CL2016003048A1 - Analogos de panonina minimas sintesis y uso de los mismos. - Google Patents

Analogos de panonina minimas sintesis y uso de los mismos.

Info

Publication number
CL2016003048A1
CL2016003048A1 CL2016003048A CL2016003048A CL2016003048A1 CL 2016003048 A1 CL2016003048 A1 CL 2016003048A1 CL 2016003048 A CL2016003048 A CL 2016003048A CL 2016003048 A CL2016003048 A CL 2016003048A CL 2016003048 A1 CL2016003048 A1 CL 2016003048A1
Authority
CL
Chile
Prior art keywords
saponin
panonin
analogues
minimizes
synthesis
Prior art date
Application number
CL2016003048A
Other languages
English (en)
Inventor
David Y Gin
Eric K Chea
Alberto Fernandez-Tejada
Derek S Tan
Jason S Lewis
Jeffrey R Gardner
Nagavarakishore Pillarsetty
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of CL2016003048A1 publication Critical patent/CL2016003048A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

<p>Se describen análogos truncados de saponina triterpénica que contienen un trisacárido o éster tetrasacárido. También se describen composiciones farmacéuticas que comprenden análogos truncados de saponina y métodos sintéticos para producir la saponina truncada. Otro aspecto de la presente solicitud se refiere a un método para inmunizar un sujeto, que comprende administrar al sujeto la composición farmacéutica que comprende un análogo de saponina mínimo y un antígeno.</p>
CL2016003048A 2014-05-30 2016-11-28 Analogos de panonina minimas sintesis y uso de los mismos. CL2016003048A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462005302P 2014-05-30 2014-05-30

Publications (1)

Publication Number Publication Date
CL2016003048A1 true CL2016003048A1 (es) 2017-06-16

Family

ID=54699970

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016003048A CL2016003048A1 (es) 2014-05-30 2016-11-28 Analogos de panonina minimas sintesis y uso de los mismos.

Country Status (14)

Country Link
US (4) US10626137B2 (es)
EP (2) EP3149015B1 (es)
JP (2) JP6774943B2 (es)
KR (1) KR102424785B1 (es)
CN (2) CN112028951A (es)
AU (3) AU2015266624A1 (es)
CA (1) CA2950750C (es)
CL (1) CL2016003048A1 (es)
DK (1) DK3149015T3 (es)
ES (1) ES2887400T3 (es)
IL (3) IL290897B2 (es)
SG (2) SG11201610004PA (es)
WO (1) WO2015184451A1 (es)
ZA (4) ZA201608255B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2280987B1 (en) * 2008-04-08 2018-05-23 Sloan-Kettering Institute for Cancer Research Triterpene saponins, methods of synthesis, and uses thereof
SG11201610004PA (en) * 2014-05-30 2016-12-29 Sloan Kettering Inst Cancer Minimal saponin analogues, synthesis and use thereof
IL286493B (en) 2015-11-06 2022-07-01 Memorial Sloan Kettering Cancer Center Triterpene saponin analogues, methods of producing same, compositions comprising same and uses thereof
DK3389669T3 (da) * 2015-12-17 2023-05-01 Memorial Sloan Kettering Cancer Center Triterpensaponinvarianter, syntesefremgangsmåder og anvendelse deraf
WO2018191598A1 (en) * 2017-04-13 2018-10-18 Adjuvance Technologies, Inc. Triterpene saponin synthesis, intermediates and adjuvant combinations
WO2018200656A1 (en) * 2017-04-25 2018-11-01 Adjuvance Technologies, Inc. Triterpene saponin analogues
AU2018258070A1 (en) 2017-04-25 2019-10-24 Adjuvance Technologies, Inc. Triterpene saponin analogues
WO2019079160A1 (en) 2017-10-16 2019-04-25 Adjuvance Technologies, Inc. TRITERPENIC SAPONIN ANALOGS
BR112021012222A8 (pt) 2018-12-21 2023-04-25 Univ Berlin Charite Molécula de ligação direcionada à célula melhorada
EP4635501A3 (en) * 2019-07-25 2026-01-28 Sapreme Technologies B.V. Saponin derivatives with improved therapeutic window
KR20220097396A (ko) * 2019-11-05 2022-07-07 아쥬반스 테크놀로지스 인코포레이티드 바리셀라 조스터
IL299358A (en) 2020-06-24 2023-02-01 Sapreme Tech Bv Medicinal preparations containing saponin derivatives
US20250025550A1 (en) * 2021-11-08 2025-01-23 Adjuvance Technologies, Inc. Adjuvant compounds and formulations
EP4190359A1 (en) 2021-12-03 2023-06-07 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Saponin-based adjuvants and vaccines
US20250114448A1 (en) 2022-01-19 2025-04-10 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Saponin-based adjuvants and vaccines
CN117106004A (zh) * 2022-05-17 2023-11-24 北京科兴中维生物技术有限公司 三萜皂苷化合物及其制备方法及应用
WO2024218268A1 (en) 2023-04-20 2024-10-24 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Saponin derivatives as adjuvants and photoaffinity probes
CN117244053B (zh) * 2023-10-16 2024-04-26 国药中生生物技术研究院有限公司 具有常春藤皂苷元-O-Ara结构的化合物的佐剂用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2280987B1 (en) * 2008-04-08 2018-05-23 Sloan-Kettering Institute for Cancer Research Triterpene saponins, methods of synthesis, and uses thereof
US8883170B2 (en) * 2008-09-03 2014-11-11 Western Illinois University Research Foundation Adjuvant
CN103768078B (zh) * 2012-10-22 2019-02-05 北京大学 三萜衍生物及其抗流感用途
CN103265606B (zh) 2013-05-31 2015-04-01 徐江平 一种常春藤皂苷元酰胺衍生物及其制备方法及其应用
CN103694375B (zh) 2013-12-13 2016-10-05 北京大学 一种三萜-环糊精共价化合物及其制备方法和用途
SG11201610004PA (en) * 2014-05-30 2016-12-29 Sloan Kettering Inst Cancer Minimal saponin analogues, synthesis and use thereof
IL286493B (en) * 2015-11-06 2022-07-01 Memorial Sloan Kettering Cancer Center Triterpene saponin analogues, methods of producing same, compositions comprising same and uses thereof
WO2019079160A1 (en) * 2017-10-16 2019-04-25 Adjuvance Technologies, Inc. TRITERPENIC SAPONIN ANALOGS

Also Published As

Publication number Publication date
US20220275017A1 (en) 2022-09-01
ZA201608255B (en) 2019-04-24
AU2021245129B2 (en) 2023-12-07
IL290897B1 (en) 2023-06-01
CN112028951A (zh) 2020-12-04
IL290897A (en) 2022-04-01
IL249196B (en) 2020-08-31
US10626137B2 (en) 2020-04-21
IL276674A (en) 2020-09-30
CA2950750A1 (en) 2015-12-03
US20210070796A1 (en) 2021-03-11
AU2015266624A1 (en) 2016-12-15
US20250223311A1 (en) 2025-07-10
WO2015184451A1 (en) 2015-12-03
JP2017518374A (ja) 2017-07-06
AU2019279971A1 (en) 2020-01-16
SG10202106403QA (en) 2021-07-29
US11274116B2 (en) 2022-03-15
CN106573951B (zh) 2020-09-11
EP3149015A1 (en) 2017-04-05
AU2019279971B2 (en) 2021-07-15
JP2021006570A (ja) 2021-01-21
US12187755B2 (en) 2025-01-07
SG11201610004PA (en) 2016-12-29
ZA202003022B (en) 2023-10-25
CA2950750C (en) 2023-01-10
CN106573951A (zh) 2017-04-19
EP3929202A1 (en) 2021-12-29
IL249196A0 (en) 2017-01-31
EP3149015B1 (en) 2021-07-21
ES2887400T3 (es) 2021-12-22
EP3149015A4 (en) 2017-12-27
ZA202304795B (en) 2024-08-28
JP7145188B2 (ja) 2022-09-30
AU2021245129A1 (en) 2021-11-04
KR20170032241A (ko) 2017-03-22
JP6774943B2 (ja) 2020-10-28
IL290897B2 (en) 2023-10-01
US20170096444A1 (en) 2017-04-06
IL276674B (en) 2022-04-01
KR102424785B1 (ko) 2022-07-25
ZA201808005B (en) 2021-04-28
DK3149015T3 (da) 2021-09-27

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