ATE240740T1 - Pegylation von polypeptiden - Google Patents

Pegylation von polypeptiden

Info

Publication number
ATE240740T1
ATE240740T1 AT92909329T AT92909329T ATE240740T1 AT E240740 T1 ATE240740 T1 AT E240740T1 AT 92909329 T AT92909329 T AT 92909329T AT 92909329 T AT92909329 T AT 92909329T AT E240740 T1 ATE240740 T1 AT E240740T1
Authority
AT
Austria
Prior art keywords
interleukin
receptor antagonist
tnf inhibitor
pegylation
polypeptides
Prior art date
Application number
AT92909329T
Other languages
English (en)
Inventor
Robert C Thompson
Lyman G Armes
Ronald J Evans
Michael T Brewer
Tadahiko Kohno
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE240740T1 publication Critical patent/ATE240740T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT92909329T 1991-03-15 1992-03-13 Pegylation von polypeptiden ATE240740T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66986291A 1991-03-15 1991-03-15
US82229692A 1992-01-17 1992-01-17
PCT/US1992/002122 WO1992016221A1 (en) 1991-03-15 1992-03-13 Pegylation of polypeptides

Publications (1)

Publication Number Publication Date
ATE240740T1 true ATE240740T1 (de) 2003-06-15

Family

ID=27100210

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92909329T ATE240740T1 (de) 1991-03-15 1992-03-13 Pegylation von polypeptiden

Country Status (13)

Country Link
EP (1) EP0575545B1 (de)
JP (1) JP3693671B2 (de)
AT (1) ATE240740T1 (de)
AU (2) AU1674292A (de)
CA (2) CA2106079C (de)
DE (1) DE69233069T2 (de)
DK (1) DK0575545T3 (de)
ES (1) ES2199935T3 (de)
FI (1) FI113943B (de)
GE (1) GEP20033082B (de)
NO (1) NO933270L (de)
SG (2) SG47099A1 (de)
WO (1) WO1992016221A1 (de)

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FI934015A0 (fi) 1993-09-14
AU708533B2 (en) 1999-08-05
FI934015L (fi) 1993-09-14
CA2288429C (en) 2006-04-25
EP0575545A1 (de) 1993-12-29
CA2106079C (en) 2000-04-25
DE69233069D1 (de) 2003-06-26
EP0575545B1 (de) 2003-05-21
EP0575545A4 (de) 1995-02-08
AU1674292A (en) 1992-10-21
WO1992016221A1 (en) 1992-10-01
DE69233069T2 (de) 2003-11-27
FI113943B (fi) 2004-07-15
GEP20033082B (en) 2003-10-27
CA2106079A1 (en) 1992-09-16
NO933270D0 (no) 1993-09-14
ES2199935T3 (es) 2004-03-01
NO933270L (no) 1993-11-01
DK0575545T3 (da) 2003-09-15
SG89295A1 (en) 2002-06-18
JP3693671B2 (ja) 2005-09-07
CA2288429A1 (en) 1992-09-16
SG47099A1 (en) 1998-03-20
JPH06506218A (ja) 1994-07-14
AU6202396A (en) 1996-10-31

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