CL2016003348A1 - Procedimiento para preparar microcápsulas entéricas de alginato de calcio que contienen diclofenaco o una de sus sales mediante gelificación iónica, opcionalmente recubiertas con un polímero de metacrilato. (divisional sol. 2465-2014) - Google Patents

Procedimiento para preparar microcápsulas entéricas de alginato de calcio que contienen diclofenaco o una de sus sales mediante gelificación iónica, opcionalmente recubiertas con un polímero de metacrilato. (divisional sol. 2465-2014)

Info

Publication number
CL2016003348A1
CL2016003348A1 CL2016003348A CL2016003348A CL2016003348A1 CL 2016003348 A1 CL2016003348 A1 CL 2016003348A1 CL 2016003348 A CL2016003348 A CL 2016003348A CL 2016003348 A CL2016003348 A CL 2016003348A CL 2016003348 A1 CL2016003348 A1 CL 2016003348A1
Authority
CL
Chile
Prior art keywords
divisional
sun
salt
procedure
calcium alginate
Prior art date
Application number
CL2016003348A
Other languages
English (en)
Inventor
Los Mario Atilio
Original Assignee
Eastbrand Holding Gmbh
Laboratorios Bago S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastbrand Holding Gmbh, Laboratorios Bago S A filed Critical Eastbrand Holding Gmbh
Publication of CL2016003348A1 publication Critical patent/CL2016003348A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

<p>COMPOSICION FARMACEUTICA MULTILPARTICULADA ORAL EN FORMA DE CAPSULAS, POLVO PARA SUSPENSION EN AGUA O COMPRIMIDOS MASTICABLES QUE COMPRENDE DICLOFENACO O SUS SALES SOLO O JUNTO A UN INHIBIDOR DE LA BOMBA DE PROTONES, TAL COMO OMEPRAZOL, EN FOMA DE MICROCAPSULAS ENTERICAS CON UNA COMPOSICION HOMOGENEA (DIVISIONAL SOL. 2465-2014).</p>
CL2016003348A 2012-03-20 2016-12-27 Procedimiento para preparar microcápsulas entéricas de alginato de calcio que contienen diclofenaco o una de sus sales mediante gelificación iónica, opcionalmente recubiertas con un polímero de metacrilato. (divisional sol. 2465-2014) CL2016003348A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2012/054904 WO2013139377A1 (en) 2012-03-20 2012-03-20 Method for producing enteric alginate microcapsules via ionic gelation containing diclofenac or one of the salts thereof and multiparticled pharmaceutical composition containing them
CL2014002465A CL2014002465A1 (es) 2012-03-20 2014-09-17 Procedimiento para producir microcapsulas entericas de alginato de calcio que contienen diclofenaco o una de sus sales; composición farmacéutica oral que las comprende; combinacion farmaceutica.

Publications (1)

Publication Number Publication Date
CL2016003348A1 true CL2016003348A1 (es) 2018-03-23

Family

ID=45855800

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2014002465A CL2014002465A1 (es) 2012-03-20 2014-09-17 Procedimiento para producir microcapsulas entericas de alginato de calcio que contienen diclofenaco o una de sus sales; composición farmacéutica oral que las comprende; combinacion farmaceutica.
CL2016003348A CL2016003348A1 (es) 2012-03-20 2016-12-27 Procedimiento para preparar microcápsulas entéricas de alginato de calcio que contienen diclofenaco o una de sus sales mediante gelificación iónica, opcionalmente recubiertas con un polímero de metacrilato. (divisional sol. 2465-2014)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2014002465A CL2014002465A1 (es) 2012-03-20 2014-09-17 Procedimiento para producir microcapsulas entericas de alginato de calcio que contienen diclofenaco o una de sus sales; composición farmacéutica oral que las comprende; combinacion farmaceutica.

Country Status (15)

Country Link
US (2) US9668978B2 (es)
EP (1) EP2827843B1 (es)
CN (1) CN104244927B (es)
AR (1) AR090187A1 (es)
BR (1) BR112014023278B1 (es)
CA (1) CA2899664C (es)
CL (2) CL2014002465A1 (es)
ES (1) ES2584403T3 (es)
MX (1) MX354454B (es)
PH (1) PH12014501981A1 (es)
PL (1) PL2827843T3 (es)
SG (1) SG11201505320TA (es)
UA (1) UA112345C2 (es)
WO (1) WO2013139377A1 (es)
ZA (1) ZA201406886B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3277267B1 (en) 2015-03-31 2021-01-06 Laboratorios Bagó S.A. Enteric-coated pellets containing a proton pump inhibitor
EP3377046A1 (en) * 2015-11-17 2018-09-26 Rontis Hellas S.A. Pharmaceutical composition containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
CN109498571B (zh) * 2018-11-19 2019-09-10 朗天药业(湖北)有限公司 一种艾司奥美拉唑钠缓释微球及其制备方法
TW202126301A (zh) 2019-10-04 2021-07-16 愛爾蘭商席歐拉斯製藥有限公司 小兒懸浮調配物
CN112494450A (zh) * 2020-12-12 2021-03-16 海南海神同洲制药有限公司 化学药专用口腔崩解片包覆结构及其制备方法
CN115317464B (zh) * 2022-09-01 2023-08-08 苏州弘森药业股份有限公司 一种双氯芬酸钾微胶囊及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0520119A1 (de) 1991-06-17 1992-12-30 Spirig Ag Pharmazeutische Präparate Neue orale Diclofenaczubereitung
ES2173096T3 (es) 1992-08-05 2002-10-16 Faulding F H & Co Ltd Composicion farmaceutica peletizada.
ES2068762B1 (es) * 1993-07-21 1995-12-01 Lipotec Sa Un nuevo preparado farmaceutico para mejorar la biodisponibilidad de drogas de dificil absorcion y procedimiento para su obtencion.
US6096344A (en) * 1995-07-28 2000-08-01 Advanced Polymer Systems, Inc. Bioerodible porous compositions
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
US7687542B2 (en) * 1996-05-17 2010-03-30 Kowa Pharmaeuticals America, Inc. Rapidly bioavailable tablet and capsule formulations of diclofenac
US6544556B1 (en) * 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
AR044398A1 (es) 2004-05-19 2005-09-14 Bago Sa Labor Procedimiento para la elaboracion de microcapsulas recubiertas que contienen agentes farmacologicamente activos y composiciones farmaceuticas conteniendo dichas microcapsulas".

Also Published As

Publication number Publication date
UA112345C2 (uk) 2016-08-25
MX354454B (es) 2018-03-06
SG11201505320TA (en) 2015-08-28
US9668978B2 (en) 2017-06-06
CA2899664A1 (en) 2013-09-26
WO2013139377A1 (en) 2013-09-26
EP2827843B1 (en) 2016-05-25
ES2584403T3 (es) 2016-09-27
CA2899664C (en) 2019-07-09
CL2014002465A1 (es) 2015-05-08
PL2827843T3 (pl) 2016-11-30
ZA201406886B (en) 2015-06-24
BR112014023278B1 (pt) 2021-11-16
US20170172934A1 (en) 2017-06-22
AR090187A1 (es) 2014-10-22
CN104244927A (zh) 2014-12-24
MX2014011289A (es) 2015-02-17
CN104244927B (zh) 2017-03-15
US20150072000A1 (en) 2015-03-12
PH12014501981B1 (en) 2014-11-24
PH12014501981A1 (en) 2014-11-24
EP2827843A1 (en) 2015-01-28
BR112014023278A2 (es) 2017-06-20
US9918941B2 (en) 2018-03-20

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