CL2015000562A1 - Método para generar planta que contiene un polinucléotido de interés a partir de un protoplasto, que comprende aislar de una población de protoplastos, al menos uno que contiene el polinucleótido de interés y un marcador fluorescente, utilizando citometría de flujo activada por fluorescencia (facs); método de producción de semilla; y planta. - Google Patents

Método para generar planta que contiene un polinucléotido de interés a partir de un protoplasto, que comprende aislar de una población de protoplastos, al menos uno que contiene el polinucleótido de interés y un marcador fluorescente, utilizando citometría de flujo activada por fluorescencia (facs); método de producción de semilla; y planta.

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Publication number
CL2015000562A1
CL2015000562A1 CL2015000562A CL2015000562A CL2015000562A1 CL 2015000562 A1 CL2015000562 A1 CL 2015000562A1 CL 2015000562 A CL2015000562 A CL 2015000562A CL 2015000562 A CL2015000562 A CL 2015000562A CL 2015000562 A1 CL2015000562 A1 CL 2015000562A1
Authority
CL
Chile
Prior art keywords
polynucleotide
interest
plant
protoplasts
protoplast
Prior art date
Application number
CL2015000562A
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English (en)
Inventor
German Spangengerg
Sareena Sahab
John Mason
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/020,694 external-priority patent/US20140075593A1/en
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of CL2015000562A1 publication Critical patent/CL2015000562A1/es

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    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D498/04Ortho-condensed systems

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CL2015000562A 2012-09-07 2015-03-06 Método para generar planta que contiene un polinucléotido de interés a partir de un protoplasto, que comprende aislar de una población de protoplastos, al menos uno que contiene el polinucleótido de interés y un marcador fluorescente, utilizando citometría de flujo activada por fluorescencia (facs); método de producción de semilla; y planta. CL2015000562A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261697899P 2012-09-07 2012-09-07
US14/020,694 US20140075593A1 (en) 2012-09-07 2013-09-06 Fluorescence activated cell sorting (facs) enrichment to generate plants

Publications (1)

Publication Number Publication Date
CL2015000562A1 true CL2015000562A1 (es) 2015-06-12

Family

ID=49170904

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2015000255A CL2015000255A1 (es) 2012-09-07 2015-02-03 Compuestos heterociclicos derivados de alcoxipirazoles, activadores de guanilato ciclasa soluble; composicion farmaceutica que los comprende; uso para tratar enfermedad cardiovascular, enfermedad renal, hiperplasia benigna de prostata, disfuncion erectil, enfermedad de alzheimer, enfermedad de parkinson, entre otras.
CL2015000562A CL2015000562A1 (es) 2012-09-07 2015-03-06 Método para generar planta que contiene un polinucléotido de interés a partir de un protoplasto, que comprende aislar de una población de protoplastos, al menos uno que contiene el polinucleótido de interés y un marcador fluorescente, utilizando citometría de flujo activada por fluorescencia (facs); método de producción de semilla; y planta.

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CL2015000255A CL2015000255A1 (es) 2012-09-07 2015-02-03 Compuestos heterociclicos derivados de alcoxipirazoles, activadores de guanilato ciclasa soluble; composicion farmaceutica que los comprende; uso para tratar enfermedad cardiovascular, enfermedad renal, hiperplasia benigna de prostata, disfuncion erectil, enfermedad de alzheimer, enfermedad de parkinson, entre otras.

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US (2) US8906904B2 (es)
EP (1) EP2892891B1 (es)
JP (1) JP5970134B2 (es)
KR (1) KR101692707B1 (es)
CN (1) CN104619695B (es)
AP (1) AP2015008231A0 (es)
AR (1) AR092869A1 (es)
AU (1) AU2013312931B2 (es)
BR (1) BR112015004529B1 (es)
CA (1) CA2880494C (es)
CL (2) CL2015000255A1 (es)
CY (1) CY1122610T1 (es)
DK (1) DK2892891T3 (es)
EA (1) EA027244B1 (es)
EC (1) ECSP15012804A (es)
ES (1) ES2748798T3 (es)
GE (1) GEP20176631B (es)
HR (1) HRP20191755T1 (es)
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IL (1) IL236987A (es)
LT (1) LT2892891T (es)
MA (1) MA37891B1 (es)
MD (1) MD4425C1 (es)
MX (1) MX338887B (es)
NZ (1) NZ703989A (es)
PE (1) PE20151001A1 (es)
PH (1) PH12015500457B1 (es)
PL (1) PL2892891T3 (es)
PT (1) PT2892891T (es)
RS (1) RS59394B1 (es)
SG (2) SG10201510668UA (es)
SI (1) SI2892891T1 (es)
TN (1) TN2015000054A1 (es)
TW (1) TWI586661B (es)
UA (1) UA115881C2 (es)
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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2748798T3 (es) * 2012-09-07 2020-03-18 Boehringer Ingelheim Int Alcoxi pirazoles como activadores de la guanilato ciclasa soluble
TW201625584A (zh) 2014-07-02 2016-07-16 諾華公司 茚滿及吲哚啉衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途
EP3172202B1 (en) * 2014-07-22 2020-01-29 Boehringer Ingelheim International GmbH Heterocyclic carboxylic acids as activators of soluble guanylate cyclase
JP2018537488A (ja) 2015-12-18 2018-12-20 ノバルティス アーゲー インダン誘導体、ならびに可溶性グアニル酸シクラーゼ活性化剤としてのその使用
CA3039735A1 (en) 2016-10-11 2018-04-19 Bayer Pharma Aktiengesellschaft Combination containing sgc activators and mineralocorticoid receptor antagonists
WO2019081456A1 (en) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT
EP3498298A1 (en) 2017-12-15 2019-06-19 Bayer AG The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi)
JP7314173B2 (ja) 2018-04-30 2023-07-25 バイエル アクチェンゲゼルシャフト 認知障害の治療のためのsGC活性化薬及びsGC刺激薬の使用
CA3100096A1 (en) 2018-05-15 2019-11-21 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization
EP3574905A1 (en) 2018-05-30 2019-12-04 Adverio Pharma GmbH Method of identifying a subgroup of patients suffering from dcssc which benefits from a treatment with sgc stimulators and sgc activators in a higher degree than a control group
EP3820470B1 (en) 2018-07-12 2024-09-11 Boehringer Ingelheim International GmbH Alkoxy pyrazoles as soluble guanylate cyclase activators for use in treating portal hypertension
EP3911675A1 (en) 2019-01-17 2021-11-24 Bayer Aktiengesellschaft Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc)
MX2022004631A (es) * 2019-10-18 2022-05-24 Fmc Corp Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico.
CN112079712B (zh) * 2020-09-18 2022-12-13 江苏美迪克化学品有限公司 一种对乙烯基水杨酸的制备方法
EP4259617B1 (en) * 2020-12-10 2024-10-23 Bayer Aktiengesellschaft Substituted pyrazolo piperidine carboxylic acids
EP4011873A1 (en) 2020-12-10 2022-06-15 Bayer Aktiengesellschaft Substituted pyrazolo piperidine carboxylic acids
GB202102895D0 (en) 2021-03-01 2021-04-14 Cambridge Entpr Ltd Novel compounds, compositions and therapeutic uses thereof
CN118900690A (zh) 2022-03-21 2024-11-05 勃林格殷格翰国际有限公司 用于治疗门脉高压的可溶性鸟苷酸环化酶活化剂
EP4536205A1 (en) 2022-06-09 2025-04-16 Bayer Aktiengesellschaft Soluble guanylate cyclase activators for use in the treatment of heart failure with preserved ejection fraction in women
WO2024097316A1 (en) 2022-11-04 2024-05-10 Boehringer Ingelheim International Gmbh Soluble guanylate cyclase activators for treating systemic sclerosis
US20240199590A1 (en) * 2022-12-09 2024-06-20 Boehringer Ingelheim International Gmbh Solid forms of a sgc activator
WO2025036839A1 (en) 2023-08-16 2025-02-20 Boehringer Ingelheim International Gmbh Soluble guanylate cyclase activators for treating clinically significant portal hypertension and decompensated cirrhosis

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9824310D0 (en) * 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
WO2002026712A2 (en) 2000-09-29 2002-04-04 Millennium Pharmaceuticals, Inc. Quaternary amines and related inhibitors of factor xa
AU2002228819A1 (en) 2000-11-22 2002-06-03 Visx Incorporated Temperature actuated positioning device for non-linear optical elements
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
GB0212785D0 (en) 2002-05-31 2002-07-10 Glaxo Group Ltd Compounds
CN1747949A (zh) 2002-12-20 2006-03-15 法马西亚公司 无环吡唑化合物
BRPI0614001A2 (pt) 2005-07-18 2011-03-01 Bayer Healthcare Ag uso de ativadores e estimuladores de guanilato ciclase solúvel para a prevenção ou tratamento de distúrbios renais
US20080045560A1 (en) 2006-08-15 2008-02-21 Wyeth Pyrrolidine and related derivatives useful as PR modulators
WO2008138483A1 (en) * 2007-05-12 2008-11-20 Bayer Schering Pharma Aktiengesellschaft sGC STIMULATORS, sGC ACTIVATORS AND COMBINATIONS FOR THE TREATMENT OF UROLOGICAL DISORDERS
KR20100059952A (ko) * 2007-09-06 2010-06-04 머크 샤프 앤드 돔 코포레이션 가용성 구아닐레이트 사이클라제 활성제
CN101815514B (zh) * 2007-10-05 2012-05-09 塞诺菲-安万特德国有限公司 磺酰基取代的2-磺酰基氨基苯甲酸n-苯基酰胺在治疗疼痛中的应用
WO2009068652A1 (en) 2007-11-30 2009-06-04 Smithkline Beecham Corporation 2, 6-disubstituted pyridines and 2, 4-disubstituted pyrimidines as soluble guanylate cyclase activators
PE20091258A1 (es) * 2007-12-03 2009-09-12 Smithkline Beecham Corp Derivados de piridina como activadores de la guanilato ciclasa soluble
CN102056907B (zh) * 2008-04-04 2014-12-31 武田药品工业株式会社 杂环衍生物及其用途
WO2010015652A2 (en) 2008-08-07 2010-02-11 Smithkline Beecham Corporation Thiazole compounds as activators of soluble guanylate cyclase
WO2010015653A1 (en) * 2008-08-07 2010-02-11 Smithkline Beecham Corporation Pyrimidine derivatives as activators of soluble guanylate cyclase
AU2009322836B2 (en) 2008-11-25 2013-04-04 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
EP2387404B1 (en) * 2009-01-17 2014-06-25 Bayer Intellectual Property GmbH Sgc stimulators and activators in combination with pde5 inhbitors for the treatment of erectile dysfunction
CN102414194A (zh) 2009-02-26 2012-04-11 默沙东公司 可溶性鸟苷酸环化酶激活剂
WO2011095553A1 (en) 2010-02-05 2011-08-11 Bayer Schering Pharma Aktiengesellschaft Sgc stimulators or sgc activators in combination with pde5 inhbitors for the treatment of erectile dysfunction
SI2531187T1 (sl) * 2010-02-05 2016-01-29 Adverio Pharma Gmbh Stimulatorji sGC ali aktivatorji sGC sami in v kombinaciji z inhibitorji PDE5 za zdravljenje cistične fibroze
SI2576548T1 (sl) * 2010-05-26 2015-11-30 Adverio Pharma Gmbh Uporaba sGC stimulatorjev, sGC aktivatorjev, samih in v kombinacijah s PDE5 inhibitorji za zdravljenje sistemske skleroze
EP2687210A1 (de) 2010-06-25 2014-01-22 Bayer Intellectual Property GmbH Verwendung von Stimulatoren und Aktivatoren der löslichen Guanylatzyklase zur Behandlung von Sichelzellanämie und Konservierung von Blutersatzstoffen
EP2632551B1 (en) 2010-10-28 2016-07-06 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
JP5715713B2 (ja) 2011-03-10 2015-05-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 可溶性グアニル酸シクラーゼ活性化因子
JP5826393B2 (ja) 2011-08-12 2015-12-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 可溶性グアニル酸シクラーゼ活性化因子
EP2594270A3 (en) 2011-11-18 2013-07-31 BIP Patents The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc)
ES2748798T3 (es) * 2012-09-07 2020-03-18 Boehringer Ingelheim Int Alcoxi pirazoles como activadores de la guanilato ciclasa soluble

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