ATE535529T1 - Verfahren zur acylierung von maytansinol mit chiralen aminosäuren - Google Patents

Verfahren zur acylierung von maytansinol mit chiralen aminosäuren

Info

Publication number: ATE535529T1
Authority: AT; Austria
Prior art keywords: maytansinol; acylation; amino acids; chiral amino; chiral
Prior art date: 2005-08-09

Application number

AT06800952T

Other languages

English (en)

Inventor

Guojie Ho

Darren Carrozzella

Original Assignee

Millennium Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-09

Filing date

2006-08-08

Publication date

2011-12-15

2006-08-08 Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE535529T1 publication Critical patent/ATE535529T1/de

Links

238000000034 method Methods 0.000 title abstract 3
150000001413 amino acids Chemical class 0.000 title abstract 2
QWPXBEHQFHACTK-RZKXNLMUSA-N CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](O)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 Chemical compound CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](O)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-RZKXNLMUSA-N 0.000 title 1
QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 title 1
230000010933 acylation Effects 0.000 title 1
238000005917 acylation reaction Methods 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
238000006345 epimerization reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT06800952T 2005-08-09 2006-08-08 Verfahren zur acylierung von maytansinol mit chiralen aminosäuren ATE535529T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US70669405P	2005-08-09	2005-08-09
PCT/US2006/030857 WO2007021674A2 (en)	2005-08-09	2006-08-08	Method of acylating maytansinol with chiral amino acids

Publications (1)

Publication Number	Publication Date
ATE535529T1 true ATE535529T1 (de)	2011-12-15

Family

ID=37758086

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06800952T ATE535529T1 (de)	2005-08-09	2006-08-08	Verfahren zur acylierung von maytansinol mit chiralen aminosäuren

Country Status (7)

Country	Link
US (1)	US7598375B2 (de)
EP (1)	EP1913002B9 (de)
JP (1)	JP5167130B2 (de)
AT (1)	ATE535529T1 (de)
AU (1)	AU2006280146B2 (de)
CA (1)	CA2617953C (de)
WO (1)	WO2007021674A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1392359T4 (da)	2001-05-11	2013-06-10	Ludwig Inst For Cancer Res Ltd	Specifikke bindingsproteiner og deres anvendelser.
US20100056762A1 (en)	2001-05-11	2010-03-04	Old Lloyd J	Specific binding proteins and uses thereof
US9090693B2 (en) *	2007-01-25	2015-07-28	Dana-Farber Cancer Institute	Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
JP5618549B2 (ja) *	2007-03-15	2014-11-05	ルードヴィッヒインスティテュートフォーキャンサーリサーチリミテッド	Ｅｇｆｒ抗体及びｓｒｃ阻害剤を用いる治療方法及び関連製剤
PE20140625A1 (es)	2007-07-16	2014-05-29	Genentech Inc	ANTICUERPOS ANTI-CD79b E INMUNOCONJUGADOS HUMANIZADOS
PT2474557E (pt)	2007-07-16	2014-12-03	Genentech Inc	Anticorpos e imunoconjugados anti-cd79b e métodos de utilização
JP5532486B2 (ja)	2007-08-14	2014-06-25	ルードヴィッヒインスティテュートフォーキャンサーリサーチ	Ｅｇｆ受容体を標的とするモノクローナル抗体１７５ならびにその誘導体および用途
DK2657253T3 (en)	2008-01-31	2017-10-09	Genentech Inc	Anti-CD79b antibodies and immune conjugates and methods of use
MA33256B1 (fr)	2009-04-01	2012-05-02	Genentech Inc	Anticorps et immunoconjugués anti-fcrh5 et procédés d'utilisation
US20110076232A1 (en) *	2009-09-29	2011-03-31	Ludwig Institute For Cancer Research	Specific binding proteins and uses thereof
UY32913A (es)	2009-10-02	2011-04-29	Sanofi Aventis	Nuevos maitansinoides y el uso de dichos maitansinoides para preparar conjugados con un anticuero
EP2640727B1 (de) *	2010-11-17	2015-05-13	Genentech, Inc.	Alaninylmaytansinol-antikörperkonjugate
SI2675480T1 (sl)	2011-02-15	2019-05-31	Immunogen, Inc.	Metode priprave konjugatov
WO2012177837A2 (en)	2011-06-21	2012-12-27	Immunogen, Inc.	Novel maytansinoid derivatives with peptide linker and conjugates thereof
AP2014007588A0 (en)	2011-09-22	2014-04-30	Amgen Inc	CD27L antigen binding proteins
AR091069A1 (es)	2012-05-18	2014-12-30	Amgen Inc	Proteinas de union a antigeno dirigidas contra el receptor st2
SMT201900170T1 (it)	2012-09-26	2019-05-10	Immunogen Inc	Metodo migliorato per l'acilazione di maytansinolo
TW201425336A (zh)	2012-12-07	2014-07-01	Amgen Inc	Ｂｃｍａ抗原結合蛋白質
CN103254213B (zh) *	2012-12-21	2015-02-25	百奥泰生物科技(广州)有限公司	类美登素酯的制备方法及用于所述方法的组合物
CN104530235A (zh)	2012-12-21	2015-04-22	百奥泰生物科技(广州)有限公司	一种抑制肿瘤生长的抗体药物衍生物及其制备方法和用途
EP2948478B1 (de)	2013-01-25	2019-04-03	Amgen Inc.	Antikörper gegen cdh19 für melanome
HK1219422A1 (zh)	2013-02-28	2017-04-07	Immunogen, Inc.	包含细胞结合剂及细胞毒素剂的轭合物
EP3964237B1 (de)	2013-03-15	2026-02-18	Regeneron Pharmaceuticals, Inc.	Biologisch aktive moleküle, konjugate davon und therapeutische verwendungen davon
HUE056580T2 (hu)	2013-05-30	2022-02-28	Kiniksa Pharmaceuticals Ltd	Onkosztatin-M-receptor antigénjét kötõ fehérjék
WO2014194030A2 (en)	2013-05-31	2014-12-04	Immunogen, Inc.	Conjugates comprising cell-binding agents and cytotoxic agents
TWI541022B (zh)	2013-12-18	2016-07-11	應克隆公司	針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法
CN105585579A (zh) *	2014-10-24	2016-05-18	南京联宁生物制药有限公司	一种化合物及其制备方法以及美登素dm1的制备方法
CN104623687B (zh) *	2015-03-11	2017-09-05	中国科学院上海高等研究院	利用美登醇制备的抗体药物偶联物及其制备方法和应用
WO2016149464A1 (en)	2015-03-17	2016-09-22	Regeneron Pharmaceuticals, Inc.	Amino acid acylation reagents and methods of using the same
CA2978340C (en)	2015-03-27	2024-05-28	Regeneron Pharmaceuticals, Inc.	Maytansinoid derivatives, conjugates thereof, and methods of use
TW201711702A (zh)	2015-06-04	2017-04-01	應克隆公司	使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法
EP3956332B1 (de)	2019-04-18	2023-02-22	Indena S.p.A.	Diasteroselektives verfahren zur herstellung von thiol- oder disulfidhaltigen maytansinoidestern und zwischenprodukten davon
TW202428283A (zh) *	2022-09-16	2024-07-16	美商伊繆諾金公司	製備美登醇（ｍａｙｔａｎｓｉｎｏｌ）之ｎ－甲基丙胺酸酯之改良方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4260609A (en) *	1977-06-01	1981-04-07	Merck & Co., Inc.	Di- and tri- substituted thiazoles
JPS5566585A (en) *	1978-11-14	1980-05-20	Takeda Chem Ind Ltd	Novel maytansinoid compound and its preparation
JPS55164686A (en) *	1979-06-11	1980-12-22	Takeda Chem Ind Ltd	Novel maytansinoid compound and its preparation
CA2026147C (en) *	1989-10-25	2006-02-07	Ravi J. Chari	Cytotoxic agents comprising maytansinoids and their therapeutic use
US5208020A (en) *	1989-10-25	1993-05-04	Immunogen Inc.	Cytotoxic agents comprising maytansinoids and their therapeutic use
US6333410B1 (en) *	2000-08-18	2001-12-25	Immunogen, Inc.	Process for the preparation and purification of thiol-containing maytansinoids
US7771727B2 (en)	2002-03-01	2010-08-10	The Administrators Of The Tulane Educational Fund	Conjugates of therapeutic or cytotoxic agents and biologically active peptides
US7301019B2 (en) *	2005-01-21	2007-11-27	Immunogen, Inc.	Method for the preparation of maytansinoid esters

2006
- 2006-08-08 AT AT06800952T patent/ATE535529T1/de active
- 2006-08-08 JP JP2008526125A patent/JP5167130B2/ja not_active Expired - Lifetime
- 2006-08-08 AU AU2006280146A patent/AU2006280146B2/en not_active Expired
- 2006-08-08 CA CA2617953A patent/CA2617953C/en not_active Expired - Lifetime
- 2006-08-08 US US11/500,378 patent/US7598375B2/en not_active Expired - Lifetime
- 2006-08-08 WO PCT/US2006/030857 patent/WO2007021674A2/en not_active Ceased
- 2006-08-08 EP EP06800952A patent/EP1913002B9/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP5167130B2 (ja)	2013-03-21
US7598375B2 (en)	2009-10-06
US20070037972A1 (en)	2007-02-15
CA2617953A1 (en)	2007-02-22
WO2007021674A3 (en)	2007-07-26
EP1913002A2 (de)	2008-04-23
EP1913002A4 (de)	2010-10-27
WO2007021674A2 (en)	2007-02-22
AU2006280146B2 (en)	2012-06-28
EP1913002B9 (de)	2012-04-25
AU2006280146A1 (en)	2007-02-22
EP1913002B1 (de)	2011-11-30
CA2617953C (en)	2013-12-17
JP2009504655A (ja)	2009-02-05

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