DK3149015T3 - Minimale saponin-analoger, syntese og anvendelse deraf - Google Patents

Minimale saponin-analoger, syntese og anvendelse deraf Download PDF

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Publication number
DK3149015T3
DK3149015T3 DK15798814.8T DK15798814T DK3149015T3 DK 3149015 T3 DK3149015 T3 DK 3149015T3 DK 15798814 T DK15798814 T DK 15798814T DK 3149015 T3 DK3149015 T3 DK 3149015T3
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DK
Denmark
Prior art keywords
analoges
saponin
synthesis
minimum
saponin analoges
Prior art date
Application number
DK15798814.8T
Other languages
English (en)
Inventor
Eric K Chea
Alberto Fernandez-Tejada
Derek S Tan
Jason S Lewis
Jeffrey R Gardner
Nagavarakishore Pillarsetty
David Y Gin
Original Assignee
Memorial Sloan Kettering Cancer Center
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Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Application granted granted Critical
Publication of DK3149015T3 publication Critical patent/DK3149015T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK15798814.8T 2014-05-30 2015-06-01 Minimale saponin-analoger, syntese og anvendelse deraf DK3149015T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462005302P 2014-05-30 2014-05-30
PCT/US2015/033567 WO2015184451A1 (en) 2014-05-30 2015-06-01 Minimal saponin analogues, synthesis and use thereof

Publications (1)

Publication Number Publication Date
DK3149015T3 true DK3149015T3 (da) 2021-09-27

Family

ID=54699970

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15798814.8T DK3149015T3 (da) 2014-05-30 2015-06-01 Minimale saponin-analoger, syntese og anvendelse deraf

Country Status (14)

Country Link
US (4) US10626137B2 (da)
EP (2) EP3149015B1 (da)
JP (2) JP6774943B2 (da)
KR (1) KR102424785B1 (da)
CN (2) CN106573951B (da)
AU (3) AU2015266624A1 (da)
CA (1) CA2950750C (da)
CL (1) CL2016003048A1 (da)
DK (1) DK3149015T3 (da)
ES (1) ES2887400T3 (da)
IL (3) IL290897B2 (da)
SG (2) SG10202106403QA (da)
WO (1) WO2015184451A1 (da)
ZA (4) ZA201608255B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102256410B1 (ko) * 2008-04-08 2021-05-26 슬로안-케테링인스티튜트퍼캔서리서치 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
KR102424785B1 (ko) * 2014-05-30 2022-07-25 메모리얼 슬로안 케터링 캔서 센터 최소 사포닌 유사체, 이의 합성법 및 용도
CN108778289B (zh) * 2015-11-06 2020-11-17 佐剂技术公司 三萜皂苷类似物
ES2944947T3 (es) 2015-12-17 2023-06-27 Memorial Sloan Kettering Cancer Center Variantes de triterpeno-saponina, métodos de síntesis y uso de las mismas
WO2018191598A1 (en) * 2017-04-13 2018-10-18 Adjuvance Technologies, Inc. Triterpene saponin synthesis, intermediates and adjuvant combinations
CA3061205A1 (en) 2017-04-25 2018-11-01 Memorial Sloan Kettering Cancer Center Triterpene saponin analogues
US20200164065A1 (en) * 2017-04-25 2020-05-28 Adjuvance Technologies, Inc. Triterpene saponin analogues
SG11202001826YA (en) * 2017-10-16 2020-03-30 Adjuvance Technologies Inc Triterpene saponin analogues
SG11202106603UA (en) 2018-12-21 2021-07-29 Sapreme Tech Bv Biologically active cluster of molecules
ES3056941T3 (en) * 2019-07-25 2026-02-25 Sapreme Tech Bv Saponin derivatives with improved therapeutic window
IL292796A (en) * 2019-11-05 2022-07-01 Adjuvance Tech Inc Varicella zoster immunogenic compositions and uses thereof
WO2021260054A2 (en) 2020-06-24 2021-12-30 Sapreme Technologies B.V. Saponin derivatives with improved therapeutic window
EP4429674A4 (en) * 2021-11-08 2025-10-08 Adjuvance Tech Inc ADJUVANT COMPOUNDS AND FORMULATIONS
EP4190359A1 (en) 2021-12-03 2023-06-07 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Saponin-based adjuvants and vaccines
EP4466278A1 (en) 2022-01-19 2024-11-27 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Saponin-based adjuvants and vaccines
CN117106004A (zh) * 2022-05-17 2023-11-24 北京科兴中维生物技术有限公司 三萜皂苷化合物及其制备方法及应用
EP4698224A1 (en) 2023-04-20 2026-02-25 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Saponin derivatives as adjuvants and photoaffinity probes
CN117244053B (zh) * 2023-10-16 2024-04-26 国药中生生物技术研究院有限公司 具有常春藤皂苷元-O-Ara结构的化合物的佐剂用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102256410B1 (ko) * 2008-04-08 2021-05-26 슬로안-케테링인스티튜트퍼캔서리서치 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
US8883170B2 (en) * 2008-09-03 2014-11-11 Western Illinois University Research Foundation Adjuvant
CN103768078B (zh) * 2012-10-22 2019-02-05 北京大学 三萜衍生物及其抗流感用途
CN103265606B (zh) 2013-05-31 2015-04-01 徐江平 一种常春藤皂苷元酰胺衍生物及其制备方法及其应用
CN103694375B (zh) 2013-12-13 2016-10-05 北京大学 一种三萜-环糊精共价化合物及其制备方法和用途
KR102424785B1 (ko) * 2014-05-30 2022-07-25 메모리얼 슬로안 케터링 캔서 센터 최소 사포닌 유사체, 이의 합성법 및 용도
CN108778289B (zh) * 2015-11-06 2020-11-17 佐剂技术公司 三萜皂苷类似物
SG11202001826YA (en) * 2017-10-16 2020-03-30 Adjuvance Technologies Inc Triterpene saponin analogues

Also Published As

Publication number Publication date
SG10202106403QA (en) 2021-07-29
IL290897A (en) 2022-04-01
SG11201610004PA (en) 2016-12-29
CA2950750A1 (en) 2015-12-03
KR102424785B1 (ko) 2022-07-25
AU2015266624A1 (en) 2016-12-15
AU2021245129A1 (en) 2021-11-04
EP3929202A1 (en) 2021-12-29
US12187755B2 (en) 2025-01-07
CN106573951A (zh) 2017-04-19
US10626137B2 (en) 2020-04-21
WO2015184451A1 (en) 2015-12-03
JP2021006570A (ja) 2021-01-21
ZA202003022B (en) 2023-10-25
IL276674A (en) 2020-09-30
CN112028951A (zh) 2020-12-04
US20170096444A1 (en) 2017-04-06
IL276674B (en) 2022-04-01
AU2021245129B2 (en) 2023-12-07
EP3149015A4 (en) 2017-12-27
IL249196A0 (en) 2017-01-31
CL2016003048A1 (es) 2017-06-16
AU2019279971B2 (en) 2021-07-15
US20220275017A1 (en) 2022-09-01
CN106573951B (zh) 2020-09-11
JP2017518374A (ja) 2017-07-06
IL249196B (en) 2020-08-31
US20210070796A1 (en) 2021-03-11
CA2950750C (en) 2023-01-10
ZA202304795B (en) 2024-08-28
EP3149015A1 (en) 2017-04-05
IL290897B2 (en) 2023-10-01
ZA201608255B (en) 2019-04-24
US20250223311A1 (en) 2025-07-10
JP6774943B2 (ja) 2020-10-28
JP7145188B2 (ja) 2022-09-30
ES2887400T3 (es) 2021-12-22
KR20170032241A (ko) 2017-03-22
EP3149015B1 (en) 2021-07-21
US11274116B2 (en) 2022-03-15
IL290897B1 (en) 2023-06-01
ZA201808005B (en) 2021-04-28
AU2019279971A1 (en) 2020-01-16

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