CL2016001496A1 - Compuestos al receptor-3 del factor de crecimiento del fibroblasto (fgfr3) y métodos de tratamiento. - Google Patents

Compuestos al receptor-3 del factor de crecimiento del fibroblasto (fgfr3) y métodos de tratamiento.

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Publication number
CL2016001496A1
CL2016001496A1 CL2016001496A CL2016001496A CL2016001496A1 CL 2016001496 A1 CL2016001496 A1 CL 2016001496A1 CL 2016001496 A CL2016001496 A CL 2016001496A CL 2016001496 A CL2016001496 A CL 2016001496A CL 2016001496 A1 CL2016001496 A1 CL 2016001496A1
Authority
CL
Chile
Prior art keywords
fgfr3
receptor
compounds
growth factor
fibroblast growth
Prior art date
Application number
CL2016001496A
Other languages
English (en)
Inventor
Paul J Balderes
Scott W Eastman
Hans K Erickson
Dale L Ludwig
Christopher M Moxham
Gregory D Plowman
Alan C Rigby
Original Assignee
Immunogen Inc
Imclone Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc, Imclone Llc filed Critical Immunogen Inc
Publication of CL2016001496A1 publication Critical patent/CL2016001496A1/es

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • A61K31/559Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing hetero atoms other than oxygen
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    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6861Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from kidney or bladder cancer cell
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6867Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
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    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475Assays involving growth factors
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    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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CL2016001496A 2013-12-18 2016-06-15 Compuestos al receptor-3 del factor de crecimiento del fibroblasto (fgfr3) y métodos de tratamiento. CL2016001496A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361917457P 2013-12-18 2013-12-18
US201461928025P 2014-01-16 2014-01-16

Publications (1)

Publication Number Publication Date
CL2016001496A1 true CL2016001496A1 (es) 2017-06-23

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CL2016001496A CL2016001496A1 (es) 2013-12-18 2016-06-15 Compuestos al receptor-3 del factor de crecimiento del fibroblasto (fgfr3) y métodos de tratamiento.

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US (1) US9375488B2 (es)
EP (1) EP3082873A1 (es)
JP (1) JP6113933B1 (es)
KR (1) KR101708603B1 (es)
CN (1) CN105916523A (es)
AP (1) AP2016009271A0 (es)
AU (1) AU2014366359A1 (es)
BR (1) BR112016013026A2 (es)
CA (1) CA2930599A1 (es)
CL (1) CL2016001496A1 (es)
EA (1) EA201691053A1 (es)
HK (1) HK1224179A1 (es)
IL (1) IL245483A0 (es)
MX (1) MX2016008072A (es)
NZ (1) NZ719936A (es)
PE (1) PE20160994A1 (es)
PH (1) PH12016501185A1 (es)
SG (1) SG11201604119YA (es)
TN (1) TN2016000204A1 (es)
TW (1) TWI541022B (es)
WO (1) WO2015094900A1 (es)

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TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類CEACAM5抗體Fab片段
BR112020023420A8 (pt) 2018-05-17 2022-07-05 Astellas Pharma Inc Complexo tendo fragmento fab de anticorpo anti-muc1 humano, peptídeo ligador e/ou ligante
SG11202103670XA (en) 2018-10-10 2021-05-28 Astellas Pharma Inc Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex
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AU2023379451A1 (en) * 2022-11-14 2025-05-01 Regeneron Pharmaceuticals, Inc. Anti-fgfr3 antibodies and antigen-binding fragments and methods of use thereof

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CN105916523A (zh) 2016-08-31
JP2017511792A (ja) 2017-04-27
BR112016013026A2 (pt) 2017-09-26
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IL245483A0 (en) 2016-06-30
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CA2930599A1 (en) 2015-06-25
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US9375488B2 (en) 2016-06-28
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