CL2014002694A1 - Composiciones y métodos para inhibir masp-1 y/o masp-3 en el tratamiento de hemoglobinuria nocturna paroxistica - Google Patents

Composiciones y métodos para inhibir masp-1 y/o masp-3 en el tratamiento de hemoglobinuria nocturna paroxistica

Info

Publication number
CL2014002694A1
CL2014002694A1 CL2014002694A CL2014002694A CL2014002694A1 CL 2014002694 A1 CL2014002694 A1 CL 2014002694A1 CL 2014002694 A CL2014002694 A CL 2014002694A CL 2014002694 A CL2014002694 A CL 2014002694A CL 2014002694 A1 CL2014002694 A1 CL 2014002694A1
Authority
CL
Chile
Prior art keywords
masp
compositions
treatment
methods
paroxysmal nocturnal
Prior art date
Application number
CL2014002694A
Other languages
English (en)
Inventor
Gregory A Demopulos
Hans-Wilhelm Schwaeble
Original Assignee
Omeros Corp
Univ Leicester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Corp, Univ Leicester filed Critical Omeros Corp
Publication of CL2014002694A1 publication Critical patent/CL2014002694A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicinal Preparation (AREA)
CL2014002694A 2012-04-06 2014-10-06 Composiciones y métodos para inhibir masp-1 y/o masp-3 en el tratamiento de hemoglobinuria nocturna paroxistica CL2014002694A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261621461P 2012-04-06 2012-04-06

Publications (1)

Publication Number Publication Date
CL2014002694A1 true CL2014002694A1 (es) 2015-08-28

Family

ID=49325295

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014002694A CL2014002694A1 (es) 2012-04-06 2014-10-06 Composiciones y métodos para inhibir masp-1 y/o masp-3 en el tratamiento de hemoglobinuria nocturna paroxistica

Country Status (29)

Country Link
US (3) US20130273053A1 (es)
EP (2) EP3366307B1 (es)
JP (3) JP6366571B2 (es)
KR (2) KR102142508B1 (es)
CN (2) CN104661676A (es)
AU (3) AU2013267909B2 (es)
BR (1) BR112014024793A2 (es)
CA (2) CA2869326C (es)
CL (1) CL2014002694A1 (es)
CY (1) CY1120736T1 (es)
DK (2) DK3366307T3 (es)
ES (2) ES2670668T3 (es)
HR (1) HRP20180671T1 (es)
HU (1) HUE036930T2 (es)
IL (2) IL234991B (es)
IN (1) IN2014KN02324A (es)
LT (1) LT2833907T (es)
MX (2) MX357540B (es)
NO (1) NO2881536T3 (es)
NZ (2) NZ629675A (es)
PL (2) PL2833907T3 (es)
PT (1) PT2833907T (es)
RS (1) RS57266B1 (es)
RU (2) RU2018114903A (es)
SI (1) SI2833907T1 (es)
SM (1) SMT201800253T1 (es)
TR (1) TR201806939T4 (es)
WO (1) WO2013180834A2 (es)
ZA (1) ZA201408100B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX347691B (es) * 2011-05-04 2017-05-09 Omeros Corp Composiciones para inhibir la activacion del complemento dependiente de la masp-2.
CN115040653A (zh) * 2012-06-18 2022-09-13 奥默罗斯公司 抑制masp-1和/或masp-2和/或masp-3的组合物和方法
US20140363433A1 (en) 2013-03-15 2014-12-11 Omeros Corporation Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same
NZ629682A (en) * 2013-03-15 2017-03-31 Omeros Corp Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same
JOP20170154B1 (ar) * 2016-08-01 2023-03-28 Omeros Corp تركيبات وطرق لتثبيط masp-3 لعلاج أمراض واضطرابات مختلفة
TWI776827B (zh) 2016-11-28 2022-09-11 日商中外製藥股份有限公司 能夠調節配體結合活性的配體結合分子
AU2017364817B2 (en) 2016-11-28 2023-11-09 Chugai Seiyaku Kabushiki Kaisha Antigen-binding domain, and polypeptide including conveying section
JP7409871B2 (ja) * 2017-04-03 2024-01-09 中外製薬株式会社 抗ｍａｓｐ－１抗体およびその使用方法
KR20200089312A (ko) 2017-11-28 2020-07-24 추가이 세이야쿠 가부시키가이샤 리간드 결합 활성을 조정 가능한 리간드 결합 분자
EP3719035A4 (en) 2017-11-28 2021-09-01 Chugai Seiyaku Kabushiki Kaisha POLYPEPTIDE WITH ANTIGEN-BINDING AREA AND CARRYING SECTION
WO2019231935A1 (en) * 2018-05-29 2019-12-05 Omeros Corporation Masp-2 inhibitors and methods of use
US12077577B2 (en) 2018-05-30 2024-09-03 Chugai Seiyaku Kabushiki Kaisha Polypeptide comprising aggrecan binding domain and carrying moiety
KR20220041846A (ko) * 2019-07-31 2022-04-01 바이오크리스트파마슈티컬즈,인코포레이티드 경구 보체 인자 d 억제제에 대한 투약 요법
EP4069238A1 (en) 2019-12-04 2022-10-12 Omeros Corporation Masp-2 inhibitors and methods of use
EP4069676A1 (en) 2019-12-04 2022-10-12 Omeros Corporation Masp-2 inhibitors and methods of use
CA3159172A1 (en) 2019-12-04 2021-06-10 Michael Cicirelli Masp-2 inhibitors and methods of use
EP3916385A1 (en) * 2020-05-26 2021-12-01 Dynamic Biosensors GmbH Cell immobilization in fluid flow at high flow velocities
EP4199954A4 (en) 2020-08-18 2024-12-25 Omeros Corporation Monoclonal antibodies, compositions and methods for detecting complement factor d
CN114295594B (zh) * 2021-12-06 2023-09-19 贵州理工学院 一种基于分子信标筛选三螺旋DNA嵌入剂的“turn on”型荧光传感器
PY22106817A (es) * 2021-12-10 2023-12-21 Omeros Corp Anticuerpos terapéuticos que se unen al dominio serina-proteasa de masp-2 y usos de estos
CN121311247A (zh) * 2023-06-09 2026-01-09 舒泰神（北京）生物制药股份有限公司 特异性结合masp3的抗体以及特异性结合masp3和masp2的多特异性抗体

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5211657A (en) 1988-11-07 1993-05-18 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5549910A (en) 1989-03-31 1996-08-27 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
DE69030172T2 (de) 1990-01-26 1997-06-19 Immunomedics Inc Impfstoffe gegen Krebs und Infektionskrankheiten
JP3218637B2 (ja) 1990-07-26 2001-10-15 大正製薬株式会社 安定なリポソーム水懸濁液
JP2958076B2 (ja) 1990-08-27 1999-10-06 株式会社ビタミン研究所 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法
JP3720353B2 (ja) 1992-12-04 2005-11-24 メディカル リサーチ カウンシル 多価および多重特異性の結合タンパク質、それらの製造および使用
US5856121A (en) 1994-02-24 1999-01-05 Case Western Reserve University Growth arrest homebox gene
US6074642A (en) 1994-05-02 2000-06-13 Alexion Pharmaceuticals, Inc. Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
US5741516A (en) 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5738868A (en) 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
CA2391402A1 (en) * 1999-12-02 2001-06-07 Jens Christian Jensenius Masp-3, a complement-fixing enzyme, and uses for it
SG98393A1 (en) 2000-05-19 2003-09-19 Inst Materials Research & Eng Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
US7043719B2 (en) * 2001-07-23 2006-05-09 Intel Corporation Method and system for automatically prioritizing and analyzing performance data for one or more, system configurations
EP1531757B1 (en) 2002-07-19 2016-09-07 Omeros Corporation Biodegradable triblock copolymers, synthesis methods therefor, and hydrogels and biomaterials made there from
US7666627B2 (en) * 2002-08-08 2010-02-23 Targetex Kft. Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
MXPA05008570A (es) * 2003-02-21 2005-11-04 Tanox Inc Metodos para la prevencion y tratamiento de danos tisulares asociados con una lesion por isquemia-reperfusion.
US20070253949A1 (en) * 2004-02-03 2007-11-01 Stefan Golz Diagnostics and Therapeutics for Diseases Associated with Plasma Kallikrein (KLKB1)
US20050169921A1 (en) * 2004-02-03 2005-08-04 Leonard Bell Method of treating hemolytic disease
US7803931B2 (en) * 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
US8840893B2 (en) * 2004-06-10 2014-09-23 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US7919094B2 (en) 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
KR20140053410A (ko) 2005-08-19 2014-05-07 아보트 러보러터리즈 이원 가변 도메인 면역글로불린 및 이의 용도
DE602006004582D1 (de) * 2006-07-31 2009-02-12 Fiat Ricerche Durch eine Fluidströmung betätigbarer elektrischer Generator
JP5537420B2 (ja) 2007-05-31 2014-07-02 ユニヴァーシティ オブ ワシントン 標的遺伝子の誘導性変異誘発
CN102643345A (zh) * 2008-09-26 2012-08-22 罗氏格黎卡特股份公司 双特异性抗-egfr/抗-igf-1r抗体
JP2013516389A (ja) * 2009-01-06 2013-05-13 ダイアックス コーポレーション カリクレイン阻害剤による粘膜炎治療
CA2753921A1 (en) * 2009-03-05 2010-09-10 Smith & Nephew, Inc. System, method, and apparatus for locating a femoral neck guide wire
EP3395828A1 (en) * 2009-07-17 2018-10-31 Rigshospitalet Inhibitors of complement activation
WO2011057158A1 (en) * 2009-11-05 2011-05-12 Taligen Therapeutics, Inc. Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis
US8795973B2 (en) * 2010-11-29 2014-08-05 University of Leceister Methods for identifying inhibitors of mannan-binding lectin associated serine protease (MASP) proteins and uses thereof
NZ731596A (en) * 2011-04-08 2022-07-01 Omeros Corp Methods for treating conditions associated with masp-2 dependent complement activation

Also Published As

Publication number Publication date
JP2015514117A (ja) 2015-05-18
SMT201800253T1 (it) 2018-07-17
IL234991A0 (en) 2014-12-31
EP3366307B1 (en) 2021-07-28
DK2833907T3 (en) 2018-05-28
CY1120736T1 (el) 2019-12-11
SI2833907T1 (en) 2018-07-31
PT2833907T (pt) 2018-05-29
KR20150003785A (ko) 2015-01-09
DK3366307T3 (da) 2021-11-01
US20220242972A1 (en) 2022-08-04
HUE036930T2 (hu) 2018-08-28
PL3366307T3 (pl) 2022-03-07
PL2833907T3 (pl) 2018-08-31
HK1206996A1 (en) 2016-01-22
MX357540B (es) 2018-07-13
RU2018114903A (ru) 2019-03-04
CA2869326A1 (en) 2013-12-05
NO2881536T3 (es) 2018-06-30
US20130273053A1 (en) 2013-10-17
NZ629675A (en) 2017-02-24
CA2869326C (en) 2021-09-21
HRP20180671T1 (hr) 2018-07-13
EP2833907B1 (en) 2018-02-28
MX2018008658A (es) 2021-10-19
RU2014144621A (ru) 2016-05-27
MX388278B (es) 2025-03-18
ES2894944T3 (es) 2022-02-16
ES2670668T3 (es) 2018-05-31
JP6366571B2 (ja) 2018-08-01
IN2014KN02324A (es) 2015-05-01
MX2014012045A (es) 2015-05-15
TR201806939T4 (tr) 2018-06-21
CA3087933A1 (en) 2013-12-05
CN104661676A (zh) 2015-05-27
IL274721A (en) 2020-07-30
KR20200097808A (ko) 2020-08-19
AU2020204163A1 (en) 2020-07-09
AU2018200721B2 (en) 2020-03-26
CN121401408A (zh) 2026-01-27
US20190382505A1 (en) 2019-12-19
BR112014024793A2 (pt) 2019-08-27
EP2833907A2 (en) 2015-02-11
AU2013267909A1 (en) 2014-11-27
RU2655299C2 (ru) 2018-05-24
WO2013180834A2 (en) 2013-12-05
EP2833907A4 (en) 2016-03-16
KR102318623B1 (ko) 2021-11-02
LT2833907T (lt) 2018-06-11
IL234991B (en) 2020-06-30
ZA201408100B (en) 2022-05-25
EP3366307A1 (en) 2018-08-29
RS57266B1 (sr) 2018-08-31
JP2018162307A (ja) 2018-10-18
JP2021001199A (ja) 2021-01-07
RU2018114903A3 (es) 2021-08-12
AU2018200721A1 (en) 2018-02-22
IL274721B (en) 2022-04-01
JP6815355B2 (ja) 2021-01-20
NZ781091A (en) 2022-04-29
KR102142508B1 (ko) 2020-08-10
NZ727063A (en) 2021-10-29
AU2013267909B2 (en) 2018-03-01
WO2013180834A3 (en) 2014-04-03

Similar Documents

Publication Publication Date Title
CL2014002694A1 (es) Composiciones y métodos para inhibir masp-1 y/o masp-3 en el tratamiento de hemoglobinuria nocturna paroxistica
IL288609B (en) Methods and compositions related to the use of low hlb surfactants in the production of synthetic nanocarriers comprising a rapalog
IL228758B (en) Masp-2 inhibiting agent for use in treating paroxysmal nocturnal hemoglobinuria
EP2831001A4 (en) COMPOSITION FOR THE TREATMENT OF WATER AND METHOD FOR USE
IL242610A0 (en) History of pyrazolopyrrolidine and their use in the treatment of diseases
ZA201505004B (en) Solid solution compositions and use in severe pain
PT3066201T (pt) Métodos e composições relacionadas com crispr com arng reguladores
HRP20180838T1 (hr) Formuliranje deksmedetomidina u obliku predsmjese
SI2861246T1 (sl) Kompozicije in postopki za zaviranje MASP-1 in/ali MASP-2 in/ali MASP-3 za zdravljenje različnih bolezni in bolezenskih stanj
HUE054783T2 (hu) Pridopidin Huntington-kór kezelésében
IL240845A0 (en) Compounds and uses thereof for the modulation of hemoglobin
PL2830654T3 (pl) Sposoby i kompozycje do leczenia zapalenia
IL240252B (en) Solid substrates for promoting cell and tissue growth
EP2911193A4 (en) COOLING STRUCTURE AND HEAT-GENERATING BODY
PL3004112T3 (pl) Pochodne pirazolo-pirolidyn-4-onu oraz ich zastosowanie w leczeniu choroby
PL2956471T3 (pl) Kompozycja inhibitora il-1beta i jej zastosowanie
CL2014003153A1 (es) Métodos para hacer complejos de coordinación micelar seguro para el tratamiento de plantas y formulaciones de estos
CL2015000537A1 (es) Siarn y su uso en los métodos y composiciones para el tratamiento y/o prevención de enfermedades de los ojos.
PL2988750T5 (pl) Zastosowanie chlorowodorku landilolu w długotrwałym leczeniu tachyarytmii
PT3373922T (pt) Composições e métodos para usar no tratamento de homocistinúria
IL243681A0 (en) Local preparations for the treatment of excessive sweating and methods of their use
PL3079684T3 (pl) Kompozycje i sposoby do leczenia chorób związanych z układem renina-angiotensyna
HRP20190041T1 (hr) Usatci za poticanje integriranja mekog i tvrdog tkiva
CO6970562A2 (es) Dispositivo y método para ayudar en el tratamiento de córnea
TH1401007652A (th) อะมิโนไตรอะโซโลไพริดีนสำหรับการใช้ในการรักษาการอักเสบ และองค์ประกอบทางเภสัชกรรมของมัน