MX385227B - Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y análogos para tratar enfermedad neoplásica y células madre de cáncer que incluyen glioblastoma multiforme y meduloblastoma. - Google Patents

Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y análogos para tratar enfermedad neoplásica y células madre de cáncer que incluyen glioblastoma multiforme y meduloblastoma.

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Publication number
MX385227B
MX385227B MX2019002917A MX2019002917A MX385227B MX 385227 B MX385227 B MX 385227B MX 2019002917 A MX2019002917 A MX 2019002917A MX 2019002917 A MX2019002917 A MX 2019002917A MX 385227 B MX385227 B MX 385227B
Authority
MX
Mexico
Prior art keywords
dianhydrogalactitol
stem cells
cancer stem
glioblastoma multiforme
meduloblastoma
Prior art date
Application number
MX2019002917A
Other languages
English (en)
Other versions
MX2019002917A (es
Inventor
Dennis Brown
Jeffrey Bacha
Sandra Dunn
Original Assignee
Del Mar Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48799821&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX385227(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Del Mar Pharmaceuticals filed Critical Del Mar Pharmaceuticals
Publication of MX2019002917A publication Critical patent/MX2019002917A/es
Publication of MX385227B publication Critical patent/MX385227B/es

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
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    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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Abstract

El uso de dianhidrogalactitol proporciona una modalidad terapéutica novedosa para el tratamiento de glioblastoma multiforme y meduloblastoma. El dianhidrogalactitol actúa como un agente alquilante en el ADN que crea la metilación en N7. El dianhidrogalactitol es efectivo en suprimir el crecimiento de células madre de cáncer y es activo en contra de tumores que son refractarios a temozolomida; el fármaco actúa independientemente del mecanismo de reparación de MGMT.
MX2019002917A 2012-01-20 2013-01-22 Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y análogos para tratar enfermedad neoplásica y células madre de cáncer que incluyen glioblastoma multiforme y meduloblastoma. MX385227B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261589029P 2012-01-20 2012-01-20
PCT/US2013/022505 WO2013110058A2 (en) 2012-01-20 2013-01-22 Use of substituted hexitols including dianhydrogalactitol and analogs to treat neoplastic disease and cancer stem cells including glioblastoma multforme and medulloblastoma

Publications (2)

Publication Number Publication Date
MX2019002917A MX2019002917A (es) 2019-07-18
MX385227B true MX385227B (es) 2025-03-14

Family

ID=48799821

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019002917A MX385227B (es) 2012-01-20 2013-01-22 Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y análogos para tratar enfermedad neoplásica y células madre de cáncer que incluyen glioblastoma multiforme y meduloblastoma.
MX2014008751A MX367614B (es) 2012-01-20 2013-01-22 Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y analogos para tratar enfermedad neoplasica y celulas madre de cancer que incluyen glioblastoma multiforme y meduloblastoma.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2014008751A MX367614B (es) 2012-01-20 2013-01-22 Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y analogos para tratar enfermedad neoplasica y celulas madre de cancer que incluyen glioblastoma multiforme y meduloblastoma.

Country Status (14)

Country Link
US (6) US10201521B2 (es)
EP (1) EP2804602B1 (es)
JP (4) JP2015511936A (es)
KR (3) KR20210048608A (es)
CN (4) CN110711188A (es)
AU (3) AU2013209394A1 (es)
BR (1) BR112014017833A2 (es)
CA (1) CA2862706C (es)
CL (1) CL2014001917A1 (es)
HK (1) HK1208365A1 (es)
IL (2) IL233722B (es)
MX (2) MX385227B (es)
SG (1) SG11201404216TA (es)
WO (1) WO2013110058A2 (es)

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