CL2015000370A1 - Compuestos derivados de pirazolo[3,4-c]cinolina y 3h-2,3,4,5-tetraazaciclopenta[a]naftaleno, inhibidores de la fosfodiesterasa del tipo 10a (pde10a); y composicion farmaceutica que los comprede. - Google Patents

Compuestos derivados de pirazolo[3,4-c]cinolina y 3h-2,3,4,5-tetraazaciclopenta[a]naftaleno, inhibidores de la fosfodiesterasa del tipo 10a (pde10a); y composicion farmaceutica que los comprede.

Info

Publication number: CL2015000370A1
Authority: CL; Chile
Prior art keywords: tetraazacyclopenta; cinoline; pde10a; pyrazolo; naphthalene
Prior art date: 2012-08-17

Application number

CL2015000370A

Other languages

English (en)

Inventor

Hervé Geneste

Michael Ochse

Karla Drescher

Clarissa Jakob

Original Assignee

Abbvie Inc

Abbvie Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-08-17

Filing date

2015-02-16

Publication date

2015-10-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48986145&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015000370(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2015-02-16 Application filed by Abbvie Inc, Abbvie Deutschland filed Critical Abbvie Inc

2015-10-02 Publication of CL2015000370A1 publication Critical patent/CL2015000370A1/es

Links

QZMDASIJKFPTSZ-UHFFFAOYSA-N 3h-pyrazolo[3,4-c]cinnoline Chemical compound C1=CC=CC2=C3C=NNC3=NN=C21 QZMDASIJKFPTSZ-UHFFFAOYSA-N 0.000 title 1
229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
239000002571 phosphodiesterase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Addiction (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

CL2015000370A 2012-08-17 2015-02-16 Compuestos derivados de pirazolo[3,4-c]cinolina y 3h-2,3,4,5-tetraazaciclopenta[a]naftaleno, inhibidores de la fosfodiesterasa del tipo 10a (pde10a); y composicion farmaceutica que los comprede. CL2015000370A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201261684290P	2012-08-17	2012-08-17

Publications (1)

Publication Number	Publication Date
CL2015000370A1 true CL2015000370A1 (es)	2015-10-02

Family

ID=48986145

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2015000370A CL2015000370A1 (es)	2012-08-17	2015-02-16	Compuestos derivados de pirazolo[3,4-c]cinolina y 3h-2,3,4,5-tetraazaciclopenta[a]naftaleno, inhibidores de la fosfodiesterasa del tipo 10a (pde10a); y composicion farmaceutica que los comprede.

Country Status (24)

Country	Link
US (1)	US9464085B2 (es)
EP (1)	EP2885299B1 (es)
JP (1)	JP2015524833A (es)
KR (1)	KR20150042798A (es)
CN (1)	CN104684912A (es)
AR (1)	AR092167A1 (es)
AU (1)	AU2013304043A1 (es)
BR (1)	BR112015003236A2 (es)
CA (1)	CA2879485A1 (es)
CL (1)	CL2015000370A1 (es)
CR (1)	CR20150082A (es)
DO (1)	DOP2015000029A (es)
EC (1)	ECSP15010205A (es)
HK (1)	HK1211284A1 (es)
IL (1)	IL236946A0 (es)
IN (1)	IN2015DN00337A (es)
MX (1)	MX2015002000A (es)
PE (1)	PE20151069A1 (es)
PH (1)	PH12015500348A1 (es)
RU (1)	RU2015109135A (es)
SG (1)	SG11201501111YA (es)
TW (1)	TW201412742A (es)
UY (1)	UY34980A (es)
WO (1)	WO2014027078A1 (es)

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CA2578996A1 (en)	2004-09-03	2006-03-16	Memory Pharmaceuticals Corporation	4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms
MX2008002207A (es)	2005-08-16	2008-03-27	Memory Pharm Corp	Inhibidores de fosfodiesterasa 10.
NL2000397C2 (nl)	2006-01-05	2007-10-30	Pfizer Prod Inc	Bicyclische heteroarylverbindingen als PDE10 inhibitoren.
WO2007082546A1 (en)	2006-01-20	2007-07-26	H. Lundbeck A/S	Use of tofisopam as a pde10a inhibitor
JP2009524637A (ja)	2006-01-27	2009-07-02	ファイザー・プロダクツ・インク	アミノフタラジン誘導体化合物
CA2643963A1 (en)	2006-02-21	2007-08-30	Amgen Inc.	Cinnoline derivatives as phosphodiesterase 10 inhibitors
WO2007098214A1 (en)	2006-02-21	2007-08-30	Amgen Inc.	Cinnoline derivatives as phosphodiesterase 10 inhibitors
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US20070287707A1 (en)	2006-02-28	2007-12-13	Arrington Mark P	Phosphodiesterase 10 inhibitors
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JP2009541481A (ja)	2006-06-26	2009-11-26	ファイザー・プロダクツ・インク	Ｐｄｅ１０阻害剤としての三環式ヘテロアリール化合物
US20080090834A1 (en)	2006-07-06	2008-04-17	Pfizer Inc	Selective azole pde10a inhibitor compounds
ES2392553T3 (es)	2006-07-10	2012-12-11	H. Lundbeck A/S	Derivados (3-aril-piperazina-1-ilo) de 6,7-dialcoxiquinazolina, 6,7-dialcoxiftalazina y 6,7-dialcoxiisoquinolina
WO2008020302A2 (en)	2006-08-17	2008-02-21	Pfizer Products Inc.	Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors
US20090062277A1 (en)	2007-08-21	2009-03-05	Essa Hu	Phosphodiesterase 10 inhibitors
WO2009025839A2 (en)	2007-08-22	2009-02-26	Amgen Inc.	Phosphodiesterase 10 inhibitors
US20090054434A1 (en)	2007-08-23	2009-02-26	Amgen Inc.	Isoquinolone derivatives as phosphodiesterase 10 inhibitors
TW200918519A (en)	2007-09-19	2009-05-01	Lundbeck & Co As H	Cyanoisoquinoline
EP2227472A1 (en)	2007-11-30	2010-09-15	Elbion Gmbh	Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10
US20090143392A1 (en)	2007-11-30	2009-06-04	Elbion Gmbh	Methods of Treating Obesity and Metabolic Disorders
US20090143361A1 (en)	2007-11-30	2009-06-04	Elbion Gmbh	Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10
KR20100110804A (ko)	2007-11-30	2010-10-13	와이어쓰 엘엘씨	포스포디에스테라제 10의 저해물질로서의 아릴 및 헤테로아릴 융합된 이미다조[1,5-ａ]피라진
WO2010054260A1 (en)	2008-11-07	2010-05-14	Biotie Therapies Gmbh	Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases
WO2011008597A1 (en)	2009-07-14	2011-01-20	Schering Corporation	Dihydroimidazoisoquinoline derivatives useful as pde10 inhibitors
TW201204727A (en)	2010-03-10	2012-02-01	Kalypsys Inc	Heterocyclic inhibitors of histamine receptors for the treatment of disease
DE102010025786A1 (de)	2010-07-01	2012-01-05	Merck Patent Gmbh	Pyrazolochinoline

2013
- 2013-08-15 US US13/968,242 patent/US9464085B2/en not_active Expired - Fee Related
- 2013-08-15 UY UY0001034980A patent/UY34980A/es not_active Application Discontinuation
- 2013-08-16 CA CA2879485A patent/CA2879485A1/en not_active Abandoned
- 2013-08-16 CN CN201380043926.2A patent/CN104684912A/zh active Pending
- 2013-08-16 BR BR112015003236A patent/BR112015003236A2/pt not_active IP Right Cessation
- 2013-08-16 EP EP13750071.6A patent/EP2885299B1/en not_active Not-in-force
- 2013-08-16 AR ARP130102932A patent/AR092167A1/es unknown
- 2013-08-16 KR KR20157004416A patent/KR20150042798A/ko not_active Withdrawn
- 2013-08-16 MX MX2015002000A patent/MX2015002000A/es unknown
- 2013-08-16 IN IN337DEN2015 patent/IN2015DN00337A/en unknown
- 2013-08-16 SG SG11201501111YA patent/SG11201501111YA/en unknown
- 2013-08-16 JP JP2015526996A patent/JP2015524833A/ja not_active Withdrawn
- 2013-08-16 RU RU2015109135A patent/RU2015109135A/ru not_active Application Discontinuation
- 2013-08-16 WO PCT/EP2013/067122 patent/WO2014027078A1/en not_active Ceased
- 2013-08-16 HK HK15111990.0A patent/HK1211284A1/xx unknown
- 2013-08-16 AU AU2013304043A patent/AU2013304043A1/en not_active Abandoned
- 2013-08-16 TW TW102129554A patent/TW201412742A/zh unknown
- 2013-08-16 PE PE2015000204A patent/PE20151069A1/es not_active Application Discontinuation
2015
- 2015-01-27 IL IL236946A patent/IL236946A0/en unknown
- 2015-02-16 DO DO2015000029A patent/DOP2015000029A/es unknown
- 2015-02-16 CL CL2015000370A patent/CL2015000370A1/es unknown
- 2015-02-17 PH PH12015500348A patent/PH12015500348A1/en unknown
- 2015-02-19 CR CR20150082A patent/CR20150082A/es unknown
- 2015-03-17 EC ECIEPI201510205A patent/ECSP15010205A/es unknown

Also Published As

Publication number	Publication date
ECSP15010205A (es)	2016-01-29
CR20150082A (es)	2015-05-25
HK1211284A1 (en)	2016-05-20
PE20151069A1 (es)	2015-08-29
US9464085B2 (en)	2016-10-11
AR092167A1 (es)	2015-03-25
MX2015002000A (es)	2015-10-09
UY34980A (es)	2014-03-31
PH12015500348A1 (en)	2015-04-20
RU2015109135A (ru)	2016-10-10
US20140051695A1 (en)	2014-02-20
AU2013304043A1 (en)	2015-02-05
BR112015003236A2 (pt)	2017-07-04
IL236946A0 (en)	2015-03-31
JP2015524833A (ja)	2015-08-27
CN104684912A (zh)	2015-06-03
WO2014027078A1 (en)	2014-02-20
DOP2015000029A (es)	2015-03-15
CA2879485A1 (en)	2014-02-20
TW201412742A (zh)	2014-04-01
IN2015DN00337A (es)	2015-06-12
EP2885299A1 (en)	2015-06-24
SG11201501111YA (en)	2015-03-30
EP2885299B1 (en)	2017-04-05
KR20150042798A (ko)	2015-04-21

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