CL2016003048A1 - Analogos de panonina minimas sintesis y uso de los mismos. - Google Patents

Analogos de panonina minimas sintesis y uso de los mismos.

Info

Publication number
CL2016003048A1
CL2016003048A1 CL2016003048A CL2016003048A CL2016003048A1 CL 2016003048 A1 CL2016003048 A1 CL 2016003048A1 CL 2016003048 A CL2016003048 A CL 2016003048A CL 2016003048 A CL2016003048 A CL 2016003048A CL 2016003048 A1 CL2016003048 A1 CL 2016003048A1
Authority
CL
Chile
Prior art keywords
saponin
panonin
analogues
minimizes
synthesis
Prior art date
Application number
CL2016003048A
Other languages
English (en)
Inventor
David Y Gin
Eric K Chea
Alberto Fernandez-Tejada
Derek S Tan
Jason S Lewis
Jeffrey R Gardner
Nagavarakishore Pillarsetty
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of CL2016003048A1 publication Critical patent/CL2016003048A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<p>Se describen análogos truncados de saponina triterpénica que contienen un trisacárido o éster tetrasacárido. También se describen composiciones farmacéuticas que comprenden análogos truncados de saponina y métodos sintéticos para producir la saponina truncada. Otro aspecto de la presente solicitud se refiere a un método para inmunizar un sujeto, que comprende administrar al sujeto la composición farmacéutica que comprende un análogo de saponina mínimo y un antígeno.</p>
CL2016003048A 2014-05-30 2016-11-28 Analogos de panonina minimas sintesis y uso de los mismos. CL2016003048A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462005302P 2014-05-30 2014-05-30

Publications (1)

Publication Number Publication Date
CL2016003048A1 true CL2016003048A1 (es) 2017-06-16

Family

ID=54699970

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016003048A CL2016003048A1 (es) 2014-05-30 2016-11-28 Analogos de panonina minimas sintesis y uso de los mismos.

Country Status (14)

Country Link
US (4) US10626137B2 (es)
EP (2) EP3149015B1 (es)
JP (2) JP6774943B2 (es)
KR (1) KR102424785B1 (es)
CN (2) CN112028951A (es)
AU (3) AU2015266624A1 (es)
CA (1) CA2950750C (es)
CL (1) CL2016003048A1 (es)
DK (1) DK3149015T3 (es)
ES (1) ES2887400T3 (es)
IL (3) IL290897B2 (es)
SG (2) SG10202106403QA (es)
WO (1) WO2015184451A1 (es)
ZA (4) ZA201608255B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102085687B1 (ko) * 2008-04-08 2020-03-06 슬로안-케테링인스티튜트퍼캔서리서치 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
WO2015184451A1 (en) 2014-05-30 2015-12-03 Memorial Sloan-Kettering Cancer Center Minimal saponin analogues, synthesis and use thereof
IL286493B (en) 2015-11-06 2022-07-01 Memorial Sloan Kettering Cancer Center Triterpene saponin analogues, methods of producing same, compositions comprising same and uses thereof
ES2944947T3 (es) 2015-12-17 2023-06-27 Memorial Sloan Kettering Cancer Center Variantes de triterpeno-saponina, métodos de síntesis y uso de las mismas
IL269963B2 (en) * 2017-04-13 2024-09-01 Adjuvance Tech Inc Triterpene saponin synthesis, intermediates and adjuvant combinations
CN110582282A (zh) 2017-04-25 2019-12-17 佐剂技术公司 三萜皂苷类似物
US20200164065A1 (en) * 2017-04-25 2020-05-28 Adjuvance Technologies, Inc. Triterpene saponin analogues
JP2020536946A (ja) 2017-10-16 2020-12-17 アジュバンス・テクノロジーズ・インコーポレーテッド トリテルペンサポニン類似物
US20220023433A1 (en) 2018-12-21 2022-01-27 Sapreme Technologies B.V. Saponin Conjugates
BR112022001389A8 (pt) * 2019-07-25 2023-04-25 Univ Berlin Charite Derivados de saponina com janela terapêutica melhorada
AU2020379738A1 (en) * 2019-11-05 2022-04-14 Adjuvance Technologies, Inc. Varicella zoster
KR20230043113A (ko) 2020-06-24 2023-03-30 사프렘 테크놀로지스 비.브이. 의약용 사포닌 유도체
WO2023081505A1 (en) * 2021-11-08 2023-05-11 Adjuvance Technologies, Inc. Adjuvant compounds and formulations
EP4190359A1 (en) 2021-12-03 2023-06-07 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Saponin-based adjuvants and vaccines
EP4466278A1 (en) 2022-01-19 2024-11-27 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Saponin-based adjuvants and vaccines
CN117106004B (zh) * 2022-05-17 2026-06-19 北京科兴中维生物技术有限公司 三萜皂苷化合物及其制备方法及应用
WO2024218268A1 (en) 2023-04-20 2024-10-24 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Saponin derivatives as adjuvants and photoaffinity probes
CN117244053B (zh) * 2023-10-16 2024-04-26 国药中生生物技术研究院有限公司 具有常春藤皂苷元-O-Ara结构的化合物的佐剂用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102085687B1 (ko) * 2008-04-08 2020-03-06 슬로안-케테링인스티튜트퍼캔서리서치 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
US8883170B2 (en) 2008-09-03 2014-11-11 Western Illinois University Research Foundation Adjuvant
CN103768078B (zh) * 2012-10-22 2019-02-05 北京大学 三萜衍生物及其抗流感用途
CN103265606B (zh) 2013-05-31 2015-04-01 徐江平 一种常春藤皂苷元酰胺衍生物及其制备方法及其应用
CN103694375B (zh) 2013-12-13 2016-10-05 北京大学 一种三萜-环糊精共价化合物及其制备方法和用途
WO2015184451A1 (en) * 2014-05-30 2015-12-03 Memorial Sloan-Kettering Cancer Center Minimal saponin analogues, synthesis and use thereof
IL286493B (en) * 2015-11-06 2022-07-01 Memorial Sloan Kettering Cancer Center Triterpene saponin analogues, methods of producing same, compositions comprising same and uses thereof
JP2020536946A (ja) * 2017-10-16 2020-12-17 アジュバンス・テクノロジーズ・インコーポレーテッド トリテルペンサポニン類似物

Also Published As

Publication number Publication date
IL249196B (en) 2020-08-31
AU2015266624A1 (en) 2016-12-15
US20220275017A1 (en) 2022-09-01
EP3929202A1 (en) 2021-12-29
EP3149015B1 (en) 2021-07-21
US10626137B2 (en) 2020-04-21
SG10202106403QA (en) 2021-07-29
IL276674B (en) 2022-04-01
JP6774943B2 (ja) 2020-10-28
IL290897B1 (en) 2023-06-01
ZA202304795B (en) 2024-08-28
US12187755B2 (en) 2025-01-07
DK3149015T3 (da) 2021-09-27
AU2019279971A1 (en) 2020-01-16
WO2015184451A1 (en) 2015-12-03
ZA201608255B (en) 2019-04-24
JP7145188B2 (ja) 2022-09-30
IL249196A0 (en) 2017-01-31
CN106573951B (zh) 2020-09-11
EP3149015A4 (en) 2017-12-27
EP3149015A1 (en) 2017-04-05
CA2950750A1 (en) 2015-12-03
IL290897B2 (en) 2023-10-01
US11274116B2 (en) 2022-03-15
SG11201610004PA (en) 2016-12-29
US20250223311A1 (en) 2025-07-10
AU2021245129A1 (en) 2021-11-04
US20170096444A1 (en) 2017-04-06
AU2021245129B2 (en) 2023-12-07
JP2021006570A (ja) 2021-01-21
JP2017518374A (ja) 2017-07-06
CN106573951A (zh) 2017-04-19
IL276674A (en) 2020-09-30
ZA202003022B (en) 2023-10-25
US20210070796A1 (en) 2021-03-11
AU2019279971B2 (en) 2021-07-15
IL290897A (en) 2022-04-01
ES2887400T3 (es) 2021-12-22
CN112028951A (zh) 2020-12-04
KR20170032241A (ko) 2017-03-22
CA2950750C (en) 2023-01-10
ZA201808005B (en) 2021-04-28
KR102424785B1 (ko) 2022-07-25

Similar Documents

Publication Publication Date Title
ZA202304795B (en) Minimal saponin analogues, synthesis and use thereof
CL2020001048A1 (es) Anticuerpos monoclonales contra bcma. (divisional solicitud 201800281)
CL2018000829A1 (es) Anticuerpos anti-cd19 humano con alta afinidad
CL2018001192A1 (es) Análogos de saponina triterpeno
BR112013022397A2 (pt) vacinas combinadas com doses menores de antígeno e/ou adjuvante
CL2020000879A1 (es) Análogos de saponina de triterpeno.
CO2018003452A2 (es) Anticuerpos biespecíficos contra el cd20 humano y el receptor de transferrina humano y métodos de uso
GT201300186A (es) Composiciones farmacéuticas que comprenden anticuerpos humanos frente a pcsk9
CO2017012786A2 (es) Nuevos derivados hidroxiéster, un proceso para su preparación y composiciones farmacéuticas que los contienen
CL2019003064A1 (es) Análogos de triterperno saponina.
ECSP18014922A (es) Composiciones de insulina de rápida acción
MX2016015636A (es) Formulaciones cannabinoides estables.
CO7081144A2 (es) Anticuerpos biespecíficos contra tweak humana e il17 humana y usos de los mismos
CO2020007018A2 (es) Proceso para preparar tapinarof
BR112017013661A8 (pt) Conjugado derivado de antraciclina (pnu), conjugado de fármaco-proteína de ligação (bpdc), método para a produção de um conjugado de fármaco-proteína de ligação (bpdc), uso de um conjugado de proteína de ligação-fármaco (bpdc) e composição farmacêutica
GT201400297A (es) Nuevos derivados tienopirimidina, un proceso para su preparación y composiciones farmacéuticas que los contienen
MX2020011104A (es) Composiciones farmaceuticas de compuestos terapeuticamente activos y sus metodos de uso.
SV2016005153A (es) Compuestos y composiciones como inhibidores de la mek
UY36224A (es) Compuestos tricíclicos de imidazo-pirimidinona
CR20150390A (es) Inhibidores de la yodoproteina basada en 2,3-dihidroimidazol[1,2-c]pirimidin-5(1-h)-ona-asociada a la fosfolipasa a2 (lp-pla2)
CL2019002876A1 (es) Síntesis de triterpeno-saponina, intermediarios y combinaciones adyuvantes.
ECSP17057131A (es) Desacetoxitubulisina h y análogos de esta
CO2018004581A2 (es) Compuestos de criptoficina y productos conjugados, y sus métodos de preparación
MX2022009886A (es) Reaccion de prins y compuestos utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos.
EA202191515A1 (ru) Фармацевтическая композиция, содержащая апиксабан