CL2016000508A1 - Compuestos derivados de (2-metil-3-fenilfenil)metoxi sustituidos, inhibidores de la interacción pd-1/proteína pd-l1/proteína; composición farmacéutica que los comprende; y su uso para tratar una enfermedad infecciosa o cáncer. - Google Patents
Compuestos derivados de (2-metil-3-fenilfenil)metoxi sustituidos, inhibidores de la interacción pd-1/proteína pd-l1/proteína; composición farmacéutica que los comprende; y su uso para tratar una enfermedad infecciosa o cáncer.Info
- Publication number
- CL2016000508A1 CL2016000508A1 CL2016000508A CL2016000508A CL2016000508A1 CL 2016000508 A1 CL2016000508 A1 CL 2016000508A1 CL 2016000508 A CL2016000508 A CL 2016000508A CL 2016000508 A CL2016000508 A CL 2016000508A CL 2016000508 A1 CL2016000508 A1 CL 2016000508A1
- Authority
- CL
- Chile
- Prior art keywords
- protein
- cancer
- treat
- substituted
- methyl
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 2
- 108090000623 proteins and genes Proteins 0.000 title 2
- -1 (2-methyl-3-phenylphenyl) methoxy Chemical group 0.000 title 1
- 208000035473 Communicable disease Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000003993 interaction Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/396—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having three-membered rings, e.g. aziridine
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- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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- C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
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- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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Abstract
COMPUESTOS DERIVADOS DE (2-METIL-3-FENILFENIL)METOXI SUSTITUIDOS, INHIBIDORES DE LA INTERACCIÓN PROTEÍNA/PROTEÍNA PD-1/PD-L1, LAS COMPOSICIONES FARMACÉUTICAS QUE LOS COMPRENDEN Y SU USO PARA TRATAR, PREVENIR O DISMINUIR EL PROGRESO DE UNA ENFERMEDAD O TRASTORNO VIROLÓGICO O CÁNCER.
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| US201361873398P | 2013-09-04 | 2013-09-04 |
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| CL2016000508A1 true CL2016000508A1 (es) | 2016-11-04 |
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| CL2016000508A CL2016000508A1 (es) | 2013-09-04 | 2016-03-04 | Compuestos derivados de (2-metil-3-fenilfenil)metoxi sustituidos, inhibidores de la interacción pd-1/proteína pd-l1/proteína; composición farmacéutica que los comprende; y su uso para tratar una enfermedad infecciosa o cáncer. |
| CL2018000150A CL2018000150A1 (es) | 2013-09-04 | 2018-01-18 | Compuestos útiles como inmunomoduladores (divisional de solicitud 201600508) |
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| Application Number | Title | Priority Date | Filing Date |
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| CL2018000150A CL2018000150A1 (es) | 2013-09-04 | 2018-01-18 | Compuestos útiles como inmunomoduladores (divisional de solicitud 201600508) |
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| EP (1) | EP3041822B1 (es) |
| JP (1) | JP6417419B2 (es) |
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| BR (1) | BR112016004194A8 (es) |
| CA (1) | CA2923184A1 (es) |
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| EP2928474B1 (en) | 2012-12-07 | 2018-11-14 | ChemoCentryx, Inc. | Diazole lactams |
| US9850225B2 (en) * | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| DK3297438T3 (da) | 2015-05-21 | 2022-01-17 | Chemocentryx Inc | Ccr2-modulatorer |
| CN107709314A (zh) | 2015-06-11 | 2018-02-16 | 巴斯利尔药物国际股份公司 | 外排泵抑制剂及其治疗性用途 |
| US10745382B2 (en) * | 2015-10-15 | 2020-08-18 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| WO2017070089A1 (en) | 2015-10-19 | 2017-04-27 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| SG10202004618TA (en) * | 2015-11-19 | 2020-06-29 | Incyte Corp | Heterocyclic compounds as immunomodulators |
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| US9850225B2 (en) | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| US10745382B2 (en) | 2015-10-15 | 2020-08-18 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
-
2014
- 2014-09-02 CN CN201480060895.6A patent/CN105705489B/zh not_active Expired - Fee Related
- 2014-09-02 EP EP14766086.4A patent/EP3041822B1/en not_active Not-in-force
- 2014-09-02 US US14/915,782 patent/US9872852B2/en active Active
- 2014-09-02 WO PCT/US2014/053695 patent/WO2015034820A1/en not_active Ceased
- 2014-09-02 ES ES14766086.4T patent/ES2642074T3/es active Active
- 2014-09-02 EA EA201690316A patent/EA029901B1/ru not_active IP Right Cessation
- 2014-09-02 BR BR112016004194A patent/BR112016004194A8/pt not_active Application Discontinuation
- 2014-09-02 SG SG11201601225RA patent/SG11201601225RA/en unknown
- 2014-09-02 AU AU2014315457A patent/AU2014315457B2/en not_active Ceased
- 2014-09-02 KR KR1020167008405A patent/KR102276644B1/ko not_active Expired - Fee Related
- 2014-09-02 MX MX2016002544A patent/MX2016002544A/es unknown
- 2014-09-02 JP JP2016540311A patent/JP6417419B2/ja not_active Expired - Fee Related
- 2014-09-02 PE PE2016000338A patent/PE20160432A1/es not_active Application Discontinuation
- 2014-09-02 CA CA2923184A patent/CA2923184A1/en not_active Abandoned
-
2016
- 2016-02-29 IL IL24434616A patent/IL244346B/en not_active IP Right Cessation
- 2016-03-04 CL CL2016000508A patent/CL2016000508A1/es unknown
-
2018
- 2018-01-18 CL CL2018000150A patent/CL2018000150A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014315457B2 (en) | 2018-05-10 |
| CN105705489A (zh) | 2016-06-22 |
| IL244346B (en) | 2019-10-31 |
| JP6417419B2 (ja) | 2018-11-07 |
| WO2015034820A1 (en) | 2015-03-12 |
| US9872852B2 (en) | 2018-01-23 |
| SG11201601225RA (en) | 2016-03-30 |
| EP3041822A1 (en) | 2016-07-13 |
| AU2014315457A1 (en) | 2016-04-28 |
| CL2018000150A1 (es) | 2018-05-11 |
| MX2016002544A (es) | 2016-06-17 |
| KR20160048946A (ko) | 2016-05-04 |
| HK1223366A1 (en) | 2017-07-28 |
| EA201690316A1 (ru) | 2016-07-29 |
| KR102276644B1 (ko) | 2021-07-13 |
| EP3041822B1 (en) | 2017-08-09 |
| ES2642074T3 (es) | 2017-11-15 |
| CN105705489B (zh) | 2019-04-26 |
| IL244346A0 (en) | 2016-04-21 |
| CA2923184A1 (en) | 2015-03-12 |
| PE20160432A1 (es) | 2016-05-11 |
| US20160194307A1 (en) | 2016-07-07 |
| JP2016536333A (ja) | 2016-11-24 |
| EA029901B1 (ru) | 2018-05-31 |
| BR112016004194A8 (pt) | 2020-02-11 |
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