CL2016003277A1 - Métodos para preparar análogos de nucleótido sustituidos - Google Patents

Métodos para preparar análogos de nucleótido sustituidos

Info

Publication number
CL2016003277A1
CL2016003277A1 CL2016003277A CL2016003277A CL2016003277A1 CL 2016003277 A1 CL2016003277 A1 CL 2016003277A1 CL 2016003277 A CL2016003277 A CL 2016003277A CL 2016003277 A CL2016003277 A CL 2016003277A CL 2016003277 A1 CL2016003277 A1 CL 2016003277A1
Authority
CL
Chile
Prior art keywords
methods
nucleotide analogs
preparing substituted
substituted nucleotide
preparing
Prior art date
Application number
CL2016003277A
Other languages
English (en)
Inventor
Leonid Beigelman
Vladimir Serebryany
Original Assignee
Alios Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alios Biopharma Inc filed Critical Alios Biopharma Inc
Publication of CL2016003277A1 publication Critical patent/CL2016003277A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

<p>SE DESCRIBEN AQUÍ MÉTODOS PARA PREPARAR UN ANÁLOGO DE NUCLEÓTIDO DE FOSFOROAMIDATO QUE SON ÚTILES AL TRATAR ENFERMEDADES Y/O CONDICIONES TAL COMO INFECCIONES VIRALES.</p>
CL2016003277A 2014-06-24 2016-12-21 Métodos para preparar análogos de nucleótido sustituidos CL2016003277A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462016229P 2014-06-24 2014-06-24

Publications (1)

Publication Number Publication Date
CL2016003277A1 true CL2016003277A1 (es) 2017-06-02

Family

ID=54869042

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016003277A CL2016003277A1 (es) 2014-06-24 2016-12-21 Métodos para preparar análogos de nucleótido sustituidos

Country Status (17)

Country Link
US (1) US20150368286A1 (es)
EP (1) EP3160979A4 (es)
JP (1) JP2017519779A (es)
KR (1) KR20170026494A (es)
CN (1) CN106661076A (es)
AU (1) AU2015280245A1 (es)
BR (1) BR112016029994A2 (es)
CA (1) CA2952812A1 (es)
CL (1) CL2016003277A1 (es)
EA (1) EA201692473A1 (es)
IL (1) IL249456A0 (es)
MX (1) MX2016017382A (es)
NZ (1) NZ727392A (es)
PH (1) PH12016502555A1 (es)
SG (1) SG11201610259SA (es)
TW (1) TW201625659A (es)
WO (1) WO2015200216A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2794630A4 (en) 2011-12-22 2015-04-01 Alios Biopharma Inc SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE
KR102072041B1 (ko) 2011-12-22 2020-01-31 앨리오스 바이오파마 인크. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
NZ631601A (en) 2012-03-21 2016-06-24 Alios Biopharma Inc Solid forms of a thiophosphoramidate nucleotide prodrug
AU2013361193B2 (en) 2012-12-21 2018-05-24 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
TW201532606A (zh) 2013-04-05 2015-09-01 Alios Biopharma Inc 使用化合物之組合治療ｃ型肝炎病毒感染
ES2952714T3 (es) 2013-06-26 2023-11-03 Janssen Pharmaceuticals Inc Nucleósidos sustituidos, nucleótidos y análogos de los mismos
AU2014302715B2 (en) 2013-06-26 2018-12-06 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CN105829333A (zh) 2013-10-11 2016-08-03 艾丽奥斯生物制药有限公司 取代的核苷、核苷酸及其类似物
US9603864B2 (en) 2014-06-24 2017-03-28 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
SG11201610597QA (en) 2014-06-24 2017-01-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
CN107108681B (zh) 2014-10-28 2021-04-06 詹森生物制药有限公司 制备取代的核苷类似物的方法
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
MA41441A (fr) 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
WO2016145103A1 (en) 2015-03-11 2016-09-15 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
WO2019237297A1 (en) * 2018-06-14 2019-12-19 Janssen Pharmaceuticals, Inc. Processes for preparing compounds/intermediates useful in the treatment of viral infections

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817978A (en) * 1971-06-16 1974-06-18 Syntex Inc 4-fluoro nucleosides and sugar intermediates, and methods of preparing
MD20140134A2 (ro) * 2012-05-22 2015-04-30 Idenix Pharmaceuticals, Inc. Compuşi ai D-aminoacizilor pentru tratamentul bolilor hepatice
US9243022B2 (en) * 2012-12-21 2016-01-26 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AU2014265293B2 (en) * 2013-05-16 2019-07-18 Riboscience Llc 4'-Fluoro-2'-methyl substituted nucleoside derivatives
ES2952714T3 (es) * 2013-06-26 2023-11-03 Janssen Pharmaceuticals Inc Nucleósidos sustituidos, nucleótidos y análogos de los mismos
CN105829333A (zh) * 2013-10-11 2016-08-03 艾丽奥斯生物制药有限公司 取代的核苷、核苷酸及其类似物
CN107108681B (zh) * 2014-10-28 2021-04-06 詹森生物制药有限公司 制备取代的核苷类似物的方法
MA41441A (fr) * 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci

Also Published As

Publication number Publication date
EA201692473A1 (ru) 2017-03-31
US20150368286A1 (en) 2015-12-24
AU2015280245A1 (en) 2017-01-05
TW201625659A (zh) 2016-07-16
KR20170026494A (ko) 2017-03-08
MX2016017382A (es) 2017-04-27
PH12016502555A1 (en) 2017-04-10
IL249456A0 (en) 2017-02-28
SG11201610259SA (en) 2017-01-27
CN106661076A (zh) 2017-05-10
WO2015200216A1 (en) 2015-12-30
EP3160979A4 (en) 2018-01-03
BR112016029994A2 (pt) 2017-08-22
NZ727392A (en) 2018-04-27
JP2017519779A (ja) 2017-07-20
EP3160979A1 (en) 2017-05-03
CA2952812A1 (en) 2015-12-30

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