917 A1 CL 2014001917A1
- Authority
- CL
- Chile
- Prior art keywords
- hexitoles
- medulloblastoma
- substituted
- stem cells
- cancer stem
- Prior art date
Links
- AAFJXZWCNVJTMK-GUCUJZIJSA-N (1s,2r)-1-[(2s)-oxiran-2-yl]-2-[(2r)-oxiran-2-yl]ethane-1,2-diol Chemical compound C([C@@H]1[C@H](O)[C@H](O)[C@H]2OC2)O1 AAFJXZWCNVJTMK-GUCUJZIJSA-N 0.000 title 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 title 1
- 208000000172 Medulloblastoma Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 229950000758 dianhydrogalactitol Drugs 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000005017 glioblastoma Diseases 0.000 title 1
- 230000001613 neoplastic effect Effects 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261589029P | 2012-01-20 | 2012-01-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014001917A1 true CL2014001917A1 (es) | 2015-08-28 |
Family
ID=48799821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014001917A CL2014001917A1 (es) | 2012-01-20 | 2014-07-18 | Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y análogos para tratar enfermedades neoplastica y células madre de cáncer que incluyen glioblastoma multiforme y meduloblastoma. |
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| JP (4) | JP2015511936A (es) |
| KR (3) | KR20150018765A (es) |
| CN (4) | CN115778934A (es) |
| AU (3) | AU2013209394A1 (es) |
| BR (1) | BR112014017833A2 (es) |
| CA (1) | CA2862706C (es) |
| CL (1) | CL2014001917A1 (es) |
| HK (1) | HK1208365A1 (es) |
| IL (2) | IL233722B (es) |
| MX (2) | MX367614B (es) |
| SG (1) | SG11201404216TA (es) |
| WO (1) | WO2013110058A2 (es) |
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| CA2863679A1 (en) * | 2011-08-17 | 2014-05-30 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dibromodulcitol |
| CN115778934A (zh) * | 2012-01-20 | 2023-03-14 | 德玛公司 | 经取代的己糖醇类用于治疗恶性肿瘤的用途 |
| CN105492011A (zh) * | 2013-04-08 | 2016-04-13 | 丹尼斯·M·布朗 | 不理想给药化学化合物的治疗增效 |
| WO2014179528A2 (en) * | 2013-05-01 | 2014-11-06 | Brown Dennis M | Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted naphthalimides such as amonafide for the treatment of immunological, metabolic, infectious, and benign or neoplastic hyperproliferative disease conditions |
| TW201536278A (zh) * | 2013-05-31 | 2015-10-01 | Del Mar Pharmaceuticals | 雙脫水半乳糖醇及其類似物與衍生物用於治療復發性惡性神經膠瘤或進行性繼發腦瘤之用途 |
| KR102359214B1 (ko) * | 2014-04-04 | 2022-02-07 | 델 마 파마슈티컬스 | 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체 |
| CN115414480A (zh) * | 2014-11-10 | 2022-12-02 | 德玛医药 | 结合放射用于治疗非小细胞肺癌和多形性胶质母细胞瘤的二去水卫矛醇 |
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| US9937223B2 (en) | 2015-01-30 | 2018-04-10 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9925233B2 (en) | 2015-01-30 | 2018-03-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9687526B2 (en) | 2015-01-30 | 2017-06-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9744209B2 (en) | 2015-01-30 | 2017-08-29 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9375478B1 (en) | 2015-01-30 | 2016-06-28 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| CA2989420A1 (en) | 2015-06-16 | 2016-12-22 | Targent, Llc | New crystalline polymorphs of 1,6-dibromo-1,6-dideoxy-dulcitol |
| US20190091195A1 (en) * | 2015-09-10 | 2019-03-28 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and derivatives thereof in the treatment of glioblastoma, lung cancer, and ovarian cancer |
| WO2017075052A1 (en) * | 2015-10-28 | 2017-05-04 | Delmar Pharmaceuticals, Inc. | Use of dianhydrogalactitol or derivatives or analogs thereof for treatment of pediatric central nervous system malignancies |
| CN105663075B (zh) * | 2016-02-23 | 2018-09-14 | 广西梧州制药(集团)股份有限公司 | 一种二溴卫矛醇肠溶片及其制备方法 |
| CN105663060B (zh) * | 2016-02-23 | 2018-08-14 | 广西梧州制药(集团)股份有限公司 | 一种去水卫矛醇脂质体冻干粉针剂及其制备方法 |
| CN105663076A (zh) * | 2016-02-23 | 2016-06-15 | 广西梧州制药(集团)股份有限公司 | 一种起效快防潮好的去水卫矛醇薄膜包衣片及其制备方法 |
| CN105663072B (zh) * | 2016-02-23 | 2018-09-28 | 广西梧州制药(集团)股份有限公司 | 一种去水卫矛醇薄膜包衣片及其制备方法 |
| WO2017210608A1 (en) * | 2016-06-02 | 2017-12-07 | Yale University | Compositions and methods for targeting and treating homologous recombination-deficient tumors |
| US20200062839A1 (en) * | 2017-05-01 | 2020-02-27 | Del Mar Pharmaceuticals (Bc) Ltd. | Use of dianhydrogalactitol or analogs and derivatives in combination with vegf inhibitors to treat cancer |
| WO2018204412A1 (en) * | 2017-05-01 | 2018-11-08 | Thomas Jefferson University | Systems-level analysis of tcga cancers reveals disease trna fragmentation patterns and associations with messenger rnas and repeat |
| CN111132672A (zh) * | 2017-09-20 | 2020-05-08 | 俄克拉荷马医学研究基金会 | 抗药性胶质瘤的治疗 |
| US11717505B2 (en) | 2017-12-01 | 2023-08-08 | Del Mar Pharmaceuticals (Bc) Limited | Dianhydrogalactitol for the treatment of diffuse intrinsic pontine gliomas |
| CA3090884A1 (en) * | 2018-02-12 | 2019-08-15 | Medicinova, Inc. | Methods and dosing regimens using ibudilast and a second agent for cancer therapy |
| US11311538B2 (en) | 2018-07-13 | 2022-04-26 | Yale University | Compositions and methods for targeting cancers |
| KR102130501B1 (ko) * | 2019-06-12 | 2020-07-07 | 브렉소젠 주식회사 | 테트란드린을 포함하는 줄기세포 유래 엑소좀 생성 촉진 및 줄기세포능 증가용 조성물 |
| CN110283047A (zh) * | 2019-07-11 | 2019-09-27 | 夏永刚 | 单糖部分甲基化阿尔迪醇乙酸酯的合成方法 |
| AU2022226605A1 (en) * | 2021-02-23 | 2023-10-12 | Edison Oncology | Compositions and methods to improve the therapeutic benefit of suboptimally administered compounds and therapies for the treatment of diseases |
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