CL2015002802A1 - Composiciones y métodos para producir cetosis elevada y sostenida - Google Patents

Composiciones y métodos para producir cetosis elevada y sostenida

Info

Publication number
CL2015002802A1
CL2015002802A1 CL2015002802A CL2015002802A CL2015002802A1 CL 2015002802 A1 CL2015002802 A1 CL 2015002802A1 CL 2015002802 A CL2015002802 A CL 2015002802A CL 2015002802 A CL2015002802 A CL 2015002802A CL 2015002802 A1 CL2015002802 A1 CL 2015002802A1
Authority
CL
Chile
Prior art keywords
compositions
methods
produce high
ketosis
sustained ketosis
Prior art date
Application number
CL2015002802A
Other languages
English (en)
Inventor
Agostino Dominic Paul D
Patrick Arnold
Shannon Kesl
Original Assignee
Univ South Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51581503&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015002802(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ South Florida filed Critical Univ South Florida
Publication of CL2015002802A1 publication Critical patent/CL2015002802A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPOSICION FARMACEUTICA QUE COMPRENDE AL MENOS UN ACIDO GRASO DE CADENA MEDIA Y AL MENOS UN COMPUESTO DE HIDROXIBUTIRATO; USO PARA ESTIMULAR LA CETOSIS, SUPRIMIR EL APETITO Y ESTIMULAR LA PERDIDA DE PESO EN UN MAMIFERO.
CL2015002802A 2013-03-19 2015-09-17 Composiciones y métodos para producir cetosis elevada y sostenida CL2015002802A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361803203P 2013-03-19 2013-03-19
US201461926664P 2014-01-13 2014-01-13

Publications (1)

Publication Number Publication Date
CL2015002802A1 true CL2015002802A1 (es) 2016-05-06

Family

ID=51581503

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2015002802A CL2015002802A1 (es) 2013-03-19 2015-09-17 Composiciones y métodos para producir cetosis elevada y sostenida
CL2018000983A CL2018000983A1 (es) 2013-03-19 2018-04-17 Composiciones y métodos para producir cetosis elevada y sostenida (divisional de solicitud n°02802-2015).

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2018000983A CL2018000983A1 (es) 2013-03-19 2018-04-17 Composiciones y métodos para producir cetosis elevada y sostenida (divisional de solicitud n°02802-2015).

Country Status (20)

Country Link
US (4) US9138420B2 (es)
EP (1) EP2976073B1 (es)
JP (2) JP6491189B2 (es)
KR (2) KR102499654B1 (es)
CN (1) CN105050594B (es)
AU (2) AU2014236004B2 (es)
BR (1) BR112015024186B1 (es)
CA (1) CA2902603C (es)
CL (2) CL2015002802A1 (es)
CR (1) CR20150579A (es)
IL (2) IL241316B (es)
MX (2) MX371259B (es)
MY (1) MY180761A (es)
NZ (1) NZ711433A (es)
PE (1) PE20151949A1 (es)
PH (1) PH12015501966B1 (es)
RU (2) RU2018120938A (es)
SG (2) SG11201506780RA (es)
WO (1) WO2014153416A1 (es)
ZA (1) ZA201506387B (es)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1648952B1 (en) 2003-06-03 2018-03-07 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Nutritional supplements and therapeutic compositions comprising (r)-3-hydroxybutyrate derivatives
US8642654B2 (en) 2009-04-16 2014-02-04 Isis Innovation Limited Hydroxybutyrate ester and medical use thereof
EP2914251B1 (en) 2012-11-05 2019-08-21 The United States of America, as represented by The Secretary, Department of Health and Human Services Ketone bodies to protect tissues from damage by ionizing radiation
GB201304467D0 (en) 2013-03-12 2013-04-24 Tdeltas Ltd Compound for use in protecting skin
AU2014240467B2 (en) 2013-03-14 2018-11-29 University Of Florida Research Foundation, Incorporated Regulation of cancer using natural compounds and/or diet
SG11201507685UA (en) 2013-03-14 2015-10-29 Isis Innovation Process for producing (r)-3-hydroxybutyl (r)-3-hydroxybutyrate
GB201314127D0 (en) * 2013-08-07 2013-09-18 Tdeltas Ltd Ketone body and ketone body ester for reducing muscle breakdown
CA2944479C (en) * 2014-04-02 2023-02-21 University Of Southern California Dietary formulation and method for treating autoimmune and inflammatory diseases
US11020372B2 (en) 2015-03-24 2021-06-01 University Of Florida Research Foundation, Incorporated Dietary and natural product management of negative side effects of cancer treatment
KR20180014194A (ko) * 2015-06-26 2018-02-07 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 천연 화합물 및/또는 식단을 사용하는 염증의 치료 방법
US10987340B2 (en) 2015-07-24 2021-04-27 Jesse Alexander Galinski Composition and method for rapidly inducing an endogenous ketosis
US10973786B2 (en) 2016-03-11 2021-04-13 Axcess Global Sciences, Llc R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, and RS-beta-hydroxybutyrate mixed salt compositions
US10736861B2 (en) 2016-03-11 2020-08-11 Axcess Global Sciences, Llc Mixed salt compositions for producing elevated and sustained ketosis
US10973792B2 (en) 2019-02-13 2021-04-13 Axcess Global Sciences, Llc Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use
US10596130B2 (en) 2017-12-19 2020-03-24 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use
US11103470B2 (en) 2017-11-22 2021-08-31 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US10245243B1 (en) * 2017-12-19 2019-04-02 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use
US10596129B2 (en) 2017-11-22 2020-03-24 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US10245242B1 (en) * 2017-11-22 2019-04-02 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US11241403B2 (en) 2016-03-11 2022-02-08 Axcess Global Sciences, Llc Beta-hydroxybutyrate mixed salt compositions and methods of use
US10292952B2 (en) * 2016-03-11 2019-05-21 Axcess Global Sciences, Llc Mixed salt compositions for maintaining or restoring electrolyte balance while producing elevated and sustained ketosis
US10596131B2 (en) 2017-11-22 2020-03-24 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US11185518B2 (en) 2017-12-19 2021-11-30 Axcess Global Sciences, Llc S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer
US20170266147A1 (en) * 2016-03-18 2017-09-21 Csilla Ari D'Agostino Methods of increasing latency of anesthetic induction using ketone supplementation
WO2017165445A1 (en) * 2016-03-21 2017-09-28 Csilla Ari D'agostino Administration of exogenous ketone to lower blood glucose
WO2017165443A1 (en) * 2016-03-21 2017-09-28 Csilla Ari D'agostino Methods of improving motor function using ketone supplementation
US12208074B2 (en) 2016-04-03 2025-01-28 Franco Cavaleri Butyrate and beta-hydroxybutyrate compositions
US10376482B2 (en) 2016-04-03 2019-08-13 Franco Cavaleri Butyrate and beta-hydroxybutyrate compositions
US12599579B2 (en) 2016-04-19 2026-04-14 Axcess Global Sciences, Llc Compositions and compounds containing ketone bodies and/or ketone body precursors and one or more amino acids
EP3445358B1 (en) * 2016-04-19 2023-11-15 Keto Patent Group, Inc. Administration of dihydroberberine
CA3021784A1 (en) * 2016-04-19 2017-10-26 Keto Patent Group, Inc. Administration of butyrate, beta-hydroxybutyrate, and related compounds in humans
US11944598B2 (en) 2017-12-19 2024-04-02 Axcess Global Sciences, Llc Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer
US12329734B2 (en) 2017-12-19 2025-06-17 Axcess Global Sciences, Llc Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow
US11806324B2 (en) 2018-04-18 2023-11-07 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies
US11202769B2 (en) 2017-11-22 2021-12-21 Axcess Global Sciences, Llc Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function
US20230346721A1 (en) 2018-04-18 2023-11-02 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies
US12521378B2 (en) 2016-04-19 2026-01-13 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans
US12109182B2 (en) 2016-04-19 2024-10-08 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate and related compounds in humans
US12533346B2 (en) 2016-04-19 2026-01-27 Axcess Global Sciences, Llc Administration of berberine metabolites
US12496283B2 (en) 2016-04-19 2025-12-16 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate and related compounds in humans
US10925843B2 (en) 2018-04-18 2021-02-23 Axcess Global Sciences, Llc Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate
US11026929B2 (en) 2016-04-19 2021-06-08 Keto Patent Group, Inc. Administration of berberine metabolites
WO2017208217A2 (en) 2016-06-01 2017-12-07 Aspi Ip Holder Llc C5 ketone compositions, and related methods, for therapeutic and performance supplementation
US20220249419A1 (en) * 2016-06-01 2022-08-11 Keto Innovations, Llc C5 ketone compositions, and related methods, for therapeutic and performance supplementation
CN114292190B (zh) 2016-06-07 2025-04-11 J大卫格莱斯顿研究机构 丁二醇的中链脂肪酸酯，其组合物、口服制剂及其应用方法
US10588877B2 (en) 2016-07-21 2020-03-17 Savind, Inc. Compositions comprising β-hydroxybutyric acid and salt, and methods of using the same
JP6935994B2 (ja) * 2016-08-19 2021-09-15 株式会社明治 ケトン体生成促進用組成物
US20180057846A1 (en) * 2016-08-30 2018-03-01 KetoneAid Inc. Partially buffered free acid and/or ketone blend for rapid onset ketosis and metabolic therapy
WO2018052758A1 (en) * 2016-09-13 2018-03-22 Abbott Laboratories Ketogenic nutritional compositions
AU2017347778A1 (en) * 2016-10-24 2019-05-16 University Of South Florida Delaying latency to seizure by combinations of ketone supplements
US20180177753A1 (en) 2016-12-23 2018-06-28 Neuroenergy Ventures, Inc. Glyceryl 3-hydroxybutyrates for migraine symptom management
US9925164B1 (en) 2017-01-12 2018-03-27 Neuroenergy Ventures, Inc. Glyceryl 3-hydroxybutyrates for traumatic brain injury
AU2018230850B2 (en) * 2017-03-08 2023-12-14 Abbott Diabetes Care Inc. Systems, devices, and methods for wellness and nutrition monitoring and management using analyte data
JP6951421B2 (ja) * 2017-03-28 2021-10-20 ロンザ・ソリューションズ・アー・ゲー 水溶性抗菌組成物
US11249087B2 (en) 2017-04-06 2022-02-15 Meiji Co., Ltd. Device for monitoring effective state of ketogenic diet
JP6968624B2 (ja) * 2017-04-06 2021-11-17 株式会社明治 ケトン食摂取量の管理方法
EP3609484A4 (en) * 2017-04-12 2020-12-16 Cavaleri, Franco BUTYRATE AND BETA HYDROXYBUTYRATE COMPOSITIONS AND METHODS FOR THEIR USE
US12171735B2 (en) 2017-04-19 2024-12-24 Axcess Global Sciences, Llc Administration of butyrate, beta-hydroxybutyrate, cannabidiol, and related compounds in humans
CN107083406B (zh) * 2017-05-27 2021-02-02 浙江华睿生物技术有限公司 (r)-3-羟基丁酸的生产方法
GB201710229D0 (en) 2017-06-27 2017-08-09 Tdeltas Ltd Compounds for new use
MX2020000734A (es) 2017-07-21 2020-07-29 Buck Inst Res Aging Enantiómeros s de beta-hidroxibutirato y butanodiol, y métodos para usarlos.
CN109394745A (zh) * 2017-08-17 2019-03-01 博瑞生物医药（苏州）股份有限公司 一种包含左旋肉碱和β-羟基丁酸化合物的组合物
US11760963B2 (en) 2017-08-23 2023-09-19 KetoneAid Inc. Ketogenic beer and alcoholic beverage mixture containing non-racemic ethyl 3-hydroxybutyrate and/or 1,3 butanediol
GB201715654D0 (en) * 2017-09-27 2017-11-08 Tdeltas Ltd Method of treatment
US20190119705A1 (en) * 2017-10-20 2019-04-25 KetoneAid Inc. Substantially non-racemic ketone ester of beta hydroxybutyrate and production process thereof
US12090129B2 (en) 2017-11-22 2024-09-17 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
EP3723511A4 (en) * 2017-12-12 2021-11-10 University of South Florida COMPOSITIONS AND METHODS FOR MAINTAINING WEIGHT LOSS
JP2021509686A (ja) * 2018-01-05 2021-04-01 テキサス・テック・ユニバーシティー・オフィス・オブ・リサーチ・コマーシャライゼーション 間欠性絶食に関連するβ−ヒドロキシ−β−メチルブチレート（ＨＭＢ）の組成物およびその使用法
WO2019147503A1 (en) 2018-01-25 2019-08-01 Buck Institute For Research On Aging Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds
AU2019215105B2 (en) * 2018-02-01 2024-12-19 Pharma Cinq, Llc Compositions and devices for systemic delivery of uridine
US10512615B1 (en) 2018-08-27 2019-12-24 Axcess Global Sciences, Llc Compositions and methods for delivering cannabidiol and ketone bodies
US11241401B2 (en) * 2020-02-06 2022-02-08 Axcess Global Sciences, Llc Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions
US11419836B2 (en) 2019-02-13 2022-08-23 Axcess Global Sciences, Llc Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions
US11129802B2 (en) 2018-08-27 2021-09-28 Axcess Global Sciences, Llc Compositions and methods for delivering cannabidiol and ketone bodies
US20200061023A1 (en) * 2018-08-27 2020-02-27 Axcess Global Sciences, Llc Compositions and methods for delivering tetrahydrocannabinol and ketone bodies
US10980772B2 (en) 2018-08-27 2021-04-20 Axcess Global Sciences, Llc Compositions and methods for delivering tetrahydrocannabinol and ketone bodies
US11484542B2 (en) 2018-05-30 2022-11-01 Adam Slank Specialized tongue spray containing gymnemic acid and exogenous ketones
ES2992080T3 (es) * 2018-06-07 2024-12-09 Nestle Sa Métodos y composiciones para incrementar los cuerpos cetónicos en animales
CA3022995C (en) 2018-06-12 2019-10-15 Ketofibe (9211-3133 Quebec Inc.) Novel ketogenic compounds, compositions, methods and use thereof
BR112020023132A2 (pt) 2018-06-21 2021-02-09 Société des Produits Nestlé S.A. composições e métodos que usam um precursor de nicotinamida adenina dinucleotídeo (nad+) e pelo menos uma cetona ou um precursor de cetona
CA3110724A1 (en) 2018-08-27 2020-03-05 Exerkine Corporation Method for treating lysosomal storage disease
US20200068939A1 (en) * 2018-09-04 2020-03-05 Jho Intellectual Property Holdings Llc Nutritional compositions to increase and sustain blood ketone levels
KR102833111B1 (ko) 2018-09-25 2025-07-10 폰세 드 리온 헬스 데지그네이티드 액티비티 컴퍼니 칼슘 알파-케토글루타레이트의 제조 방법
GB2577723A (en) 2018-10-04 2020-04-08 Tdeltas Ltd Compounds for new use
JP2022504250A (ja) * 2018-10-05 2022-01-13 アンパサンド バイオファーマシューティカルズ インコーポレイテッド ケトンの経皮投与のための製剤および方法
WO2020092451A1 (en) * 2018-10-29 2020-05-07 Keto Patent Group, Inc. Administration of butyrate, bete-hydroxybutyrate, cannabidiol, and related compounds in humans
CN109480284A (zh) * 2018-12-05 2019-03-19 上海欣海生物科技有限公司 一种生酮食品及其制备方法
CN119285469A (zh) 2018-12-18 2025-01-10 雀巢产品有限公司 混合的甘油三酯
CN109734575A (zh) * 2019-01-04 2019-05-10 上海欣海国际贸易有限公司 一种制备3-羟基丁酸氨基酸盐复合物的方法
CA3129411A1 (en) * 2019-02-11 2020-08-20 Axcess Global Sciences, Llc Beta-hydroxybutyrate mixed salt-acid compositions and methods of use
CA3129751A1 (en) * 2019-02-11 2020-08-20 Axcess Global Sciences, Llc S-beta-hydroxybutyrate compounds and compositions enriched with s-enantiomer
JP7448555B2 (ja) * 2019-02-11 2024-03-12 アクセス・グローバル・サイエンシーズ・エルエルシー ラセミベータ－ヒドロキシブチレート混合塩－酸組成物および使用方法
EP3934630A4 (en) * 2019-03-04 2022-11-23 Cerecin Inc. MEDIUM CHAIN TRIGLYCERIDE FORMULATIONS WITH IMPROVED BIOAVAILABILITY AND RELATED METHODS
JP7281927B2 (ja) * 2019-03-14 2023-05-26 大阪瓦斯株式会社 心拍数低減剤
WO2020186154A1 (en) * 2019-03-14 2020-09-17 The Regents Of The University Of California Methods and compositions for supporting renal health
BR112021015861A2 (pt) * 2019-03-22 2021-10-05 Société des Produits Nestlé S.A. Métodos que usam administração de triglicerídeos de cadeia média (tcm) antes de uma refeição para aumentar a produção de cetonas a partir dos tcms
AU2020247196B2 (en) 2019-03-22 2025-11-13 Société des Produits Nestlé S.A. Methods using medium chain triglycerides administered prior to a meal to decrease postprandial glucose from the meal
US12472200B2 (en) 2019-05-15 2025-11-18 Axcess Global Sciences, Llc Autobiotic compositions and method for promoting healthy gut microbiome
EP4656238A3 (de) * 2019-06-12 2026-02-25 KetoLipix Therapeutics GmbH Verfahren zur herstellung von acylverkappten 3-hydroxycarbonsäuren sowie deren salzen und estern
CN114008014B (zh) * 2019-06-12 2024-03-22 凯托利皮克斯治疗有限责任公司 用于生产酰基封端的3-羟基羧酸的多元醇基酯的方法
US12167993B2 (en) 2019-06-21 2024-12-17 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
US11969430B1 (en) 2023-03-10 2024-04-30 Axcess Global Sciences, Llc Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance
US11033553B2 (en) 2019-06-21 2021-06-15 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
US11950616B2 (en) 2019-06-21 2024-04-09 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
US11915605B2 (en) 2019-10-17 2024-02-27 Nicolas Tzenios Ketogenic diet recommendation to a user based on a blood low-density lipoprotein (LDL) level and a blood C-reactive protein level and/or a blood erythrocyte sedimentation rate (ESR) thereof
WO2021150928A1 (en) * 2020-01-23 2021-07-29 University Of South Florida Prevention and treatment of effects of aging and age-associated disorders with ketone supplementation
WO2021178547A1 (en) 2020-03-05 2021-09-10 Devon Price COMPOSITION OF (D)-β-HYDROXYBUTYRIC ACID, (D)-β-HYDROXYVALERIC ACID, AND (D)-1,3 BUTANEDIOL AS A NUTRITIONAL SUPPLEMENT AND THERAPEUTIC AGENT
WO2021195477A1 (en) 2020-03-27 2021-09-30 Ketoneaid, Inc. Ketone ester as a therapeutic treatment of covid-19, long covid, and related viral infections
JP2023529504A (ja) * 2020-06-14 2023-07-10 エル－ニュートラ・インコーポレイテッド ファスティング状態を維持及び延長する断続的なファスティングバー／ドリンク
CA3188646A1 (en) * 2020-07-02 2022-01-06 Ponce De Leon Health Designated Activity Company Compositions and methods for treating crp-mediated diseases
US12186297B2 (en) 2020-08-26 2025-01-07 Axcess Global Sciences, Llc Compositions and methods for increasing lean-to-fat mass ratio
CN112137115A (zh) * 2020-09-25 2020-12-29 深圳市捷利康生物科技有限公司 具有增强免疫力功效的生酮营养粉及其制备方法
US20240180891A1 (en) * 2020-12-22 2024-06-06 Buck Institute For Research On Aging Synergistic modulators of alpha-dicarbonyl detoxification and their use for inducing weight loss and the treatment of diabetic pathologies
CA3159213A1 (en) * 2021-04-16 2022-10-16 Nanjing Nutrabuilding Bio-Tech Co., Ltd. Low-lead and low-arsenic beta-hydroxybutyrate salts and methods for producing the same
WO2022232106A1 (en) * 2021-04-26 2022-11-03 University Of South Florida Methods for treating symptoms of kabuki syndrome
RU2769242C1 (ru) * 2021-06-16 2022-03-29 Александр Владимирович Чемоданов Кетогенная композиция
CA3223325A1 (en) 2021-06-28 2023-01-05 Roberto Vianna Nonato Methods to produce therapeutic formulations comprising hydroxybutirate and hydroxyvalerate, therapeutic formulations and uses thereof
AU2022345781A1 (en) 2021-09-15 2024-03-07 Lingo Sensing Technology Unlimited Company Systems, devices, and methods for applications for communication with ketone sensors
AU2022417093A1 (en) * 2021-12-14 2024-06-13 Suntory Holdings Limited Beverage containing 3-hydroxybutyric acid and lower aliphatic alcohol, and method for improving taste
CN118541034A (zh) * 2021-12-14 2024-08-23 三得利控股株式会社 碳酸饮料及增强碳酸饮料的碳酸感的方法
CN114306308A (zh) * 2021-12-24 2022-04-12 苏州麦轮生物科技有限公司 一种含有酮酯的营养补充剂及其应用
WO2023139357A1 (en) * 2022-01-18 2023-07-27 Today Inc. Molecules, nutritional formulations, and methods of providing nutritional support
US12023382B2 (en) 2022-01-18 2024-07-02 Today Inc. Molecules, formulations, and methods for nutritional support of athletes, patients, and others
JP7223193B1 (ja) 2022-05-26 2023-02-15 大阪瓦斯株式会社 内臓脂肪低減剤およびその用途
CN115192603B (zh) * 2022-07-06 2023-04-21 西北农林科技大学 锂盐在制备防治奶牛酮病制剂中的应用
CN115251375A (zh) * 2022-07-11 2022-11-01 珠海麦得发生物科技股份有限公司 一种(r)-3-羟基丁酸生酮产品及其制备方法
US12059398B2 (en) 2022-08-26 2024-08-13 Health Via Modern Nutrition Inc. Compositions of 1,3-butanediol and beta-hydroxybutyric acid to provide optimal therapeutic ketosis
AU2024336654A1 (en) 2023-09-05 2026-04-16 The Regents Of The University Of California Enzymes for oxidizing beta-hydroxybutyrate (bhb), test strips, and sensors of using the same
WO2026037224A1 (zh) * 2024-08-14 2026-02-19 南京纽邦生物科技有限公司 提高或维持酮体水平、改善代谢功能的方法和组合物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8803141L (sv) * 1988-09-07 1990-03-08 Kabivitrum Ab Naeringsmedel foer maenniskor och djur
US5654266A (en) * 1992-02-10 1997-08-05 Chen; Chung-Ho Composition for tissues to sustain viability and biological functions in surgery and storage
US6316038B1 (en) 1997-03-17 2001-11-13 Btg International Limited Therapeutic compositions
US6323237B1 (en) 1997-03-17 2001-11-27 Btg International Limited Therapeutic compositions
CA2283642C (en) * 1997-03-17 2012-05-15 Btg International Limited Therapeutic compositions
US20090253781A1 (en) 2002-05-24 2009-10-08 Btg International Limited Therapeutic compositions
JPH1160434A (ja) 1997-08-12 1999-03-02 Kanebo Ltd 皮膚老化防止化粧料
US6380244B2 (en) 1998-07-22 2002-04-30 Metabolix, Inc. Nutritional and therapeutic uses of 3-hydroxyalkanoate oligomers
WO2000015216A1 (en) 1998-09-15 2000-03-23 Btg International Limited Therapeutic compositions (ii)
TWI249401B (en) * 1999-04-14 2006-02-21 Takeda Chemical Industries Ltd Agent for improving ketosis
US8124589B2 (en) * 2000-05-01 2012-02-28 Accera, Inc. Use of ketogenic compounds for treatment of age-associated memory impairment
US20020006959A1 (en) 2000-05-01 2002-01-17 Henderson Samuel T. Use of medium chain triglycerides for the treatment and prevention of Alzheimer's Disease and other diseases resulting from reduced Neuronal Metabolism
US6613356B1 (en) 2000-10-10 2003-09-02 Victor Vlahakos Weight loss medication and method
US20050129783A1 (en) * 2001-04-19 2005-06-16 Mccleary Edward L. Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health
US8158184B2 (en) * 2004-03-08 2012-04-17 Bunge Oils, Inc. Structured lipid containing compositions and methods with health and nutrition promoting characteristics
GB0410266D0 (en) * 2004-05-07 2004-06-09 Ketocytonyx Inc Treatment of apoptosis
GB0420856D0 (en) 2004-09-20 2004-10-20 Ketocytonyx Inc Cns modulators
EP1915144A4 (en) * 2005-06-20 2009-08-19 Accera Inc METHOD FOR REDUCING OXIDATIVE DAMAGE AND IMPROVING MITOCHONDRIA EFFICIENCY
US7807718B2 (en) 2006-06-30 2010-10-05 Sami A. Hashim Glyceride esters for the treatment of diseases associated with reduced neuronal metabolism of glucose
BRPI0811052A2 (pt) * 2007-04-12 2015-01-27 Univ Minnesota Composições de proteção de isquemia/reperfusão e métodos de uso.
DK2240017T3 (da) * 2008-01-04 2019-06-17 Univ Oxford Innovation Ltd Ketonlegemer og ketonlegemsestere som blodlipid-sænkende midler
GB201002983D0 (en) * 2010-02-22 2010-04-07 Tdeltas Ltd Nutritinal composition
GB201206192D0 (en) 2012-04-05 2012-05-23 Tdeltas Ltd Ketone bodies and ketone body esters and for maintaining or improving muscle power output

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