CL2016002461A1 - Derivados macrocíclicos de pirimidina - Google Patents
Derivados macrocíclicos de pirimidinaInfo
- Publication number
- CL2016002461A1 CL2016002461A1 CL2016002461A CL2016002461A CL2016002461A1 CL 2016002461 A1 CL2016002461 A1 CL 2016002461A1 CL 2016002461 A CL2016002461 A CL 2016002461A CL 2016002461 A CL2016002461 A CL 2016002461A CL 2016002461 A1 CL2016002461 A1 CL 2016002461A1
- Authority
- CL
- Chile
- Prior art keywords
- pyrimidine
- macrocyclic derivatives
- macrocyclic
- derivatives
- pyrimidine macrocyclic
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14163443 | 2014-04-03 | ||
| EP14183747 | 2014-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2016002461A1 true CL2016002461A1 (es) | 2017-06-23 |
Family
ID=52781117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2016002461A CL2016002461A1 (es) | 2014-04-03 | 2016-09-29 | Derivados macrocíclicos de pirimidina |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10017509B2 (es) |
| EP (1) | EP3126364B1 (es) |
| JP (1) | JP6529513B2 (es) |
| KR (1) | KR102390276B1 (es) |
| CN (2) | CN106164075B (es) |
| AU (1) | AU2015239098B2 (es) |
| BR (1) | BR112016021982B1 (es) |
| CA (1) | CA2942636C (es) |
| CL (1) | CL2016002461A1 (es) |
| EA (1) | EA031246B1 (es) |
| ES (1) | ES2667723T3 (es) |
| IL (1) | IL248005B (es) |
| MA (1) | MA39822A (es) |
| MX (1) | MX369798B (es) |
| MY (1) | MY185491A (es) |
| NZ (1) | NZ725399A (es) |
| PE (1) | PE20161362A1 (es) |
| PH (1) | PH12016501963B1 (es) |
| SG (1) | SG11201608240RA (es) |
| UA (1) | UA118219C2 (es) |
| WO (1) | WO2015150555A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3416945T3 (pl) | 2016-02-19 | 2020-12-28 | Sprint Bioscience Ab | Związki 6-arylo-4-(morfolin-4-ylo)-1h-pirydyn-2-onu przydatne w leczeniu nowotworu i cukrzycy |
| PT3416957T (pt) | 2016-02-19 | 2020-09-25 | Sprint Bioscience Ab | Compostos 6-heterociclil-4-morfolin-4-ilpiridin-2-ona úteis para o tratamento do cancro e da diabetes |
| EP3601253B1 (en) | 2017-03-28 | 2021-09-15 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
| CA3057891A1 (en) | 2017-03-28 | 2018-10-04 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
| IL302356A (en) | 2017-08-23 | 2023-06-01 | Sprint Bioscience Ab | Pyridylpyridone compounds |
| PL3672948T3 (pl) | 2017-08-23 | 2022-12-05 | Sprint Bioscience Ab | Związki pirydynoamino-pirydonu i pirymidynoamino-pirydonu |
| IL302355A (en) | 2017-08-23 | 2023-06-01 | Sprint Bioscience Ab | Azaindolylpyridone and diazaindolylpyridone compounds |
| HRP20220497T1 (hr) | 2017-08-23 | 2022-05-27 | Sprint Bioscience Ab | Spoj morfolinilpiridona |
| JP2023513854A (ja) * | 2020-02-18 | 2023-04-03 | テーセウス ファーマシューティカルズ, インコーポレイテッド | 大環状化合物およびその使用 |
| MX2022012558A (es) * | 2020-04-07 | 2023-02-22 | iTeos Belgium SA | Derivados de diaminas macrocíclicas como inhibidores de ent para el tratamiento de cánceres y combinación de estos con antagonistas del receptor de adenosina. |
| CN113735879B (zh) * | 2020-05-27 | 2022-05-17 | 百极弘烨(广东)医药科技有限公司 | 一种大环jak抑制剂及其应用 |
| CN113735856A (zh) * | 2020-05-29 | 2021-12-03 | 百极弘烨(南通)医药科技有限公司 | 大环jak抑制剂及其应用 |
| CN116113621A (zh) * | 2020-07-22 | 2023-05-12 | 弗格制药有限公司 | 氨基酸 |
| WO2023046030A1 (zh) * | 2021-09-23 | 2023-03-30 | 河南晟翔医药科技有限公司 | 一种egfr小分子抑制剂、含其的药物组合物及其用途 |
| EP4413003A1 (en) * | 2021-10-06 | 2024-08-14 | iTeos Belgium SA | Processes for preparing a macrocyclic compound having ent1 inhibiting activity |
| KR102613509B1 (ko) * | 2021-12-15 | 2023-12-13 | 환인제약 주식회사 | 마크로사이클릭 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 신경 퇴행성 질환의 예방 또는 치료용 약학적 조성물 |
| WO2024078263A1 (zh) * | 2022-10-09 | 2024-04-18 | 药雅科技(上海)有限公司 | 大环杂环类化合物作为egfr抑制剂的制备及其应用 |
| CN117229300A (zh) * | 2023-03-12 | 2023-12-15 | 药雅科技(上海)有限公司 | Egfr抑制剂的制备及其应用 |
| WO2024094171A1 (zh) * | 2022-11-04 | 2024-05-10 | 江苏恒瑞医药股份有限公司 | 取代的氨基嘧啶类化合物、其制备方法及其在医药上的应用 |
| CN116478076A (zh) * | 2023-04-26 | 2023-07-25 | 南京优氟医药科技有限公司 | 一种(2s,4s)-1-叔丁氧羰基-2-(二氟甲基)-4-羟基吡咯烷的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7151096B2 (en) * | 2003-03-05 | 2006-12-19 | Irm Llc | Cyclic compounds and compositions as protein kinase inhibitors |
| ZA200507806B (en) | 2003-03-24 | 2007-03-28 | Actimis Pharmaceuticals Inc | 2-phenoxy- and 2-enysulfomamide derivatives with CCR3 antagonistic acitivity for the treatment of asthma and other inflammatory or immunolgical disorders |
| JO2785B1 (en) | 2003-05-27 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinazoline derivatives |
| AU2004298448B2 (en) | 2003-12-18 | 2010-09-09 | Janssen Pharmaceutica N.V. | Pyrido- and pyrimidopyrimidine derivatives as anti- proliferative agents |
| EA200601176A1 (ru) | 2003-12-18 | 2006-10-27 | Янссен Фармацевтика Н.В. | 3-цианохинолиновые производные с антипролиферативной активностью |
| MY169441A (en) * | 2004-12-08 | 2019-04-11 | Janssen Pharmaceutica Nv | 2,4, (4,6) pyrimidine derivatives |
| JO3088B1 (ar) | 2004-12-08 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف |
| UA92608C2 (en) * | 2005-06-30 | 2010-11-25 | Янссен Фармацевтика Н.В. | Cyclic anilino - pyridinotriazines as gsk-3 inhibitors |
| CN101360751B (zh) | 2005-11-16 | 2011-09-14 | S*Bio私人有限公司 | 氧连接的嘧啶衍生物 |
| WO2007059628A1 (en) | 2005-11-24 | 2007-05-31 | Oz Communications Inc. | Method for securely associating data with http and https sessions |
| EP2170827B1 (en) | 2007-06-21 | 2013-08-14 | Janssen Pharmaceutica, N.V. | Indolin-2-ones and aza-indolin-2-ones |
| AU2008281849B2 (en) | 2007-07-27 | 2013-11-28 | Janssen Pharmaceutica Nv | Pyrrolopyrimidines |
| US20090264431A1 (en) | 2007-08-20 | 2009-10-22 | Palovich Michael R | Novel cathepsin c inhibitors and their use |
| WO2009112439A1 (en) * | 2008-03-10 | 2009-09-17 | Janssen Pharmaceutica Nv | 4-aryl-2-anilino-pyrimidines as plk kinase inhibitors |
| BRPI0915105A2 (pt) | 2008-06-13 | 2019-09-24 | Novartis Ag | composto de 2,4'-biripidinila como inibidores da proteína cinase d úteis para o tratamento de ia insuficiência cardíaca e cancer |
| CN102458116B (zh) | 2009-05-28 | 2014-12-31 | 泰特拉洛吉克药业公司 | Iap抑制剂 |
| WO2011008788A1 (en) | 2009-07-14 | 2011-01-20 | Dawei Zhang | Fluoro-substituted compounds as kinase inhibitors and methods of use thereof |
| TWI513695B (zh) | 2009-10-27 | 2015-12-21 | Merck Sharp & Dohme | (1,1,1,3,3,3-六氟-2-羥基丙-2-基)苯基衍生物 |
-
2015
- 2015-04-01 MA MA039822A patent/MA39822A/fr unknown
- 2015-04-02 EP EP15713522.9A patent/EP3126364B1/en active Active
- 2015-04-02 NZ NZ725399A patent/NZ725399A/en unknown
- 2015-04-02 PE PE2016001882A patent/PE20161362A1/es unknown
- 2015-04-02 EA EA201692003A patent/EA031246B1/ru not_active IP Right Cessation
- 2015-04-02 WO PCT/EP2015/057399 patent/WO2015150555A1/en not_active Ceased
- 2015-04-02 US US15/300,956 patent/US10017509B2/en active Active
- 2015-04-02 CN CN201580018080.6A patent/CN106164075B/zh active Active
- 2015-04-02 CN CN202111600011.XA patent/CN114213415A/zh active Pending
- 2015-04-02 MX MX2016012992A patent/MX369798B/es active IP Right Grant
- 2015-04-02 AU AU2015239098A patent/AU2015239098B2/en not_active Ceased
- 2015-04-02 CA CA2942636A patent/CA2942636C/en active Active
- 2015-04-02 KR KR1020167028764A patent/KR102390276B1/ko not_active Expired - Fee Related
- 2015-04-02 ES ES15713522.9T patent/ES2667723T3/es active Active
- 2015-04-02 JP JP2016560825A patent/JP6529513B2/ja active Active
- 2015-04-02 SG SG11201608240RA patent/SG11201608240RA/en unknown
- 2015-04-02 UA UAA201611005A patent/UA118219C2/uk unknown
- 2015-04-02 BR BR112016021982-1A patent/BR112016021982B1/pt not_active IP Right Cessation
- 2015-04-02 MY MYPI2016001777A patent/MY185491A/en unknown
-
2016
- 2016-09-25 IL IL248005A patent/IL248005B/en active IP Right Grant
- 2016-09-29 CL CL2016002461A patent/CL2016002461A1/es unknown
- 2016-10-03 PH PH12016501963A patent/PH12016501963B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR102390276B1 (ko) | 2022-04-22 |
| KR20160142316A (ko) | 2016-12-12 |
| WO2015150555A1 (en) | 2015-10-08 |
| PE20161362A1 (es) | 2016-12-17 |
| BR112016021982B1 (pt) | 2022-07-26 |
| NZ725399A (en) | 2023-01-27 |
| MA39822A (fr) | 2018-02-06 |
| CA2942636A1 (en) | 2015-10-08 |
| IL248005B (en) | 2018-12-31 |
| CA2942636C (en) | 2023-03-21 |
| EA201692003A1 (ru) | 2017-06-30 |
| US10017509B2 (en) | 2018-07-10 |
| UA118219C2 (uk) | 2018-12-10 |
| US20170022202A1 (en) | 2017-01-26 |
| MX369798B (es) | 2019-11-21 |
| EA031246B1 (ru) | 2018-12-28 |
| JP2017509687A (ja) | 2017-04-06 |
| AU2015239098A1 (en) | 2016-09-29 |
| BR112016021982A2 (es) | 2017-08-15 |
| MX2016012992A (es) | 2016-12-07 |
| CN106164075B (zh) | 2021-11-26 |
| AU2015239098B2 (en) | 2019-08-01 |
| ES2667723T3 (es) | 2018-05-14 |
| PH12016501963A1 (en) | 2017-01-09 |
| EP3126364B1 (en) | 2018-02-07 |
| CN106164075A (zh) | 2016-11-23 |
| PH12016501963B1 (en) | 2017-01-09 |
| SG11201608240RA (en) | 2016-10-28 |
| JP6529513B2 (ja) | 2019-06-12 |
| CN114213415A (zh) | 2022-03-22 |
| EP3126364A1 (en) | 2017-02-08 |
| MY185491A (en) | 2021-05-19 |
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