CL2017000105A1 - Novedosas pirimidinas 2,5-sustituidas. - Google Patents

Novedosas pirimidinas 2,5-sustituidas.

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Publication number
CL2017000105A1
CL2017000105A1 CL2017000105A CL2017000105A CL2017000105A1 CL 2017000105 A1 CL2017000105 A1 CL 2017000105A1 CL 2017000105 A CL2017000105 A CL 2017000105A CL 2017000105 A CL2017000105 A CL 2017000105A CL 2017000105 A1 CL2017000105 A1 CL 2017000105A1
Authority
CL
Chile
Prior art keywords
medications
innovative
substituted pyrimidines
variable
chemical
Prior art date
Application number
CL2017000105A
Other languages
English (en)
Inventor
Antonio Nardi
Florian Jakob
Ingo Konetzki
Tobias Craan
Christian Hesslinger
Andre Welbers
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of CL2017000105A1 publication Critical patent/CL2017000105A1/es

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

<p>COMPUESTOS NOVEDOSOS DE PIRIMIDINA SUSTITUIDOS DE FÓRMULA GENERAL (I):</p> <p>* incluir figura de estructura de hoja resumen escrito 13-01-2017 (Pag 355)</p> <p>EN LOS CUALES LOS GRUPOS QUÍMICOS, SUSTITUYENTES, VARIABLES E ÍNDICES SON TAL COMO SE LOS DEFINE EN LA DESCRIPCIÓN, Y A SU USO COMO MEDICAMENTOS, EN EN LOS CUALES LOS GRUPOS QUÍMICOS, SUSTITUYENTES, VARIABLES E ÍNDICES SON TAL COMO SE LOS DEFINE EN LA DESCRIPCIÓN, Y A SU USO COMO MEDICAMENTOS, EN PARTICULAR COMO MEDICAMENTOS PARA EL TRATAMIENTO DE CONDICIONES Y ENFERMEDADES QUE SE PUEDEN TRATAR POR INHIBICIÓN DE LA ENZIMA PDE4.</p>
CL2017000105A 2014-07-16 2017-01-13 Novedosas pirimidinas 2,5-sustituidas. CL2017000105A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14002451 2014-07-16

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CL2017000105A1 true CL2017000105A1 (es) 2017-07-21

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CL2017000105A CL2017000105A1 (es) 2014-07-16 2017-01-13 Novedosas pirimidinas 2,5-sustituidas.

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Country Link
US (1) US9315490B2 (es)
EP (2) EP3415509A1 (es)
JP (1) JP6726655B2 (es)
KR (1) KR20170032420A (es)
CN (1) CN106488916A (es)
AR (1) AR101197A1 (es)
AU (1) AU2015291477B2 (es)
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WO2017144633A1 (en) * 2016-02-25 2017-08-31 Asceneuron S. A. Glycosidase inhibitors
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WO2018234353A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH Novel substituted indole and indazole compounds as phosphodiesterase inhibitors
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