CL2017001204A1 - Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteína quinasa - Google Patents

Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteína quinasa

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Publication number
CL2017001204A1
CL2017001204A1 CL2017001204A CL2017001204A CL2017001204A1 CL 2017001204 A1 CL2017001204 A1 CL 2017001204A1 CL 2017001204 A CL2017001204 A CL 2017001204A CL 2017001204 A CL2017001204 A CL 2017001204A CL 2017001204 A1 CL2017001204 A1 CL 2017001204A1
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CL
Chile
Prior art keywords
deaza
amino
protein kinase
bicyclo
kinase inhibitors
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CL2017001204A
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English (en)
Inventor
Laura Buffa
Francesca Quartieri
Ilaria Motto
Maria Menichincheri
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Nerviano Medical Sciences Srl
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Publication date
Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl
Publication of CL2017001204A1 publication Critical patent/CL2017001204A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<p>LA PRESENTE INVENCIÓN SE REFIERE A DERIVADOS DE 6-AMINO-7-BICICLO-7-DEAZA-PURINA, QUE MODULAN LA ACTIVIDAD DE LAS PROTEÍNAS QUINASAS Y SON POR LO TANTO ÚTILES EN EL TRATAMIENTO DE ENFERMEDADES CAUSADAS POR LA ACTIVIDAD DESREGULADA DE LA PROTEÍNA QUINASA. LA PRESENTE INVENCIÓN TAMBIÉN PROPORCIONA MÉTODOS PARA PREPARAR ESTOS COMPUESTOS, COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN ESTOS COMPUESTOS, Y MÉTODOS DE TRATAMIENTO DE ENFERMEDADES QUE UTILIZAN COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN ESTOS COMPUESTOS.</p>
CL2017001204A 2014-11-14 2017-05-11 Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteína quinasa CL2017001204A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14193197 2014-11-14

Publications (1)

Publication Number Publication Date
CL2017001204A1 true CL2017001204A1 (es) 2017-12-29

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ID=51904767

Family Applications (1)

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Country Link
US (1) US10221181B2 (es)
EP (1) EP3218378B1 (es)
JP (1) JP6421241B2 (es)
KR (1) KR102562866B1 (es)
CN (1) CN107108631B (es)
AU (1) AU2015345054B2 (es)
CA (1) CA2967125C (es)
CL (1) CL2017001204A1 (es)
EA (1) EA039885B1 (es)
ES (1) ES2792036T3 (es)
MX (1) MX382607B (es)
PL (1) PL3218378T3 (es)
WO (1) WO2016075224A1 (es)

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MX2017006366A (es) 2018-02-01
ES2792036T3 (es) 2020-11-06
EA039885B1 (ru) 2022-03-23
KR102562866B1 (ko) 2023-08-04
CA2967125A1 (en) 2016-05-19
EP3218378A1 (en) 2017-09-20
JP2017533932A (ja) 2017-11-16
PL3218378T3 (pl) 2020-10-19
AU2015345054B2 (en) 2020-03-05
CN107108631A (zh) 2017-08-29
US20170327506A1 (en) 2017-11-16
CA2967125C (en) 2022-10-25
KR20170082637A (ko) 2017-07-14
MX382607B (es) 2025-03-13
AU2015345054A1 (en) 2017-06-29
WO2016075224A1 (en) 2016-05-19
CN107108631B (zh) 2020-06-16
US10221181B2 (en) 2019-03-05
EA201791018A1 (ru) 2018-03-30
EP3218378B1 (en) 2020-01-08
JP6421241B2 (ja) 2018-11-07

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