CL2016001349A1 - Uso de derivados de bencimidazol-prolina - Google Patents

Uso de derivados de bencimidazol-prolina

Info

Publication number
CL2016001349A1
CL2016001349A1 CL2016001349A CL2016001349A CL2016001349A1 CL 2016001349 A1 CL2016001349 A1 CL 2016001349A1 CL 2016001349 A CL2016001349 A CL 2016001349A CL 2016001349 A CL2016001349 A CL 2016001349A CL 2016001349 A1 CL2016001349 A1 CL 2016001349A1
Authority
CL
Chile
Prior art keywords
benzimidazole
proline derivatives
proline
derivatives
sunstrame
Prior art date
Application number
CL2016001349A
Other languages
English (en)
Inventor
Markus Gude
Christoph Boss
Christine Brotschi
Bibia Heidmann
Thierry Sifferlen
Jodi T Williams
Catherine Roch
Francois Jenck
Michel Steiner
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of CL2016001349A1 publication Critical patent/CL2016001349A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

USO DE UN COMPUESTO DERIVADO DE (1H-BENZIMIDAZOL-2-IL)(2-METILPIRROLIDIN-1-IL)METANONA PARA LA PREVENCIÓN O TRATAMIIENTO DE SINDROME DEL OCASO, ASOCIADO A ALZHEIMER
CL2016001349A 2013-12-04 2016-06-02 Uso de derivados de bencimidazol-prolina CL2016001349A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2013060630 2013-12-04

Publications (1)

Publication Number Publication Date
CL2016001349A1 true CL2016001349A1 (es) 2017-01-27

Family

ID=52347368

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016001349A CL2016001349A1 (es) 2013-12-04 2016-06-02 Uso de derivados de bencimidazol-prolina

Country Status (29)

Country Link
US (1) US9914721B2 (es)
EP (1) EP3077391B1 (es)
JP (1) JP6421185B2 (es)
KR (1) KR102330133B1 (es)
CN (1) CN105873921B (es)
AU (1) AU2014358766B2 (es)
CA (1) CA2930053A1 (es)
CL (1) CL2016001349A1 (es)
CY (1) CY1121089T1 (es)
DK (1) DK3077391T3 (es)
EA (1) EA029725B1 (es)
ES (1) ES2696708T3 (es)
HK (1) HK1225734B (es)
HR (1) HRP20181710T1 (es)
HU (1) HUE040555T2 (es)
IL (1) IL245914B (es)
LT (1) LT3077391T (es)
MA (1) MA39165A1 (es)
MX (1) MX366642B (es)
MY (1) MY179605A (es)
PH (1) PH12016500985B1 (es)
PL (1) PL3077391T3 (es)
PT (1) PT3077391T (es)
SA (1) SA516371253B1 (es)
SI (1) SI3077391T1 (es)
TR (1) TR201815342T4 (es)
UA (1) UA116053C2 (es)
WO (1) WO2015083094A1 (es)
ZA (1) ZA201604502B (es)

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US20230134935A1 (en) * 2020-04-19 2023-05-04 Idorsia Pharmaceuticals Ltd Medical use of daridorexant
JP7681113B2 (ja) * 2021-02-02 2025-05-21 メッドシャイン ディスカバリー インコーポレイテッド テトラヒドロピロロ環化合物及びその使用
WO2023160004A1 (zh) * 2022-02-25 2023-08-31 南京知和医药科技有限公司 具有镇痛活性的稠环化合物及其制备方法与用途
WO2026012316A1 (zh) * 2024-07-08 2026-01-15 石药集团中奇制药技术（石家庄）有限公司 苯并咪唑衍生物及其用途
CN120392749A (zh) * 2025-04-28 2025-08-01 天津大学 一种构造原发性纤毛运动障碍脑积水模型的方法

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Also Published As

Publication number Publication date
IL245914A0 (en) 2016-08-02
HRP20181710T1 (hr) 2018-12-28
AU2014358766A1 (en) 2016-07-21
NZ721697A (en) 2021-09-24
EP3077391B1 (en) 2018-08-15
TR201815342T4 (tr) 2018-11-21
CN105873921B (zh) 2019-03-15
SI3077391T1 (sl) 2018-11-30
US9914721B2 (en) 2018-03-13
SA516371253B1 (ar) 2018-07-24
HUE040555T2 (hu) 2019-03-28
CY1121089T1 (el) 2019-12-11
ZA201604502B (en) 2019-07-31
MY179605A (en) 2020-11-11
LT3077391T (lt) 2018-10-25
EA029725B1 (ru) 2018-05-31
EP3077391A1 (en) 2016-10-12
WO2015083094A1 (en) 2015-06-11
ES2696708T3 (es) 2019-01-17
IL245914B (en) 2019-09-26
KR20160093686A (ko) 2016-08-08
MA39165A1 (fr) 2017-10-31
US20170001985A1 (en) 2017-01-05
MX2016007313A (es) 2016-09-07
JP6421185B2 (ja) 2018-11-07
UA116053C2 (uk) 2018-01-25
EA201600434A1 (ru) 2016-11-30
MX366642B (es) 2019-07-17
CN105873921A (zh) 2016-08-17
DK3077391T3 (en) 2018-10-22
PT3077391T (pt) 2018-11-26
JP2016539157A (ja) 2016-12-15
PH12016500985B1 (en) 2019-02-20
HK1225734B (en) 2017-09-15
PH12016500985A1 (en) 2016-06-20
CA2930053A1 (en) 2015-06-11
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AU2014358766B2 (en) 2019-01-17
PL3077391T3 (pl) 2019-01-31

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