CL2016002386A1 - Formulaciones de factor ix liofilizadas. - Google Patents

Formulaciones de factor ix liofilizadas.

Info

Publication number
CL2016002386A1
CL2016002386A1 CL2016002386A CL2016002386A CL2016002386A1 CL 2016002386 A1 CL2016002386 A1 CL 2016002386A1 CL 2016002386 A CL2016002386 A CL 2016002386A CL 2016002386 A CL2016002386 A CL 2016002386A CL 2016002386 A1 CL2016002386 A1 CL 2016002386A1
Authority
CL
Chile
Prior art keywords
fix
formulations
liofilized
polipeptide
agent
Prior art date
Application number
CL2016002386A
Other languages
English (en)
Inventor
Brian M Thome
Cherie Parkhurst-Lang
Brandon W Leveille
Original Assignee
Bioverativ Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54196282&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016002386(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioverativ Therapeutics Inc filed Critical Bioverativ Therapeutics Inc
Publication of CL2016002386A1 publication Critical patent/CL2016002386A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mechanical Engineering (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Monitoring And Testing Of Transmission In General (AREA)
  • Mobile Radio Communication Systems (AREA)

Abstract

<p>LA PRESENTE INVENCIÓN PROVEE, ENTRE OTRAS COSAS, FORMULACIONES PRE-LIOFILIZACIÓN, FORMULACIONES RECONSTITUIDAS Y FORMULACIONES DE POLVO LIOFILIZADO QUE COMPRENDEN UN POLIPÉPTIDO DE FACTOR IX (FIX). LA PRESENTE INVENCIÓN PROPORCIONA TAMBIÉN MÉTODOS DE LIOFILIZACIÓN PARA PRODUCIR UN POLVO LIOFILIZADO QUE COMPRENDE UN POLIPÉPTIDO DE FIX. LA PRESENTE INVENCIÓN SE REFIERE A UNA FORMULACIÓN PRE-LIOFILIZACIÓN QUE COMPRENDE: (A) UN POLIPÉPTIDO (FIX) DE FACTOR IX QUE TIENE ACTIVIDAD DE COAGULACIÓN FIX; (B) UN AGENTE AMORTIGUADOR; (C) UN AGENTE ESTABILIZANTE; (D) UN AGENTE ESPESANTE; Y € UN TENSIOACTIVO, DONDE LA FORMULACION TIENE UN VOLUMEN DE RELLENO MENOR QUE ALREDEDOR DE 5ML Y DONDE CADA UNO DE (A)- (C) SE ENCUENTRAN EN UNA CANTIDAD POR VIAL (MG/VIAL) SUFICIENTE PARA PERMITIR (L) MEJOR ESTABILIDAD DEL POLIPÉPTIDO DE FIX AL LIOFILIZARSE.</p>
CL2016002386A 2014-03-24 2016-09-22 Formulaciones de factor ix liofilizadas. CL2016002386A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461969801P 2014-03-24 2014-03-24

Publications (1)

Publication Number Publication Date
CL2016002386A1 true CL2016002386A1 (es) 2017-06-23

Family

ID=54196282

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016002386A CL2016002386A1 (es) 2014-03-24 2016-09-22 Formulaciones de factor ix liofilizadas.

Country Status (16)

Country Link
US (3) US10772942B2 (es)
EP (1) EP3123090A4 (es)
JP (4) JP7058940B2 (es)
KR (1) KR102385372B1 (es)
AR (1) AR099838A1 (es)
AU (3) AU2015236340B2 (es)
CA (1) CA2943034C (es)
CL (1) CL2016002386A1 (es)
EA (2) EA202092926A3 (es)
IL (3) IL247869B (es)
MA (1) MA39779A (es)
MX (2) MX387269B (es)
PH (1) PH12016501877A1 (es)
SG (3) SG10201913735SA (es)
TW (1) TWI700101B (es)
WO (1) WO2015148444A1 (es)

Families Citing this family (8)

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MX2019006444A (es) * 2016-12-02 2019-10-30 Bioverativ Therapeutics Inc Métodos de tratamiento de artropatía hemofílica utilizando factores de coagulación quiméricos.
WO2019014338A1 (en) * 2017-07-11 2019-01-17 Universal Stabilization Technologies, Inc. METHOD FOR PRESERVING BIOPHARMACEUTICAL PRODUCTS
CN112175088B (zh) * 2019-07-02 2023-03-28 江苏晟斯生物制药有限公司 改进的fix融合蛋白、缀合物及其应用
BR112022015272A2 (pt) 2020-02-04 2022-09-20 Regeneron Pharma Teor de umidade residual alvo para produto de fármaco liofilizado
US20210395325A1 (en) * 2020-05-11 2021-12-23 Alkermes Pharma Ireland Limited Il-2 fusion polypeptide compositions and methods of making and using the same
CN118557531B (zh) * 2024-08-02 2024-10-18 成都蓉生药业有限责任公司 一种重组人凝血因子VIII-Fc融合蛋白冻干制剂的制备方法

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Also Published As

Publication number Publication date
CA2943034A1 (en) 2015-10-01
TW201605492A (zh) 2016-02-16
EA202092926A3 (ru) 2021-10-29
US20170173122A1 (en) 2017-06-22
MX387269B (es) 2025-03-18
JP7058940B2 (ja) 2022-04-25
IL247869B (en) 2020-02-27
KR102385372B1 (ko) 2022-04-11
JP2017510585A (ja) 2017-04-13
AU2015236340B2 (en) 2020-02-06
IL247869A0 (en) 2016-11-30
AU2020202863A1 (en) 2020-05-21
JP2020063313A (ja) 2020-04-23
AU2022215218B2 (en) 2025-12-18
WO2015148444A1 (en) 2015-10-01
JP7503583B2 (ja) 2024-06-20
IL272257A (en) 2020-02-27
EA202092926A2 (ru) 2021-07-30
AU2020202863B2 (en) 2022-09-01
US20210069307A1 (en) 2021-03-11
SG10201808249VA (en) 2018-10-30
MA39779A (fr) 2017-02-01
IL281197A (en) 2021-04-29
KR20160137577A (ko) 2016-11-30
AU2022215218A1 (en) 2022-09-01
BR112016021777A2 (pt) 2017-10-03
NZ724351A (en) 2023-10-27
JP2022044689A (ja) 2022-03-17
JP2024053015A (ja) 2024-04-12
EA201691807A1 (ru) 2017-03-31
SG10201913735SA (en) 2020-03-30
IL281197B (en) 2022-06-01
US12128092B2 (en) 2024-10-29
EP3123090A1 (en) 2017-02-01
PH12016501877A1 (en) 2016-12-19
TWI700101B (zh) 2020-08-01
JP7759978B2 (ja) 2025-10-24
MX2021012939A (es) 2021-11-25
AR099838A1 (es) 2016-08-24
EA038573B1 (ru) 2021-09-16
CA2943034C (en) 2022-06-14
IL272257B (en) 2021-03-25
EP3123090A4 (en) 2017-12-13
AU2015236340A1 (en) 2016-09-29
US10772942B2 (en) 2020-09-15
SG11201607642RA (en) 2016-10-28
US20250121042A1 (en) 2025-04-17
MX2016012447A (es) 2017-01-06

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