CL2016000507A1 - Hidrogel que comprende los grupos 1, 2-diol o 1, 3-diol acetilados con una especie radiopaca; composición que comprende un hidrogel; método para realizar un polímero radiopaco; método para formar una microesfera de hidrogel radiopaca; y uso de hidrogel o composición. - Google Patents

Hidrogel que comprende los grupos 1, 2-diol o 1, 3-diol acetilados con una especie radiopaca; composición que comprende un hidrogel; método para realizar un polímero radiopaco; método para formar una microesfera de hidrogel radiopaca; y uso de hidrogel o composición.

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Publication number
CL2016000507A1
CL2016000507A1 CL2016000507A CL2016000507A CL2016000507A1 CL 2016000507 A1 CL2016000507 A1 CL 2016000507A1 CL 2016000507 A CL2016000507 A CL 2016000507A CL 2016000507 A CL2016000507 A CL 2016000507A CL 2016000507 A1 CL2016000507 A1 CL 2016000507A1
Authority
CL
Chile
Prior art keywords
hydrogel
radiopaque
composition
diol
making
Prior art date
Application number
CL2016000507A
Other languages
English (en)
Inventor
Stéphane Hohn
Andrew Lennard Lewis
Sean Leo Willis
Matthew R Dreher
Yiqing Tang
Koorosh Ashrafi
Original Assignee
Biocompatible Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatible Uk Ltd filed Critical Biocompatible Uk Ltd
Publication of CL2016000507A1 publication Critical patent/CL2016000507A1/es

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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
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Abstract

En esta solicitud se propone hidrogel que comprende los grupos 1,2-diol a 1,3-diol acetilados con una especie radiopaca; composición que comprende un hidrogel; método para realizar un polímero radiopaco; método para formar una microesfera de hidrogel radiopaca; y uso de un hidrogel.
CL2016000507A 2013-09-06 2016-03-04 Hidrogel que comprende los grupos 1, 2-diol o 1, 3-diol acetilados con una especie radiopaca; composición que comprende un hidrogel; método para realizar un polímero radiopaco; método para formar una microesfera de hidrogel radiopaca; y uso de hidrogel o composición. CL2016000507A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1315923.1A GB2521997A (en) 2013-09-06 2013-09-06 Radiopaque polymers

Publications (1)

Publication Number Publication Date
CL2016000507A1 true CL2016000507A1 (es) 2016-10-21

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ID=49486860

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016000507A CL2016000507A1 (es) 2013-09-06 2016-03-04 Hidrogel que comprende los grupos 1, 2-diol o 1, 3-diol acetilados con una especie radiopaca; composición que comprende un hidrogel; método para realizar un polímero radiopaco; método para formar una microesfera de hidrogel radiopaca; y uso de hidrogel o composición.

Country Status (19)

Country Link
US (4) US10350295B2 (es)
EP (2) EP3041515B1 (es)
JP (3) JP6606078B2 (es)
KR (2) KR102193612B1 (es)
CN (3) CN105517581B (es)
AU (3) AU2014316839B2 (es)
BR (1) BR112016004806A8 (es)
CA (1) CA2922964C (es)
CL (1) CL2016000507A1 (es)
GB (1) GB2521997A (es)
HK (1) HK1223276A1 (es)
IL (1) IL244269B (es)
MX (1) MX2016002973A (es)
MY (1) MY181356A (es)
PH (1) PH12016500279A1 (es)
RU (1) RU2016109543A (es)
SG (2) SG11201601315PA (es)
WO (1) WO2015033093A1 (es)
ZA (1) ZA201602110B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2803370B1 (en) 2009-10-06 2019-02-27 Regents of the University of Minnesota Bioresorbable embolization microspheres
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
GB2521997A (en) * 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
EP3660061B1 (en) 2015-01-12 2023-06-21 Biosphere Medical, Inc. Radiopaque monomers, polymers, microspheres, and methods related thereto
GB201515602D0 (en) 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
US10182979B2 (en) 2016-03-22 2019-01-22 Regents Of The University Of Minnesota Biodegradable microspheres
EP3541368B1 (en) 2016-11-16 2023-07-12 The United States of America, as represented by the Secretary, Department of Health and Human Services Imageable particles, methods of making and methods of use thereof
JP2020063191A (ja) * 2017-02-20 2020-04-23 国立大学法人東京工業大学 薬物送達用担体及び薬物送達システム
GB2566091B (en) * 2017-09-04 2023-03-29 Univ Limerick Formulation for 3D printing and a 3D printed article
EP3755308B1 (en) 2018-02-23 2022-02-16 van Rijn Beheer B.V. Porous embolization microspheres comprising drugs
GB201810784D0 (en) * 2018-06-29 2018-08-15 Biocompatibles Uk Ltd Radiopaque polymers
US11702498B2 (en) * 2018-06-29 2023-07-18 Biocompatibles Uk Limited Radiopaque polymers
GB201810788D0 (en) 2018-06-29 2018-08-15 Biocompatibles Uk Ltd Biodegradable polymer
CN108785691A (zh) * 2018-07-06 2018-11-13 中南大学湘雅二医院 一种对微小病灶进行定位检测的人造结节及定位方法
CA3310035A1 (en) 2018-09-20 2026-06-21 Reva Medical, Llc Porous bioresorbable radiopaque embolic microspheres for drug delivery
CN109289081B (zh) * 2018-09-30 2021-01-19 华中科技大学鄂州工业技术研究院 一种抗粘连的聚乙烯醇栓塞微球及其制备方法和应用
CN113348001B (zh) * 2018-11-13 2022-10-21 上海盛迪医药有限公司 一种聚合物及其组合物
EP3937989A1 (en) 2019-03-11 2022-01-19 Biocompatibles UK Limited Radioactive microshperes for the treatment of cns tumours
EP3941437A1 (en) * 2019-03-22 2022-01-26 Biocompatibles UK Limited Embolic microspheres and methods
GB201910286D0 (en) * 2019-07-18 2019-09-04 Biocompatibles Uk Ltd Radiopaque polymers
CN110372484B (zh) * 2019-07-23 2020-05-22 赵修文 一种不透射线的聚乙烯醇微球
WO2021050474A1 (en) * 2019-09-12 2021-03-18 Endoshape, Inc. Radiopaque polymers for medical devices
EP4121130A4 (en) * 2020-03-17 2024-03-27 MicroVention, Inc. LIQUID EMBOLIZATION AGENTS
CA3191526A1 (en) * 2020-09-04 2022-03-10 Suresh S. Pai Liquid embolic compositions with controlled release of radiopaque and therapeutic compounds and methods of using the same
CN114057600B (zh) * 2021-12-02 2024-02-02 上海汇禾医疗科技股份有限公司 一种可x射线显影分子、载药栓塞微球及其制备方法
JP2025501572A (ja) 2021-12-23 2025-01-22 ボストン サイエンティフィック メディカル デバイス リミテッド 化学塞栓用組成物とそれを使用する治療方法
CN114146190B (zh) * 2021-12-30 2024-01-26 科睿驰（深圳）医疗科技发展有限公司 一种高悬浮性显影微球及其制备方法
CN114262279B (zh) * 2021-12-30 2022-12-16 上海汇禾医疗科技有限公司 一种x射线可显影分子、栓塞微球及其制备方法
CN115487342B (zh) * 2022-08-17 2023-11-24 海南百迈科医疗科技股份有限公司 一种自显影可吸收栓塞微球及其制备方法
CN116256442A (zh) * 2022-09-26 2023-06-13 科睿驰（深圳）医疗科技发展有限公司 一种聚乙烯醇栓塞微球中含碘化合物的检测方法
CN118286496A (zh) * 2023-01-05 2024-07-05 上海拓脉医疗科技有限公司 栓塞微球的制备方法
US20250049964A1 (en) * 2023-08-08 2025-02-13 Boston Scientific Scimed, Inc. Injectable shear-thinning and self-assembling hydrogels
CN117323459B (zh) * 2023-09-25 2024-10-18 至微(深圳)医学科技有限公司 一种可显影栓塞微球及其制备方法与应用

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2860986A (en) 1956-08-31 1958-11-18 Eastman Kodak Co Partially acetalized polyvinyl alcohol containing active halogen
US3631225A (en) * 1970-04-28 1971-12-28 Union Carbide Corp Preparation of polyvinyl acetals
US3840482A (en) 1971-09-13 1974-10-08 Ici Australia Ltd Process for curing poly(vinyl alcohol)matrix beads
US4406878A (en) * 1978-08-02 1983-09-27 Eastman Kodak Company Iodinated contrast agent for radiography
US4306031A (en) 1979-08-14 1981-12-15 Mitsubishi Chemical Industries Limited Weakly acidic cation exchange resin and process for producing same
JPS5649734A (en) * 1979-09-29 1981-05-06 Nitto Electric Ind Co Ltd Crosslinking of polyvinyl alcohol type polymer
US5011797A (en) 1988-01-29 1991-04-30 The Curators Of The University Of Missouri Composition and method for radiation synovectomy of arthritic joints
EP0391741B1 (en) * 1989-04-06 1995-04-19 Merocel Corporation Polymeric broad-spectrum antimicrobial materials
JP2981566B2 (ja) * 1989-08-03 1999-11-22 三菱化学株式会社 熱転写記録用受像体
US5082909A (en) * 1990-10-12 1992-01-21 Hercules Incorporated Pure tungsten oxyphenolate complexes as DCPD polymerization catalysts
JP3227190B2 (ja) * 1990-12-26 2001-11-12 キヤノン株式会社 電子写真感光体、それを用いた電子写真装置および装置ユニット
CA2110590A1 (en) 1991-06-03 1992-12-10 Jo Klaveness Improvements in or relating to contrast agents
JPH0656676A (ja) 1992-08-05 1994-03-01 Hori Shinichi 血管塞栓用懸濁液
US5330739A (en) * 1992-12-04 1994-07-19 Sterling Winthrop Inc. Iodinated benzoyl acetals and ketals for x-ray imaging
TW272976B (es) 1993-08-06 1996-03-21 Ciba Geigy Ag
US5885547A (en) 1994-01-21 1999-03-23 Paragon Medical Ltd. Particulate material
AU4438696A (en) * 1995-02-03 1996-08-21 Novartis Ag Crosslinked polymers
TW360671B (en) 1995-02-03 1999-06-11 Novartis Ag Process for producing mold body and the cross-linkable polymer used therein
US6433056B1 (en) * 1997-10-17 2002-08-13 Hercules Incorporated Fluidized polymer suspension of hydrophobically modified poly(acetal- or ketal-polyether) polyurethane and polyacrylate
WO2000029034A1 (en) 1998-11-12 2000-05-25 Nycomed Amersham Plc Products and methods
US6255033B1 (en) * 1999-07-30 2001-07-03 Creo, Ltd. Positive acting photoresist compositions and imageable element
JP2003516810A (ja) * 1999-11-15 2003-05-20 バイオキュア・インコーポレーテッド 分解性ポリ（ビニルアルコール）ヒドロゲル
ATE327262T1 (de) 2000-03-13 2006-06-15 Biocure Inc Zusammensetzungen zur erhöhung des gewebevolumens und beschichtungszusammensetzungen
US6652883B2 (en) * 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
WO2001068720A1 (en) 2000-03-13 2001-09-20 Biocure, Inc. Embolic compositions
EP1180698A1 (en) * 2000-08-08 2002-02-20 THOMSON multimedia Lens sheet for a display device
US6911219B2 (en) * 2001-09-27 2005-06-28 Surgica Corporation Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
EP1490120B1 (en) 2002-03-29 2009-11-11 Boston Scientific Limited Embolization
DE10223338B4 (de) * 2002-05-25 2005-06-16 Forschungszentrum Karlsruhe Gmbh Technik Und Umwelt Polymere mit Halogenfunktionen und Verfahren zu deren Herstellung und deren Verwendung
US8012454B2 (en) * 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
CN103393605B (zh) 2003-02-12 2018-05-29 生物相容英国有限公司 用于实体瘤的化学栓塞治疗的组合物
EP1729822B1 (en) 2004-03-05 2014-05-07 XL Sci-Tech, Inc. Particulate materials and compositions for radio therapy
US7201918B2 (en) 2004-11-16 2007-04-10 Microvention, Inc. Compositions, systems and methods for treatment of defects in blood vessels
CN101237857A (zh) 2005-05-09 2008-08-06 生物领域医疗公司 使用微球和非离子型造影剂的组合物和方法
JP3984277B2 (ja) * 2005-11-21 2007-10-03 日東電工株式会社 ナフチル基を有する重合体を含有する光学フィルム
EP1810698A1 (en) * 2006-01-24 2007-07-25 Biocompatibles UK Limited Process for producing radiopaque embolic microspheres
WO2007098041A1 (en) * 2006-02-17 2007-08-30 Medtronic, Inc. Polyketal polymers, and methods of making and using same
WO2008051291A2 (en) 2006-04-11 2008-05-02 Ordway Research Institute Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof
EP2034951B2 (en) 2006-06-22 2020-03-25 Biocompatibles UK Limited Rehydratable pharmaceutical product
WO2008039827A2 (en) 2006-09-26 2008-04-03 Aeris Therapeutics, Inc. Polymer systems for lung volume reduction therapy
JP2010526914A (ja) 2007-05-11 2010-08-05 エアリス セラピューティクス エルエルシー 架橋した非天然ポリマーを用いる肺容量減少療法
EP1992371A1 (de) 2007-05-15 2008-11-19 Occlutech GmbH Bioresorbierbare röntgenopake Polymermaterialien und daraus hergestellte Occlussionsinstrumente
RU2010102865A (ru) * 2007-07-24 2011-08-27 НексБио, Инк. (US) Технология изготовления микрочастиц
CA2695008A1 (en) * 2007-07-30 2009-02-05 Auspex Pharmaceuticals, Inc. Substituted indoles
EP2090592A1 (en) 2007-07-31 2009-08-19 OctoPlus Sciences B.V. Biodegradable hydrogels based on click chemistry
CN101810587B (zh) * 2007-08-10 2012-05-23 苏州迦俐生生物医药科技有限公司 微球型栓塞剂的制备工艺
CN101125225A (zh) * 2007-08-10 2008-02-20 苏州迦俐生生物医药科技有限公司 微球型栓塞剂及其制备工艺
US20090092675A1 (en) * 2007-10-05 2009-04-09 Boston Scientific Scimed, Inc. Compositions containing multiple polymers and particles made using the compositions
GB0725070D0 (en) * 2007-12-21 2008-01-30 Iopharma Technologies Ab Product
US20090169471A1 (en) 2007-12-28 2009-07-02 Boston Scientific Scimed, Inc. Particles for injection and processes for forming the same
US20090269390A1 (en) 2008-04-25 2009-10-29 Medtronic, Inc. Medical devices, polymers, compositions, and methods for delivering a haloacetate
CA2722425A1 (en) 2008-04-28 2009-11-05 Surmodics, Inc. Poly-.alpha.(1-4)glucopyranose-based matrices with hydrazide crosslinking
CN102639159B (zh) 2009-08-04 2015-04-01 皮斯洛克斯有限公司 离子取代的磷酸钙颗粒
EP2365009A1 (en) * 2010-03-10 2011-09-14 Universite Claude Bernard Lyon 1 (UCBL) Radiopaque, non-biodegradable, water-insoluble iodinated benzyl ethers of poly(vinyl alcohol), preparation method thereof, injectable embolizing compositions containing thereof and use thereof
ES2368307B1 (es) 2010-04-28 2012-10-17 Universidade De Santiago De Compostela Hidrogeles elaborados a base de polímeros aniónicos de origen natural.
HUP1000362A2 (en) 2010-07-12 2012-11-28 Egis Gyogyszergyar Nyrt Antiseptic and disinfecting compositions having reduced iodine content
ES2542242T3 (es) 2010-11-29 2015-08-03 Centre Hospitalier Universitaire Vaudois Composición de quimioembolización que comprende agentes antiangiogénicos
RU2587326C2 (ru) 2010-12-09 2016-06-20 Торэй Индастриз, Инк. Биоразлагаемые частицы, материал для окклюзии сосудов и способ получения биоразлагаемых частиц
GB201101429D0 (en) 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
CN104245618B (zh) * 2011-12-02 2017-08-25 住友金属矿山株式会社 热线遮蔽膜、热线遮蔽夹层透明基体材料、以及安装该热线遮蔽夹层透明基体材料作为窗口材料的汽车、以及使用该热线遮蔽夹层透明基体材料作为窗口材料的建造物
WO2014151885A1 (en) 2013-03-15 2014-09-25 Iris International, Inc. Conjugation of multiple vancomycin molecules on a polyvinyl alcohol backbone for the capture of microorganisms
WO2014152488A2 (en) 2013-03-15 2014-09-25 Dreher Matthew R Imageable embolic microsphere
GB2519738A (en) 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
GB2521997A (en) 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers

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